{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:07:43Z","timestamp":1769767663088,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Veteran\u2019s Administration Merit Review","award":["BX003443-01"],"award-info":[{"award-number":["BX003443-01"]}]},{"name":"Veteran\u2019s Administration Merit Review","award":["DK-67420"],"award-info":[{"award-number":["DK-67420"]}]},{"name":"Veteran\u2019s Administration Merit Review","award":["DK-108054"],"award-info":[{"award-number":["DK-108054"]}]},{"name":"Veteran\u2019s Administration Merit Review","award":["P20GM121299-01A1"],"award-info":[{"award-number":["P20GM121299-01A1"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["BX003443-01"],"award-info":[{"award-number":["BX003443-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK-67420"],"award-info":[{"award-number":["DK-67420"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK-108054"],"award-info":[{"award-number":["DK-108054"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM121299-01A1"],"award-info":[{"award-number":["P20GM121299-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Dysfunctions of metabolic syndrome (MetS) have been identified as a significant risk factor for colorectal cancer (CRC). However, current colon cancer guidelines do not classify patients with MetS as high risk, thereby leaving these individuals vulnerable. Consequently, we explored the relationship between MetS, its individual components, and the development of CRC in a cohort of patients with MetS to assess the necessity for CRC screening in these individuals. Methods: This study included patients ages 18 and older that received a service from the Marshall-Health (MH) practice plan, Cabell-Huntington Hospital (CHH), MU\/JCESOM\u2019s Edwards Comprehensive Cancer Center (ECCC), or the University of Kentucky HealthCare (UKHC) system between 2010 and 2018. We implemented log-binomial regression models to assess the individual and collective effects of MetS components after adjusting other CRC risk factors. Results: Given that CRC prevalence increases in the older population (aged 65 years and above), and that multiple components of MetS are observed within the same population, we analyzed the concurrent impact of all MetS components on CRC. Log-binomial regression models were implemented to assess the risk of CRC due to MetS components after adjusting other risk factors. Conclusions: We identified specific components that markedly increased CRC risk, suggesting that individuals with these components should be prioritized for early screening. These findings could significantly influence early CRC screening protocols, with the ultimate aim to reduce mortality associated with the disease.<\/jats:p>","DOI":"10.3390\/cancers16193350","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:45:27Z","timestamp":1727675127000},"page":"3350","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk of Colorectal Cancer among Patients with One or Multiple Metabolic Syndrome Components"],"prefix":"10.3390","volume":"16","author":[{"given":"Shanmuga","family":"Sundaram","sequence":"first","affiliation":[{"name":"Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-7819","authenticated-orcid":false,"given":"Rajan","family":"Lamichhane","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3304-2920","authenticated-orcid":false,"given":"Usha","family":"Murughiyan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA"},{"name":"Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-6740","authenticated-orcid":false,"given":"Uma","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Clinical and Translational Sciences, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Drive, Huntington, WV 25701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref_1","unstructured":"American Cancer Society (2021, April 01). Cancer Facts & Figures 2020. Atlanta: American Cancer Society. 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