{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:42:29Z","timestamp":1759970549081,"version":"build-2065373602"},"reference-count":197,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"M\u00e9tropole Europ\u00e9enne de Lille","award":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"],"award-info":[{"award-number":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"]}]},{"name":"le dispositif StaRs de la r\u00e9gion Hauts-de-France","award":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"],"award-info":[{"award-number":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"]}]},{"name":"la ligue contre le cancer (Septentrion)","award":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"],"award-info":[{"award-number":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"]}]},{"name":"Agence Nationale pour la Recherche","award":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"],"award-info":[{"award-number":["MEL N\u00b0Convention_2021_ESR_11","Arret\u00e9 n\u00b0 22000953","ANR CPJ_Sobolewski","ANR-24-CE14-0137"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Chronic liver diseases, such as those encountered with obesity, chronic\/abusive alcohol consumption or viral infections, represent not only major public health concerns with limited therapeutic options but also important risk factors for the onset of hepatocellular carcinoma (HCC). Deciphering the molecular traits underlying these disorders is of high interest for designing new and effective treatments. The tristetraprolin (TTP) family members are of particular importance given their ability to control the expression of a wide range of genes involved in metabolism, inflammation and carcinogenesis at the post-transcriptional level. This regulation can occur within small cytoplasmic granules, namely, processing bodies (P-bodies), where the mRNA degradation occurs. Increasing evidence indicates that TTP family members and P-bodies are involved in the development of chronic liver diseases and cancers. In this review, we discuss the role of this regulatory mechanism in metabolic-dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), hepatic viral infections and HCC.<\/jats:p>","DOI":"10.3390\/cancers17030348","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:47:32Z","timestamp":1737460052000},"page":"348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tristetraprolin Family Members and Processing Bodies: A Complex Regulatory Network Involved in Fatty Liver Disease, Viral Hepatitis and Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"17","author":[{"given":"No\u00e9mie","family":"Gell\u00e9e","sequence":"first","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Legrand","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4832-9604","authenticated-orcid":false,"given":"Micka\u00ebl","family":"Jouve","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Jean","family":"Devaux","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3596-5497","authenticated-orcid":false,"given":"Laurent","family":"Dubuquoy","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-6290","authenticated-orcid":false,"given":"Cyril","family":"Sobolewski","sequence":"additional","affiliation":[{"name":"Univ Lille, Inserm, CHU Lille, U1286-INFINITE-Institute for Translational Research in Inflammation, F-59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: Trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat. 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