{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:39:21Z","timestamp":1760146761220,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T00:00:00Z","timestamp":1733616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: With the advent of effective chemotherapy, conversion surgery (CS) has been performed in patients who have responded to pretreatment, even for pancreatic cancer diagnosed as unresectable (UR) at the time of initial diagnosis. In CS, major arterial resection and reconstruction are necessary for complete radical resection. Methods: We discuss the key points for safely performing pancreatectomy with celiac axis (CA) resection combined with reconstruction, divided into resection and arterial reconstruction. The possibility of safe pancreatectomy concurrent with CA resection and reconstruction depends on the ability to create a \u201cgolden view\u201d that provides an unimpaired view of the Abdominal Aorta, CA, Superior Mesenteric Artery, Inferior Vena Cava, and left renal vein from the ventral side. Pancreatectomy concurrent with CA resection requires arterial reconstruction. Postoperatively, arterial blood flow must be maintained. To achieve this, tension-free and short bypass should be observed. Results: From 2014 to 2024, sixteen URLA patients underwent CS, requiring major artery en bloc resection after pretreatment. We performed DP-CAR in eight patients, gastrectomy-distal pancreatectomy-splenectomy (Appleby procedure) procedure in one patient, PD-CHAR in two patients, PD-CAR in two patients, TP-CAR(spleen preserving) in one patient, and TP-CAR+TG in two patients. In total, five patients required surgery with CA reconstruction. Histopathologically, four of the five patients had T4 pancreatic cancer. The R0 surgical rate was 80%. Complication of Clavien\u2013Dindo IIIa or higher was observed in one patient. There were no deaths. Conclusions: Parallel to the determination of pretreatment, surgeons must be prepared to safely and reliably perform pancreatectomies that require concurrent major arterial resection and reconstruction.<\/jats:p>","DOI":"10.3390\/cancers16234115","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T08:17:49Z","timestamp":1733732269000},"page":"4115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatectomy with Celiac Axis Resection and Reconstruction for Locally Advanced Pancreatic Cancer"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-2321","authenticated-orcid":false,"given":"Satoshi","family":"Mizutani","sequence":"first","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Taniai","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-7243","authenticated-orcid":false,"given":"Makoto","family":"Sukegawa","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Haruna","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Furuki","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Takata","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Ueda","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Aimoto","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-6756","authenticated-orcid":false,"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Nippon Medical School Musashikosugi Hospital, 1-383 Kosugimachi, Nakahara, Kawasaki 211-8533, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-5337","authenticated-orcid":false,"given":"Yoshiharu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, Inzai 270-1694, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1039\/D3MO00250K","article-title":"Pancreatic cancer environment: From patient-derived models to single-cell omics","volume":"20","author":"Gu","year":"2024","journal-title":"Mol. 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