{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:07:23Z","timestamp":1793761643079,"version":"4.6.1"},"reference-count":111,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Minerals constitute only 5% of the typical human diet but are vital for health and functionality. Copper, a trace element, is absorbed by the human gut at 30\u201340% from diets typical of industrialized countries. The liver produces metallothioneins, which store copper. Copper is crucial for mitochondrial respiration, pigmentation, iron transport, antioxidant defense, hormone production, and extracellular matrix biosynthesis. Copper deficiency, often caused by mutations in the ATP7A gene, results in Menkes disease, an X-linked recessive disorder. On the contrary, Wilson disease is characterized by toxic copper accumulation. Cuproptosis, a unique form of cell death regulated by copper, is a subtype of necrosis induced by enhanced mitochondrial metabolism and intracellular copper accumulation. This process can reduce the malignant potential of tumor cells by inhibiting glucose metabolism. Therapeutically, copper and its complexes have shown efficacy in malignancy treatments. The disruption of copper homeostasis and excessive cuproplasia are significant in colorectal cancer development and metastasis. Therefore, manipulating copper status presents a potential therapeutic target for colorectal cancer, using copper chelators to inhibit copper formation or copper ion carriers to promote cuproptosis. This review highlights the role of copper in human physiology and pathology, emphasizing its impact on colorectal cancer and potential therapeutic strategies. Future AI-based approaches are anticipated to accelerate the development of new compounds targeting cuproptosis and copper disruption in colorectal cancer.<\/jats:p>","DOI":"10.3390\/cancers16213691","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T08:44:04Z","timestamp":1730364244000},"page":"3691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Copper and Colorectal Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Maciej","family":"Ma\u0142yszko","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5851-2856","authenticated-orcid":false,"given":"Adam","family":"Przyby\u0142kowski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref_1","unstructured":"Medicine, I.O. (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, The National Academies Press."},{"key":"ref_2","unstructured":"Ross, A.C., Caballero, B., Cousins, R.J., Tucker, K.L., and Ziegler, T.R. (2012). Modern Nutrition in Health and Disease, Wolters Kluwer Health Adis (ESP)."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00017285-199001000-00003","article-title":"Copper: Its Role in Human Nutrition","volume":"25","author":"Johnson","year":"1990","journal-title":"Nutr. Today"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101018","DOI":"10.1016\/j.drup.2023.101018","article-title":"Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance","volume":"72","author":"Wang","year":"2024","journal-title":"Drug Resist. Updat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1054S","DOI":"10.1093\/ajcn\/67.5.1054S","article-title":"Copper absorption and bioavailability","volume":"67","author":"Wapnir","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Montoro-Huguet, M.A., Belloc, B., and Dom\u00ednguez-Cajal, M. (2021). Small and Large Intestine (I): Malabsorption of Nutrients. Nutrients, 13.","DOI":"10.3390\/nu13041254"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ncl.2006.11.001","article-title":"Nutritional Neuropathies","volume":"25","author":"Kumar","year":"2007","journal-title":"Neurol. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0032-1322583","article-title":"Metabolic and Toxic Myelopathies","volume":"32","author":"Kumar","year":"2012","journal-title":"Semin. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.nu.08.070188.001315","article-title":"Copper deficiency in humans","volume":"8","author":"Danks","year":"1988","journal-title":"Annu. Rev. Nutr."},{"key":"ref_10","first-page":"118","article-title":"Copper deficiency in humans","volume":"20","author":"Williams","year":"1983","journal-title":"Semin. Hematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10534-013-9668-5","article-title":"Intestinal expression of metal transporters in Wilson\u2019s disease","volume":"26","author":"Gromadzka","year":"2013","journal-title":"BioMetals"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.mam.2005.07.010","article-title":"Iron and copper metabolism","volume":"26","author":"Arredondo","year":"2005","journal-title":"Mol. Asp. Med."},{"key":"ref_13","unstructured":"Prohaska, J.R. (1988). Biochemical Functions of Copper in Animals, Essential and Toxic Trace Elements. Human Health and Disease, Alan R Liss."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Song, Y., Chen, S., Li, L., Zeng, Y., and Hu, X. (2022). The Hypopigmentation Mechanism of Tyrosinase Inhibitory Peptides Derived from Food Proteins: An Overview. Molecules, 27.","DOI":"10.3390\/molecules27092710"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41556-020-0481-4","article-title":"Copper is an essential regulator of the autophagic kinases ULK1\/2 to drive lung adenocarcinoma","volume":"22","author":"Tsang","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s12094-023-03107-7","article-title":"The huge potential of targeting copper status in the treatment of colorectal cancer","volume":"25","author":"Jiang","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Grasso, M., Bond, G.J., Kim, Y.J., Boyd, S., Dzebo, M.M., Valenzuela, S., Tsang, T., Schibrowsky, N.A., Alwan, K.B., and Blackburn, N.J. (2021). The copper chaperone CCS facilitates copper binding to MEK1\/2 to promote kinase activation. J. Biol. Chem., 297.","DOI":"10.1016\/j.jbc.2021.101314"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chojnowski, J.E., Li, R., Tsang, T., Alfaran, F.H., Dick, A., Cocklin, S., Brady, D.C., and Strochlic, T.I. (2022). Copper Modulates the Catalytic Activity of Protein Kinase CK2. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.878652"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2004303","DOI":"10.1002\/advs.202004303","article-title":"Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner","volume":"8","author":"Guo","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Vitaliti, A., De Luca, A., and Rossi, L. (2022). Copper-Dependent Kinases and Their Role in Cancer Inception, Progression and Metastasis. Biomolecules, 12.","DOI":"10.3390\/biom12101520"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Leli\u00e8vre, P., Sancey, L., Coll, J.-L., Deniaud, A., and Busser, B. (2020). The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy. Cancers, 12.","DOI":"10.20944\/preprints202010.0353.v1"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sigel, A., Sigel, H., and Sigel, R.K.O. (2013). Copper: Effects of Deficiency and Overload. Interrelations Between Essential Metal Ions and Human Diseases, Springer.","DOI":"10.1007\/978-94-007-7500-8"},{"key":"ref_23","unstructured":"Global Cancer Observatory (2024, January 20). International Agency for Research on Cancer. World Health Organization. Available online: https:\/\/gco.iarc.fr\/en."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1002\/cncr.26677","article-title":"Socioeconomic status and the risk of colorectal cancer: An analysis of more than a half million adults in the National Institutes of Health-AARP Diet and Health Study","volume":"118","author":"Doubeni","year":"2012","journal-title":"Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3322\/caac.21565","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103663","DOI":"10.1016\/j.critrevonc.2022.103663","article-title":"Latest evidence on immune checkpoint inhibitors in metastatic colorectal cancer: A 2022 update","volume":"173","author":"Boukouris","year":"2022","journal-title":"Crit. Rev. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3322\/caac.21601","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3322\/caac.21731","article-title":"Cancer treatment and survivorship statistics, 2022","volume":"72","author":"Miller","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Gebremedhn, E.G., Shortland, P.J., and Mahns, D.A. (2018). The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: A systematic review. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4185-0"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1002\/ijc.25640","article-title":"Tumor-reactive CD4+ CD8\u03b1\u03b2+ CD103+ \u03b1\u03b2T cells: A prevalent tumor-reactive T-cell subset in metastatic colorectal cancers","volume":"128","author":"Sarrabayrouse","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1158\/0008-5472.CAN-11-0268","article-title":"Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy","volume":"71","author":"Halama","year":"2011","journal-title":"Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.3748\/wjg.v21.i21.6470","article-title":"Different treatment strategies and molecular features between right-sided and left-sided colon cancers","volume":"21","author":"Shen","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.7150\/ijbs.64077","article-title":"Immunotherapy in colorectal cancer: Current achievements and future perspective","volume":"17","author":"Fan","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: From transition metal signalling to metalloplasia","volume":"22","author":"Ge","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1039\/C6MT00202A","article-title":"Defining the human copper proteome and analysis of its expression variation in cancers","volume":"9","author":"Blockhuys","year":"2017","journal-title":"Metallomics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"D\u2019amico, M., and De Amicis, F. (2024). Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer. Cells, 13.","DOI":"10.3390\/cells13131083"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.tim.2020.02.012","article-title":"Redox Partners: Function Modulators of Bacterial P450 Enzymes","volume":"28","author":"Li","year":"2020","journal-title":"Trends Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hendricks, A.L., Wachnowsky, C., Fries, B., Fidai, I., and Cowan, J.A. (2021). Characterization and Reconstitution of Human Lipoyl Synthase (LIAS) Supports ISCA2 and ISCU as Primary Cluster Donors and an Ordered Mechanism of Cluster Assembly. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041598"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-023-01732-y","article-title":"Cuproptosis: Mechanisms and links with cancers","volume":"22","author":"Xie","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","article-title":"Cuproptosis: A copper-triggered modality of mitochondrial cell death","volume":"32","author":"Tang","year":"2022","journal-title":"Cell Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"da Silva, D.A., De Luca, A., Squitti, R., Rongioletti, M., Rossi, L., Machado, C.M., and Cerchiaro, G. (2022). Copper in tumors and the use of copper-based compounds in cancer treatment. J. Inorg. Biochem., 226.","DOI":"10.1016\/j.jinorgbio.2021.111634"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2217\/nnm-2021-0374","article-title":"Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes","volume":"17","author":"Jiang","year":"2022","journal-title":"Nanomedicine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1002\/cbic.202000553","article-title":"Immunogenic Cell Death of Breast Cancer Stem Cells Induced by an Endoplasmic Reticulum-Targeting Copper(II) Complex","volume":"21","author":"Kaur","year":"2020","journal-title":"ChemBioChem"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Hu, Y., Qian, Y., Wei, J., Jin, T., Kong, X., Cao, H., and Ding, K. (2021). The Disulfiram\/Copper Complex Induces Autophagic Cell Death in Colorectal Cancer by Targeting ULK1. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.752825"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.2703","article-title":"Innate and adaptive immune cells in the tumor microenvironment","volume":"14","author":"Gajewski","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and Cancer: Triggers, Mechanisms, and Consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tox.2013.01.001","article-title":"Copper induced immunotoxicity promote differential apoptotic pathways in spleen and thymus","volume":"306","author":"Mitra","year":"2013","journal-title":"Toxicology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41568-021-00353-1","article-title":"Long noncoding RNAs in cancer metastasis","volume":"21","author":"Liu","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"152983","DOI":"10.1016\/j.prp.2020.152983","article-title":"Gene expression regulations by long noncoding RNAs and their roles in cancer","volume":"216","author":"Du","year":"2020","journal-title":"Pathol.-Res. Pract."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ncrna.2022.02.004","article-title":"Long noncoding RNAs as promising biomarkers in cancer","volume":"7","author":"Beylerli","year":"2022","journal-title":"Non-Coding RNA Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"14506","DOI":"10.18632\/aging.103496","article-title":"Identification of lncRNA biomarkers for lung cancer through integrative cross-platform data analyses","volume":"12","author":"Zhao","year":"2020","journal-title":"Aging"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lei, L., Li, N., Yuan, P., and Liu, D. (2022). A new risk model based on a 11-m6A-related lncRNA signature for predicting prognosis and monitoring immunotherapy for gastric cancer. BMC Cancer, 22.","DOI":"10.1186\/s12885-021-09062-2"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e24244","DOI":"10.1002\/jcla.24244","article-title":"Immune-related lncRNA signature delineates an immune-excluded subtype of liver cancer with unfavorable clinical outcomes","volume":"36","author":"Chen","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e24302","DOI":"10.1002\/jcla.24302","article-title":"Necroptosis-related lncRNA to establish novel prognostic signature and predict the immunotherapy response in breast cancer","volume":"36","author":"Chen","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bulcan.2021.10.005","article-title":"A long noncoding RNA, LncRNA-LOC100127888, is associated with poor prognosis in colorectal cancer patients","volume":"109","author":"Zhou","year":"2022","journal-title":"Bull. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10543","DOI":"10.1007\/s00432-023-04916-7","article-title":"A novel copper-induced cell death-related lncRNA prognostic signature associated with immune infiltration and clinical value in gastric cancer","volume":"149","author":"Wang","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.7150\/jca.79640","article-title":"Distinct tumor microenvironment landscapes in gastric cancer classified by cuproptosis-related lncRNAs","volume":"13","author":"Huang","year":"2022","journal-title":"J. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Balihodzic, A., Barth, D.A., Prinz, F., and Pichler, M. (2021). Involvement of Long Non-Coding RNAs in Glucose Metabolism in Cancer. Cancers, 13.","DOI":"10.3390\/cancers13050977"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Lossow, K., Schwarz, M., and Kipp, A.P. (2021). Are trace element concentrations suitable biomarkers for the diagnosis of cancer?. Redox Biol., 42.","DOI":"10.1016\/j.redox.2021.101900"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1134\/S1022795423030122","article-title":"The ATOX1 Gene Role in Copper Metabolism and the Pathogenesis of Copper-Induced Diseases","volume":"59","author":"Zhalsanova","year":"2023","journal-title":"Russ. J. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1074\/jbc.M709463200","article-title":"Novel role of Antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation","volume":"283","author":"Itoh","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Jana, A., Das, A., Krett, N.L., Guzman, G., Thomas, A., Mancinelli, G., Bauer, J., Ushio-Fukai, M., Fukai, T., and Jung, B. (2020). Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227916"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nchem.2381","article-title":"Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation","volume":"7","author":"Wang","year":"2015","journal-title":"Nat. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1038\/s41467-020-17549-y","article-title":"Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer","volume":"11","author":"Aubert","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/2211-5463.12060","article-title":"Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1,SCO1, and COX11 in colorectal cancer","volume":"6","author":"Barresi","year":"2016","journal-title":"FEBS Open Bio"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"R123","DOI":"10.1530\/JOE-16-0594","article-title":"STEAP4: Its emerging role in metabolism and homeostasis of cellular iron and copper","volume":"234","author":"Scarl","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41467-020-14698-y","article-title":"Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis","volume":"11","author":"Liao","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Liu, S., Cao, Q., An, G., Yan, B., and Lei, L. (2020). Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249359"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Wang, Z., Yang, L., Wu, L., Mao, H., Zhou, Y., Zhang, P., and Dai, G. (2018). Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy. Braz. J. Med. Biol. Res., 51.","DOI":"10.1590\/1414-431x20176793"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40246-023-00469-5","article-title":"Comprehensive analysis of cuproptosis-related long noncoding RNA for predicting prognostic and diagnostic value and immune landscape in colorectal adenocarcinoma","volume":"17","author":"Liu","year":"2023","journal-title":"Hum. Genom."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network, Weinstein, J.N., Collisson, E.A., Mills, G.B., Shaw, K.R.M., Ozenberger, B.A., Ellrott, K., Shmulevich, I., Sander, C., and Stuart, J.M. (2013). The Cancer Genome Atlas Pan-Cancer analysis project. Nat. Genet., 45, 1113\u20131120.","DOI":"10.1038\/ng.2764"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"14422","DOI":"10.18632\/aging.205324","article-title":"Integrative analysis of single-cell and bulk RNA seq to reveal the prognostic model and tumor microenvironment remodeling mechanisms of cuproptosis-related genes in colorectal cancer","volume":"15","author":"Chu","year":"2023","journal-title":"Aging"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.187.4.655","article-title":"B cell\u2013attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1\/CXCR5","volume":"187","author":"Legler","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1139\/cjpp-2023-0118","article-title":"A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma","volume":"101","author":"Su","year":"2023","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.21037\/tcr-24-546","article-title":"Comprehensive analysis of cuproptosis-related genes involved in prognosis and tumor microenvironment infiltration of colorectal cancer","volume":"13","author":"Chen","year":"2024","journal-title":"Transl. Cancer Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"122972","DOI":"10.1016\/j.lfs.2024.122972","article-title":"A spotlight on the role of copper in the epithelial to mesenchymal transition","volume":"354","author":"Focaccio","year":"2024","journal-title":"Life Sci."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Laczko, R., and Csiszar, K. (2020). Lysyl Oxidase (LOX): Functional Contributions to Signaling Pathways. Biomolecules, 10.","DOI":"10.3390\/biom10081093"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1038\/onc.2012.202","article-title":"Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK","volume":"32","author":"Baker","year":"2013","journal-title":"Oncogene"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1021\/acs.biomac.0c00045","article-title":"3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate","volume":"21","author":"Nicolas","year":"2020","journal-title":"Biomacromolecules"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s10528-020-09974-x","article-title":"MELK Accelerates the Progression of Colorectal Cancer via Activating the FAK\/Src Pathway","volume":"58","author":"Liu","year":"2020","journal-title":"Biochem. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Tam, S.Y., Wu, V.W.C., and Law, H.K.W. (2020). Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1\u03b1 and Beyond. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.00486"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/mol.108.051516","article-title":"Copper Regulation of Hypoxia-Inducible Factor-1 Activity","volume":"75","author":"Feng","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"34158","DOI":"10.18632\/oncotarget.5779","article-title":"Copper activates HIF-1\u03b1\/GPER\/VEGF signalling in cancer cells","volume":"6","author":"Rigiracciolo","year":"2015","journal-title":"Oncotarget"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbpa.2016.12.011","article-title":"Developing drugs targeting transition metal homeostasis","volume":"37","author":"Weekley","year":"2017","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2013.05.027","article-title":"D-penicillamine and other low molecular weight thiols: Review of anticancer effects and related mechanisms","volume":"337","author":"Wadhwa","year":"2013","journal-title":"Cancer Lett."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Baldari, S., Di Rocco, G., Heffern, M.C., Su, T.A., Chang, C.J., and Toietta, G. (2019). Effects of Copper Chelation on BRAF(V600E) Positive Colon Carcinoma Cells. Cancers, 11.","DOI":"10.3390\/cancers11050659"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10637-008-9165-9","article-title":"A pilot trial of the anti-angiogenic copper lowering agent tetrathiomolybdate in combination with irinotecan, 5-flurouracil, and leucovorin for metastatic colorectal cancer","volume":"27","author":"Gartner","year":"2009","journal-title":"Investig. New Drugs"},{"key":"ref_92","first-page":"213","article-title":"Combination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma development and angiogenesis in mice","volume":"14","author":"Yoshiji","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1021\/cb400198p","article-title":"Increasing intracellular bioavailable copper selectively targets prostate cancer cells","volume":"8","author":"Cater","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"37064","DOI":"10.18632\/oncotarget.9245","article-title":"Copper as a target for prostate cancer therapeutics: Copper-ionophore pharmacology and altering systemic copper distribution","volume":"7","author":"Denoyer","year":"2016","journal-title":"Oncotarget"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"R897","DOI":"10.1186\/bcr1322","article-title":"Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells","volume":"7","author":"Daniel","year":"2005","journal-title":"Breast Cancer Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/BJ20110123","article-title":"Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): Therapeutic indication for prostate cancer","volume":"436","author":"Cater","year":"2011","journal-title":"Biochem. J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"41118","DOI":"10.1021\/acsami.8b14940","article-title":"Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers","volume":"10","author":"Chen","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"100492","DOI":"10.1016\/j.apmt.2019.100492","article-title":"Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer","volume":"18","author":"Chang","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Babak, M.V., and Ahn, D. (2021). Modulation of Intracellular Copper Levels as the Mechanism of Action of Anticancer Copper Complexes: Clinical Relevance. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080852"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1200\/JCO.2008.17.1579","article-title":"Phase II, randomized, controlled, double-blinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma","volume":"27","author":"Gonzalez","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ygyno.2018.10.001","article-title":"A phase II evaluation of elesclomol sodium and weekly paclitaxel in the treatment of recurrent or persistent platinum-resistant ovarian, fallopian tube or primary peritoneal cancer: An NRG oncology\/gynecologic oncology group study","volume":"151","author":"Monk","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/cancers1010023","article-title":"N\u20321,N\u20323-Dimethyl-N\u20321,N\u20323-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS)","volume":"1","author":"Wangpaichitr","year":"2009","journal-title":"Cancers"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"14296","DOI":"10.1038\/srep14296","article-title":"Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1\u03b1 in cancer cells","volume":"5","author":"Kim","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ijc.10740","article-title":"The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production","volume":"102","author":"Moriguchi","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s10495-012-0746-x","article-title":"d-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis","volume":"17","author":"Qiao","year":"2012","journal-title":"Apoptosis"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/mmr.2016.6022","article-title":"Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review)","volume":"15","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in copper complexes as anticancer agents","volume":"114","author":"Santini","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2017.09.003","article-title":"Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells","volume":"815","author":"Chen","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Chen, X., Dou, Q.P., Liu, J., and Tang, D. (2021). Targeting Ubiquitin\u2013Proteasome System with Copper Complexes for Cancer Therapy. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.649151"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1039\/C8DT00794B","article-title":"Hypotoxic copper complexes with potent anti-metastatic and anti-angiogenic activities against cancer cells","volume":"47","author":"Shi","year":"2018","journal-title":"Dalton Trans."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/21\/3691\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:25:26Z","timestamp":1760113526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/21\/3691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":111,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["cancers16213691"],"URL":"https:\/\/doi.org\/10.3390\/cancers16213691","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]}}}