{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:21:35Z","timestamp":1784823695822,"version":"3.55.0"},"reference-count":102,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Industrial Technological Development (CDTI), \u201cCervera\u201d Transfer R&amp;D Projects","award":["IDI-20210622"],"award-info":[{"award-number":["IDI-20210622"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Dysgeusia contributes to the derangement of nutritional status in patients with cancer as well as worsening the quality of life. There has been a lack of effective treatments for taste disorders provided by the pharmaceutical industry. Methods: This was a pilot randomized, parallel, triple-blind, and placebo-controlled intervention clinical trial in which 31 malnourished patients with cancer and dysgeusia receiving antineoplastic treatment were randomized into three arms [standard dose of DMB (150 mg DMB\/tablet), high dose of DMB (300 mg DMB\/tablet) or placebo (300 mg freeze-dried strawberry)] for three months. Patients consumed a DMB or placebo tablet before each main meal. Using the nanopore methodology, we analyzed the oral microbiome of patients with cancer using saliva samples. Results: All patients with cancer and dysgeusia had dysbiosis in terms of lower bacterial diversity and richness. DMB consumption was associated with changes in oral microbiome composition. Neither selected bacteria nor taste perception, type of diet, and cytokine levels were associated with mucositis. Likewise, alcohol and tobacco consumption as well as general and digestive toxicity due to systemic therapy were not associated with specific changes of the oral microbiome, according to logistic binary regression. The standard dose of DMB resulted in a lower abundance of Veillonella compared with the high DMB dose and placebo at 3 months after intervention with DMB. In particular, some species such as Streptococcus parasanguinis, Veillonella parvula, and Streptococcus mutans were less abundant in the DMB standard-dose group. Additionally, the consumption of a standard dose of DMB revealed a negative association between the concentrations of TNF-\u03b1 and the abundance of species such as Streptococcus thermophilus, Streptococcus pneumoniae, Streptococcus dysgalactiae and Streptococcus agalactiae. Conclusions: Accordingly, regular DMB consumption could modify the oral microbiome in patients with cancer and dysgeusia, which may contribute to maintaining an appropriate immune response. However, as the present pilot study involved a small number of participants, further studies are necessary to draw robust conclusions from the data.<\/jats:p>","DOI":"10.3390\/cancers16193414","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:02:10Z","timestamp":1728388930000},"page":"3414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of a Novel Food Rich in Miraculin on the Oral Microbiome of Malnourished Oncologic Patients with Dysgeusia"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-9408","authenticated-orcid":false,"given":"Julio","family":"Plaza-Diaz","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"Children\u2019s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4452-0855","authenticated-orcid":false,"given":"Francisco Javier","family":"Ruiz-Ojeda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"RU Adipocytes and Metabolism, Helmholtz Diabetes Center at Helmholtz Munich, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Center of Biomedical Research, University of Granada, Avda. del Conocimiento s\/n. Armilla, 18016 Granada, Spain"},{"name":"CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9310-1545","authenticated-orcid":false,"given":"Bricia","family":"L\u00f3pez-Plaza","sequence":"additional","affiliation":[{"name":"Food, Nutrition and Health Platform, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain"},{"name":"Medicine Department, Faculty of Medicine, Complutense University of Madrid, Plaza de Ram\u00f3n y Cajal, s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5836-5008","authenticated-orcid":false,"given":"Marco","family":"Brandimonte-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8476-9970","authenticated-orcid":false,"given":"Ana Isabel","family":"\u00c1lvarez-Mercado","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Center of Biomedical Research, University of Granada, Avda. del Conocimiento s\/n. Armilla, 18016 Granada, Spain"},{"name":"Department of Pharmacology, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-0301","authenticated-orcid":false,"given":"Luc\u00eda","family":"Arcos-Castellanos","sequence":"additional","affiliation":[{"name":"Food, Nutrition and Health Platform, Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-1420","authenticated-orcid":false,"given":"Jaime","family":"Feli\u00fa-Batlle","sequence":"additional","affiliation":[{"name":"Oncology Department, Hospital La Paz Institute for Health Research-IdiPAZ, Hospital Universitario La Paz, 28029 Madrid, Spain"},{"name":"CIBERONC (CIBER Cancer), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Medicine Department, Faculty of Medicine, Autonomous University of Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[{"name":"Smell & Taste Clinic, Department of Otorhinolaryngology, Technische Universit\u00e4t Dresden, Fetscherstra\u00dfe 74, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0187-1495","authenticated-orcid":false,"given":"Samara","family":"Palma-Milla","sequence":"additional","affiliation":[{"name":"Medicine Department, Faculty of Medicine, Autonomous University of Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain"},{"name":"Nutrition Department, Hospital University La Paz, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-0939","authenticated-orcid":false,"given":"Angel","family":"Gil","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix\u201d, Center of Biomedical Research, University of Granada, Avda. del Conocimiento s\/n. Armilla, 18016 Granada, Spain"},{"name":"CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1158\/1541-7786.MCR-23-0411","article-title":"Updating the Definition of Cancer","volume":"21","author":"Brown","year":"2023","journal-title":"Mol. Cancer Res."},{"key":"ref_2","first-page":"210","article-title":"The Effects of Taste Changes on the Quality of Life of Patients Receiving Chemotherapy Treatment","volume":"5","author":"Dolu","year":"2023","journal-title":"Med. 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