{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:54:09Z","timestamp":1784357649430,"version":"3.55.0"},"reference-count":157,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Neurological Disorders and Stroke","award":["R01 NS109147"],"award-info":[{"award-number":["R01 NS109147"]}]},{"name":"National Institute of Neurological Disorders and Stroke","award":["NS119547"],"award-info":[{"award-number":["NS119547"]}]},{"name":"Four Diamonds Fund for Pediatric Cancer Research","award":["R01 NS109147"],"award-info":[{"award-number":["R01 NS109147"]}]},{"name":"Four Diamonds Fund for Pediatric Cancer Research","award":["NS119547"],"award-info":[{"award-number":["NS119547"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Neutrophils, the most abundant circulating white blood cells, are essential for the initial immune response to infection and injury. Emerging research reveals a dualistic function of neutrophils in cancer, where they can promote or inhibit tumor progression. This dichotomy is influenced by the tumor microenvironment, with neutrophils capable of remodeling the extracellular matrix, promoting angiogenesis, or alternatively inducing cancer cell death and enhancing immune responses. An intriguing yet poorly understood aspect of neutrophil\u2013cancer interactions is the phenomenon of neutrophil engulfment by cancer cells, which has been observed across various cancers. This process, potentially mediated by LC3-associated phagocytosis (LAP), raises questions about whether it serves as a mechanism for immune evasion or contributes to tumor cell death through pathways like ferroptosis. This review examines current knowledge on neutrophil development, their roles in cancer, and the mechanisms of LAP in neutrophil engulfment by tumor cells. We discuss how manipulating LAP impacts cancer progression and may represent a therapeutic strategy. We also explore neutrophils\u2019 potential as delivery vehicles for cancer therapeutic agents. Understanding the complex functions of tumor-associated neutrophils (TANs) and the molecular mechanisms underlying LAP in cancer may open new avenues for effective therapeutic interventions and mitigate potential risks.<\/jats:p>","DOI":"10.3390\/cancers17030384","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T06:17:52Z","timestamp":1737699472000},"page":"384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neutrophil Engulfment in Cancer: Friend or Foe?"],"prefix":"10.3390","volume":"17","author":[{"given":"Tong","family":"Lu","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-4309","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"},{"name":"Penn State Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA"},{"name":"Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrc.2016.52","article-title":"Neutrophils in cancer: Neutral no more","volume":"16","author":"Coffelt","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-62703-845-4_1","article-title":"The role of neutrophils in the immune system: An overview","volume":"1124","author":"Malech","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cell.2020.10.003","article-title":"Co-option of Neutrophil Fates by Tissue Environments","volume":"183","author":"Ballesteros","year":"2020","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-021-00571-6","article-title":"Neutrophils in cancer: Heterogeneous and multifaceted","volume":"22","author":"Hedrick","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/B:AGEN.0000029415.62384.ba","article-title":"Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor","volume":"6","author":"Kusumanto","year":"2003","journal-title":"Angiogenesis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ccr.2004.08.031","article-title":"Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis","volume":"6","author":"Yang","year":"2004","journal-title":"Cancer Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12943-024-02004-z","article-title":"Neutrophils in Cancer immunotherapy: Friends or foes?","volume":"23","author":"Huang","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","article-title":"Neutrophil diversity and plasticity in tumour progression and therapy","volume":"20","author":"Jaillon","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Carnevale, S., Di Ceglie, I., Grieco, G., Rigatelli, A., Bonavita, E., and Jaillon, S. (2023). Neutrophil diversity in inflammation and cancer. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1180810"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.2174\/1381612823666170704125420","article-title":"Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils","volume":"23","author":"Vols","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/030089169107700615","article-title":"Pleomorphic carcinoma of the gallbladder: Report of a case","volume":"77","author":"Caruso","year":"1991","journal-title":"Tumori"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1002\/1097-0142(19940615)73:12<2936::AID-CNCR2820731210>3.0.CO;2-U","article-title":"Pleomorphic (spindle\/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases","volume":"73","author":"Fishback","year":"1994","journal-title":"Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/1097-0142(19880501)61:9<1872::AID-CNCR2820610925>3.0.CO;2-Q","article-title":"Undifferentiated carcinoma of the gallbladder. A clinicopathologic, histochemical, and immunohistochemical study of 21 patients with a poor prognosis","volume":"61","author":"Guo","year":"1988","journal-title":"Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/modpathol.3800460","article-title":"Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils","volume":"18","author":"Khayyata","year":"2005","journal-title":"Mod. Pathol."},{"key":"ref_16","first-page":"306","article-title":"Neutrophil-tumor cell phagocytosis (cannibalism) in human tumors: An update and literature review","volume":"34","author":"Caruso","year":"2012","journal-title":"Exp. Oncol."},{"key":"ref_17","first-page":"17","article-title":"Cell-in-cell phenomena of intracellular neutrophils in a recurrent pleomorphic xanthoastrocytoma","volume":"5","author":"Fote","year":"2024","journal-title":"Free Neuropathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.it.2010.05.006","article-title":"Neutrophil kinetics in health and disease","volume":"31","author":"Summers","year":"2010","journal-title":"Trends Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11872","DOI":"10.1073\/pnas.172384399","article-title":"Prospective isolation of human clonogenic common myeloid progenitors","volume":"99","author":"Manz","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.it.2019.04.013","article-title":"The Neutrophil Life Cycle","volume":"40","author":"Hidalgo","year":"2019","journal-title":"Trends Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1189\/jlb.1206713","article-title":"Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1","volume":"82","author":"Sasmono","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.4049\/jimmunol.164.9.4783","article-title":"Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis","volume":"164","author":"Schwarzenberger","year":"2000","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1182\/blood.V98.12.3309","article-title":"Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice","volume":"98","author":"Forlow","year":"2001","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2005.01.011","article-title":"Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17","volume":"22","author":"Stark","year":"2005","journal-title":"Immunity"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Rosales, C. (2018). Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.00113"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1074-7613(00)80046-1","article-title":"The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment","volume":"10","author":"Ma","year":"1999","journal-title":"Immunity"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1074-7613(03)00263-2","article-title":"Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence","volume":"19","author":"Martin","year":"2003","journal-title":"Immunity"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1182\/blood-2003-10-3638","article-title":"Role of the CXCR4\/SDF-1 chemokine axis in circulating neutrophil homeostasis","volume":"104","author":"Suratt","year":"2004","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1182\/blood-2008-09-177287","article-title":"CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions","volume":"113","author":"Eash","year":"2009","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI41649","article-title":"CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow","volume":"120","author":"Eash","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1182\/blood-2010-09-308387","article-title":"G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands","volume":"117","author":"Hasenberg","year":"2011","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.182.1.604","article-title":"Crosstalk between CXCR4\/stromal derived factor-1 and VLA-4\/VCAM-1 pathways regulates neutrophil retention in the bone marrow","volume":"182","author":"Petty","year":"2009","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pathol-020712-164023","article-title":"The multifaceted functions of neutrophils","volume":"9","author":"Mayadas","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.yexcr.2004.09.027","article-title":"GCP-2\/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors","volume":"303","author":"Gijsbers","year":"2005","journal-title":"Exp. Cell Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1038\/sj.onc.1209237","article-title":"K-ras activation generates an inflammatory response in lung tumors","volume":"25","author":"Ji","year":"2006","journal-title":"Oncogene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0300985812469883","article-title":"Getting leukocytes to the site of inflammation","volume":"50","author":"Muller","year":"2013","journal-title":"Vet. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1083\/jcb.200112126","article-title":"Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes","volume":"157","author":"Barreiro","year":"2002","journal-title":"J. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1084\/jem.20040965","article-title":"Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration","volume":"200","author":"Shaw","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1172\/JCI113983","article-title":"Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4","volume":"83","author":"Doerfler","year":"1989","journal-title":"J. Clin. Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1182\/blood.V73.1.301.301","article-title":"Respiratory burst in adherent human neutrophils: Triggering by colony-stimulating factors CSF-GM and CSF-G","volume":"73","author":"Nathan","year":"1989","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/152308602753625870","article-title":"Neutrophil priming in host defense: Role of oxidants as priming agents","volume":"4","author":"Swain","year":"2002","journal-title":"Antioxid. Redox Signal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1189\/jlb.0810457","article-title":"Phagosome dynamics during phagocytosis by neutrophils","volume":"90","author":"Nordenfelt","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1084\/jem.184.2.627","article-title":"Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages","volume":"184","author":"Allen","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00018-011-0834-z","article-title":"Inflammation and repeated infections in CGD: Two sides of a coin","volume":"69","author":"Kuijpers","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.00047-08","article-title":"Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock","volume":"22","author":"Vanlaere","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Luchian, I., Goriuc, A., Sandu, D., and Covasa, M. (2022). The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031806"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2353\/ajpath.2008.080081","article-title":"Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro","volume":"173","author":"Lin","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/cr.2010.150","article-title":"Neutrophil extracellular trap cell death requires both autophagy and superoxide generation","volume":"21","author":"Remijsen","year":"2011","journal-title":"Cell Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/ijc.25815","article-title":"Reactive species and DNA damage in chronic inflammation: Reconciling chemical mechanisms and biological fates","volume":"128","author":"Lonkar","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0891-5849(98)00285-8","article-title":"Neutrophils cause oxidative DNA damage in alveolar epithelial cells","volume":"27","author":"Knaapen","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ccell.2017.11.004","article-title":"Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis","volume":"32","author":"Canli","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1172\/JCI122085","article-title":"Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing","volume":"129","author":"Bui","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"20262","DOI":"10.1073\/pnas.0706438104","article-title":"Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis","volume":"104","author":"Ardi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neo.2014.08.013","article-title":"Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment","volume":"16","author":"Deryugina","year":"2014","journal-title":"Neoplasia"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2353\/ajpath.2010.080642","article-title":"Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo","volume":"176","author":"Ebrahem","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nm.2084","article-title":"Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth","volume":"16","author":"Houghton","year":"2010","journal-title":"Nat. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"361ra138","DOI":"10.1126\/scitranslmed.aag1711","article-title":"Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps","volume":"8","author":"Park","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4049\/jimmunol.1900543","article-title":"Anaplastic Thyroid Cancer Cells Induce the Release of Mitochondrial Extracellular DNA Traps by Viable Neutrophils","volume":"204","author":"Cristinziano","year":"2020","journal-title":"J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/ijc.24448","article-title":"IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer","volume":"125","author":"Rotondo","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"19585","DOI":"10.1074\/jbc.M111451200","article-title":"Reactive oxygen species differentially affect T cell receptor-signaling pathways","volume":"277","author":"Cemerski","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cmet.2016.10.019","article-title":"Arginine Arms T Cells to Thrive and Survive","volume":"24","author":"Kishton","year":"2016","journal-title":"Cell Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1182\/bloodadvances.2019031609","article-title":"Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair","volume":"3","author":"Aarts","year":"2019","journal-title":"Blood Adv."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.4049\/jimmunol.167.5.2595","article-title":"Inhibition of activated\/memory (CD45RO+) T cells by oxidative stress associated with block of NF-\u03baB activation","volume":"167","author":"Malmberg","year":"2001","journal-title":"J. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13046-015-0256-0","article-title":"Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1\/PD-1 signalling pathway in hepatocellular carcinoma","volume":"34","author":"He","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1136\/gutjnl-2016-313075","article-title":"Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway","volume":"66","author":"Wang","year":"2017","journal-title":"Gut"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/ijc.28770","article-title":"Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17\u2014A new mechanism of impaired antitumor immunity","volume":"135","author":"Mishalian","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.4049\/jimmunol.1402164","article-title":"Ex vivo and in vitro effect of serum amyloid a in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils","volume":"194","author":"Sun","year":"2015","journal-title":"J. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Moges, R., De Lamache, D.D., Sajedy, S., Renaux, B.S., Hollenberg, M.D., Muench, G., Abbott, E.M., and Buret, A.G. (2018). Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1\u03b1, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1. Front. Vet. Sci., 5.","DOI":"10.3389\/fvets.2018.00057"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The role of macrophages in the resolution of inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature14407","article-title":"MET is required for the recruitment of anti-tumoural neutrophils","volume":"522","author":"Finisguerra","year":"2015","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.7150\/ijbs.29297","article-title":"Neutrophil Suppresses Tumor Cell Proliferation via Fas\/Fas Ligand Pathway Mediated Cell Cycle Arrested","volume":"14","author":"Sun","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1158\/0008-5472.CAN-11-4135","article-title":"Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response","volume":"72","author":"Mittendorf","year":"2012","journal-title":"Cancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ijc.2910350119","article-title":"Anti-tumor effect of inflammatory neutrophils: Characteristics of in vivo generation and in vitro tumor cell lysis","volume":"35","author":"Lichtenstein","year":"1985","journal-title":"Int. J. Cancer"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.4049\/jimmunol.174.9.5472","article-title":"Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors","volume":"174","author":"Otten","year":"2005","journal-title":"J. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.4049\/jimmunol.171.10.5124","article-title":"Polymorphonuclear granulocytes induce antibody-dependent apoptosis in human breast cancer cells","volume":"171","author":"Stockmeyer","year":"2003","journal-title":"J. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"112132","DOI":"10.18632\/oncotarget.22792","article-title":"The regulation of pre-metastatic niche formation by neutrophils","volume":"8","author":"Jablonska","year":"2017","journal-title":"Oncotarget"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.4049\/jimmunol.122.6.2605","article-title":"Role of the myeloperoxidase-H2O2-halide system in concanavalin A-induced tumor cell killing by human neutrophils","volume":"122","author":"Clark","year":"1979","journal-title":"J. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1084\/jem.141.6.1442","article-title":"Neutrophil-mediated tumor cell cytotoxicity: Role of the peroxidase system","volume":"141","author":"Clark","year":"1975","journal-title":"J. Exp. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1038\/s41467-020-19193-y","article-title":"Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression","volume":"11","author":"Yee","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1016\/j.cell.2021.04.016","article-title":"Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis","volume":"184","author":"Cui","year":"2021","journal-title":"Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1158\/0008-5472.CAN-03-1808","article-title":"Neutrophil-derived TNF-related apoptosis-inducing ligand (TRAIL): A novel mechanism of antitumor effect by neutrophils","volume":"64","author":"Koga","year":"2004","journal-title":"Cancer Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12621","DOI":"10.18632\/oncotarget.2181","article-title":"Neutrophils with protumor potential could efficiently suppress tumor growth after cytokine priming and in presence of normal NK cells","volume":"5","author":"Sun","year":"2014","journal-title":"Oncotarget"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2023.02.032","article-title":"A neutrophil response linked to tumor control in immunotherapy","volume":"186","author":"Gungabeesoon","year":"2023","journal-title":"Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cell.2019.05.047","article-title":"Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors","volume":"178","author":"Ponzetta","year":"2019","journal-title":"Cell"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.4049\/jimmunol.1103414","article-title":"T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses","volume":"188","author":"Tillack","year":"2012","journal-title":"J. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ccell.2016.06.001","article-title":"Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer","volume":"30","author":"Singhal","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1182\/blood-2006-12-063826","article-title":"Neutrophils efficiently cross-prime naive T cells in vivo","volume":"110","author":"Beauvillain","year":"2007","journal-title":"Blood"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ccell.2024.08.008","article-title":"Glioblastoma induces the recruitment and differentiation of dendritic-like \u201chybrid\u201d neutrophils from skull bone marrow","volume":"42","author":"Lad","year":"2024","journal-title":"Cancer Cell"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"109480","DOI":"10.1016\/j.celrep.2021.109480","article-title":"Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow","volume":"36","author":"Magod","year":"2021","journal-title":"Cell Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e2310318","DOI":"10.1002\/adma.202310318","article-title":"Engineering and Targeting Neutrophils for Cancer Therapy","volume":"36","author":"Zhang","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nnano.2017.54","article-title":"Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence","volume":"12","author":"Xue","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e1804191","DOI":"10.1002\/smll.201804191","article-title":"Neoadjuvant Chemotherapy Based on Abraxane\/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer","volume":"15","author":"Ju","year":"2019","journal-title":"Small"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"108499","DOI":"10.1016\/j.celrep.2020.108499","article-title":"Photosensitizer-Laden Neutrophils Are Controlled Remotely for Cancer Immunotherapy","volume":"33","author":"Li","year":"2020","journal-title":"Cell Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e2004381","DOI":"10.1002\/advs.202004381","article-title":"Neutrophil Delivered Hollow Titania Covered Persistent Luminescent Nanosensitizer for Ultrosound Augmented Chemo\/Immuno Glioblastoma Therapy","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"111128","DOI":"10.1016\/j.celrep.2022.111128","article-title":"Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy","volume":"40","author":"Chang","year":"2022","journal-title":"Cell Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1038\/s41467-023-37872-4","article-title":"CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy","volume":"14","author":"Chang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41419-023-05931-9","article-title":"Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling","volume":"14","author":"Quarato","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2141.1956.tb06700.x","article-title":"Biological interaction between lymphocytes and other cells","volume":"2","author":"Humble","year":"1956","journal-title":"Br. J. Haematol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e44031","DOI":"10.7554\/eLife.44031","article-title":"Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets","volume":"8","author":"Cunin","year":"2019","journal-title":"eLife"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/09537104.2019.1693035","article-title":"Megakaryocyte emperipolesis: A new frontier in cell-in-cell interaction","volume":"31","author":"Cunin","year":"2020","journal-title":"Platelets"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1182\/bloodadvances.2021005097","article-title":"Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis","volume":"6","author":"Huang","year":"2022","journal-title":"Blood Adv."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/030098589703400511","article-title":"Adhesion molecule LFA-1\/ICAM-1 influences on LPS-induced megakaryocytic emperipolesis in the rat bone marrow","volume":"34","author":"Tanaka","year":"1997","journal-title":"Vet. Pathol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1016\/j.cell.2024.07.014","article-title":"Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay","volume":"187","author":"Mihlan","year":"2024","journal-title":"Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/1097-0142(19891215)64:12<2557::AID-CNCR2820641225>3.0.CO;2-G","article-title":"Pleomorphic (giant cell) carcinoma of the intestine. An immunohistochemical and electron microscopic study","volume":"64","author":"Bak","year":"1989","journal-title":"Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/dc.2840080513","article-title":"Needle aspiration cytology, immunocytochemistry, and electron microscopic study of unusual pancreatic carcinoma with pleomorphic giant cells","volume":"8","author":"Gupta","year":"1992","journal-title":"Diagn. Cytopathol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Fan, J., Fang, Q., Yang, Y., Cui, M., Zhao, M., Qi, J., Luo, R., Du, W., Liu, S., and Sun, Q. (2020). Role of Heterotypic Neutrophil-in-Tumor Structure in the Prognosis of Patients With Buccal Mucosa Squamous Cell Carcinoma. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.541878"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1186\/s13256-021-03066-z","article-title":"Spindle cell squamous cell carcinoma exhibiting prominent neutrophil phagocytosis: A case report","volume":"15","author":"Yamazaki","year":"2021","journal-title":"J. Med. Case Rep."},{"key":"ref_112","first-page":"99","article-title":"Cytotoxicity of natural killer cells: Correlation with emperipolesis and surface enzymes","volume":"47","author":"Burns","year":"1982","journal-title":"Lab. Investig."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1159\/000327064","article-title":"Emperipolesis in a common breast malignancy: A case report","volume":"46","author":"Saxena","year":"2002","journal-title":"Acta Cytol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Chen, Y.H., Wang, S., He, M.F., Wang, Y., Zhao, H., Zhu, H.Y., Yu, X.M., Ma, J., Che, X.J., and Wang, J.F. (2013). Prevalence of heterotypic tumor\/immune cell-in-cell structure in vitro and in vivo leading to formation of aneuploidy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059418"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/dc.21421","article-title":"Neutrophil phagocytosis by tumor cells\u2014A cytological study","volume":"39","author":"Singhal","year":"2011","journal-title":"Diagn. Cytopathol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/tbj.13563","article-title":"Neutrophilic emperipolesis in micropapillary carcinoma breast","volume":"26","author":"Madakshira","year":"2020","journal-title":"Breast J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/01913120290104593","article-title":"Morphological evidence of neutrophil-tumor cell phagocytosis (cannibalism) in human gastric adenocarcinomas","volume":"26","author":"Caruso","year":"2002","journal-title":"Ultrastruct. Pathol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1038\/s44318-024-00130-4","article-title":"LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma","volume":"43","author":"Lu","year":"2024","journal-title":"EMBO J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s00018-016-2207-0","article-title":"Mechanisms and consequences of entosis","volume":"73","author":"Krishna","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","article-title":"The clearance of dead cells by efferocytosis","volume":"21","author":"Martinez","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"eabn1702","DOI":"10.1126\/sciadv.abn1702","article-title":"Beyond autophagy: LC3-associated phagocytosis and endocytosis","volume":"8","author":"Rickman","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Grijmans, B.J.M., van der Kooij, S.B., Varela, M., and Meijer, A.H. (2021). LAPped in Proof: LC3-Associated Phagocytosis and the Arms Race Against Bacterial Pathogens. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.809121"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nature06421","article-title":"Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis","volume":"450","author":"Sanjuan","year":"2007","journal-title":"Nature"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Yuan, J., Zhang, Q., Chen, S., Yan, M., and Yue, L. (2022). LC3-Associated Phagocytosis in Bacterial Infection. Pathogens, 11.","DOI":"10.3390\/pathogens11080863"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2018.01.018","article-title":"The \u03b22 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes","volume":"23","author":"Gluschko","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/infdis\/jiu290","article-title":"Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages","volume":"210","author":"Tam","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"34149","DOI":"10.1074\/jbc.M112.382812","article-title":"Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens","volume":"287","author":"Ma","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.4049\/jimmunol.1300132","article-title":"Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1\/Syk kinase signaling","volume":"191","author":"Kyrmizi","year":"2013","journal-title":"J. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/cmi.12616","article-title":"LC3-associated phagocytosis: A crucial mechanism for antifungal host defence against Aspergillus fumigatus","volume":"18","author":"Sprenkeler","year":"2016","journal-title":"Cell. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1126\/science.aad9948","article-title":"Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease","volume":"352","author":"Chu","year":"2016","journal-title":"Science"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Asare, P.F., Roscioli, E., Hurtado, P.R., Tran, H.B., Mah, C.Y., and Hodge, S. (2020). LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.01298"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI1112","article-title":"Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-beta, PGE2, and PAF","volume":"101","author":"Fadok","year":"1998","journal-title":"J. Clin. Investig."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.immuni.2004.09.009","article-title":"Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells","volume":"21","author":"Kim","year":"2004","journal-title":"Immunity"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1016\/j.jmb.2017.08.012","article-title":"LC3-Associated Phagocytosis and Inflammation","volume":"429","author":"Heckmann","year":"2017","journal-title":"J. Mol. Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mib.2013.10.007","article-title":"Macrophages clean up: Efferocytosis and microbial control","volume":"17","author":"Martin","year":"2014","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.4049\/jimmunol.181.5.3575","article-title":"Transcriptional and translational regulation of TGF-\u03b2 production in response to apoptotic cells","volume":"181","author":"Xiao","year":"2008","journal-title":"J. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/nm.2048","article-title":"PPAR-\u03b4 senses and orchestrates clearance of apoptotic cells to promote tolerance","volume":"15","author":"Mukundan","year":"2009","journal-title":"Nat. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"jcs222984","DOI":"10.1242\/jcs.222984","article-title":"LC3-associated phagocytosis at a glance","volume":"132","author":"Heckmann","year":"2019","journal-title":"J. Cell Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/ncb2363","article-title":"Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes","volume":"13","author":"Florey","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s12276-024-01227-w","article-title":"Entosis: The core mechanism and crosstalk with other cell death programs","volume":"56","author":"Kim","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.cell.2007.10.040","article-title":"A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion","volume":"131","author":"Overholtzer","year":"2007","journal-title":"Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijmm.2017.10.014","article-title":"LC3-associated phagocytosis in microbial pathogenesis","volume":"308","author":"Schille","year":"2018","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.immuni.2012.09.014","article-title":"Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes","volume":"37","author":"Henault","year":"2012","journal-title":"Immunity"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"17396","DOI":"10.1073\/pnas.1113421108","article-title":"Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells","volume":"108","author":"Martinez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tcb.2015.08.003","article-title":"An Apoptotic \u2019Eat Me\u2019 Signal: Phosphatidylserine Exposure","volume":"25","author":"Segawa","year":"2015","journal-title":"Trends Cell Biol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ncb1846","article-title":"Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages","volume":"11","author":"Matsunaga","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1182\/blood-2007-11-126029","article-title":"Fc\u03b3R-stimulated activation of the NADPH oxidase: Phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome","volume":"112","author":"Tian","year":"2008","journal-title":"Blood"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1073\/pnas.0811045106","article-title":"Activation of antibacterial autophagy by NADPH oxidases","volume":"106","author":"Huang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00281-010-0221-0","article-title":"The many roles of NOX2 NADPH oxidase-derived ROS in immunity","volume":"32","author":"Lam","year":"2010","journal-title":"Semin. Immunopathol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1038\/sj.emboj.7601346","article-title":"PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation","volume":"25","author":"Ellson","year":"2006","journal-title":"EMBO J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cell.2018.08.061","article-title":"LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance","volume":"175","author":"Cunha","year":"2018","journal-title":"Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"eaax7881","DOI":"10.1126\/sciadv.aax7881","article-title":"Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1\/PD-L1 immunotherapy","volume":"6","author":"Noman","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e153157","DOI":"10.1172\/JCI153157","article-title":"LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation","volume":"132","author":"Moore","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ccell.2019.01.007","article-title":"Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance","volume":"35","author":"Cooper","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: Biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat. Rev. 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Immunol., 10.","DOI":"10.3389\/fimmu.2019.02388"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/3\/384\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:35:21Z","timestamp":1759919721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/3\/384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":157,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["cancers17030384"],"URL":"https:\/\/doi.org\/10.3390\/cancers17030384","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]}}}