{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:04:10Z","timestamp":1792011850250,"version":"4.4.0"},"reference-count":55,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Advances in cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC) have improved outcomes for selected patients with peritoneal surface malignancies (PSMs). Methods: This retrospective study analyzed 743 PSM patients treated at Fondazione Policlinico Universitario Agostino Gemelli from January 2016 to February 2024. The primary aim was to assess median overall survival (mOS), median disease-free survival (mDFS), and median progression-free survival (mPFS) stratified by tumor origin. Secondary outcomes examined the role of diagnostic laparoscopy in the management of PSMs and intra- and postoperative complications\u2019 rates. Results: A total of 1113 procedures were performed: 389 CRS, 370 PIPAC, and 354 diagnostic laparoscopies. Colorectal cancer was the predominant indication for CRS (52.4%), with a mOS of 52 months and mDFS of 22 months. Patients affected by gastric cancer undergoing CRS had a mOS of 18 months and a mDFS of 13 months, while PIPAC yielded a mOS of 9 months and a mPFS of 4 months. Among patients with pseudomyxoma peritonei undergoing CRS, the 5-year DFS rate was 64.1%, and OS rate was 89%. Patients affected by mesothelioma and treated with CRS exhibited a median OS of 43 months and a DFS of 26 months. Pancreatic and hepatobiliary cancers were treated with PIPAC, with a respective mOS of 12 and 8 months. Postoperative complications occurred in 12.6% of CRS, 3.2% of PIPAC, and 1.7% of diagnostic laparoscopies. High peritoneal cancer index (PCI), gastric resection, and blood loss over 500 mL were identified as risk factors for major complications in a multivariate analysis. Conclusions: Developing a highly experienced multidisciplinary team is crucial for delivering tailored treatment strategies which aim to achieve optimal oncological outcomes while preserving patients\u2019 quality of life.<\/jats:p>","DOI":"10.3390\/cancers16244229","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:59:43Z","timestamp":1734580783000},"page":"4229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and Insights from an Extensive Series of Cytoreductive Surgery for Peritoneal Neoplasms: A High-Volume Single-Center Experience"],"prefix":"10.3390","volume":"16","author":[{"given":"Matteo","family":"Aulicino","sequence":"first","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Santullo","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"D\u2019Annibale","sequence":"additional","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-3815","authenticated-orcid":false,"given":"Carlo","family":"Abatini","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2007-0969","authenticated-orcid":false,"given":"Miriam","family":"Attalla El Halabieh","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6025-2222","authenticated-orcid":false,"given":"Cecilia","family":"Orsini","sequence":"additional","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Barberis","sequence":"additional","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Tersigni","sequence":"additional","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Pacelli","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Sciences and Translational Medicine, Sant \u2019Andrea University Hospital, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Lodoli","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-1145","authenticated-orcid":false,"given":"Andrea","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-2231","authenticated-orcid":false,"given":"Federica","family":"Ferracci","sequence":"additional","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pacelli","sequence":"additional","affiliation":[{"name":"General Surgery Department, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"},{"name":"Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12957-021-02145-1","article-title":"Thirty-three long-term survivors after cytoreductive surgery in patients with peritoneal metastases from colorectal cancer: A retrospective descriptive study","volume":"19","author":"Kamada","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/pp-2022-0102","article-title":"Consensus statement for treatment protocols in pressurized intraperitoneal aerosol chemotherapy (PIPAC)","volume":"7","author":"Sgarbura","year":"2022","journal-title":"Pleura Peritoneum"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41572-021-00326-6","article-title":"Primary and metastatic peritoneal surface malignancies","volume":"7","author":"Alyami","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E114","DOI":"10.1016\/j.ejso.2021.12.190","article-title":"Treatment response after pressurized intraperitoneal aerosol chemotherapy (PIPAC) for peritoneal metastases of colorectal origin","volume":"48","author":"Farinha","year":"2022","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sugarbaker, P.H. (2007). Peritonectomy Procedures. Peritoneal Carcinomatosis, Springer.","DOI":"10.1007\/978-0-387-48993-3_15"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJMoa1708618","article-title":"Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer","volume":"378","author":"Koole","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejca.2019.10.034","article-title":"Indications for hyperthermic intraperitoneal chemotherapy with cytoreductive surgery: A systematic review","volume":"127","author":"Auer","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e186847","DOI":"10.1001\/jamanetworkopen.2018.6847","article-title":"Morbidity and Mortality Rates following Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemotherapy Compared with Other High-Risk Surgical Oncology Procedures","volume":"2","author":"Foster","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12957-024-03386-6","article-title":"Repeat cytoreductive surgery with HIPEC for colorectal peritoneal metastases: A systematic review","volume":"22","author":"Sarofim","year":"2024","journal-title":"World J. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.21037\/jgo-20-284","article-title":"A narrative review of intraperitoneal chemotherapy and cytoreductive surgery (CRS) for peritoneal metastases in gastric cancer","volume":"12","author":"Boerner","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1001\/jamaoncol.2021.0580","article-title":"Hyperthermic Intraperitoneal Chemotherapy for Ovarian and Colorectal Cancer: A Review","volume":"7","author":"Aalbers","year":"2021","journal-title":"JAMA Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.ejso.2018.04.020","article-title":"Concentrations of cisplatin and doxorubicin in ascites and peritoneal tumor nodules before and after pressurized intraperitoneal aerosol chemotherapy (PIPAC) in patients with peritoneal metastasis","volume":"44","author":"Tempfer","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Di Giorgio, A., Macr\u00ec, A., Ferracci, F., Robella, M., Visaloco, M., De Manzoni, G., Sammartino, P., Sommariva, A., Biacchi, D., and Roviello, F. (2023). 10 Years of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): A Systematic Review and Meta-Analysis. Cancers, 15.","DOI":"10.3390\/cancers15041125"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1016\/S1470-2045(19)30318-3","article-title":"Pressurised intraperitoneal aerosol chemotherapy: Rationale, evidence, and potential indications","volume":"20","author":"Alyami","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jacquet, P., and Sugarbaker, P.H. (1996). Clinical Research Methodologies in Diagnosis and Staging of Patients with Peritoneal Carcinomatosis. Peritoneal Carcinomatosis: Principles of Management, Springer.","DOI":"10.1007\/978-1-4613-1247-5_23"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ejso.2021.10.028","article-title":"Consensus guidelines for pressurized intraperitoneal aerosol chemotherapy: Technical aspects and treatment protocols: PIPAC practice guidelines","volume":"48","author":"Alyami","year":"2022","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1515\/pp-2021-0125","article-title":"Consensus statement on safety measures for pressurized intraperitoneal aerosol chemotherapy","volume":"6","author":"Clerc","year":"2021","journal-title":"Pleura Peritoneum"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1200\/JCO.2008.20.2879","article-title":"Pooled safety and efficacy analysis examining the effect of performance status on outcomes in nine first-line treatment trials using individual data from patients with metastatic colorectal cancer","volume":"27","author":"Sargent","year":"2009","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Manzanedo, I., Pereira, F., Cascales-Campos, P., Mu\u00f1oz-Casares, C., Asensio, E., Torres-Melero, J., Prada-Villaverde, A., Caravaca-Garc\u00eda, I., Guti\u00e9rrez-Calvo, A., and Vaqu\u00e9, J. (2023). Treatment of Peritoneal Surface Malignancies by Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Spain: Results of the National Registry of the Spanish Group of Peritoneal Oncologic Surgery (REGECOP). J. Clin. Med., 12.","DOI":"10.3390\/jcm12113774"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s12094-023-03155-z","article-title":"Morbimortality after 1321 consecutive CRS + HIPEC procedures: Seeking excellence in surgery for peritoneal surface malignancy","volume":"25","year":"2023","journal-title":"Clin. Transl. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Santullo, F., Abatini, C., Attalla El Halabieh, M., Ferracci, F., Lodoli, C., Barberis, L., Giovinazzo, F., Di Giorgio, A., and Pacelli, F. (2022). The Road to Technical Proficiency in Cytoreductive Surgery for Peritoneal Carcinomatosis: Risk-Adjusted Cumulative Summation Analysis. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.877970"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102976","DOI":"10.1016\/j.esmoop.2024.102976","article-title":"Prognostic value of specific KRAS mutations in patients with colorectal peritoneal metastases","volume":"9","author":"Tonello","year":"2024","journal-title":"ESMO Open"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejso.2022.07.019","article-title":"Patterns and Timing of Recurrence following CRS and HIPEC in Colorectal Cancer Peritoneal Metastasis","volume":"49","author":"Hassan","year":"2023","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1470-2045(20)30599-4","article-title":"Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): A multicentre, randomised, open-label, phase 3 trial","volume":"22","author":"Elias","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Pereira, F., Serrano, A., Manzanedo, I., P\u00e9rez-Viejo, E., Gonz\u00e1lez-Moreno, S., Gonz\u00e1lez-Bay\u00f3n, L., Arjona-S\u00e1nchez, A., Torres, J., Ramos, I., and Barrios, M.E. (2022). GECOP-MMC: Phase IV randomized clinical trial to evaluate the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) with mytomicin-C after complete surgical cytoreduction in patients with colon cancer peritoneal metastases. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09572-7"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Aulicino, M., Orsini, C., D\u2019Annibale, G., Barberis, L., Catania, P., Abatini, C., Attalla El Halabieh, M., Ferracci, F., Lodoli, C., and Santullo, F. (2024). How to Implement Pressurized Intraperitoneal Aerosol Chemotherapy into a National Health System Scenario: A Single-Center Retrospective Analysis of Costs and Economic Sustainability at a High-Volume Italian Hospital. Cancers, 16.","DOI":"10.3390\/cancers16152637"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7848","DOI":"10.1007\/s00464-022-09525-y","article-title":"Feasibility of pressurized intra peritoneal aerosol chemotherapy using an ultrasound aerosol generator (usPIPAC)","volume":"36","author":"Sautkin","year":"2022","journal-title":"Surg. Endosc."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mimouni, M., Richard, C., Adenot, P., Letheule, M., Tarrade, A., Sandra, O., Dahirel, M., Lilin, T., Lecuelle, B., and G\u00e9lin, V. (2021). Pressurized intra-peritoneal aerosol chemotherapy (PIPAC): Increased intraperitoneal pressure does not affect distribution patterns but leads to deeper penetration depth of doxorubicin in a sheep model. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-07955-w"},{"key":"ref_29","first-page":"6185313","article-title":"Increased Tissue Penetration of Doxorubicin in Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) after High-Intensity Ultrasound (HIUS)","volume":"2019","author":"Khosrawipour","year":"2019","journal-title":"Int. J. Surg. Oncol."},{"key":"ref_30","first-page":"CD004064","article-title":"Chemotherapy for advanced gastric cancer","volume":"8","author":"Wagner","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00423-023-03163-1","article-title":"Gastric cancer with peritoneal metastases: A single center outline and comparison of different surgical and intraperitoneal treatments","volume":"408","author":"Santullo","year":"2023","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Manzanedo, I., Pereira, F., P\u00e9rez-Viejo, E., and Serrano, \u00c1. (2023). Gastric Cancer with Peritoneal Metastases: Current Status and Prospects for Treatment. Cancers, 15.","DOI":"10.3390\/cancers15061777"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1245\/s10434-015-5081-3","article-title":"Patients with Peritoneal Carcinomatosis from Gastric Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is Cure a Possibility?","volume":"23","author":"Chia","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1245\/s10434-011-1631-5","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: Final results of a phase III randomized clinical trial","volume":"18","author":"Yang","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1200\/JCO.18.01688","article-title":"Cytoreductive Surgery with or Without Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer with Peritoneal Metastases (CYTO-CHIP study): A Propensity Score Analysis","volume":"37","author":"Bonnot","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1245\/s10434-021-11316-z","article-title":"Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Combined with Surgery: A 12-Year Meta-Analysis of this Promising Treatment Strategy for Advanced Gastric Cancer at Different Stages","volume":"29","author":"Zhang","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1245\/s10434-022-12312-7","article-title":"Impact of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer with Peritoneal Carcinomatosis: A Systematic Review and Meta-analysis","volume":"29","author":"Martins","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1016\/j.ejso.2021.05.016","article-title":"Prognostic impact of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer patients: A meta-analysis of randomized controlled trials","volume":"47","author":"Granieri","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1200\/JCO.22.02867","article-title":"Effect of Hyperthermic Intraperitoneal Chemotherapy on Cytoreductive Surgery in Gastric Cancer with Synchronous Peritoneal Metastases: The Phase III GASTRIPEC-I Trial","volume":"42","author":"Rau","year":"2024","journal-title":"J. Clin. Oncology."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Al-Batran, S.E., Goetze, T.O., Mueller, D.W., Vogel, A., Winkler, M., Lorenzen, S., Novotny, A., Pauligk, C., Homann, N., and Jumgbluth, T. (2017). The RENAISSANCE (AIO-FLOT5) trial: Effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction-a phase III trial of the German AIO\/CAO-V\/CAOGI. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3918-9"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1245\/s10434-023-13572-7","article-title":"Bidirectional Approach with PIPAC and Systemic Chemotherapy for Patients with Synchronous Gastric Cancer Peritoneal Metastases (GCPM)","volume":"30","author":"Casella","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejso.2019.06.028","article-title":"Unresectable peritoneal metastasis treated by pressurized intraperitoneal aerosol chemotherapy (PIPAC) leading to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"47","author":"Alyami","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1515\/pp-2022-0111","article-title":"Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in multimodal therapy for patients with oligometastatic peritoneal gastric cancer: A randomized multicenter phase III trial PIPAC VEROne","volume":"7","author":"Casella","year":"2022","journal-title":"Pleura Peritoneum"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4240\/wjgs.v10.i5.49","article-title":"Approach to pseudomyxoma peritonei","volume":"10","author":"Rizvi","year":"2018","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_45","first-page":"e20233421","article-title":"Assessing morbidity, mortality, and survival in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"50","author":"Vallejo","year":"2023","journal-title":"Rev. Col. Bras. Cir."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s11605-019-04239-4","article-title":"Outcomes Following Cytoreduction and HIPEC for Pseudomyxoma Peritonei: 10-Year Experience","volume":"24","author":"Narasimhan","year":"2020","journal-title":"J. Gastrointest. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Santullo, F., Pacelli, F., Abatini, C., Attalla El Halabieh, M., Fortunato, G., Lodoli, C., Giovinazzo, F., Rotolo, S., and Di Giorgio, A. (2021). Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei of Appendiceal Origin: A Single Center Experience. Front. Surg., 8.","DOI":"10.3389\/fsurg.2021.715119"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12957-023-03232-1","article-title":"Long-term survival in patients with PMP: A single-institutional retrospective study from China","volume":"21","author":"Yang","year":"2023","journal-title":"World J. Surg. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e206363","DOI":"10.1001\/jamasurg.2020.6363","article-title":"The Role of Hyperthermic Intraperitoneal Chemotherapy in Pseudomyxoma Peritonei after Cytoreductive Surgery","volume":"156","author":"Kusamura","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejso.2020.02.012","article-title":"Appendiceal tumours and pseudomyxoma peritonei: Literature review with PSOGI\/EURACAN clinical practice guidelines for diagnosis and treatment","volume":"47","author":"Govaerts","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1245\/s10434-014-3978-x","article-title":"Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma: A Systematic Review and Meta-analysis","volume":"22","author":"Helm","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1016\/j.ejca.2013.05.027","article-title":"Diffuse malignant peritoneal mesothelioma: Long-term survival with complete cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC)","volume":"49","author":"Baratti","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/jclinpath-2020-206607","article-title":"Next-generation sequencing and histological response assessment in peritoneal metastasis from pancreatic cancer treated with PIPAC","volume":"74","author":"Nielsen","year":"2021","journal-title":"J. Clin. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1515\/pp-2023-0038","article-title":"What is long-term survival in patients with peritoneal metastasis from gastric, pancreatic, or colorectal cancer? A study of patients treated with systemic chemotherapy and pressurized intraperitoneal aerosol chemotherapy (PIPAC)","volume":"8","author":"Fristrup","year":"2023","journal-title":"Pleura Peritoneum"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1515\/pp-2023-0004","article-title":"Pressurized intraperitoneal aerosol chemotherapy, reasons for interrupting treatment: A systematic review of the literature","volume":"8","author":"Ezanno","year":"2023","journal-title":"Pleura Peritoneum"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/24\/4229\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:17Z","timestamp":1760115317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/24\/4229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":55,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["cancers16244229"],"URL":"https:\/\/doi.org\/10.3390\/cancers16244229","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}