{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:36:33Z","timestamp":1768455393676,"version":"3.49.0"},"reference-count":66,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DFG","award":["SFB\/TRR152 P04"],"award-info":[{"award-number":["SFB\/TRR152 P04"]}]},{"name":"DFG","award":["SFB1328 A21"],"award-info":[{"award-number":["SFB1328 A21"]}]},{"name":"DFG","award":["DFG GR4315\/2-2"],"award-info":[{"award-number":["DFG GR4315\/2-2"]}]},{"name":"DFG","award":["DFG GR4315\/6-1"],"award-info":[{"award-number":["DFG GR4315\/6-1"]}]},{"name":"DFG","award":["DFG GR4315\/7-1"],"award-info":[{"award-number":["DFG GR4315\/7-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Two-pore channel 2 (TPC2) is expressed in endolysosomes throughout the human body, as well as in melanosomes of melanocytes. Melanocytes produce pigment, i.e., melanin, which determines hair and skin color but also protects from UV light. Extensive exposure to UV light is one of the major risk factors for the development of melanoma, which develops from pigment-producing cells, i.e., melanocytes. In recent years, several human TPC2 single nucleotide polymorphisms have been identified to increase the likelihood of carriers presenting with blond hair and hypopigmentation. These variants were all characterized as gain-of-function versions of TPC2. Vice versa, the loss of function of TPC2 increases melanin production and reduces cancer hallmarks such as proliferation, migration, invasion, tumor growth, and metastasis formation. The activity of TPC2 is controlled in a complex manner, with several endogenous ligands as well as a number of interacting proteins being involved. We will discuss here the role of TPC2 in pigmentation and its potential to impact melanoma development and progression and highlight recent findings on Rab7a as an enhancer of TPC2 activity.<\/jats:p>","DOI":"10.3390\/cancers16234065","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T10:07:10Z","timestamp":1733306830000},"page":"4065","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["TPC2: From Blond Hair to Melanoma?"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-8004","authenticated-orcid":false,"given":"Carla","family":"Abrahamian","sequence":"first","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig Maximilians University, 80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4648-3641","authenticated-orcid":false,"given":"Lina","family":"Ouologuem","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ludwig Maximilians University, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Tang","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig Maximilians University, 80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-3211","authenticated-orcid":false,"given":"Thomas","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Laboratory for Functional Genome Analysis LAFUGA, Gene Center, Ludwig Maximilians University, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-547X","authenticated-orcid":false,"given":"Karin","family":"Bartel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ludwig Maximilians University, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-5559","authenticated-orcid":false,"given":"Christian","family":"Grimm","sequence":"additional","affiliation":[{"name":"Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig Maximilians University, 80336 Munich, Germany"},{"name":"Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 80333 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","first-page":"121","article-title":"Blonde hair evolved more than once","volume":"489","author":"Corbyn","year":"2012","journal-title":"Nat. News"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/ng.2991","article-title":"A molecular basis for classic blond hair color in Europeans","volume":"46","author":"Guenther","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1126\/science.1217849","article-title":"Melanesian blond hair is caused by an amino acid change in TYRP1","volume":"336","author":"Kenny","year":"2012","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ajhg.2015.03.012","article-title":"The Kalash genetic isolate: Ancient divergence, drift, and selection","volume":"96","author":"Ayub","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.1243518","article-title":"A genetic atlas of human admixture history","volume":"343","author":"Hellenthal","year":"2014","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"552","DOI":"10.24272\/j.issn.2095-8137.2020.052","article-title":"Exploring European ancestry among the Kalash population: A mitogenomic perspective","volume":"41","author":"Rahman","year":"2020","journal-title":"Zool. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1080\/23802359.2021.1952119","article-title":"Current pool of ultimate collection of mitochondrial DNA from remnants of Kalash","volume":"6","author":"Siddiqi","year":"2021","journal-title":"Mitochondrial DNA Part B Resour."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1038\/s41467-018-07691-z","article-title":"Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability","volume":"9","author":"Morgan","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ng.160","article-title":"Two newly identified genetic determinants of pigmentation in Europeans","volume":"40","author":"Sulem","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"E8595","DOI":"10.1073\/pnas.1705739114","article-title":"TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms","volume":"114","author":"Chao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"B\u00f6ck, J., Krogsaeter, E., Passon, M., Chao, Y.K., Sharma, S., Grallert, H., Peters, A., and Grimm, C. (2021). Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect. PLoS Genet., 17.","DOI":"10.1371\/journal.pgen.1009236"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41467-023-35786-9","article-title":"A gain-of-function TPC2 variant R210C increases affinity to PI(3,5)P2 and causes lysosome acidification and hypopigmentation","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1073\/pnas.1600108113","article-title":"TPC2 controls pigmentation by regulating melanosome pH and size","volume":"113","author":"Ambrosio","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Netcharoensirisuk, P., Abrahamian, C., Tang, R., Chen, C.C., Rosato, A.S., Beyers, W., Chao, Y.K., Filippini, A., Di Pietro, S., and Bartel, K. (2021). Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal\/melanosomal TPC2. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-88196-6"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.celrep.2019.07.086","article-title":"TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling","volume":"28","author":"Kasitinon","year":"2019","journal-title":"Cell Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"109848","DOI":"10.1016\/j.celrep.2021.109848","article-title":"Lysosomal Zn(2+) release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma","volume":"37","author":"Du","year":"2021","journal-title":"Cell Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.abb.2014.06.020","article-title":"Ion transport in pigmentation","volume":"563","author":"Bellono","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ng.161","article-title":"ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma","volume":"40","author":"Gudbjartsson","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_19","unstructured":"Heistein, J.B., Acharya, U., and Mukkamalla, S.K.R. (2023). Malignant Melanoma. StatPearls, StatPearls Publishing LLC."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/jnci\/92.12.1006","article-title":"Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations","volume":"92","author":"Goldstein","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/ijc.24327","article-title":"Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians","volume":"125","author":"Nan","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/jid.2009.258","article-title":"Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma","volume":"130","author":"Duffy","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1016\/j.bjps.2022.08.031","article-title":"Racial and geographic disparities in reconstructive procedures following melanoma resection","volume":"75","author":"Hauc","year":"2022","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2147\/CCID.S87645","article-title":"Melanoma risk perception and prevention behavior among African-Americans: The minority melanoma paradox","volume":"8","author":"Goldenberg","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/0008-5472.CAN-16-0852","article-title":"Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells","volume":"77","author":"Nguyen","year":"2017","journal-title":"Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.chembiol.2021.01.023","article-title":"Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth","volume":"28","author":"Gerndt","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"eabd5605","DOI":"10.1126\/scisignal.abd5605","article-title":"Essential requirement for JPT2 in NAADP-evoked Ca(2+) signaling","volume":"14","author":"Gunaratne","year":"2021","journal-title":"Sci. Signal"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1038\/s41467-021-24735-z","article-title":"Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"eabd5647","DOI":"10.1126\/scisignal.abd5647","article-title":"HN1L\/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation","volume":"14","author":"Roggenkamp","year":"2021","journal-title":"Sci. Signal."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1038\/s41467-024-54324-9","article-title":"Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3\u03b2\/\u03b2-Catenin\/MITF-axis","volume":"15","author":"Abrahamian","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ccr.2014.04.030","article-title":"RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway","volume":"26","author":"Cifdaloz","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.0022-202x.2001.01402.x","article-title":"Identification of rab7 as a melanosome-associated protein involved in the intracellular transport of tyrosinase-related protein 1","volume":"117","author":"Gomez","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1038\/ncomms5699","article-title":"High susceptibility to fatty liver disease in two-pore channel 2-deficient mice","volume":"5","author":"Grimm","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1074\/jbc.M504175200","article-title":"rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome","volume":"281","author":"Ceresa","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Guerra, F., and Bucci, C. (2016). Multiple Roles of the Small GTPase Rab7. Cells, 5.","DOI":"10.3390\/cells5030034"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1038\/ncomms10689","article-title":"PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7","volume":"7","author":"Shinde","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e15377","DOI":"10.15252\/emmm.202115377","article-title":"TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease","volume":"14","author":"Krogsaeter","year":"2022","journal-title":"EMBO Mol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1038\/s41467-020-19032-0","article-title":"A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export","volume":"11","author":"Sienkiewicz","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Prat Castro, S., Kudrina, V., Ja\u015blan, D., B\u00f6ck, J., Scotto Rosato, A., and Grimm, C. (2022). Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!. Cells, 11.","DOI":"10.3390\/cells11182807"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Guadagno, N.A., and Progida, C. (2019). Rab GTPases: Switching to Human Diseases. Cells, 8.","DOI":"10.3390\/cells8080909"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"R\u00fchl, P., Rosato, A.S., Urban, N., Gerndt, S., Tang, R., Abrahamian, C., Leser, C., Sheng, J., Jha, A., and Vollmer, G. (2021). Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-87817-4"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Frey, N., Ouologuem, L., Blenninger, J., Siow, W.X., Thorn-Seshold, J., St\u00f6ckl, J., Abrahamian, C., Fr\u00f6hlich, T., Vollmar, A.M., and Grimm, C. (2024). Endolysosomal TRPML1 channel regulates cancer cell migration by altering intracellular trafficking of E-cadherin and \u03b2(1)-integrin. J. Biol. Chem., 300.","DOI":"10.1016\/j.jbc.2023.105581"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"jcs259455","DOI":"10.1242\/jcs.259455","article-title":"Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells","volume":"135","author":"Siow","year":"2022","journal-title":"J. Cell Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ceca.2019.02.010","article-title":"The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways","volume":"79","author":"Xu","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e46685","DOI":"10.15252\/embr.201846685","article-title":"HRAS-driven cancer cells are vulnerable to TRPML1 inhibition","volume":"20","author":"Jung","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102082","DOI":"10.1016\/j.ceca.2019.102082","article-title":"TRPing the homeostatic alarm\u2014Melanoma cells are selectively vulnerable to TRPML1 deletion","volume":"84","author":"Jung","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1080\/15548627.2021.1917132","article-title":"MCOLN1\/TRPML1 finely controls oncogenic autophagy in cancer by mediating zinc influx","volume":"17","author":"Qi","year":"2021","journal-title":"Autophagy"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature07311","article-title":"The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel","volume":"455","author":"Dong","year":"2008","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.15252\/embj.201490009","article-title":"Expression of Ca\u00b2\u207a-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells","volume":"34","author":"Ruas","year":"2015","journal-title":"Embo J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41467-021-27860-x","article-title":"Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice","volume":"13","author":"Spix","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"107713","DOI":"10.1016\/j.pharmthera.2020.107713","article-title":"Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis","volume":"220","author":"Rosato","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1038\/s41467-019-13572-w","article-title":"TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKbeta\/VPS34 pathway","volume":"10","author":"Montefusco","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Yun, C.W., and Lee, S.H. (2018). The Roles of Autophagy in Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113466"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/B978-0-12-407173-5.00003-0","article-title":"Autophagy: Cancer\u2019s friend or foe?","volume":"118","author":"Bhutia","year":"2013","journal-title":"Adv. Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1242\/jcs.146365","article-title":"TFEB at a glance","volume":"129","author":"Napolitano","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ballesteros-\u00c1lvarez, J., Dilshat, R., Fock, V., M\u00f6ller, K., Karl, L., Larue, L., \u00d6gmundsd\u00f3ttir, M.H., and Steingr\u00edmsson, E. (2020). MITF and TFEB cross-regulation in melanoma cells. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238546"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ceca.2017.06.006","article-title":"TRPML1: The Ca(2+)retaker of the lysosome","volume":"69","author":"Medina","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kuchitsu, Y., and Fukuda, M. (2018). Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies. Cells, 7.","DOI":"10.3390\/cells7110215"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cell.2013.01.023","article-title":"mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state","volume":"152","author":"Cang","year":"2013","journal-title":"Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"jcs259221","DOI":"10.1242\/jcs.259221","article-title":"Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton","volume":"134","author":"Vestre","year":"2021","journal-title":"J. Cell Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4161\/cib.3.5.12341","article-title":"Rab7b and receptors trafficking","volume":"3","author":"Bucci","year":"2010","journal-title":"Commun. Integr. Biol."},{"key":"ref_63","unstructured":"PDQ Adult Treatment Editorial Board (2002). Melanoma Treatment (PDQ\u00ae): Health Professional Version, PDQ Cancer Information Summaries."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1080\/15384047.2019.1640032","article-title":"Current state of melanoma diagnosis and treatment","volume":"20","author":"Davis","year":"2019","journal-title":"Cancer Biol. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Schulz, A., Raetz, J., Karitzky, P.C., Dinter, L., Tietze, J.K., Kolbe, I., K\u00e4ubler, T., Renner, B., Beissert, S., and Meier, F. (2022). Head-to-Head Comparison of BRAF\/MEK Inhibitor Combinations Proposes Superiority of Encorafenib Plus Trametinib in Melanoma. Cancers, 14.","DOI":"10.3390\/cancers14194930"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/COC.0000000000000239","article-title":"CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition","volume":"39","author":"Buchbinder","year":"2016","journal-title":"Am. J. Clin. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/23\/4065\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:46:59Z","timestamp":1760114819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/23\/4065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":66,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["cancers16234065"],"URL":"https:\/\/doi.org\/10.3390\/cancers16234065","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]}}}