{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:34:00Z","timestamp":1790361240019,"version":"4.1.0"},"reference-count":102,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004296","name":"University of Campania &quot;Luigi Vanvitelli&quot;","doi-asserted-by":"publisher","award":["dd195\/2023"],"award-info":[{"award-number":["dd195\/2023"]}],"id":[{"id":"10.13039\/501100004296","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The oral cavity may suffer from diseases and lesions of different natures that can result in changes to the underlying microvasculature. These changes are typically observed during the examination of biopsy samples, but there is still a need to investigate methods for characterizing them in live tissues. Capillaroscopy, a medical imaging technique using polarized light and magnification, has shown promise in providing enhanced imaging of the oral mucosa microvasculature in preliminary studies. The present work proposed to review the literature on what capillaroscopy is, its applications in the imaging of oral mucosa microvasculature, and its diagnostic and prognostic significance in various diseases and conditions. While there is the limited literature available, further research in oral capillaroscopy, particularly in the field of oral oncology, is needed to determine its potential benefits in diagnosing and predicting outcomes for potentially malignant oral disorders and cancers.<\/jats:p>","DOI":"10.3390\/cancers16223774","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T03:53:14Z","timestamp":1731383594000},"page":"3774","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral Mucosa Capillaroscopy: A Narrative Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-6694","authenticated-orcid":false,"given":"Maria","family":"Contaldo","sequence":"first","affiliation":[{"name":"Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.21873\/anticanres.12587","article-title":"Potentially Malignant Oral Disorders and Cancer Transformation","volume":"38","author":"Ganesh","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.oooo.2018.03.011","article-title":"Clinical Features and Presentation of Oral Potentially Malignant Disorders","volume":"125","author":"Warnakulasuriya","year":"2018","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Cirillo, N. (2024). Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review. Cancers, 16.","DOI":"10.3390\/cancers16081550"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tenore, G., Mohsen, A., Rocchetti, F., Rossi, G., Cassoni, A., Battisti, A., Della Monaca, M., Di Gioia, C.R.T., De Felice, F., and Botticelli, A. (2023). Risk of Oral Squamous Cell Carcinoma in One Hundred Patients with Oral Lichen Planus: A Follow-Up Study of Umberto I University Hospital of Rome. Cancers, 15.","DOI":"10.3390\/cancers15113004"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Di Spirito, F., Amato, A., Romano, A., Dipalma, G., Xhajanka, E., Baroni, A., Serpico, R., Inchingolo, F., and Contaldo, M. (2022). Analysis of Risk Factors of Oral Cancer and Periodontitis from a Sex- and Gender-Related Perspective: Gender Dentistry. Appl. Sci., 12.","DOI":"10.3390\/app12189135"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1158\/1940-6207.CAPR-21-0047","article-title":"Oral Squamous Cell Carcinoma Associated with Precursor Lesions","volume":"14","author":"McCord","year":"2021","journal-title":"Cancer Prev. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.oooo.2024.03.006","article-title":"Differences among Oral Carcinomas Arising de Novo from Those Associated with Oral Potentially Malignant Disorders: A Systematic Review and Meta-Analysis","volume":"137","author":"Piemonte","year":"2024","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.23736\/S2784-8671.23.07676-4","article-title":"Immune-Mediated Oral Mucosal Pathology: A Comprehensive Review and Update for Clinicians Part I","volume":"158","author":"Alrashdan","year":"2023","journal-title":"Ital. J. Dermatol. Venereol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.23736\/S2784-8671.23.07690-9","article-title":"Immune-Mediated Oral Mucosal Pathology: A Comprehensive Review and Update for Clinicians\u2014Part II","volume":"159","author":"Alrashdan","year":"2024","journal-title":"Ital. J. Dermatol. Venereol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41432-022-0240-4","article-title":"What Is the Malignant Transformation Potential of Oral Lichen Planus?","volume":"23","author":"Offen","year":"2022","journal-title":"Evid. Based Dent."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105114","DOI":"10.1016\/j.dib.2020.105114","article-title":"Histopathological Imaging Database for Oral Cancer Analysis","volume":"29","author":"Rahman","year":"2020","journal-title":"Data Brief"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"105042","DOI":"10.1016\/j.oraloncology.2020.105042","article-title":"Reprint of \u201cSquamous Cell Carcinoma of the Oral Cavity, Larynx, Oropharynx and Hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up\u201d","volume":"113","author":"Machiels","year":"2021","journal-title":"Oral Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1007\/s00784-021-03870-3","article-title":"Patient Perception after Oral Biopsies: An Observational Outpatient Study","volume":"25","author":"Lajolo","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"901","DOI":"10.14219\/jada.archive.2001.0302","article-title":"Oral Lichen Planus: Patient Profile, Disease Progression and Treatment Responses","volume":"132","author":"Silvermam","year":"2001","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Romano, A., Di Stasio, D., Petruzzi, M., Fiori, F., Lajolo, C., Santarelli, A., Lucchese, A., Serpico, R., and Contaldo, M. (2021). Noninvasive Imaging Methods to Improve the Diagnosis of Oral Carcinoma and Its Precursors: State of the Art and Proposal of a Three-Step Diagnostic Process. Cancers, 13.","DOI":"10.3390\/cancers13122864"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jdsr.2023.12.004","article-title":"Adjunctive Aids for the Detection of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review of Systematic Reviews","volume":"60","author":"Lau","year":"2024","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.sdentj.2023.10.011","article-title":"Effectiveness of Adjunctive Screening Tools for Potentially Malignant Oral Disorders and Oral Cancer: A Systematic Review","volume":"36","year":"2024","journal-title":"Saudi Dent. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/ijd.14574","article-title":"Intraoral Confocal Microscopy of Suspicious Oral Lesions: A Prospective Case Series","volume":"59","author":"Contaldo","year":"2020","journal-title":"Int. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/ijd.14410","article-title":"In Vivo Reflectance Confocal Microscopy of Oral Lichen Planus","volume":"58","author":"Contaldo","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1158\/1078-0432.CCR-23-1361","article-title":"A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer","volume":"30","author":"Zanoni","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Russo, A., Patan\u00e8, V., Fusco, L., Faggioni, L., Boschetti, C.E., Santagata, M., Neri, E., Cappabianca, S., and Reginelli, A. (2024). Reliability of Ultrasonographic Assessment of Depth of Invasion and Tumor Thickness in Intraoral Mucosa Lesions: A Preliminary Experience. J. Clin. Med., 13.","DOI":"10.3390\/jcm13092595"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"106023","DOI":"10.1016\/j.oraloncology.2022.106023","article-title":"Application and Accuracy of Ultrasound-Guided Resections of Tongue Cancer","volume":"133","author":"Klijn","year":"2022","journal-title":"Oral Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.oraloncology.2019.03.006","article-title":"Intra-Operative Point-of-Procedure Delineation of Oral Cancer Margins Using Optical Coherence Tomography","volume":"92","author":"Sunny","year":"2019","journal-title":"Oral Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Malone, J., Hill, C., Tanskanen, A., Liu, K., Ng, S., MacAulay, C., Poh, C.F., and Lane, P.M. (2024). Imaging Biomarkers of Oral Dysplasia and Carcinoma Measured with In Vivo Endoscopic Optical Coherence Tomography. Cancers, 16.","DOI":"10.20944\/preprints202407.0625.v1"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hed.27232","article-title":"Efficacy of Optical Coherence Tomography in the Diagnosing of Oral Cancerous Lesion: Systematic Review and Meta-Analysis","volume":"45","author":"Kim","year":"2023","journal-title":"Head. Neck"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Liu, D., Zheng, J., Zhang, Q., Zhang, L., and Gao, F. (2023). A Combined Autofluorescence and Diffuse Reflectance Spectroscopy for Mucosa Tissue Diagnosis: Dual-Distance System and Data-Driven Decision. J. Biophotonics, 16.","DOI":"10.1002\/jbio.202300086"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lajolo, C., Tranfa, M., Patini, R., Fiorino, A., Musarra, T., Boniello, R., and Moro, A. (2022). Clinical Evaluation of the Optical Filter for Autofluorescence Glasses for Oral Cancer Curing Light Exposed (GOCCLES\u00ae) in the Management of Potentially Premalignant Disorders: A Retrospective Study. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19095579"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"della Vella, F., Lauritano, D., Lajolo, C., Lucchese, A., Di Stasio, D., Contaldo, M., Serpico, R., and Petruzzi, M. (2019). The Pseudolesions of the Oral Mucosa: Differential Diagnosis and Related Systemic Conditions. Appl. Sci., 9.","DOI":"10.3390\/app9122412"},{"key":"ref_29","first-page":"11","article-title":"Evaluation of the Intraepithelial Papillary Capillary Loops in Benign & Malignant Oral Lesions by in Vivo Virtual Chromoendoscopic Magnification: A Preliminary Study","volume":"31","author":"Contaldo","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1475-097X.2009.00913.x","article-title":"Human Microvascular Imaging: A Review of Skin and Tongue Videomicroscopy Techniques and Analysing Variables","volume":"30","author":"Awan","year":"2010","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/BOR.0000000000000901","article-title":"Imaging Techniques for Assessment of Vascular Involvement in Systemic Sclerosis","volume":"34","author":"Frech","year":"2022","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/CH-248001","article-title":"History of the Cutaneous Microcirculation from Antiquity to Modern Times","volume":"86","author":"Jung","year":"2024","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_33","unstructured":"Malpighi, M. (1661). De Pulmonibus Observationes Anatomicae, Libreria Oreste Gozzini snc."},{"key":"ref_34","unstructured":"Van Leeuenhoek, A. (1688). 65th Letter to the Royal Society: On the Circulation of the Blood, Hes & De Graaf."},{"key":"ref_35","unstructured":"Boerhave, H. (1703). De Usu Rationicii in Medicina, Project Gutenberg."},{"key":"ref_36","unstructured":"(1965). Callandar PI Capillary Form and Function. Bibl. Anat., 7, 9\u201328."},{"key":"ref_37","first-page":"24","article-title":"Nailfold Video-Capillaroscopy in the Study of Cardiovascular Disease: A Systematic Review","volume":"28","author":"Lim","year":"2023","journal-title":"Blood Press. Monit."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"H318","DOI":"10.1152\/ajpheart.1977.233.2.H318","article-title":"A Microscope-Television System for Studying Flow Velocity in Human Skin Capillaries","volume":"233","author":"Fagrell","year":"1977","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e1045","DOI":"10.1111\/j.1741-2358.2011.00608.x","article-title":"Oral Microcirculation in Post-Menopause: A Possible Correlation with Periodontitis","volume":"29","author":"Scardina","year":"2012","journal-title":"Gerodontology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1067\/mhj.2002.121461","article-title":"Morphologic Changes in the Microcirculation Induced by Chronic Smoking Habit: A Videocapillaroscopic Study on the Human Labial Mucosa","volume":"143","author":"Lova","year":"2002","journal-title":"Am. Heart J."},{"key":"ref_41","first-page":"39","article-title":"Study of the Microcirculation of Oral Mucosa in Healthy Subjects","volume":"108","author":"Scardina","year":"2003","journal-title":"Ital. J. Anat. Embryol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.12659\/MSM.902612","article-title":"Diabetic Microagiopathy of Oral Mucosa Depends on Disease Duration and Therapy","volume":"23","author":"Scardina","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_43","first-page":"295","article-title":"Oral Capillaroscopy: A New Diagnostic Method|L\u2019esame Capillaroscopico Orale: Nuova Metodica Diagnostica","volume":"57","author":"Carini","year":"2005","journal-title":"Reumatismo"},{"key":"ref_44","first-page":"266","article-title":"Microvascular Characteristics of the Human Interdental Papilla","volume":"36","author":"Scardina","year":"2007","journal-title":"J. Vet. Med. Ser. C: Anat. Histol. Embryol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.aanat.2009.08.001","article-title":"Anatomical Evaluation of Oral Microcirculation: Capillary Characteristics Associated with Sex or Age Group","volume":"191","author":"Scardina","year":"2009","journal-title":"Ann. Anat."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/ard.52.8.564","article-title":"Labial Capillary Microscopy in Systemic Sclerosis","volume":"52","author":"Grassi","year":"1993","journal-title":"Ann. Rheum. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1902\/jop.2005.76.11.1991","article-title":"Periodontal Microcirculatory Abnormalities in Patients with Systemic Sclerosis","volume":"76","author":"Scardina","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Antonacci, A., Praino, E., Abbinante, A., Favia, G., Rotondo, C., Bartolomeo, N., Giotta, M., Iannone, F., Orr\u00f9, G., and Agneta, M.T. (2024). Orofacial Manifestation of Systemic Sclerosis: A Cross-Sectional Study and Future Prospects of Oral Capillaroscopy. Diagnostics, 14.","DOI":"10.3390\/diagnostics14040437"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.aanat.2006.04.004","article-title":"Microvascular Abnormalities in Patients with Rheumatoid Arthritis","volume":"188","author":"Scardina","year":"2006","journal-title":"Ann. Anat."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.aanat.2009.01.001","article-title":"Evaluation of Labial Microvessels in Sjogren Syndrome: A Videocapillaroscopic Study","volume":"191","author":"Scardina","year":"2009","journal-title":"Ann. Anat."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0003319709344576","article-title":"Periodontal Disease and Sj\u00f6gren Syndrome: A Possible Correlation?","volume":"61","author":"Scardina","year":"2010","journal-title":"Angiology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.aanat.2007.12.004","article-title":"Modifications of Interdental Papilla Microcirculation: A Possible Cause of Periodontal Disease in Hashimoto\u2019s Thyroiditis?","volume":"190","author":"Scardina","year":"2008","journal-title":"Ann. Anat."},{"key":"ref_53","first-page":"e2021116","article-title":"Potential Utility of Oral Mucosal Capillaroscopy as an Indicator of Microvascular Damage in Beh\u00e7et Disease: A Preliminary Study","volume":"11","author":"Elmas","year":"2021","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_54","first-page":"81","article-title":"In Vivo Evaluation of Labial Microcirculation in Diabetics: A Comparison with Healthy Subjects","volume":"53","author":"Scardina","year":"2011","journal-title":"Panminerva Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"CR58","DOI":"10.12659\/MSM.882456","article-title":"Periodontal Microcirculation in Diabetics: An in Vivo Non-Invasive Analysis by Means of Videocapillaroscopy","volume":"18","author":"Scardina","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Scardina, G.A., Guercio, G., Valenti, C.F., Tegolo, D., and Messina, P. (2020). Videocapillaroscopy of the Oral Mucosa in Patients with Diabetic Foot: Possible Diagnostic Role of Microangiopathic Damage?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9113641"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"104222","DOI":"10.1016\/j.mvr.2021.104222","article-title":"Evaluation of Gingival Microcirculation in Patients with Gestational Diabetes Mellitus","volume":"138","author":"Yilmaz","year":"2021","journal-title":"Microvasc. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"940","DOI":"10.14219\/jada.archive.2008.0281","article-title":"Burning Mouth Syndrome: An Evaluation of in Vivo Microcirculation","volume":"139","author":"Scardina","year":"2008","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1016\/j.tripleo.2006.10.022","article-title":"Study of Microcirculation in Oral Lichen Planus by Video-Capillaroscopy","volume":"103","author":"Scardina","year":"2007","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4103\/0970-9290.59434","article-title":"Correlation of \u201cin Vivo\u201d Microcirculation and Degeneration of the Basal Cells of the Epithelium in Lingual Lichen Planus","volume":"20","author":"Scardina","year":"2009","journal-title":"Indian. J. Dent. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2334\/josnusd.51.193","article-title":"Morphological Characteristics of Microcirculation in Oral Lichen Planus Involving the Lateral Border of the Tongue","volume":"51","author":"Scardina","year":"2009","journal-title":"J. Oral Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00005-011-0150-1","article-title":"Angiogenesis in Oral Lichen Planus: An in Vivo and Immunohistological Evaluation","volume":"59","author":"Scardina","year":"2011","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_63","first-page":"95","article-title":"Smoking Habit and Labial Microcirculation","volume":"109","author":"Scardina","year":"2004","journal-title":"Ital. J. Anat. Embryol."},{"key":"ref_64","first-page":"301","article-title":"Morphologic Changes in the Microcirculation Induced by Chronic Smoking Habit: A Videocapillaroscopic Study on the Human Gingival Mucosa","volume":"18","author":"Scardina","year":"2005","journal-title":"Am. J. Dent."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10266-005-0050-0","article-title":"The Effect of Cigar Smoking on the Lingual Microcirculation","volume":"93","author":"Scardina","year":"2005","journal-title":"Odontology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"866","DOI":"10.12659\/MSM.912279","article-title":"Permanence of Modifications in Oral Microcirculation in Ex-Smokers","volume":"25","author":"Scardina","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Hassan, R., Faruqui, H., Alquraa, R., Eissa, A., Alshaiki, F., and Cheikh, M. (2021). Classification Criteria and Clinical Practice Guidelines for Rheumatic Diseases. Skills in Rheumatology, Springer.","DOI":"10.1007\/978-981-15-8323-0_25"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3126\/kumj.v11i2.12498","article-title":"Burning Mouth Syndrome: An Enigmatic Disorder","volume":"11","author":"Javali","year":"2013","journal-title":"Kathmandu Univ. Med. J. (KUMJ)"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ijom.2010.01.007","article-title":"Detecting Early Oral Cancer: Narrowband Imaging System Observation of the Oral Mucosa Microvasculature","volume":"39","author":"Takano","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.medcli.2022.10.007","article-title":"Sj\u00f6gren Syndrome","volume":"160","author":"Retamozo","year":"2023","journal-title":"Med. Clin."},{"key":"ref_71","first-page":"35","article-title":"Association between Denture Stomatitis, Candida Species and Diabetic Status","volume":"33","author":"Contaldo","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_72","first-page":"119","article-title":"Periodontal Capillary Imaging in Vivo by Endoscopic Capillaroscopy","volume":"30","author":"Townsend","year":"2010","journal-title":"J. Med. Biol. Eng."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/jre.12150","article-title":"Preliminary Study of Video Imaging of Blood Vessels in Tissues Lining the Gingival Sulcus in Periodontally Healthy Individuals","volume":"49","author":"Townsend","year":"2014","journal-title":"J. Periodontal Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/HYPERTENSIONAHA.114.05119","article-title":"Characteristics and Determinants of the Sublingual Microcirculation in Populations of Different Ethnicity","volume":"65","author":"Gu","year":"2015","journal-title":"Hypertension"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/B978-0-323-09138-1.00034-6","article-title":"The Eye in Rheumatic Disease","volume":"Volume 1\u20132","author":"Thorne","year":"2015","journal-title":"Rheumatology"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Rome, K., and Stewart, S. (2020). Rheumatic Diseases. Neale\u2019s Disorders of the Foot and Ankle, Elsevier.","DOI":"10.1016\/B978-0-7020-6223-0.00009-1"},{"key":"ref_77","first-page":"205","article-title":"Sj\u00f6gren Syndrome","volume":"8","author":"Srinivasan","year":"2007","journal-title":"Compr. Ophthalmol. Update"},{"key":"ref_78","unstructured":"Adil, A., Goyal, A., and Quint, J.M. (2024, August 30). Behcet Disease, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470257\/."},{"key":"ref_79","unstructured":"Goyal, R., Singhal, M., and Jialal, I. (2024, August 30). Type 2 Diabetes, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513253\/."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/1570161117666190502103733","article-title":"Microvascular Complications of Type 2 Diabetes Mellitus","volume":"18","author":"Faselis","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/odi.13868","article-title":"Worldwide Prevalence Estimates of Burning Mouth Syndrome: A Systematic Review and Meta-Analysis","volume":"28","author":"Wu","year":"2022","journal-title":"Oral Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic Pain as a Symptom or a Disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/jcim-2022-0239","article-title":"Innovative Histological and Histochemical Characterization of Tongue Biopsies from Patients with Burning Mouth Syndrome","volume":"20","year":"2023","journal-title":"J. Integr. Complement. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1034\/j.1600-0714.2003.00125.x","article-title":"Lack of Clinicopathologic Correlation in the Diagnosis of Oral Lichen Planus Based on the Presently Available Diagnostic Criteria and Suggestions for Modifications","volume":"32","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.resp.2013.01.013","article-title":"Cigarette Smoking and Inflammation Revisited","volume":"187","author":"Rom","year":"2013","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9587971","DOI":"10.1155\/2020\/9587971","article-title":"Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View","volume":"2020","author":"Contaldo","year":"2020","journal-title":"J. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ca.22300","article-title":"Changes of Oral Microcirculation in Chemotherapy Patients: A Possible Correlation with Mucositis?","volume":"27","author":"Scardina","year":"2014","journal-title":"Clin. Anat."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1902\/jop.2014.140189","article-title":"Severe Chronic Periodontitis Is Associated with Endothelial and Microvascular Dysfunctions: A Pilot Study","volume":"85","author":"Figueredo","year":"2014","journal-title":"J. Periodontol."},{"key":"ref_89","first-page":"412","article-title":"In Vivo Evaluation of Periodontal Microcirculatory Changes Associated with Endodontic Treatment","volume":"15","author":"Cumbo","year":"2014","journal-title":"Eur. J. Paediatr. Dent. Off. J. Eur. Acad. Paediatr. Dent."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijom.2012.06.008","article-title":"Microcirculation in the Healing of Surgical Wounds in the Oral Cavity","volume":"42","author":"Scardina","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/jmi.12975","article-title":"Real-Time Optical Vascular Imaging, a New Method for the Diagnosis and Monitoring of Oral Diseases","volume":"288","author":"Bastos","year":"2022","journal-title":"J. Microsc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/205016841600500112","article-title":"Real Time Optical Vascular Imaging: A Potential Technique for the Diagnosis of Mucosal Disease Including Early Oral Cancer","volume":"5","author":"Bastos","year":"2016","journal-title":"Prim. Dent. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1007\/s00405-020-06578-4","article-title":"Narrow Band Imaging Observed Oral Mucosa Microvasculature as a Tool to Detect Early Oral Cancer: An Indian Experience","volume":"278","author":"Nair","year":"2021","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"106099","DOI":"10.1016\/j.oraloncology.2022.106099","article-title":"Comparison of Narrow Band and Fluorescence Molecular Imaging to Improve Intraoperative Tumour Margin Assessment in Oral Cancer Surgery","volume":"134","author":"Voskuil","year":"2022","journal-title":"Oral Oncol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Ota, A., Miyamoto, I., Ohashi, Y., Chiba, T., Takeda, Y., and Yamada, H. (2022). Diagnostic Accuracy of High-Grade Intraepithelial Papillary Capillary Loops by Narrow Band Imaging for Early Detection of Oral Malignancy: A Cross-Sectional Clinicopathological Imaging Study. Cancers, 14.","DOI":"10.3390\/cancers14102415"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s12070-020-02070-x","article-title":"A Prospective Study to Evaluate the Role of Narrow Band Imaging and Toludine Blue in the Screening of Premalignant and Malignant Lesions of the Oral Cavity in a Tertiary Referral Centre","volume":"74","author":"Sachdeva","year":"2022","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Maslennikova, A.V., Sirotkina, M.A., Moiseev, A.A., Finagina, E.S., Ksenofontov, S.Y., Gelikonov, G.V., Matveev, L.A., Kiseleva, E.B., Zaitsev, V.Y., and Zagaynova, E.V. (2017). In-Vivo Longitudinal Imaging of Microvascular Changes in Irradiated Oral Mucosa of Radiotherapy Cancer Patients Using Optical Coherence Tomography. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-16823-2"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Graves, D.T., and Uribe, S.E. (2024). Advanced Imaging in Dental Research: From Gene Mapping to AI Global Data. J. Dent. Res., 220345241293040.","DOI":"10.1177\/00220345241293040"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Taormina, V., Raso, G., Gentile, V., Abbene, L., Buttacavoli, A., Bonsignore, G., Valenti, C., Messina, P., Scardina, G.A., and Cascio, D. (2023). Automated Stabilization, Enhancement and Capillaries Segmentation in Videocapillaroscopy. Sensors, 23.","DOI":"10.3390\/s23187674"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Popecki, P., Jurczyszyn, K., Zi\u0119tek, M., and Kozakiewicz, M. (2022). Texture Analysis in Diagnosing Skin Pigmented Lesions in Normal and Polarized Light-A Preliminary Report. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092505"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"de Oliveira, L.A.P., Lopes, D.L.G., Gomes, J.P.P., da Silveira, R.V., Nozaki, D.V.A., Santos, L.F., Castellano, G., de Castro Lopes, S.L.P., and Costa, A.L.F. (2024). Enhanced Diagnostic Precision: Assessing Tumor Differentiation in Head and Neck Squamous Cell Carcinoma Using Multi-Slice Spiral CT Texture Analysis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13144038"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Contaldo, M., Di Spirito, F., Di Palo, M.P., Amato, A., Fiori, F., and Serpico, R. (2024). Fractal Analysis Applied to the Diagnosis of Oral Cancer and Oral Potentially Malignant Disorders: A Comprehensive Review. Appl. Sci., 14.","DOI":"10.3390\/app14020777"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/22\/3774\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:29:04Z","timestamp":1760113744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/22\/3774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":102,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["cancers16223774"],"URL":"https:\/\/doi.org\/10.3390\/cancers16223774","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]}}}