{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:13:34Z","timestamp":1792800814794,"version":"4.5.0"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: The clinical outcome of inoperable sarcoma patients treated with LATTICE (LRT) is limited and therefore the objective of our study was to report treatment response, overall survival (OS), local-recurrence free survival (LRFS) and toxicity. Methods: This retrospective observational study includes 15 histologically proven inoperable non-extremity sarcoma patients with no treatment options or no response to systemic therapy, treated at our institution between 2020 and 2024. The patients were treated with a combination of LRT and normo- or hypo-fractionated external beam radiotherapy. Treatment response was evaluated by RECIST1.1 criteria, toxicity by CTCAE 5.0 and OS and LRFS by Kaplan\u2013Meier curves. Results: The median follow-up (F-UP) since the beginning of the treatment was 10 months (range 4\u201332). Nine patients were male and six female. Their mean age was 60 years. The median gross tumor volume (GTV) was 1058 cm3 (range 142\u20136103 cm3). The median number of spheres was 9 (4\u201330). All patients with symptoms reported symptoms\u2019 relief. Based on RECIST1.1 criteria, 10 patients (67%) had stable local disease at 1\u20132 months F-UP on computed tomography (CT). Surgical resection was feasible in five patients. Three of them are alive without disease and two died due to metastatic progression. From 10 (67%) non operated patients, 5 patients died (50%) due to disease. The remaining five patients (50%) are alive, three with stable disease at 21, 22, and 32 months of F-UP and two with disease progression who are currently receiving palliative chemotherapy treatment. Reported G2 toxicity was as follows: gastrointestinal (2), asthenia (1). Two patients had G3 toxicity: esophagitis (1) and inguinal dermatitis (1). No acute or chronic G4\u2013G5 toxicity was observed. Conclusions: LRT is a feasible and well-tolerated radiation technique for inoperable bulky soft-tissue sarcomas. Further studies are needed to establish protocols to determine which patients could benefit from palliative or preoperative treatment.<\/jats:p>","DOI":"10.3390\/cancers17040624","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:10:22Z","timestamp":1739423422000},"page":"624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Role of Spatially Fractionated Radiotherapy (LATTICE) Treatment in Inoperable Bulky Soft-Tissue Sarcomas"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-587X","authenticated-orcid":false,"given":"Katarina","family":"Majercakova","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-5959","authenticated-orcid":false,"given":"Natalia Tejedor","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Radioprotection, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-3615","authenticated-orcid":false,"given":"Josep","family":"Isern Verdum","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0394-6152","authenticated-orcid":false,"given":"Helena Vivancos","family":"Bargall\u00f3","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Radioprotection, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Vila","family":"Capel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Mancera Soto","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Radioprotection, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"G\u00f3mez de Segura Melc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Radiophysics and Radioprotection, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1246-2503","authenticated-orcid":false,"given":"Jady Vivian Rojas","family":"Cordero","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8630-1952","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Gonz\u00e1lez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-7231","authenticated-orcid":false,"given":"Silvia Bagu\u00e9","family":"Rosell","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Hernandez","family":"Jover","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba Rabi","family":"Mitre","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9806-0695","authenticated-orcid":false,"given":"Ana Peir\u00f3","family":"Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-2370","authenticated-orcid":false,"given":"Ana","family":"Sebio","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Sancho-Pardo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital de la Santa Creu i Sant Pau, Calle Sant Quint\u00ed 89, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.suc.2008.03.006","article-title":"Sarcoma Epidemiology and Etiology: Potential Environmental and Genetic 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