{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:48:15Z","timestamp":1781909295414,"version":"3.54.5"},"reference-count":52,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: The present study evaluates predictive implications of the pretherapeutic Fibrinogen\u2013Albumin-Ratio Index (FARI) in high-grade serous ovarian cancer (HGSOC) patients undergoing primary cytoreductive surgery. Methods: This retrospective study included 161 patients with HGSOC International Federation of Gynecology and Obstetrics (FIGO) stage \u2265 IIb, who underwent primary cytoreductive surgery followed by platinum-based chemotherapy. Associations between the FARI and complete tumor resection status were described by receiver operating characteristics, and binary logistic regression models were fitted. Results: Higher preoperative FARI values correlated with higher ascites volumes (r = 0.371, p &lt; 0.001), and higher CA125 levels (r = 0.271, p = 0.001). A high FARI cut at its median (\u226511.06) was associated with lower rates of complete tumor resection (OR 3.13, 95% CI [1.63\u20136.05], p = 0.001), and retrained its predictive value in a multivariable model independent of ascites volumes, CA125 levels, FIGO stage, and Charlson Comorbidity Index (CCI). Conclusions: The FARI appears to act as a surrogate for higher intra-abdominal tumor load. After clinical validation, FARI could serve as a readily available serologic biomarker to complement preoperative patient assessment, helping to identify patients who are likely to achieve complete tumor resection during primary cytoreductive surgery.<\/jats:p>","DOI":"10.3390\/cancers16193295","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T06:10:27Z","timestamp":1727417427000},"page":"3295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Predictive Value of the Fibrinogen\u2013Albumin-Ratio Index on Surgical Outcomes in Patients with Advanced High-Grade Serous Ovarian Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Magdalena","family":"Postl","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0289-3738","authenticated-orcid":false,"given":"Melina","family":"Danisch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridolin","family":"Schrott","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-1481","authenticated-orcid":false,"given":"Paul","family":"Kofler","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9980-5312","authenticated-orcid":false,"given":"Patrik","family":"Petrov","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6760-949X","authenticated-orcid":false,"given":"Stefanie","family":"Aust","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Concin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-4505","authenticated-orcid":false,"given":"Stephan","family":"Polterauer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1938-1574","authenticated-orcid":false,"given":"Thomas","family":"Bartl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of General Gynecology and Gynecologic Oncology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/cncr.24149","article-title":"Role of Surgical Outcome as Prognostic Factor in Advanced Epithelial Ovarian Cancer: A Combined Exploratory Analysis of 3 Prospectively Randomized Phase 3 Multicenter Trials: By the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d\u2019Investigateurs Nationaux Pour Les Etudes Des Cancers de l\u2019Ovaire (GINECO)","volume":"115","author":"Reuss","year":"2009","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1056\/NEJMoa0908806","article-title":"Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer","volume":"363","author":"Vergote","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(14)62223-6","article-title":"Primary Chemotherapy versus Primary Surgery for Newly Diagnosed Advanced Ovarian Cancer (CHORUS): An Open-Label, Randomised, Controlled, Non-Inferiority Trial","volume":"386","author":"Kehoe","year":"2015","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1136\/ijgc-2020-001640","article-title":"Randomized Trial of Primary Debulking Surgery versus Neoadjuvant Chemotherapy for Advanced Epithelial Ovarian Cancer (SCORPION-NCT01461850)","volume":"30","author":"Fagotti","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejca.2020.02.020","article-title":"Comparison of Survival between Primary Debulking Surgery and Neoadjuvant Chemotherapy for Stage III\/IV Ovarian, Tubal and Peritoneal Cancers in Phase III Randomised Trial","volume":"130","author":"Onda","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/ijgc-2019-000682","article-title":"TRUST: Trial of Radical Upfront Surgical Therapy in Advanced Ovarian Cancer (ENGOT Ov33\/AGO-OVAR OP7)","volume":"29","author":"Reuss","year":"2019","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.annonc.2023.11.015","article-title":"ESGO\u2013ESMO\u2013ESP Consensus Conference Recommendations on Ovarian Cancer: Pathology and Molecular Biology and Early, Advanced and Recurrent Disease","volume":"35","author":"Ledermann","year":"2024","journal-title":"Ann. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ygyno.2022.06.010","article-title":"Predictive Biomarker for Surgical Outcome in Patients with Advanced Primary High-Grade Serous Ovarian Cancer. Are We There yet? An Analysis of the Prospective Biobank for Ovarian Cancer","volume":"166","author":"Keunecke","year":"2022","journal-title":"Gynecol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1479-5876-3-25","article-title":"Ovarian Cancer, the Coagulation Pathway, and Inflammation","volume":"3","author":"Wang","year":"2005","journal-title":"J. Transl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.3748\/wjg.v20.i26.8583","article-title":"Prognostic Significance of Preoperative Fibrinogen in Patients with Colon Cancer","volume":"20","author":"Sun","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1245\/s10434-013-2968-8","article-title":"Preoperative Plasma Hyperfibrinogenemia Is Predictive of Poor Prognosis in Patients with Nonmetastatic Colon Cancer","volume":"20","author":"Son","year":"2013","journal-title":"Ann. Surg. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000355502","article-title":"Elevated Plasma Fibrinogen Levels Are Associated with a Poor Prognosis in Patients with Hepatocellular Carcinoma","volume":"85","author":"Kinoshita","year":"2013","journal-title":"Oncology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/bjc.2013.815","article-title":"Circulating Fibrinogen Is a Prognostic and Predictive Biomarker in Malignant Pleural Mesothelioma","volume":"110","author":"Ghanim","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1634\/theoncologist.2009-0079","article-title":"Plasma Fibrinogen Levels and Prognosis in Patients with Ovarian Cancer: A Multicenter Study","volume":"14","author":"Polterauer","year":"2009","journal-title":"Oncologist"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-3-319-49674-0_13","article-title":"Fibrin Formation, Structure and Properties","volume":"82","author":"Weisel","year":"2017","journal-title":"Subcell. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1016\/S1470-2045(14)70263-3","article-title":"Cancer-Related Inflammation and Treatment Effectiveness","volume":"15","author":"Diakos","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4925498","DOI":"10.1155\/2018\/4925498","article-title":"A Novel Inflammation-Based Prognostic Score: The Fibrinogen\/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma","volume":"2018","author":"Xu","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1475-2891-9-69","article-title":"Pretreatment Serum Albumin as a Predictor of Cancer Survival: A Systematic Review of the Epidemiological Literature","volume":"9","author":"Gupta","year":"2010","journal-title":"Nutr. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12957-021-02330-2","article-title":"Fibrinogen\/Albumin Ratio Index Is an Independent Predictor of Recurrence-Free Survival in Patients with Intrahepatic Cholangiocarcinoma Following Surgical Resection","volume":"19","author":"Liu","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1245\/s10434-019-07586-3","article-title":"Fibrinogen-Albumin Ratio Index (FARI): A More Promising Inflammation-Based Prognostic Marker for Patients Undergoing Hepatectomy for Colorectal Liver Metastases","volume":"26","author":"Wang","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.7150\/jca.16491","article-title":"A Novel Blood Tool of Cancer Prognosis in Esophageal Squamous Cell Carcinoma: The Fibrinogen\/Albumin Ratio","volume":"8","author":"Tan","year":"2017","journal-title":"J. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liang, Y., Wang, W., Que, Y., Guan, Y., Xiao, W., Fang, C., Zhang, X., and Zhou, Z. (2018). Prognostic Value of the Fibrinogen\/Albumin Ratio (FAR) in Patients with Operable Soft Tissue Sarcoma. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4856-x"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Onoprienko, A., Hofstetter, G., Dorittke, T., Bekos, C., Grimm, C., Polterauer, M., Bartl, T., and Polterauer, S. (2022). The Prognostic Value of the Fibrinogen-Albumin-Ratio Index (FARI) in Patients with Advanced Vulvar Cancer. J. Pers. Med., 12.","DOI":"10.3390\/jpm12111882"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2147\/CMAR.S275173","article-title":"Fibrinogen\/Albumin Ratio as a Promising Marker for Predicting Survival in Pancreatic Neuroendocrine Neoplasms","volume":"13","author":"Deng","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chen, W., Shan, B., Zhou, S., Yang, H., and Ye, S. (2022). Fibrinogen\/Albumin Ratio as a Promising Predictor of Platinum Response and Survival in Ovarian Clear Cell Carcinoma. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09204-0"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13048-019-0563-8","article-title":"Preoperative Albumin-to-Fibrinogen Ratio Predicts Chemotherapy Resistance and Prognosis in Patients with Advanced Epithelial Ovarian Cancer","volume":"12","author":"Yu","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.2147\/CMAR.S211524","article-title":"Prognostic Significance of FA Score Based on Plasma Fibrinogen and Serum Albumin in Patients with Epithelial Ovarian Cancer","volume":"11","author":"Li","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/000456328502200604","article-title":"The Measurement of Albumin in Serum and Plasma","volume":"22","author":"Hill","year":"1985","journal-title":"Ann. Clin. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00404-019-05278-7","article-title":"Pre-Operative Hypoalbuminemia Is Associated with Complication Rate and Overall Survival in Patients with Vulvar Cancer Undergoing Surgery","volume":"300","author":"Bekos","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000205234","article-title":"Rapid physiological coagulation method in determination of fibrinogen","volume":"17","author":"Clauss","year":"1957","journal-title":"Acta Haematol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bekos, C., Grimm, C., Brodowicz, T., Petru, E., Hefler, L., Reimer, D., Koch, H., Reinthaller, A., Polterauer, S., and Polterauer, M. (2017). Prognostic Role of Plasma Fibrinogen in Patients with Uterine Leiomyosarcoma\u2014A Multicenter Study. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-13934-8"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Charkhchi, P., Cybulski, C., Gronwald, J., Wong, F.O., Narod, S.A., and Akbari, M.R. (2020). CA125 and Ovarian Cancer: A Comprehensive Review. Cancers, 12.","DOI":"10.3390\/cancers12123730"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"b604","DOI":"10.1136\/bmj.b604","article-title":"Prognosis and Prognostic Research: Developing a Prognostic Model","volume":"338","author":"Royston","year":"2009","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"An, Q., Liu, W., Yang, Y., and Yang, B. (2020). Preoperative Fibrinogen-to-Albumin Ratio, a Potential Prognostic Factor for Patients with Stage IB-IIA Cervical Cancer. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07191-8"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/1724600820915916","article-title":"Diagnostic Value of Albumin to Fibrinogen Ratio in Cervical Cancer","volume":"35","author":"Huang","year":"2020","journal-title":"Int. J. Biol. Markers"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4048\/jbc.2017.20.3.254","article-title":"Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer","volume":"20","author":"Hwang","year":"2017","journal-title":"J. Breast Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cca.2020.03.011","article-title":"Prognostic Value of Combined Preoperative Fibrinogen-Albumin Ratio and Platelet-Lymphocyte Ratio Score in Patients with Breast Cancer: A Prognostic Nomogram Study","volume":"506","author":"Zheng","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sahin, T.K., Rizzo, A., Aksoy, S., and Guven, D.C. (2024). Prognostic Significance of the Royal Marsden Hospital (RMH) Score in Patients with Cancer: A Systematic Review and Meta-Analysis. Cancers, 16.","DOI":"10.3390\/cancers16101835"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/2396987320984003","article-title":"Interleukin-6, C-Reactive Protein, Fibrinogen, and Risk of Recurrence after Ischaemic Stroke: Systematic Review and Meta-Analysis","volume":"6","author":"McCabe","year":"2021","journal-title":"Eur. Stroke J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102509","DOI":"10.1016\/j.msard.2020.102509","article-title":"Fibrinogen: A Potential Biomarker for Predicting Disease Severity in Multiple Sclerosis","volume":"46","author":"Ahmad","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hung, K.-C., Huang, Y.-T., Chang, Y.-J., Yu, C.-H., Wang, L.-K., Wu, C.-Y., Liu, P.-H., Chiu, S.-F., and Sun, C.-K. (2022). Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis. Diagnostics, 12.","DOI":"10.3390\/diagnostics12071678"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.3802\/jgo.2017.28.e36","article-title":"Elevated Plasma Fibrinogen Levels and Prognosis of Epithelial Ovarian Cancer: A Cohort Study and Meta-Analysis","volume":"28","author":"Luo","year":"2017","journal-title":"J. Gynecol. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Seebacher, V., Aust, S., D\u2019Andrea, D., Grimm, C., Reiser, E., Tiringer, D., Von Mersi, H., Polterauer, S., Reinthaller, A., and Helmy-Bader, S. (2017). Development of a Tool for Prediction of Ovarian Cancer in Patients with Adnexal Masses: Value of Plasma Fibrinogen. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182383"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ygyno.2015.07.005","article-title":"Pre-Operative Serum Albumin Is Associated with Post-Operative Complication Rate and Overall Survival in Patients with Epithelial Ovarian Cancer Undergoing Cytoreductive Surgery","volume":"138","author":"Ataseven","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00404-017-4511-9","article-title":"The Preoperative Albumin Level Is an Independent Prognostic Factor for Optimally Debulked Epithelial Ovarian Cancer","volume":"296","author":"Ayhan","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/08941939.2020.1827314","article-title":"Serum Albumin as a Predictor of Survival after Interval Debulking Surgery for Advanced Ovarian Cancer (AOC): A Retrospective Study","volume":"35","author":"Dai","year":"2022","journal-title":"J. Investig. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1016\/S1470-2045(22)00139-5","article-title":"Clinical Research in Ovarian Cancer: Consensus Recommendations from the Gynecologic Cancer InterGroup","volume":"23","author":"Vergote","year":"2022","journal-title":"Lancet Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Brons, P.E., Nieuwenhuyzen-de Boer, G.M., Ramakers, C., Willemsen, S., Kengsakul, M., and van Beekhuizen, H.J. (2022). Preoperative Cancer Antigen 125 Level as Predictor for Complete Cytoreduction in Ovarian Cancer: A Prospective Cohort Study and Systematic Review. Cancers, 14.","DOI":"10.3390\/cancers14235734"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.21873\/anticanres.12799","article-title":"Preoperative CA-125 Value as a Predictive Factor for Postoperative Outcome in First Relapse of Platinum-Sensitive Serous Ovarian Cancer","volume":"38","author":"Parashkevova","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/147323000703500512","article-title":"The Correlation between Plasma Fibrinogen Levels and the Clinical Features of Patients with Ovarian Carcinoma","volume":"35","author":"Ma","year":"2007","journal-title":"J. Int. Med. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2008.06.052","article-title":"Prospective Validation of a Laparoscopic Predictive Model for Optimal Cytoreduction in Advanced Ovarian Carcinoma","volume":"199","author":"Fagotti","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ygyno.2015.07.095","article-title":"Definition of a Dynamic Laparoscopic Model for the Prediction of Incomplete Cytoreduction in Advanced Epithelial Ovarian Cancer: Proof of a Concept","volume":"139","author":"Petrillo","year":"2015","journal-title":"Gynecol. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/19\/3295\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:04:48Z","timestamp":1760112288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/19\/3295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":52,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["cancers16193295"],"URL":"https:\/\/doi.org\/10.3390\/cancers16193295","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]}}}