{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:36:34Z","timestamp":1787027794900,"version":"build-2736575974"},"reference-count":274,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Modulated electro-hyperthermia (mEHT) is unique due to its combination of thermal and non-thermal effects. Method: This report summarizes the literature on the effects of mEHT observed in vitro and in vivo. Results: The thermal and electrical heterogeneity of tissues allows the radiofrequency signal to selectively target malignant tissue. The applied modulation appears to activate various apoptotic pathways, predominantly leading to immunogenic cell death (ICD). ICD promotes the release of damage-associated molecular patterns, potentially producing tumour-specific antigen-presenting cells. This abscopal-type effect may target distant metastases while treating the primary tumour locally. This immune memory effect is like vaccination mechanisms. Conclusions: The application of mEHT has the potential to expand from local to systemic disease, enabling the simultaneous treatment of micro- and macro-metastases.<\/jats:p>","DOI":"10.3390\/cancers16233908","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T12:25:42Z","timestamp":1732191942000},"page":"3908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Synergy of Thermal and Non-Thermal Effects in Hyperthermic Oncology"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-7134","authenticated-orcid":false,"given":"Carrie Anne","family":"Minnaar","sequence":"first","affiliation":[{"name":"Department of Radiation Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-9992","authenticated-orcid":false,"given":"Gyula Peter","family":"Szigeti","sequence":"additional","affiliation":[{"name":"John von Neumann Faculty of Informatics, O\u0301buda University, 1034 Budapest, Hungary"},{"name":"MedTech Innovation and Education Center, University Research and Innovation Center, \u00d3buda University, 1034 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-1183","authenticated-orcid":false,"given":"Andras","family":"Szasz","sequence":"additional","affiliation":[{"name":"Department of Biotechnics, Hungarian University of Agriculture and Life Sciences, 2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(01)06374-7","article-title":"Curative power of fever","volume":"358","author":"Duffell","year":"2001","journal-title":"Lancet"},{"key":"ref_2","first-page":"374","article-title":"Hyperthermia combined with chemotherapy\u2014Biological rationale, clinical application, and treatment results","volume":"22","author":"Issels","year":"1999","journal-title":"Onkologie"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3109\/02656736.2015.1040471","article-title":"Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry","volume":"31","author":"Cihoric","year":"2015","journal-title":"Int. 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