{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:56:08Z","timestamp":1771548968069,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Traditional treatment methods for non-melanoma skin cancer (NMSC) include surgical excision with histological evaluation, yet advancements such as reflectance confocal microscopy (RCM) and superficial radiation therapy (SRT) offer non-invasive management alternatives. This study aims to evaluate the use of RCM for the evaluation of treatment outcomes after SRT in managing localized NMSC. Methods: A prospective interventional case series study was conducted on patients treated for NMSC with SRT between March 2020 and December 2023. Suspected NMSC lesions were initially evaluated with a handheld dermoscope and then imaged at multiple depths using a VivaScope 1500 RCM. Two dermatologists trained in RCM reviewed the images. Confirmed NMSC lesions were biopsied and treated with SRT, followed by RCM imaging at six months post-treatment to assess cancer clearance, scarring, and inflammation. Results: Of the 38 lesions (composed of SCC (24) and BCC (14)) treated affecting the 29 patients, all lesions showed no residual tumor activity upon conducting follow-up RCM (100% clearance). Scarring and mild erythema were noted clinically. Six lesions demonstrated moderate to severe inflammation at a 6-month follow-up. Conclusions: This study demonstrates successful non-invasive management of localized NMSC using RCM and SRT. RCM was able to non-invasively demonstrate complete tumor clearance achieved by SRT with minimal adverse effects. These findings support considering the use of RCM and SRT as primary diagnostic, monitoring, and treatment options for NMSC without the need for biopsies, especially for elderly patients or those unsuitable for surgery due to medical conditions.<\/jats:p>","DOI":"10.3390\/cancers16213557","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:11:25Z","timestamp":1729577485000},"page":"3557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cutting-Edge Technology Without Cutting: Treating Skin Cancer in This Era\u2014A Case Series"],"prefix":"10.3390","volume":"16","author":[{"given":"Babar","family":"Rao","sequence":"first","affiliation":[{"name":"Rao Dermatology, New York, NY 10003, USA"},{"name":"Rutgers Center for Dermatology, Somerset, NJ 08873, USA"},{"name":"Department of Dermatology, Weill Cornell Medicine, New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Moreno","sequence":"additional","affiliation":[{"name":"Rao Dermatology, Fresno, CA 93720, USA"},{"name":"Department of Human Nutritional Sciences, California State University, Fresno, CA 93740, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7060-7436","authenticated-orcid":false,"given":"Muhammad Shahmir","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6952-0661","authenticated-orcid":false,"given":"Noah","family":"Musolff","sequence":"additional","affiliation":[{"name":"Rao Dermatology, New York, NY 10003, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Sanabria","sequence":"additional","affiliation":[{"name":"Rutgers Center for Dermatology, Somerset, NJ 08873, USA"},{"name":"Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlad","family":"Voiculescu","sequence":"additional","affiliation":[{"name":"Department of Oncological Dermatology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Elias Emergency University Hospital, 011461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/jid.2013.304","article-title":"Non-melanoma skin cancer incidence and impact of skin cancer screening on incidence","volume":"134","author":"Eisemann","year":"2014","journal-title":"J. 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