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Key areas of focus include raising population awareness about the importance of screening, educating high-risk populations, and improving and developing early diagnostic methods. The primary goal of this review is to provide a concise overview of recent trends and progress in CRC secondary prevention based on available information from clinical trials.<\/jats:p>","DOI":"10.3390\/cancers17030367","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T09:01:13Z","timestamp":1737622873000},"page":"367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Current Progress in Clinical Research in Secondary Prevention and Early Detection of Colorectal Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6359-2902","authenticated-orcid":false,"given":"Olga","family":"Partyka","sequence":"first","affiliation":[{"name":"Department of Health Economics and Medical Law, Medical University of Warsaw, 02-091 Warsaw, 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WHO Colorectal Cancer. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/colorectal-cancer."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Roshandel, G., Ghasemi-Kebria, F., and Malekzadeh, R. (2024). Colorectal Cancer: Epidemiology, Risk Factors, and Prevention. Cancers, 16.","DOI":"10.3390\/cancers16081530"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1056\/NEJMoa054967","article-title":"Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia","volume":"355","author":"Regula","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1053\/j.gastro.2009.11.044","article-title":"Population-based family history-specific risks for colorectal cancer: A constellation approach","volume":"138","author":"Taylor","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2019.06.005","article-title":"Lifestyle and dietary environmental factors in colorectal cancer susceptibility","volume":"69","author":"Murphy","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10654-022-00954-6","article-title":"Is the association of overweight and obesity with colorectal cancer underestimated? An umbrella review of systematic reviews and meta-analyses","volume":"38","author":"Mandic","year":"2023","journal-title":"Eur. J. Epidemiol."},{"key":"ref_7","unstructured":"Deptala, A., and Wojtukiewicz, M.Z. (2017). Epidemiologia, wska\u017aniki prze\u017cycia, \u015brodowiskowe uwarunkowania rozwoju raka jelita grubego [Epidemiology, survival rates, environmental determinants of colorectal cancer development]. Rak Jelita Grubego [Colorectal Cancer], Termedia."},{"key":"ref_8","unstructured":"(2024, June 25). Available online: https:\/\/www.cancer.org\/cancer\/types\/colon-rectal-cancer\/detection-diagnosis-staging\/acs-recommendations.html."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.3748\/wjg.v23.i28.5086","article-title":"Colorectal cancer screening: An updated review of the available options","volume":"23","author":"Issa","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_10","unstructured":"(2024, October 04). Available online: https:\/\/cancer-screening-and-care.jrc.ec.europa.eu\/en\/ecicc\/european-colorectal-cancer-guidelines?topic=283&usertype=282&updatef2=0."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41571-020-00445-1","article-title":"Rising incidence of early-onset colorectal cancer\u2014A call to action","volume":"18","author":"Akimoto","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Ullah, F., Pillai, A.B., Omar, N., Dima, D., and Harichand, S. (2023). Early-Onset Colorectal Cancer: Current Insights. Cancers, 15.","DOI":"10.3390\/cancers15123202"},{"key":"ref_13","first-page":"293","article-title":"Early-onset Colorectal Cancer is Distinct From Traditional Colorectal Cancer","volume":"16","author":"Yeo","year":"2017","journal-title":"Clin. Color. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa2208375","article-title":"Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death","volume":"387","author":"Bretthauer","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_15","unstructured":"Deptala, A., Stec, R., Smoter, M., and Mackiewicz, J. (2024). Nowotwory dolnego odcinka przewodu pokarmowego [Cancers of the lower digestive tract]. Onkologia. Podr\u0119cznik dla Student\u00f3w Medycyny. Pomoc Dydaktyczna dla Lekarzy Specjalizuj\u0105cych si\u0119 w Onkologii [Oncology. Textbook for Medical Students. Teaching Aid for Doctors Specializing in Oncology], AsteriaMed."},{"key":"ref_16","unstructured":"(2024, March 06). Health at Glance: Europe 2020: State of Health in the EU Cycle. Available online: https:\/\/www.oecd-ilibrary.org\/sites\/429ff2a5-en\/index.html?itemId=\/content\/component\/429ff2a5-en."},{"key":"ref_17","unstructured":"(2024, March 04). Colorectal Cancer Early Detection, Diagnosis, and Staging. Available online: https:\/\/www.cancer.org\/cancer\/types\/colon-rectal-cancer\/detection-diagnosis-staging.html."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gordon, N.P., and Green, B.B. (2015). Factors associated with use and non-use of the Fecal Immunochemical Test (FIT) kit for Colorectal Cancer Screening in Response to a 2012 outreach screening program: A survey study. BMC Public Health, 15.","DOI":"10.1186\/s12889-015-1908-x"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"220001","DOI":"10.5888\/pcd19.220001","article-title":"Adults Who Have Never Been Screened for Colorectal Cancer, Behavioral Risk Factor Surveillance System, 2012 and 2020","volume":"19","author":"Richardson","year":"2022","journal-title":"Prev. Chronic Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Green, B.B., BlueSpruce, J., Tuzzio, L., Vernon, S.W., Aubree Shay, L., and Catz, S.L. (2017). Reasons for never and intermittent completion of colorectal cancer screening after receiving multiple rounds of mailed fecal tests. BMC Public Health, 17.","DOI":"10.1186\/s12889-017-4458-6"},{"key":"ref_21","unstructured":"(2024, June 27). An Interactive Video Educational Tool Improves the Quality of Bowel Preparation for Colonoscopy, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04491565."},{"key":"ref_22","unstructured":"(2024, March 10). Colorectal Cancer Screening Based on Predicted Risk (PRESENT), Available online: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05357508."},{"key":"ref_23","unstructured":"(2024, March 10). Flatbush FHC Proactive Colorectal Cancer Screening and Navigation, Available online: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05646355."},{"key":"ref_24","unstructured":"(2024, June 21). The PRIME-CRC Trial to Promote CRC Screening in Rural Communities, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04313114?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:act%20rec%20not&start=2019-01-01_2023-12-31&limit=100&rank=22."},{"key":"ref_25","unstructured":"(2024, June 21). Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05810714."},{"key":"ref_26","unstructured":"(2024, August 10). A Multicenter Clinical Trial of Stool-based DNA Testing for Early Detection of Colon Cancer in China, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04722055?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:com&start=2019-01-01_2023-12-31&limit=100&rank=86."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/jrh.12772","article-title":"Video brochures in a mailed fecal immunochemical test outreach program provide cancer screening information in a user-friendly format for rural Appalachian community members","volume":"40","author":"Katz","year":"2024","journal-title":"J. Rural Health"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"48832","DOI":"10.18632\/oncotarget.9453","article-title":"Circulating tumor DNA: A promising biomarker in the liquidbiopsy of cancer","volume":"7","author":"Cheng","year":"2016","journal-title":"Oncotarget."},{"key":"ref_29","unstructured":"(2024, July 02). The Effect of Bowel Preparation Training Given to Patients Undergoing Colonoscopy (Training), Available online: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT06159855."},{"key":"ref_30","first-page":"100920","article-title":"Utilization of colorectal cancer screening tests across European countries: A cross-sectional analysis of the European health interview survey 2018\u20132020","volume":"41","author":"Ola","year":"2024","journal-title":"Lancet Reg. Health\u2013Eur."},{"key":"ref_31","unstructured":"(2024, July 02). Direct Information to At-Risk Relatives (DIRECT), Available online: https:\/\/clinicaltrials.gov\/study\/NCT04197856."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41416-023-02337-4","article-title":"Colorectal cancer detected by liquid biopsy 2 years prior to clinical diagnosis in the HUNT study","volume":"129","author":"Brenne","year":"2023","journal-title":"Br. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cgh.2006.10.006","article-title":"Improved fecal DNA test for colorectal cancer screening","volume":"5","author":"Itzkowitz","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Camilloni, L., Ferroni, E., Cendales, B.J., Pezzarossi, A., Furnari, G., Borgia, P., Guasticchi, G., Rossi, P.G., and the Methods to increase participation Working Group (2013). Methods to increase participation in organised screening programs: A systematic review. BMC Public Health, 13.","DOI":"10.1186\/1471-2458-13-464"},{"key":"ref_35","unstructured":"(2024, June 25). Optimising Colorectal Cancer Screening Participation, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04292366?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:com&start=2019-01-01_2023-12-31&limit=100&rank=12."},{"key":"ref_36","unstructured":"(2024, June 25). Health Service Intervention for the Improvement of Access and Adherence to Colorectal Cancer Screening, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04607291."},{"key":"ref_37","unstructured":"(2024, June 20). General Practitioners and Participation Rate in ColoRectal Cancer Screening (AMDepCCR), Available online: https:\/\/clinicaltrials.gov\/study\/NCT04492215?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:act%20rec%20not&start=2019-01-01_2023-12-31&limit=100&page=1&rank=36."},{"key":"ref_38","unstructured":"(2024, June 26). Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings, SMARTER CRC (SMARTER CRC), Available online: https:\/\/clinicaltrials.gov\/study\/NCT04890054."},{"key":"ref_39","unstructured":"(2024, July 02). Screen to Save 2: Rural Cancer Screening Educational Intervention, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04414306."},{"key":"ref_40","unstructured":"Jensen, T.S., Chin, J., Evans, M., Ashby, L., Li, C., and Long, K. (2024, February 20). Decision Memo for Screening for Colorectal Cancer\u2014Blood-Based Biomarker Tests (CAG-00454N), CMS 2021, Available online: https:\/\/www.cms.gov\/medicare-coverage-database\/view\/ncacal-decision-memo.aspx?proposed=N&NCAId=299."},{"key":"ref_41","unstructured":"(2024, June 26). Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans, Available online: https:\/\/clinicaltrials.gov\/study\/NCT03640208."},{"key":"ref_42","unstructured":"(2024, March 10). Test Up Now Education Program (TUNE-UP), Available online: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04304001."},{"key":"ref_43","unstructured":"(2024, June 25). Multilevel Intervention Based on Colorectal Cancer (CRC) and Cervical Cancer Self-Screening in Rural, Segregated Areas, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04471194?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=results:with,status:com&start=2019-01-01_2023-12-31&limit=100&rank=3."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"107229","DOI":"10.1016\/j.ypmed.2022.107229","article-title":"The impact of pre-notifications and reminders on participation in colorectal cancer screening\u2014A randomised controlled trial","volume":"164","author":"Larsen","year":"2022","journal-title":"Prev. Med."},{"key":"ref_45","unstructured":"(2024, June 27). Impact of Colorectal Cancer and Nutrition Education Program Among Minority Patients with Type 2 Diabetes, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05765214?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:act%20rec%20not&start=2019-01-01_2023-12-31&limit=100&rank=87."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MEG.0000000000000759","article-title":"Screening for colorectal cancer: The role of the primary care physician","volume":"29","author":"Triantafillidis","year":"2017","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4103\/ijnmr.ijnmr_96_22","article-title":"The Effect of a Pre-Colonoscopy Education Program on Fear and Anxiety of Patients: A Randomized Clinical Trial Study","volume":"27","author":"Shahrbabaki","year":"2022","journal-title":"Iran J. Nurs. Midwifery Res."},{"key":"ref_48","unstructured":"(2024, July 10). Comparing the Effectiveness of Written vs Verbal Advice for First Degree Relatives of Colorectal Cancer Patients, Available online: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT06242197."},{"key":"ref_49","unstructured":"(2024, July 24). A Video Intervention to Decrease Patient Fear of Colonoscopy After a Positive Fecal Immunochemical Test, Available online: https:\/\/clinicaltrials.gov\/study\/NCT05458986?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:com&start=2019-01-01_2023-12-31&limit=100&rank=68."},{"key":"ref_50","unstructured":"(2024, July 30). Prevention of Colorectal Cancer Through Multiomics Blood Testing (PREEMPT CRC), Available online: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04369053."},{"key":"ref_51","unstructured":"(2024, July 30). Identification of New Diagnostic Protein Markers for Colorectal Cancer (EXOSCOL01), Available online: https:\/\/clinicaltrials.gov\/study\/NCT04394572?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:com&start=2019-01-01_2023-12-31&limit=100&rank=84."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1056\/NEJMoa033403","article-title":"Colorectal Cancer Study Group Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population","volume":"351","author":"Imperiale","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wu, G., Wang, Y.M., Yen, A.M., Wong, J.M., Lai, H.C., Warwick, J., and Chen, T.H. (2006). Cost-effectiveness analysis of colorectal cancer screening with stool DNA testing in intermediate-incidence countries. BMC Cancer, 6.","DOI":"10.1186\/1471-2407-6-136"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1155\/2008\/761208","article-title":"Fecal DNA screening in colorectal cancer","volume":"22","author":"Richter","year":"2008","journal-title":"Can. J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.annonc.2021.05.806","article-title":"Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set","volume":"32","author":"Klein","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_56","unstructured":"Medical Advisory Secretariat (2009). Magnetic Resonance (MR) Colonography for Colorectal Cancer Screening: An Evidence-Based Analysis. Ont. Health Technol. Assess. Ser., 9, 1\u201335."},{"key":"ref_57","unstructured":"(2024, August 20). Computer Aided Detection of Polyps in Colonoscopy, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04754347?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:com&start=2019-01-01_2023-12-31&limit=100&rank=95."},{"key":"ref_58","unstructured":"(2024, August 20). Improving Optical Diagnosis of Colorectal Polyps Using CADx and BASIC, Available online: https:\/\/clinicaltrials.gov\/study\/NCT04349787?cond=Colorectal%20Cancer&term=Screening&viewType=Table&aggFilters=status:com&start=2019-01-01_2023-12-31&limit=100&rank=83."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/3\/367\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:34:32Z","timestamp":1759919672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/3\/367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["cancers17030367"],"URL":"https:\/\/doi.org\/10.3390\/cancers17030367","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]}}}