{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:47:21Z","timestamp":1787168841019,"version":"build-2736575974"},"reference-count":79,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"John Turner Cancer Research Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Epithelial ovarian cancer is aggressive and causes high mortality among women worldwide. Members of the plakin family are essential to maintain cytoskeletal integrity and key cellular processes. In this study we characterised the expression of plakins, particularly plectin (PLEC), periplakin (PPL), envoplakin (EVPL), and EMT-related proteins by immunohistochemistry in n = 48 patients\u2019 samples to evaluate a potential correlation of plakin expression with EMT as EOC progresses. These tissue plakin and EMT expression analyses were further evaluated by in vitro cell line expression and correlated with the expression of these molecules using publicly available datasets such as Cancer Genome Atlas (TCGA) and Clinical Proteome Tumour Analysis Consortium (CPTAC) datasets. We demonstrate that the expression of PPL and PLEC plakins is decreased in high-grade compared to low-grade EOCs with mixed EMT marker protein expression. This is supported by the correlation of high PPL and PLEC expression with an epithelial rather than mesenchymal phenotype. Our data suggest a partial loss of plakin expression as EOC tumours progress. This may impact the connections of plakins with membrane-bound receptors, which impede the downstream signalling required for the initiation of EMT as the tumours progress.<\/jats:p>","DOI":"10.3390\/cancers16234087","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T03:44:47Z","timestamp":1733456687000},"page":"4087","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plakin Expression in Serous Epithelial Ovarian Cancer Has the Potential to Impede Metastatic Spread and Epithelial\u2013Mesenchymal Transition: A Comparative Expression Analysis of Immunohistochemical and In Silico Datasets"],"prefix":"10.3390","volume":"16","author":[{"given":"Tamsin","family":"Wesley","sequence":"first","affiliation":[{"name":"Fiona Elsey Cancer Research Institute, Ballarat, VIC 3353, Australia"},{"name":"Health Innovation and Transformation Centre, Mt Helen Campus, Federation University Australia, Ballarat, VIC 3353, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Escalona","sequence":"additional","affiliation":[{"name":"Fiona Elsey Cancer Research Institute, Ballarat, VIC 3353, Australia"},{"name":"Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kannourakis","sequence":"additional","affiliation":[{"name":"Fiona Elsey Cancer Research Institute, Ballarat, VIC 3353, Australia"},{"name":"Health Innovation and Transformation Centre, Mt Helen Campus, Federation University Australia, Ballarat, VIC 3353, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8379-5053","authenticated-orcid":false,"given":"Nuzhat","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Fiona Elsey Cancer Research Institute, Ballarat, VIC 3353, Australia"},{"name":"Health Innovation and Transformation Centre, Mt Helen Campus, Federation University Australia, Ballarat, VIC 3353, Australia"},{"name":"Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia"},{"name":"Department of Molecular & Translational Science, Monash University, Clayton, VIC 3168, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC 3050, Australia"},{"name":"Department of Surgery, St Vincent Hospital, University of Melbourne, Fitzroy, VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. 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