{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:12:00Z","timestamp":1787505120947,"version":"build-2736575974"},"reference-count":102,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"la Ligue Contre le Cancer","award":["CD87"],"award-info":[{"award-number":["CD87"]}]},{"name":"la Ligue Contre le Cancer","award":["CD23"],"award-info":[{"award-number":["CD23"]}]},{"name":"Comit\u00e9 de la Haute-Vienne","award":["CD87"],"award-info":[{"award-number":["CD87"]}]},{"name":"Comit\u00e9 de la Haute-Vienne","award":["CD23"],"award-info":[{"award-number":["CD23"]}]},{"name":"Comit\u00e9 de la Creuse","award":["CD87"],"award-info":[{"award-number":["CD87"]}]},{"name":"Comit\u00e9 de la Creuse","award":["CD23"],"award-info":[{"award-number":["CD23"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["CD87"],"award-info":[{"award-number":["CD87"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["CD23"],"award-info":[{"award-number":["CD23"]}]},{"name":"R\u00e9gion Nouvelle Aquitaine and D\u00e9l\u00e9gation INSERM Nouvelle Aquitaine","award":["CD87"],"award-info":[{"award-number":["CD87"]}]},{"name":"R\u00e9gion Nouvelle Aquitaine and D\u00e9l\u00e9gation INSERM Nouvelle Aquitaine","award":["CD23"],"award-info":[{"award-number":["CD23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This review examines the pivotal role of c-MYC in Chronic Lymphocytic Leukemia (CLL), focusing on how its overexpression leads to increased genetic instability, thereby accelerating disease progression. MYC, a major oncogene, encodes a transcription factor that regulates essential cellular processes, including cell cycle control, proliferation, and apoptosis. In CLL cases enriched with unmutated immunoglobulin heavy chain variable (IGHV) genes, MYC is significantly overexpressed and associated with active rearrangements in the IGH immunoglobulin heavy chain locus. This overexpression results in substantial DNA damage, including double-strand breaks, chromosomal translocations, and an increase in abnormal repair events. Consequently, c-MYC plays a dual role in CLL: it promotes aggressive cell proliferation while concurrently driving genomic instability through its involvement in genetic recombination. This dynamic contributes not only to CLL progression but also to the overall aggressiveness of the disease. Additionally, the review suggests that c-MYC\u2019s influence on genetic rearrangements makes it an attractive target for therapeutic strategies aimed at mitigating CLL malignancy. These findings underscore c-MYC\u2019s critical importance in advancing CLL progression, highlighting the need for further research to explore its potential as a target in future treatment approaches.<\/jats:p>","DOI":"10.3390\/cancers16223749","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T09:16:51Z","timestamp":1730884611000},"page":"3749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased c-MYC Expression Associated with Active IGH Locus Rearrangement: An Emerging Role for c-MYC in Chronic Lymphocytic Leukemia"],"prefix":"10.3390","volume":"16","author":[{"given":"Kenza","family":"Guiyedi","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8572-0284","authenticated-orcid":false,"given":"Mil\u00e8ne","family":"Parquet","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-2664","authenticated-orcid":false,"given":"Said","family":"Aoufouchi","sequence":"additional","affiliation":[{"name":"Gustave Roussy, B-Cell and Genome Plasticity Team, CNRS UMR9019, Villejuif, France and Universit\u00e9 Paris-Saclay, 91400 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Chauzeix","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"},{"name":"Laboratoire d\u2019H\u00e9matologie Biologique, Centre Hospitalier Universitaire de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-4329","authenticated-orcid":false,"given":"David","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"},{"name":"Laboratoire d\u2019H\u00e9matologie Biologique, Centre Hospitalier Universitaire de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israa","family":"Al Jamal","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"},{"name":"Faculty of Sciences, GSBT Genomic Surveillance and Biotherapy Team, Mont Michel Campus, Lebanese University, Tripoli 1300, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Feuillard","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"},{"name":"Laboratoire d\u2019H\u00e9matologie Biologique, Centre Hospitalier Universitaire de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Gachard","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"},{"name":"Laboratoire d\u2019H\u00e9matologie Biologique, Centre Hospitalier Universitaire de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Peron","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique (CNRS), Unit\u00e9 Mixte de Recherche (UMR) 7276\/INSERM U1262, Universit\u00e9 de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Report from the International Workshop on Chronic Lymphocytic Leukemia Updating the National Cancer Institute-Working Group 1996 Guidelines","volume":"111","author":"Hallek","year":"2008","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical Staging of Chronic 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