{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:07:49Z","timestamp":1782979669727,"version":"3.54.5"},"reference-count":174,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"Fundaci\u00f3n Mutua Madrile\u00f1a","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"Fondos FEDER (EU) and Consejer\u00eda Educaci\u00f3n Junta Castilla y Le\u00f3n","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca-IBSAL-Herencia Juan Salvador Escudero","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"Proyectos de Investigaci\u00f3n del SACYL, Spain, Gerencia Regional de Salud de Castilla y Le\u00f3n","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]},{"name":"European Union","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"European Union","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"European Union","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"European Union","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"European Union","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"European Union","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"European Union","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"European Union","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"European Union","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"European Union","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"European Union","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en C\u00e1ncer (RTICC) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]},{"name":"Colfuturo Scholarship-Credit","award":["FMM21\/002 (AP176752021)"],"award-info":[{"award-number":["FMM21\/002 (AP176752021)"]}]},{"name":"Colfuturo Scholarship-Credit","award":["SA118P20"],"award-info":[{"award-number":["SA118P20"]}]},{"name":"Colfuturo Scholarship-Credit","award":["SA198P24"],"award-info":[{"award-number":["SA198P24"]}]},{"name":"Colfuturo Scholarship-Credit","award":["IBPED21\/00001"],"award-info":[{"award-number":["IBPED21\/00001"]}]},{"name":"Colfuturo Scholarship-Credit","award":["GRS 2385\/A\/21"],"award-info":[{"award-number":["GRS 2385\/A\/21"]}]},{"name":"Colfuturo Scholarship-Credit","award":["GRS 2386\/A\/21"],"award-info":[{"award-number":["GRS 2386\/A\/21"]}]},{"name":"Colfuturo Scholarship-Credit","award":["GRS2506\/A22"],"award-info":[{"award-number":["GRS2506\/A22"]}]},{"name":"Colfuturo Scholarship-Credit","award":["GRS2823\/A1\/2023"],"award-info":[{"award-number":["GRS2823\/A1\/2023"]}]},{"name":"Colfuturo Scholarship-Credit","award":["RD12\/0036\/0069"],"award-info":[{"award-number":["RD12\/0036\/0069"]}]},{"name":"Colfuturo Scholarship-Credit","award":["CIBERONC CB16\/12\/00233"],"award-info":[{"award-number":["CIBERONC CB16\/12\/00233"]}]},{"name":"Colfuturo Scholarship-Credit","award":["CM23\/00101"],"award-info":[{"award-number":["CM23\/00101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Acute lymphoblastic leukemia (ALL) is a hematological neoplasm characterized by the clonal expansion of abnormal lymphoid precursors in bone marrow, which leads to alterations in the processes of cell differentiation and maturation as a consequence of genetic alterations. The integration of conventional methods, such as cytogenetics and immunophenotyping, and next-generation sequencing (NGS) has led to significant improvements at diagnosis and patient stratification; this has also allowed the discovery of several novel molecular entities with specific genetic variants that may drive the processes of leukemogenesis. Nevertheless, the understanding of the process of leukemogenesis remains a challenge since this disease persists as the most frequent cancer in children; it accounts for approximately one-quarter of adult acute leukemias, and the patient management may take into consideration the high intra- and inter-tumor heterogeneity and the relapse risk due to the various molecular events that can occur during clonal evolution. Some germline variants have been identified as risk factors or have been found to be related to the response to treatment. Therefore, better knowledge of the genetic alterations in B-ALL will have a prognostic impact from the perspective of personalized medicine. This review aims to compare, synthesize, and highlight recent findings concerning ALL obtained through NGS that have led to a better understanding of new molecular subtypes based on immunophenotypic characteristics, mutational profiles, and expression profiles.<\/jats:p>","DOI":"10.3390\/cancers16233965","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T09:10:14Z","timestamp":1732612214000},"page":"3965","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the Genetic Heterogeneity of Acute Lymphoblastic Leukemia Based on NGS Applications"],"prefix":"10.3390","volume":"16","author":[{"given":"Valentina","family":"Ram\u00edrez Maldonado","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n del C\u00e1ncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josgrey","family":"Navas Acosta","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n del C\u00e1ncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-2524","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Maldonado Marcos","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n del C\u00e1ncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-7218","authenticated-orcid":false,"given":"\u00c1ngela","family":"Villaverde Ramiro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n del C\u00e1ncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-3096","authenticated-orcid":false,"given":"Alberto","family":"Hern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n del C\u00e1ncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain"},{"name":"Servicio de Hematolog\u00eda, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9661-9371","authenticated-orcid":false,"given":"Jes\u00fas M.","family":"Hern\u00e1ndez Rivas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n del C\u00e1ncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain"},{"name":"Servicio de Hematolog\u00eda, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-4198","authenticated-orcid":false,"given":"Roc\u00edo","family":"Benito S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n del C\u00e1ncer, IBMCC, CSIC, Universidad de Salamanca, IBSAL (Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca) Campus, Miguel de Unamuno, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s11899-021-00641-5","article-title":"Application of Next-Generation Sequencing-Based Mutational Profiling in Acute Lymphoblastic Leukemia","volume":"16","author":"Aleem","year":"2021","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lejman, M., Cha\u0142upnik, A., Chilimoniuk, Z., and Dobosz, M. (2022). Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052755"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/S0140-6736(12)62187-4","article-title":"Acute lymphoblastic leukaemia","volume":"381","author":"Inaba","year":"2013","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0140-6736(19)33018-1","article-title":"Acute lymphoblastic leukaemia","volume":"395","author":"Malard","year":"2020","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1182\/asheducation-2016.1.580","article-title":"T-cell acute lymphoblastic leukemia","volume":"1","author":"Raetz","year":"2016","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1038\/bcj.2017.53","article-title":"Acute lymphoblastic leukemia: A comprehensive review and 2017 update","volume":"7","author":"Terwilliger","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13023-020-01536-z","article-title":"Diagnosis of Rare Diseases: A scoping review of clinical decision support systems","volume":"15","author":"Schaaf","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s10552-015-0657-6","article-title":"Acute lymphoblastic leukemia: An assessment of international incidence, survival, and disease burden","volume":"26","author":"Katz","year":"2015","journal-title":"Cancer Causes Control"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ajh.26156","article-title":"Acute lymphoblastic leukemia: A population-based study of outcome in the United States based on the surveillance, epidemiology, and end results (SEER) database, 1980\u20132017","volume":"96","author":"Sasaki","year":"2021","journal-title":"Am. J. Hematol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ng.2287","article-title":"The pediatric cancer genome project","volume":"44","author":"Downing","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1056\/NEJMra1400972","article-title":"Acute lymphoblastic leukemia in children","volume":"373","author":"Hunger","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Beneduce, G., De Matteo, A., Stellato, P., Testi, A.M., Bertorello, N., Colombini, A., Putti, M.C., Rizzari, C., Cesaro, S., and Cellini, M. (2022). Blinatumomab in Children and Adolescents with Relapsed\/Refractory B Cell Precursor Acute Lymphoblastic Leukemia: A Real-Life Multicenter Retrospective Study in Seven AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) Centers. Cancers, 14.","DOI":"10.3390\/cancers14020426"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jped.2018.07.013","article-title":"Treatment outcomes of children with acute lymphoblastic leukemia in a middle-income developing country: High mortalities, early relapses, and poor survival","volume":"96","author":"Abdelmabood","year":"2020","journal-title":"J. Pediatr. (Rio J.)"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/ejh.13247","article-title":"Survival in adult acute lymphoblastic leukaemia (ALL): A report from the Swedish ALL Registry","volume":"103","author":"Lennmyr","year":"2019","journal-title":"Eur. J. Haematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1200\/JCO.2016.70.7836","article-title":"Genetic basis of acute lymphoblastic leukemia","volume":"35","author":"Iacobucci","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.semcancer.2020.10.013","article-title":"The genomic landscape of pediatric acute lymphoblastic leukemia and precision medicine opportunities","volume":"84","author":"Tran","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood.2021014309","article-title":"Guiding the global evolution of cytogenetic testing for hematologic malignancies","volume":"139","author":"Akkari","year":"2020","journal-title":"Blood"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1182\/blood-2006-10-051912","article-title":"Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): Analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII\/Eastern Cooperative Oncology Group (ECOG) 2993 trial","volume":"109","author":"Moorman","year":"2007","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bendari, M., Sraidi, S., and Khoubila, N. (2021). Genetic Abnormalities in ALL. Cytogenetics-Classical and Molecular Strategies for Analysing Heredity Material. Cap 8, IntechOpen.","DOI":"10.5772\/intechopen.97429"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13039-015-0153-4","article-title":"High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia","volume":"8","author":"Othman","year":"2015","journal-title":"Mol. Cytogenet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1182\/blood-2015-02-580043","article-title":"Redefining ALL classification: Toward detecting high-risk ALL and implementing precision medicine","volume":"125","author":"Hunger","year":"2015","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.6004\/jnccn.2021.0042","article-title":"Acute lymphoblastic leukemia, version 2.2021","volume":"19","author":"Brown","year":"2021","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.18632\/oncotarget.2218","article-title":"Mutational spectrum of adult T-ALL","volume":"6","author":"Neumann","year":"2014","journal-title":"Oncotarget"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21037\/tp.2020.01.07","article-title":"Ras pathway mutation feature in the same individuals at diagnosis and relapse of childhood acute lymphoblastic leukemia","volume":"9","author":"Zhang","year":"2020","journal-title":"Transl. Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Pavlovic, S., Kotur, N., Stankovic, B., Zukic, B., Gasic, V., and Dokmanovic, L. (2019). Pharmacogenomic and pharmacotranscriptomic profiling of childhood acute lymphoblastic leukemia: Paving the way to personalized treatment. Genes, 10.","DOI":"10.3390\/genes10030191"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.blre.2015.01.001","article-title":"Pharmacogenetics predictive of response and toxicity in acute lymphoblastic leukemia therapy","volume":"29","author":"Mei","year":"2015","journal-title":"Blood Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.semcancer.2017.09.001","article-title":"Epigenetics in pediatric acute lymphoblastic leukemia","volume":"51","author":"Nordlund","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Dro\u017cak, P., Bryli\u0144ski, \u0141., and Zawitkowska, J. (2022). A Comprehensive Overview of Recent Advances in Epigenetics in Pediatric Acute Lymphoblastic Leukemia. Cancers, 14.","DOI":"10.3390\/cancers14215384"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1182\/blood.2023023568","article-title":"Management of ALL in adults: 2024 ELN recommendations from a European expert panel","volume":"143","author":"Boissel","year":"2024","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41375-022-01799-4","article-title":"Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial","volume":"37","author":"Schwab","year":"2023","journal-title":"Leukemia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.critrevonc.2018.04.002","article-title":"Genomics and pharmacogenomics of pediatric acute lymphoblastic leukemia","volume":"126","author":"Wu","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_32","first-page":"242","article-title":"Pharmacogenetics of asparaginase in acute lymphoblastic leukemia","volume":"2","author":"Abaji","year":"2019","journal-title":"Cancer Drug Resist."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13045-023-01409-5","article-title":"The evolution of acute lymphoblastic leukemia research and therapy at MD Anderson over four decades","volume":"16","author":"Jabbour","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.seminhematol.2013.06.007","article-title":"A 50-year journey to cure childhood acute lymphoblastic leukemia","volume":"50","author":"Pui","year":"2013","journal-title":"Semin. Hematol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Inaba, H., Azzato, E.M., and Mullighan, C.G. (2017). Integration of next-generation sequencing to treat acute lymphoblastic leukemia with targetable lesions: The St. Jude Children\u2019s Research Hospital approach. Front. Pediatr., 5.","DOI":"10.3389\/fped.2017.00258"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"E11711","DOI":"10.1073\/pnas.1814397115","article-title":"Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1223 cases","volume":"115","author":"Li","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood-2018-10-882142","article-title":"PAX5 P80R mutation identifies a novel subtype of B-cellprecursor acute lymphoblastic leukemia with favorable outcome","volume":"133","author":"Passet","year":"2019","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00277-018-3554-8","article-title":"Panel-based next-generation sequencing identifies prognostic and actionable genes in childhood acute lymphoblastic leukemia and is suitable for clinical sequencing","volume":"98","author":"Ishida","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13045-018-0692-3","article-title":"Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia","volume":"12","author":"James","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1158\/0008-5472.CAN-20-1145","article-title":"Evolution of the epigenetic landscape in childhood B Acute lymphoblastic leukemia and its role in drug resistance","volume":"80","author":"Evensen","year":"2020","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e12104","DOI":"10.15252\/emmm.202012104","article-title":"Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors","volume":"12","author":"Kunz","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jmoldx.2021.05.007","article-title":"LYmphoid NeXt-Generation Sequencing (LYNX) Panel: A Comprehensive Capture-Based Sequencing Tool for the Analysis of Prognostic and Predictive Markers in Lymphoid Malignancies","volume":"23","author":"Navrkalova","year":"2021","journal-title":"J. Mol. Diagn."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1080\/0284186X.2021.1900908","article-title":"Genomic landscape of B-other acute lymphoblastic leukemia in an adult retrospective cohort with a focus on BCR-ABL1-like subtype","volume":"60","author":"Hrabovsky","year":"2021","journal-title":"Acta Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Alsuwaidi, L., Hachim, M., and Senok, A. (2021). Novel Markers in Pediatric Acute Lymphoid Leukemia: The Role of ADAM6 in B Cell Leukemia. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.706129"},{"key":"ref_45","first-page":"3188","article-title":"Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders","volume":"5","author":"Stewart","year":"2021","journal-title":"Blood Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41375-021-01154-z","article-title":"Potential and pitfalls of whole transcriptome-based immunogenetic marker identification in acute lymphoblastic leukemia; a EuroMRD and EuroClonality-NGS Working Group study","volume":"35","author":"Cazzaniga","year":"2021","journal-title":"Leukemia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s43018-022-00370-5","article-title":"Acute lymphoblastic leukemia displays a distinct highly methylated genome","volume":"3","author":"Hetzel","year":"2022","journal-title":"Nat. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"293","DOI":"10.17219\/acem\/144170","article-title":"MicroRNA gene methylation landscape in pediatric B-cell precursor acute lymphoblastic leukemia","volume":"31","author":"Chaber","year":"2022","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"146211","DOI":"10.1016\/j.gene.2022.146211","article-title":"Meta-analysis of microRNA profiling data does not reveal a consensus signature for B cell acute lymphoblastic leukemia","volume":"821","author":"Longjohn","year":"2022","journal-title":"Gene"},{"key":"ref_50","first-page":"1","article-title":"Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures","volume":"3","author":"Barnett","year":"2023","journal-title":"bioRxiv"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/ajh.27175","article-title":"A framework for the clinical implementation of optical genome mapping in hematologic malignancies","volume":"99","author":"Levy","year":"2024","journal-title":"Am. J. Hematol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jmoldx.2022.09.009","article-title":"Clinical Validation and Diagnostic Utility of Optical Genome Mapping for Enhanced Cytogenomic Analysis of Hematological Neoplasms","volume":"24","author":"Sahajpal","year":"2022","journal-title":"J. Mol. Diagn."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Gordeeva, V., Sharova, E., and Arapidi, G. (2022). Progress in Methods for Copy Number Variation Profiling. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042143"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Song, Y., Fang, Q., and Mi, Y. (2022). Prognostic significance of copy number variation in B-cell acute lymphoblastic leukemia. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.981036"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: Integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"ref_57","unstructured":"MLL M\u00fcnchner Leuk\u00e4mielabor GmbH (2024, March 18). MLL ALL Classification. Available online: https:\/\/www.mll.com\/en\/acute-lymphoblastic-leukemia-all\/acute-lymphoblastic-leukemia-all#:~:text=ALL%3A%20Classification,lymphoblastic%20lymphoma%20(Swerdlow%20et%20al."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00428-022-03448-8","article-title":"International Consensus Classification of acute lymphoblastic leukemia\/lymphoma","volume":"482","author":"Duffield","year":"2023","journal-title":"Virchows Archiv."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Nishiwaki, S., Kim, J.H., Ito, M., Maeda, M., Okuno, Y., Koyama, D., Ozawa, Y., Gunji, M., Osaki, M., and Kitamura, K. (2020). Multi-Lineage BCR-ABL Expression in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Is Associated With Improved Prognosis but No Specific Molecular Features. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.586567"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1182\/blood.2023023583","article-title":"Uncovering new layers of Ph+ ALL biology","volume":"143","author":"Rathana","year":"2024","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/s41588-023-01429-4","article-title":"Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia","volume":"55","author":"Kim","year":"2023","journal-title":"Nat. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3324\/haematol.2018.196055","article-title":"Prognostic implications of additional genomic lesions in adult Philadelphia chromosomepositive acute lymphoblastic leukemia","volume":"104","author":"Fedullo","year":"2019","journal-title":"Haematologica"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1182\/blood.2023021752","article-title":"Developmental trajectories and cooperating genomic events define molecular subtypes of BCR::ABL1-positive ALL","volume":"143","author":"Bastian","year":"2023","journal-title":"Blood"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1182\/blood-2016-07-726588","article-title":"Ph-like acute lymphoblastic leukemia: A high-risk subtype in adults","volume":"129","author":"Jain","year":"2017","journal-title":"Blood"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.3324\/haematol.2020.252916","article-title":"ABL-class fusion positive acute lymphoblastic leukemia: Can targeting ABL cure ALL?","volume":"105","author":"Tran","year":"2020","journal-title":"Haematologica"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/S2352-3026(20)30353-7","article-title":"Outcomes of paediatric patients with B-cell acute lymphocytic leukaemia with ABL-class fusion in the pre-tyrosine-kinase inhibitor era: A multicentre, retrospective, cohort study","volume":"8","author":"Cario","year":"2021","journal-title":"Lancet Haematol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1200\/JCO.2016.69.0073","article-title":"High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults","volume":"35","author":"Roberts","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Norvilas, R., Dirse, V., Semaskeviciene, R., Mickeviciute, O., Gineikiene, E., Stoskus, M., Vaitkeviciene, G., Rascon, J., and Griskevicius, L. (2021). Low incidence of ABL-class and JAK-STAT signaling pathway alterations in uniformly treated pediatric and adult B-cell acute lymphoblastic leukemia patients using MRD risk-directed approach\u2014A population-based study. BMC Cancer, 21.","DOI":"10.1186\/s12885-020-07781-6"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1182\/blood-2016-12-758979","article-title":"Targetable kinase gene fusions in high-risk B-ALL: A study from the Children\u2019s Oncology Group","volume":"129","author":"Reshmi","year":"2017","journal-title":"Blood"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Downes, C.E., McClure, B.J., McDougal, D.P., Heatley, S.L., Bruning, J.B., Thomas, D., Yeung, D.T., and White, D.L. (2022). JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.942053"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.3324\/haematol.2018.207019","article-title":"BCR-ABL1-like acute lymphoblastic leukemia in childhood and targeted therapy","volume":"105","author":"Cario","year":"2020","journal-title":"Haematologica"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000519782","article-title":"BCR\/ABL1-Like Acute Lymphoblastic Leukemia: From Diagnostic Approaches to Molecularly Targeted Therapy","volume":"145","author":"Lewandowski","year":"2022","journal-title":"Acta Haematol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1182\/blood-2018-05-849554","article-title":"Etv6-ntrk3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective trk inhibition","volume":"132","author":"Roberts","year":"2018","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00018-017-2620-z","article-title":"Molecular processes involved in B cell acute lymphoblastic leukaemia","volume":"75","author":"Malouf","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1002\/cam4.3928","article-title":"RAG1 co-expression signature identifies ETV6-RUNX1-like B-cell precursor acute lymphoblastic leukemia in children","volume":"10","author":"Chen","year":"2021","journal-title":"Cancer Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11790","DOI":"10.1038\/ncomms11790","article-title":"Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia","volume":"7","author":"Henningsson","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/gcc.22464","article-title":"ETV6\/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27\/CD44 immunophenotype","volume":"56","author":"Zaliova","year":"2017","journal-title":"Genes. Chromosomes Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/asheducation-2018.1.137","article-title":"Genetics and prognosis of ALL in chlidren vs adults","volume":"1","author":"Roberts","year":"2018","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41375-022-01806-8","article-title":"Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia","volume":"37","author":"Ryan","year":"2023","journal-title":"Leukemia"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Lee, S.H.R., Li, Z., Tai, S.T., Oh, B.L.Z., and Yeoh, A.E.J. (2021). Genetic alterations in childhood acute lymphoblastic leukemia: Interactions with clinical features and treatment response. Cancers, 13.","DOI":"10.3390\/cancers13164068"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1158\/2643-3230.BCD-20-0229","article-title":"Clinical Significance of Novel Subtypes of Acute Lymphoblastic Leukemia in the Context of Minimal Residual Disease\u2013Directed Therapy","volume":"2","author":"Jeha","year":"2021","journal-title":"Blood Cancer Discov."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1182\/bloodadvances.2021005894","article-title":"ALLSorts: An RNA-Seq subtype classifier for B-cell acute lymphoblastic leukemia","volume":"6","author":"Schmidt","year":"2022","journal-title":"Blood Adv."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.3324\/haematol.2020.250423","article-title":"DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch","volume":"106","author":"Novakova","year":"2021","journal-title":"Haematologica"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Iacobucci, I., Kimura, S., and Mullighan, C.G. (2021). Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia. J. Clin. Med., 10.","DOI":"10.3390\/jcm10173792"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1182\/bloodadvances.2021005318","article-title":"A novel class of ZNF384 aberrations in acute leukemia","volume":"5","author":"Zaliova","year":"2021","journal-title":"Blood Adv."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1200\/JCO.2013.51.3242","article-title":"IGH Translocations Are Prevalent in Teenagers and Young Adults With Acute Lymphoblastic Leukemia and Are Associated With a Poor Outcome","volume":"32","author":"Russell","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nrclinonc.2015.38","article-title":"Genomics in acute lymphoblastic leukaemia: Insights and treatment implications","volume":"12","author":"Roberts","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1038\/bcj.2013.72","article-title":"Highly aggressive T-cell acute lymphoblastic leukemia with t(8;14)(q24;q11): Extensive genetic characterization and achievement of early molecular remission and long-term survival in an adult patient","volume":"4","author":"Parolini","year":"2014","journal-title":"Blood Cancer J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3324\/haematol.2021.280557","article-title":"Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement","volume":"108","author":"Bomken","year":"2023","journal-title":"Haematologica"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/BS9.0000000000000073","article-title":"MYC in T-cell acute lymphoblastic leukemia: Functional implications and targeted strategi","volume":"3","author":"Li","year":"2021","journal-title":"Blood Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pcl.2014.09.004","article-title":"Biology of childhood acute lymphoblastic leukemia","volume":"62","author":"Bhojwani","year":"2015","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/bjh.17869","article-title":"Genetic characterisation of childhood B-other-acute lymphoblastic leukaemia in UK patients by fluorescence in situ hybridisation and Multiplex Ligation-dependent Probe Amplification","volume":"196","author":"Schwab","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/MPH.0b013e31828f8746","article-title":"Biology of Childhood Acute Lymphoblastic Leukemia","volume":"35","author":"Nigro","year":"2013","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/s41588-022-01159-z","article-title":"The genomic landscape of pediatric acute lymphoblastic leukemia","volume":"54","author":"Brady","year":"2022","journal-title":"Nat. Genet."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3324\/haematol.2015.136366","article-title":"Adults with philadelphia chromosome\u2013like acute lymphoblastic leukemia frequently have igh-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis","volume":"102","author":"Herold","year":"2017","journal-title":"Haematologica"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa1403088","article-title":"Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia","volume":"371","author":"Roberts","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.exphem.2015.05.015","article-title":"Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia","volume":"43","author":"Ghazavi","year":"2015","journal-title":"Exp. Hematol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.3324\/haematol.2018.199885","article-title":"B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene","volume":"104","author":"Osumi","year":"2019","journal-title":"Haematologica"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41408-019-0239-z","article-title":"Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia\/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3\/TEF gene fusion","volume":"9","author":"Rowsey","year":"2019","journal-title":"Blood Cancer J."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Tirado, C.A., Shabsovich, D., Yeh, L., Pullarkat, S.T., Yang, L., Kallen, M., and Rao, N. (2015). A (1;19) translocation involving TCF3-PBX1 fusion within the context of a hyperdiploid karyotype in adult B-ALL: A case report and review of the literature. Biomark. Res., 3.","DOI":"10.1186\/s40364-015-0029-0"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1182\/blood.2021010745","article-title":"HLF expression defines the human hematopoietic stem cell state","volume":"138","author":"Lehnertz","year":"2021","journal-title":"Blood"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2141.2007.06644.x","article-title":"Characterisation of genomic translocation breakpoints and identification of an alternative TCF3\/PBX1 fusion transcript in t(1;19)(q23;p13)-positive acute lymphoblastic leukaemias","volume":"138","author":"Paulsson","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Lin, N., Yan, X., Cai, D., and Wang, L. (2021). Leukemia With TCF3-ZNF384 Rearrangement as a Distinct Subtype of Disease With Distinct Treatments: Perspectives From A Case Report and Literature Review. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.709036"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.3362","article-title":"Genomics and drug profiling of fatal TCF3-HLF\u00e2 \u2019positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options","volume":"47","author":"Fischer","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1080\/10428194.2019.1602267","article-title":"The first case of elderly TCF3-HLF-positive B-cell acute lymphoblastic leukemia","volume":"60","author":"Takeda","year":"2019","journal-title":"Leuk Lymphoma"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Lejman, M., W\u0142odarczyk, M., Zawitkowska, J., and Kowalczyk, J.R. (2020). Comprehensive chromosomal aberrations in a case of a patient with TCF3-HLF-positive BCP-ALL. BMC Med. Genom., 13.","DOI":"10.1186\/s12920-020-0709-y"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.3324\/haematol.2018.210104","article-title":"Durable remissions in TCF3-HLF positive acute lymphoblastic leukemia with blinatumomab and stem cell transplantation","volume":"104","author":"Mouttet","year":"2019","journal-title":"Haematologica"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.clml.2021.01.014","article-title":"Successful Treatment of TCF3-HLF\u2013positive Childhood B-ALL with Chimeric Antigen Receptor T-Cell Therapy","volume":"21","author":"Wang","year":"2021","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1182\/bloodadvances.2021004895","article-title":"Distinct clinical characteristics of DUX4- And PAX5-altered childhood B-lymphoblastic leukemia","volume":"5","author":"Li","year":"2021","journal-title":"Blood Adv."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood.2020010144","article-title":"Molecular classification improves risk assessment in adult BCR-ABL1\u2013negative B-ALL","volume":"138","author":"Paietta","year":"2021","journal-title":"Blood"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ng.3535","article-title":"Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults","volume":"48","author":"Yasuda","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ebiom.2016.04.038","article-title":"Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia","volume":"8","author":"Liu","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/ng.3691","article-title":"Deregulation of DUX4 and ERG in acute lymphoblastic leukemia","volume":"48","author":"Zhang","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1182\/blood-2017-05-742643","article-title":"New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia","volume":"130","author":"Fioretos","year":"2017","journal-title":"Blood"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1182\/blood-2019-123236","article-title":"Acute Lymphoblastic Leukemia with Zinc-Finger Protein 384 (ZNF384)-Related Rearrangements: A Retrospective Analysis from the Ponte Di Legno Childhood ALL Working Group","volume":"134","author":"Hirabayashi","year":"2019","journal-title":"Blood"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Qin, Y.-Z., Jiang, Q., Xu, L.-P., Wang, Y., Jiang, H., Dao, F.-T., Chen, W.-M., Zhao, X.-S., Liu, Y.-R., and Zhang, X.-H. (2021). The Prognostic Significance of ZNF384 Fusions in Adult Ph-Negative B-Cell Precursor Acute Lymphoblastic Leukemia: A Comprehensive Cohort Study From a Single Chinese Center. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.632532"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/10732748231182787","article-title":"ZNF384-Related Fusion Genes in Acute Lymphoblastic Leukemia","volume":"30","author":"Zhu","year":"2023","journal-title":"Cancer Control"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a034835","article-title":"The biology of B-progenitor acute lymphoblastic leukemia","volume":"10","author":"Roberts","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3324\/haematol.2016.151035","article-title":"ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype","volume":"102","author":"Shinsuke","year":"2017","journal-title":"Haematologica"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1093\/emboj\/cdg380","article-title":"Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C\/EBP\u03b1 and GATA factors","volume":"22","author":"Heavey","year":"2003","journal-title":"EMBO J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/lymphatics1020011","article-title":"Diagnosis and Molecular Pathology of Lymphoblastic Leukemias and Lymphomas in the Era of Genomics and Precision Medicine: Historical Evolution and Current Concepts\u2014Part 2: B-\/T-Cell Acute Lymphoblastic Leukemias","volume":"1","author":"Kansal","year":"2023","journal-title":"Lymphatics"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1101\/gr.209163.116","article-title":"Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP","volume":"27","author":"Qian","year":"2017","journal-title":"Genome Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3324\/haematol.2017.186320","article-title":"Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion","volume":"104","author":"Ohki","year":"2019","journal-title":"Haematologica"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"13331","DOI":"10.1038\/ncomms13331","article-title":"Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia","volume":"7","author":"Gu","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41375-022-01737-4","article-title":"Clinical characteristics and outcomes of B-cell precursor ALL with MEF2D rearrangements: A retrospective study by the Ponte di Legno Childhood ALL Working Group","volume":"37","author":"Ohki","year":"2023","journal-title":"Leukemia"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1182\/bloodadvances.2022008992","article-title":"Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia","volume":"7","author":"Leongamornlert","year":"2023","journal-title":"Blood Adv."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.3324\/haematol.2022.281712","article-title":"Characterization of a novel MEF2D-BCL9 fusion-positive acute lymphoblastic leukemia cell line","volume":"108","author":"Hormann","year":"2023","journal-title":"Haematologica"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1182\/blood.2022016241","article-title":"Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion","volume":"140","author":"Zhang","year":"2022","journal-title":"Blood"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1038\/s41375-021-01333-y","article-title":"Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study","volume":"35","author":"Boer","year":"2021","journal-title":"Leukemia"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3324\/haematol.2018.206961","article-title":"NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2","volume":"104","author":"Hormann","year":"2019","journal-title":"Haematologica"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/cts.13535","article-title":"The expanding universe of NUTM1 fusions in pediatric cancer","volume":"16","author":"Charlab","year":"2023","journal-title":"Clin. Transl. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1182\/blood-2020-139376","article-title":"NUTM1-Rearranged Infant and Pediatric B Cell Precursor Acute Lymphoblastic Leukemia: A Good Prognostic Subtype Identified in a Collaborative International Study","volume":"136","author":"Boer","year":"2020","journal-title":"Blood"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/bjh.17995","article-title":"Two novel cases of NUTM1-rearranged B-cell acute lymphoblastic leukaemia presenting with high-risk features","volume":"196","author":"McClure","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1182\/blood.2022015444","article-title":"Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia","volume":"136","author":"Kimura","year":"2022","journal-title":"Blood"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.2021014723","article-title":"Concurrent CDX2 cis-deregulation and UBTF::ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL","volume":"136","author":"Passet","year":"2022","journal-title":"Blood"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1182\/blood.2019004684","article-title":"13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking","volume":"136","author":"Yang","year":"2020","journal-title":"Blood"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/s41375-022-01557-6","article-title":"UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment","volume":"36","author":"Bastian","year":"2022","journal-title":"Leukemia"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1002\/1878-0261.12982","article-title":"CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGF\u03b2 inhibition","volume":"15","author":"Galland","year":"2021","journal-title":"Mol. Oncol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.leukres.2018.07.021","article-title":"The clinical significance of CDX2 in leukemia: A new perspective for leukemia research","volume":"72","author":"Darvishi","year":"2018","journal-title":"Leuk. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/gcc.22882","article-title":"Frequency and prognostic impact of PAX5 p.P80R in pediatric acute lymphoblastic leukemia patients treated on an AIEOP-BFM acute lymphoblastic leukemia protocol","volume":"59","author":"Jung","year":"2020","journal-title":"Genes. Chromosomes Cancer"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Jia, Z., and Gu, Z. (2022). PAX5 alterations in B-cell acute lymphoblastic leukemia. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1023606"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41588-018-0315-5","article-title":"PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia","volume":"51","author":"Gu","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/s41375-019-0430-z","article-title":"PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia","volume":"33","author":"Bastian","year":"2019","journal-title":"Leukemia"},{"key":"ref_144","first-page":"2396046","article-title":"IKZF1 in acute lymphoblastic leukemia: The rise before the fall?","volume":"29","author":"Boer","year":"2024","journal-title":"Leuk. Lymphoma"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1182\/blood.2019000813","article-title":"IKZF1 deletions in pediatric acute lymphoblastic leukemia: Still a poor prognostic marker?","volume":"135","author":"Stanulla","year":"2020","journal-title":"Blood"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Tsai, H.K., Gogakos, T., Lip, V., Tsai, J., Li, Y.D., Fisch, A., Weiss, J., Grimmett, L., Tran, T.H., and Caron, M. (2022). Outlier expression of isoforms by targeted RNA sequencing as clinical markers of genomic variants in B lymphoblastic leukemia and other tumor types. medRxiv.","DOI":"10.1101\/2022.07.29.22278149"},{"key":"ref_147","first-page":"211","article-title":"The Role of PAX5 in ALL","volume":"1","author":"Fazio","year":"2011","journal-title":"Nov. Asp. Acute Lymphoblstic Leuk."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Fazio, G., Bresolin, S., Silvestri, D., Quadri, M., Saitta, C., Vendramini, E., Buldini, B., Palmi, C., Bardini, M., and Grioni, A. (2022). PAX5 fusion genes are frequent in poor-risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120. EBioMedicine, 83.","DOI":"10.1016\/j.ebiom.2022.104224"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1182\/bloodadvances.2017006734","article-title":"Intragenic amplification of PAX5: A novel subgroup in B-cell precursor acute lymphoblastic leukemia?","volume":"1","author":"Schwab","year":"2017","journal-title":"Blood Adv."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/bloodadvances.2021006328","article-title":"Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping","volume":"6","author":"Jean","year":"2022","journal-title":"Blood Adv."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.21037\/tcr-20-2748","article-title":"\u2018Double hit\u2019 B-lymphoblastic lymphoma with concurrent IGH\/BCL2 and 8q24\/MYC translocations: A case report","volume":"10","author":"He","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Genesc\u00e0, E., and la Starza, R. (2022). Early T-Cell Precursor ALL and Beyond: Immature and Ambiguous Lineage T-ALL Subsets. Cancers, 14.","DOI":"10.3390\/cancers14081873"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Mullighan","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature10725","article-title":"The genetic basis of early T-cell precursor acute lymphoblastic leukaemia","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1182\/blood-2015-08-661702","article-title":"Early T-cell precursor acute lymphoblastic leukemia\/lymphoma (ETP-ALL\/LBL) in adolescents and adults: A high-risk subtype","volume":"127","author":"Jain","year":"2016","journal-title":"Blood"},{"key":"ref_156","first-page":"E335","article-title":"A novel germline variant in PIK3R1 results in SHORT syndrome associated withTAL\/LMO T-cell acute lymphoblastic leukemia","volume":"95","author":"Patel","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Bardelli, V., Arniani, S., Pierini, V., Di Giacomo, D., Pierini, T., Gorello, P., Mecucci, C., and La Starza, R. (2021). T-cell acute lymphoblastic leukemia: Biomarkers and their clinical usefulness. Genes, 12.","DOI":"10.3390\/genes12081118"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/bjh.14474","article-title":"Genomic characterization of paediatric acute lymphoblastic leukaemia: An opportunity for precision medicine therapeutics","volume":"176","author":"Tasian","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Mroczek, A., Zawitkowska, J., Kowalczyk, J., and Lejman, M. (2021). Comprehensive overview of gene rearrangements in childhood T-cell acute lymphoblastic leukaemia. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020808"},{"key":"ref_160","first-page":"231","article-title":"Multidisciplinary analysis of pediatric T-ALL: 9q34 gene fusions","volume":"1","author":"Papenhausen","year":"2019","journal-title":"Cancer Genet."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/ng.3909","article-title":"The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia","volume":"49","author":"Liu","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1002\/cam4.4024","article-title":"The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia","volume":"10","author":"Mansur","year":"2021","journal-title":"Cancer Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ajh.26069","article-title":"CDKN2A deletions are associated with poor outcomes in 101 adults with T-cell acute lymphoblastic leukemia","volume":"96","author":"Wang","year":"2021","journal-title":"Am. J. Hematol."},{"key":"ref_164","first-page":"103431","article-title":"Cytogenetics in the management of T-cell acute lymphoblastic leukemia (T-ALL): Guidelines from the Groupe Francophone de Cytog\u00e9n\u00e9tique H\u00e9matologique (GFCH)","volume":"71","author":"Quessada","year":"2023","journal-title":"Curr. Res. Transl. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1182\/blood.2023022072","article-title":"Closing the circle for ETP ALL","volume":"142","author":"Conter","year":"2023","journal-title":"Blood"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Sin, C.F., and Man, P.H.M. (2021). Early T-Cell Precursor Acute Lymphoblastic Leukemia: Diagnosis, Updates in Molecular Pathogenesis, Management, and Novel Therapies. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.750789"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"E107","DOI":"10.3324\/haematol.2019.220863","article-title":"Genomic and outcome analysis of adult T-cell lymphoblastic lymphoma","volume":"105","author":"Li","year":"2020","journal-title":"Haematologica"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41591-022-01720-7","article-title":"Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia","volume":"28","author":"Khabirova","year":"2022","journal-title":"Nat. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1182\/blood.2022016954","article-title":"Single-cell analysis of acute lymphoblastic and linage-ambiguous leukemia: Approaches and molecular insights","volume":"141","author":"Iacobucci","year":"2023","journal-title":"Blood"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zeng, L., Wang, Y., Pan, J., Li, X., Feng, B., and Yang, Q. (2022). Gene Mutations Related to Glucocorticoid Resistance in Pediatric Acute Lymphoblastic Leukemia. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.831229"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1158\/0008-5472.BCD-19-0041","article-title":"Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia","volume":"1","author":"Waanders","year":"2020","journal-title":"Blood Cancer Discov."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/s41375-024-02403-7","article-title":"Mutational mechanisms in multiply relapsed pediatric acute lymphoblastic leukemia","volume":"38","author":"Suurenbroek","year":"2024","journal-title":"Leukemia"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Ching, T., Duncan, M.E., Newman-Eerkes, T., McWhorter, M.M.E., Tracy, J.M., Steen, M.S., Brown, R.P., Venkatasubbarao, S., Akers, N.K., and Vignali, M. (2020). Analytical evaluation of the clonoSEQ Assay for establishing measurable (minimal) residual disease in acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07077-9"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Gil, J.V., Such, E., Sargas, C., Simarro, J., Miralles, A., P\u00e9rez, G., de Juan, I., Palanca, S., Avetisyan, G., and Santiago, M. (2023). Design and Validation of a Custom Next-Generation Sequencing Panel in Pediatric Acute Lymphoblastic Leukemia. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054440"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/23\/3965\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:39:54Z","timestamp":1760114394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/23\/3965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":174,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["cancers16233965"],"URL":"https:\/\/doi.org\/10.3390\/cancers16233965","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]}}}