{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:51:06Z","timestamp":1760057466139,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Acute kidney disease (AKD) is a recent definition reflecting ongoing physiopathological processes of an acute renal injury (AKI). Information on AKD in hematopoietic stem cell transplant (HSCT) is scarce and there is no available data on long-term outcomes. We aimed to determine the cumulative incidence of AKD in the first 100 days after HSCT; to identify risk factors for AKD in HSCT; and to determine the impact of AKD in 3-year overall survival and relapse-free survival in HSCT. Methods: A retrospective cohort study was conducted, considering AKD when AKI was present and the patient continued to meet the KDIGO criteria (creatinine and\/or urinary output criteria) for 7 days or more. Survival analysis methods considering competing events were used for risk factors and disease-free survival, Cox proportional regression for overall survival, and stepwise regression methods for multivariable models. Results: We enrolled 422 patients. AKD incidence was 22.9% (95% CI: 19.2\u201327.4%). Higher body mass index (HR: 1.05, 95% CI 1.01\u20131.10; p = 0.034), HCT-CI score \u2265 2 (HR: 1.83, 95% CI 1.11\u20133.13; p = 0.027), allogeneic transplantation (HR:2.03, 95% CI 1.26\u20133.33; p = 0.004), higher C-reactive protein (HR:1.01, 95% CI 1.01\u20131.02; p &lt; 0.001), and exposure to nephrotoxic drugs (HR: 4.81, 95% CI 1.54\u20134.95; p = 0.038) were independently associated with AKD. AKD had a significant impact on overall survival (HR: 1.75; 95% CI 1.27\u20132.39; p = 0.001). Conclusion: An awareness of the risk factors for AKD allows the identification of high-risk patients, enabling the timely implementation of preventive measures to alleviate the progression and impact of the disease.<\/jats:p>","DOI":"10.3390\/cancers17030538","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T10:09:52Z","timestamp":1738750192000},"page":"538","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk Factors and Long-Term Outcomes of Acute Kidney Disease in Hematopoietic Stem Cell Transplant\u2014Cohort Study"],"prefix":"10.3390","volume":"17","author":[{"given":"Natacha","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"},{"name":"Faculdade de Medicina da Universidade de Lisboa, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-0253","authenticated-orcid":false,"given":"Carolina","family":"Branco","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gon\u00e7alo","family":"Sousa","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Lisboa, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6468-1306","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-7342","authenticated-orcid":false,"given":"Filipe","family":"Marques","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"},{"name":"Faculdade de Medicina da Universidade de Lisboa, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Division of Haematology, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Martins","sequence":"additional","affiliation":[{"name":"Division of Haematology, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ant\u00f3nio","family":"Lopes","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Renal Transplantation, Unidade Local de Sa\u00fade Santa Maria, 1649-035 Lisbon, Portugal"},{"name":"Faculdade de Medicina da Universidade de Lisboa, 1649-035 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e670","DOI":"10.1016\/S2352-3026(22)00165-X","article-title":"The Epidemiological Landscape of Multiple Myeloma: A Global Cancer Registry Estimate of Disease Burden, Risk Factors, and Temporal Trends","volume":"9","author":"Huang","year":"2022","journal-title":"Lancet Haematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41409-022-01691-w","article-title":"Indications for Haematopoietic Cell Transplantation for Haematological Diseases, Solid Tumours and Immune Disorders: Current Practice in Europe, 2022","volume":"57","author":"Snowden","year":"2022","journal-title":"Bone Marrow Transpl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"409.e1","DOI":"10.1016\/j.jtct.2022.04.012","article-title":"Updated Trends in Hematopoietic Cell Transplantation in the United States with an Additional Focus on Adolescent and Young Adult Transplantation Activity and Outcomes","volume":"28","author":"Phelan","year":"2022","journal-title":"Transplant. 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