{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:33:48Z","timestamp":1778308428908,"version":"3.51.4"},"reference-count":24,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The optimal management of bone tumors requires a multidisciplinary strategy to guarantee high-quality care. At specialized centers, the medical team responsible for managing patients with bone cancer comprises oncologists, surgeons, radiologists, pathologists, and rehabilitation specialists. The goal of treatment is to achieve long-term survival with minimal disability and pain. Postoperative rehabilitation is a fundamental therapeutic approach to enhance functionality and sustain the utmost quality of life following a limb-sparing surgery. Currently, megaprostheses are used for reconstructing bone defects after tumor resection, but in the literature, only a few studies have investigated rehabilitation outcomes in terms of functionality and impact on daily activities. This narrative review explores the functional and quality of life outcomes after the implantation of MUTARS\u00ae prostheses in patients with lower extremity bone tumors. A comprehensive search was conducted on PubMed and Scopus using the following MESH terms: \u201cMUTARS\u201d, \u201cMegaprosthesis\u201d, \u201cbone\u201d, \u201ctumors\u201d, \u201cmetastasis\u201d, \u201clower limb\u201d, \u201crehabilitation\u201d, \u201coutcome\u201d, and \u201cquality of life\u201d, and 10 studies were included. The most frequent oncological pathology was found to be primitive bone tumors treated with modular prostheses. The outcome measures used were the Henderson et al. classification, Harris Hip Scale, Musculoskeletal Tumor Society score, Visual Analog Scale, Range Of Motion, Karnofsky Performance Scale, and quality of life questionnaire. MUTARS\u00ae is a well-established treatment option after bone tumor resection, although it involves extensive and complex post-resection reconstruction that exposes joints and tissues to substantial mechanical stress. Proper rehabilitation after MUTARS\u00ae surgery is a fundamental therapeutic step, although there is still insufficient evidence in the literature focusing on functional and rehabilitative outcomes. Therefore, more studies and guidelines are needed to define standardized rehabilitation protocols for clinical practice after orthopedic oncologic surgery.<\/jats:p>","DOI":"10.3390\/cancers16193357","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:39:35Z","timestamp":1727678375000},"page":"3357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modular Universal Tumor and Revision System Prostheses in Patients with Bone Cancer of the Lower Limbs: A Narrative Review of Functional Outcomes"],"prefix":"10.3390","volume":"16","author":[{"given":"Paola E.","family":"Ferrara","sequence":"first","affiliation":[{"name":"Department of Aging, Orthopedic and Rheumatological Sciences, University Polyclinic Foundation A. Gemelli IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariantonietta","family":"Ariani","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Sense Organs and Thorax, Catholic University of the Sacred Heart, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefora","family":"Codazza","sequence":"additional","affiliation":[{"name":"Department of Aging, Orthopedic and Rheumatological Sciences, University Polyclinic Foundation A. Gemelli IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelaide","family":"Aprovitola","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Sense Organs and Thorax, Catholic University of the Sacred Heart, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Polisano","sequence":"additional","affiliation":[{"name":"Physical and Rehabilitation Medicine, University of Rome Tor Vergata, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Ronconi","sequence":"additional","affiliation":[{"name":"Department of Aging, Orthopedic and Rheumatological Sciences, Catholic University of the Sacred Heart, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/PAP.0000000000000293","article-title":"The 2020 WHO Classification of Tumors of Bone: An Updated Review","volume":"28","author":"Choi","year":"2021","journal-title":"Adv. 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