{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:21:14Z","timestamp":1790356874669,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation Roi Baudouin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Hypnosis sedation has recently been used for anesthesia in breast oncologic surgery. Methods: Between January 2017 and October 2019, 284 patients from our Breast Clinic (Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain) and from the Jolimont Hospital were prospectively included in an interventional non-randomized study approved by our two local ethics committees and registered on clinicaltrials.gov (NCT03330117). Ninety-three consecutive patients underwent surgery while on general anesthesia (GA group). Ninety-two consecutive patients underwent surgery while on general anesthesia preceded by a hypnorelaxation session (GAVRH group). Ninety-five consecutive patients underwent surgery while exclusively on hypnosis sedation (HYPS group). Clinical parameters (pain score, anxiety and distress score) were measured on days 0, 1 and 8 for all patients. All evaluable patients underwent NLR (neutrophil-to-lymphocyte ratio) and CRP (C-reactive protein) dosage on days 0, 1 and 8. Results: Pain scores and anxiety scores were statistically lower in the HYPS group on days 1 and 8, as was the duration of NSAID consumption. NLR and CRP values were significantly inferior on day 1 for all patients who benefited from hypnosis sedation. Conclusions: Some benefits of hypnosis sedation (reduction in postoperative pain, decrease in NSAID consumption) are correlated with a significant reduction in inflammatory parameters in the perioperative process.<\/jats:p>","DOI":"10.3390\/cancers17010049","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T04:30:58Z","timestamp":1735273858000},"page":"49","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypnosis Sedation Used in Breast Oncologic Surgery Significantly Decreases Perioperative Inflammatory Reaction"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-9867","authenticated-orcid":false,"given":"Martine","family":"Berliere","sequence":"first","affiliation":[{"name":"Breast Clinic, King Albert II Cancer Institute, Clniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Roelants","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Cliniiques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9 Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois P.","family":"Duhoux","sequence":"additional","affiliation":[{"name":"Breast Clinic, King Albert II Cancer Institute, Clniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Gerday","sequence":"additional","affiliation":[{"name":"Breast Clinic, King Albert II Cancer Institute, Clniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2862-5471","authenticated-orcid":false,"given":"Nathan","family":"Piette","sequence":"additional","affiliation":[{"name":"Department of Pneumology, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, CHU UCL Namur, 5000 Namur, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Agnes","family":"Docquier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Cliniiques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9 Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Samartzi","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Hopital de Jolimont, 7100 La Louvi\u00e8re, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maude","family":"Coyette","sequence":"additional","affiliation":[{"name":"Breast Clinic, King Albert II Cancer Institute, Clniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hammer","sequence":"additional","affiliation":[{"name":"Breast Clinic, King Albert II Cancer Institute, Clniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-959X","authenticated-orcid":false,"given":"Nassim","family":"Touil","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Cliniiques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9 Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"Azzouzi","sequence":"additional","affiliation":[{"name":"Breast Clinic, King Albert II Cancer Institute, Clniques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9-Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Piette","sequence":"additional","affiliation":[{"name":"Medical and Financial Department, Grand Hopital de Charleroi, 6000 Charleroi, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Watremez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Cliniiques Universitaires Saint Luc, Universit\u00e9 Catholique de Louvain, 1200 Woluw\u00e9 Saint-Lambert, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.breast.2012.01.019","article-title":"Post-Mastectomy Pain Syndrome: Incidence and Risks","volume":"21","author":"Bergmann","year":"2012","journal-title":"Breast Edinb. 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