{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:17:53Z","timestamp":1787501873694,"version":"build-2736575974"},"reference-count":167,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014NextGenerationEU","award":["NPOO.C3.2.R3-I1.05.0060"],"award-info":[{"award-number":["NPOO.C3.2.R3-I1.05.0060"]}]},{"name":"European Union\u2014NextGenerationEU","award":["DOK-2021-02"],"award-info":[{"award-number":["DOK-2021-02"]}]},{"name":"European Union\u2014NextGenerationEU","award":["21585"],"award-info":[{"award-number":["21585"]}]},{"name":"European Union\u2014NextGenerationEU","award":["MOBDOK-2023"],"award-info":[{"award-number":["MOBDOK-2023"]}]},{"name":"Croatian Science Foundation\u2019s Young Researchers\u2019 Career Development Programme","award":["NPOO.C3.2.R3-I1.05.0060"],"award-info":[{"award-number":["NPOO.C3.2.R3-I1.05.0060"]}]},{"name":"Croatian Science Foundation\u2019s Young Researchers\u2019 Career Development Programme","award":["DOK-2021-02"],"award-info":[{"award-number":["DOK-2021-02"]}]},{"name":"Croatian Science Foundation\u2019s Young Researchers\u2019 Career Development Programme","award":["21585"],"award-info":[{"award-number":["21585"]}]},{"name":"Croatian Science Foundation\u2019s Young Researchers\u2019 Career Development Programme","award":["MOBDOK-2023"],"award-info":[{"award-number":["MOBDOK-2023"]}]},{"name":"Associazione Italiana per la Ricerca sul Cancro (AIRC), Milano, Italy","award":["NPOO.C3.2.R3-I1.05.0060"],"award-info":[{"award-number":["NPOO.C3.2.R3-I1.05.0060"]}]},{"name":"Associazione Italiana per la Ricerca sul Cancro (AIRC), Milano, Italy","award":["DOK-2021-02"],"award-info":[{"award-number":["DOK-2021-02"]}]},{"name":"Associazione Italiana per la Ricerca sul Cancro (AIRC), Milano, Italy","award":["21585"],"award-info":[{"award-number":["21585"]}]},{"name":"Associazione Italiana per la Ricerca sul Cancro (AIRC), Milano, Italy","award":["MOBDOK-2023"],"award-info":[{"award-number":["MOBDOK-2023"]}]},{"name":"Outbound Mobility of Research Assistants Programme","award":["NPOO.C3.2.R3-I1.05.0060"],"award-info":[{"award-number":["NPOO.C3.2.R3-I1.05.0060"]}]},{"name":"Outbound Mobility of Research Assistants Programme","award":["DOK-2021-02"],"award-info":[{"award-number":["DOK-2021-02"]}]},{"name":"Outbound Mobility of Research Assistants Programme","award":["21585"],"award-info":[{"award-number":["21585"]}]},{"name":"Outbound Mobility of Research Assistants Programme","award":["MOBDOK-2023"],"award-info":[{"award-number":["MOBDOK-2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Algae are a rich source of bioactive compounds that have a wide range of beneficial effects on human health and can show significant potential in the treatment of hematological malignancies such as leukemia, lymphoma, and multiple myeloma. These diseases often pose a therapeutic challenge despite recent advances in treatment (e.g., the use of immunomodulatory drugs, proteasome inhibitors, CD38 monoclonal antibodies, stem cell transplant, and targeted therapy). A considerable number of patients experience relapses or resistance to the applied therapies. Algal compounds, alone or in combination with chemotherapy or other more advanced therapies, have exhibited antitumor and immunomodulatory effects in preclinical studies that may improve disease outcomes. These include the ability to induce apoptosis, inhibit tumor growth, and improve immune responses. However, most of these studies are conducted in vitro, often without in vivo validation or clinical trials. This paper summarizes the current evidence on the in vitro effects of algae extracts and isolated compounds on leukemia, lymphoma, and myeloma cell lines. In addition, we address the current advances in the application of algae-derived compounds as targeted drug carriers and their synergistic potential against hematologic malignancies.<\/jats:p>","DOI":"10.3390\/cancers17020318","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T09:11:13Z","timestamp":1737364273000},"page":"318","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies"],"prefix":"10.3390","volume":"17","author":[{"given":"Tamara","family":"Vujovi\u0107","sequence":"first","affiliation":[{"name":"Laboratory for Aquaculture Biotechnology, Division of Materials Chemistry, Rudjer Boskovic Institute, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-8932","authenticated-orcid":false,"given":"Tina","family":"Parad\u017eik","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Rudjer Boskovic Insitute, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-4332","authenticated-orcid":false,"given":"Sanja","family":"Babi\u0107 Br\u010di\u0107","sequence":"additional","affiliation":[{"name":"Laboratory for Aquaculture Biotechnology, Division of Materials Chemistry, Rudjer Boskovic Institute, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-3470","authenticated-orcid":false,"given":"Roberto","family":"Piva","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy"},{"name":"Medical Genetics Unit, Citt\u00e0 della Salute e della Scienza University Hospital, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/encyclopedia1010017","article-title":"Macroalgae","volume":"1","author":"Pereira","year":"2021","journal-title":"Encyclopedia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"baaa062","DOI":"10.1093\/database\/baaa062","article-title":"NCBI Taxonomy: A Comprehensive Update on Curation, Resources and Tools","volume":"2020","author":"Schoch","year":"2020","journal-title":"Database"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Matin, M., Koszarska, M., Atanasov, A.G., Kr\u00f3l-Szmajda, K., J\u00f3\u017awik, A., Stelmasiak, A., and Hejna, M. 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