{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:56:12Z","timestamp":1770893772814,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Thyroglobulin (Tg) is the specific tumor marker for epithelial thyroid cancer. It holds significant value in the postoperative period, and somehow, the goal of surgery in papillary thyroid cancer (PTC) undergoing total thyroidectomy is to achieve undetectable levels of postoperative thyroglobulin (uTg). Methods: This is a retrospective single-center study in which first basal Tg values were evaluated post-surgery in PTC patients undergoing total thyroidectomy. Patients with elevated antithyroglobulin antibodies were excluded. The impact of various demographic, clinical, therapeutic, tumor-stage related, and histopathological variables on the achievement of undetectable thyroglobulin levels (uTg, &lt;1 ng\/mL) was studied. A descriptive and logistic regression-based bivariate and multivariate analysis was planned using STATA vs. 16.1. program. The significance level was stated at 0.05. Results: Basal athyroglobulinemia was obtained in 89.6% of 202 patients operated on between January 2015 and June 2023 in a single referral institution. Due to the limited number of cases with detectable Tg, multivariate analysis could not be performed. The main factors that favored its achievement on bivariate analysis were a smaller tumor size (p = 0.003), no need for extended resections due to local invasion beyond the thyroid gland (p = 0.003) or neck dissection (p = 0.039), absence of distant metastases (p = 0.000), and a lower MACIS score (p &lt; 0.000). Conclusions: The achievement of uTg was closely related to factors related to tumor stage (tumor diameter, lymph node spread, and metastatic disease), and it was not influenced by differences in epidemiological data, clinic manifestations, preoperative diagnosis, multifocality, or the presence of aggressive cytological variants.<\/jats:p>","DOI":"10.3390\/cancers16244129","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T06:44:05Z","timestamp":1733899445000},"page":"4129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Factors of Athyroglobulinemia After Total Thyroidectomy for Papillary Thyroid Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Marta","family":"Fern\u00e1ndez-Baeza","sequence":"first","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria V.","family":"Mu\u00f1oz-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"Medical School, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Rold\u00e1n-Ortiz","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"Alonso-Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco M.","family":"Carbajo-Barbosa","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Rej\u00f3n-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Olvera-Porcel","sequence":"additional","affiliation":[{"name":"Biostatistics, Unidad de Gesti\u00f3n y Apoyo a la Investigaci\u00f3n, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Becerra-Massare","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan I.","family":"Arcelus-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"Medical School, University of Granada, 18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-6739","authenticated-orcid":false,"given":"Jes\u00fas Mar\u00eda","family":"Villar-del-Moral","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, General Surgery Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"Medical School, University of Granada, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref_1","first-page":"518","article-title":"Thyroglobulin as a tumor marker in differentiated thyroid cancer\u2014Clinical considerations","volume":"57","author":"Franceschi","year":"2018","journal-title":"Acta Clin. Croat."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e26092","DOI":"10.1016\/j.heliyon.2024.e26092","article-title":"The effect of positive thyroglobulin antibodies on the prognosis and treatment response in patients with papillary thyroid carcinoma","volume":"10","author":"Sanjari","year":"2024","journal-title":"Heliyon"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.12998\/wjcc.v8.i8.1350","article-title":"Predictive factors for central lymph node metastases in papillary thyroid microcarcinoma","volume":"8","author":"Wu","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kim, H., Park, S.Y., Choe, J.H., Kim, J.S., Hahn, S.Y., Kim, S.W., Chung, J.H., Jung, J., and Kim, T.H. (2020). Preoperative serum thyroglobulin and its correlation with the burden and extent of differentiated thyroid cancer. Cancers, 12.","DOI":"10.3390\/cancers12030625"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1515\/cclm-2022-0154","article-title":"Is thyroglobulin a reliable biomarker of differentiated thyroid cancer in patients treated by lobectomy? A systematic review and meta-analysis","volume":"60","author":"Giovanella","year":"2022","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"key":"ref_6","first-page":"624","article-title":"Long-term survival in patients with differentiated thyroid cancer: A study of the impact of age and sex","volume":"103","author":"Durante","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1210\/jc.2002-021925","article-title":"Recombinant human thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma","volume":"88","author":"Pacini","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.surg.2019.03.002","article-title":"The 2015 American Thyroid Association guidelines are associated with an increasing rate of hemithyroidectomy for thyroid cancer","volume":"166","author":"Ullmann","year":"2019","journal-title":"Surgery"},{"key":"ref_10","first-page":"54","article-title":"Niveles s\u00e9ricos de tiroglobulina como marcador de malignidad en pacientes con n\u00f3dulo tiroideo","volume":"8","year":"2009","journal-title":"Gac. Mex. De Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1001\/jama.2019.0803","article-title":"Thyroglobulin for monitoring for thyroid cancer recurrence","volume":"321","author":"Peiris","year":"2019","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E1074","DOI":"10.1210\/jc.2015-1967","article-title":"Thyroglobulin (Tg) testing revisited: Tg assays, TgAb assays, and correlation of results with clinical outcomes","volume":"100","author":"Netzel","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1210\/jc.2014-1203","article-title":"Serum thyroglobulin (Tg) monitoring of patients with differenciated thyroid cancer using sensitive (second-generation) immunometric assays can be disrupted by false-negative and false-positive serum thyroglobulin autoantibody misclassifications","volume":"99","author":"Spencer","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","unstructured":"Ali, S.Z., and Cibas, E. (2011). El Sistema Bethesda para Informar la Citopatolog\u00eda de Tiroides, Journal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1089\/thy.2021.0666","article-title":"Serum thyroglobulin measurement following surgery without radioactive iodine for differentiated thyroid cancer: A systematic review","volume":"32","author":"Chou","year":"2022","journal-title":"Thyroid"},{"key":"ref_16","first-page":"1050","article-title":"Predicting outcome in papillary thyroid carcinoma: Development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989","volume":"114","author":"Hay","year":"1993","journal-title":"Surgery"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ecl.2007.04.004","article-title":"Papillary thyroid cancer: Monitoring and therapy","volume":"36","author":"Tuttle","year":"2007","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1210\/jc.2003-031573","article-title":"Factors Influencing the Basal and Recombinant Human Thyrotropin-Stimulated Serum Thyroglobulin in Patients with Metastatic Thyroid Carcinoma","volume":"89","author":"Robbins","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1245\/s10434-011-1833-x","article-title":"Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma","volume":"19","author":"Lang","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00595-006-3673-z","article-title":"Results of surgical treatment in multinodular goiter with an intrathoracic component","volume":"38","author":"Galindo","year":"2008","journal-title":"Surg. Today"},{"key":"ref_21","first-page":"958","article-title":"The intraoperative incidence of detectable bilateral and multicentric disease in papillary cancer of the thyroid","volume":"108","author":"Gerfo","year":"1990","journal-title":"Surgery"},{"key":"ref_22","first-page":"1139","article-title":"Papillary thyroid microcarcinoma: A study of 535 cases observed in a 50-year period","volume":"112","author":"Hay","year":"1992","journal-title":"Surgery"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1245\/s10434-009-0565-7","article-title":"High recurrent rate of multicentric papillary thyroid carcinoma","volume":"16","author":"Lin","year":"2009","journal-title":"Ann. Surg. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.eprac.2021.04.007","article-title":"American Association of Clinical Endocrinology and Associazione Medici Endocrinologi Thyroid Nodule Algorithmic Tool","volume":"27","author":"Garber","year":"2021","journal-title":"Endocr. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1756-6614-4-12","article-title":"Histological subtype is the most important determinant of survival in metastatic papillary thyroid cancer","volume":"4","author":"Chrisoulidou","year":"2011","journal-title":"Thyroid Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1210\/jcem.84.2.5443","article-title":"Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma","volume":"84","author":"Loh","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bjorl.2017.05.005","article-title":"Influence of chronic lymphocytic thyroiditis on the risk of persistent and recurrent disease in patients with papillary thyroid carcinoma and elevated antithyroglobulin antibodies after initial therapy","volume":"84","author":"Carvalho","year":"2018","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/jc.2011-2812","article-title":"Lymphocytic thyroiditis on histology correlates with serum thyroglobulin autoantibodies in patients with papillary thyroid carcinoma: Impact on detection of serum thyroglobulin","volume":"97","author":"Latrofa","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1210\/jc.2005-0285","article-title":"Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and\/or tumor extension beyond the thyroid capsule at initial diagnosis","volume":"90","author":"Leboulleux","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_30","first-page":"51","article-title":"Impacto del compromiso ganglionar en el pron\u00f3stico y la evoluci\u00f3n del carcinoma papilar de tiroides","volume":"54","author":"Mac","year":"2017","journal-title":"Rev. Argent. De Endocrinol. Y Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.surg.2007.06.011","article-title":"Papillary thyroid carcinoma with distant metastases: Survival predictors and the importance of local control","volume":"143","author":"Sugitani","year":"2008","journal-title":"Surgery"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1515\/JPEM.2004.17.3.339","article-title":"The MACIS score predicts the clinical course of papillary thyroid carcinoma in children and adolescents","volume":"17","author":"Powers","year":"2004","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ejso.2005.12.008","article-title":"Predictors of outcome in patients with papillary thyroid carcinoma","volume":"32","author":"Kjellman","year":"2006","journal-title":"Eur. J. Surg. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/24\/4129\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:52:11Z","timestamp":1760115131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/24\/4129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":33,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["cancers16244129"],"URL":"https:\/\/doi.org\/10.3390\/cancers16244129","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}