{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:38:51Z","timestamp":1791722331579,"version":"4.3.4"},"reference-count":32,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Due to the increasing global prevalence of non-alcoholic fatty liver disease (NAFLD), which is closely linked to metabolic disorders, there has been a rise in the number of patients with NAFLD undergoing hepatectomy. The metabolic disorders, as well as NAFLD, increase venous thrombotic risk. NAFLD was recently updated to a new concept of hepatic steatosis: metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to investigate the impact of MASLD on post-hepatectomy portal vein thrombosis (PH-PVT). Methods: A total of 106 patients who underwent hepatectomy for liver cancer were included. Steatotic liver disease (SLD) was diagnosed using a CT L\/S ratio of &lt;1.1. SLD was classified as follows: MASLD, SLD associated with metabolic factors without alcohol consumption; MetALD, SLD with metabolic factors and moderate alcohol consumption; Other SLD, alcohol or other specific etiology of SLD; and No SLD, no hepatic steatosis. Results: PH-PVT was detected in 12\/106 patients (11.3%); MASLD, 7\/20 (35%); MetALD, 1\/5 (20%); Other SLD, 1\/13 (8%); and No SLD, 3\/68 (4.4%). Multivariate analysis showed that the MASLD group (including MASLD and MetALD) (odds ratio [OR], 9.27) and left lateral sectionectomy (OR, 6.22) were significant independent risk factors for PH-PVT. Additionally, the incidence of PH-PVT was significantly higher in patients with MASLD than in those without SLD, along with metabolic factors, excluding alcohol consumption. Conclusions: MASLD and MetALD were identified as independent and significant risk factors for PH-PVT. Consideration was given to the idea that hepatic steatosis and metabolic dysfunction play synergistic roles in PH-PVT development.<\/jats:p>","DOI":"10.3390\/cancers16223844","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T04:53:05Z","timestamp":1731991985000},"page":"3844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of MASLD on Portal Vein Thrombosis Following Hepatectomy for Liver Cancer"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-7775","authenticated-orcid":false,"given":"Yoshito","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-8386","authenticated-orcid":false,"given":"Shigeo","family":"Shimose","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamichi","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaaki","family":"Shimokobe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Torigoe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyoaikai Tobata Kyoritsu Hospital, Kitakyushu 804-0093, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00423-006-0084-y","article-title":"Liver resective surgery: A multivariate analysis of postoperative outcome and complication","volume":"392","author":"Benzoni","year":"2007","journal-title":"Langenbecks Arch. 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