{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:24:56Z","timestamp":1787793896645,"version":"build-2784847793"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with significant morbidity. Although cutaneous squamous cell carcinoma (cSCC) is a rare complication, it has serious consequences, particularly when associated with high-risk human papillomavirus (HPV) infections. This study examines two cases of HPV-16-induced cSCC in patients with long-standing HS and explores the potential role of HPV vaccination in preventing such malignancies. Methods and results: We report on two male patients with severe HS (Hurley stage III) and cutaneous squamous cell carcinoma with positive detection of HPV DNA in the tumour tissue. Conclusions: HPV vaccination may offer a preventive approach to cSCC in HS patients by reducing high-risk HPV infections. Incorporating vaccination into the management of HS, particularly in high-risk individuals, could potentially reduce the incidence of malignant transformation and improve long-term outcomes. Further research is warranted to validate these findings and refine prevention strategies.<\/jats:p>","DOI":"10.3390\/cancers17040702","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:34:26Z","timestamp":1739943266000},"page":"702","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["HPV-16-Induced Squamous Cell Carcinoma in Hidradenitis Suppurativa: HPV Vaccination May Be Useful"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-0743","authenticated-orcid":false,"given":"Nessr","family":"Abu Rached","sequence":"first","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riina","family":"K\u00e4pynen","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Doerler","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Ocker","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Frost","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5995-5458","authenticated-orcid":false,"given":"Yannik","family":"Haven","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-521X","authenticated-orcid":false,"given":"Falk G.","family":"Bechara","sequence":"additional","affiliation":[{"name":"International Centre for Hidradenitis Suppurativa\/Acne Inversa (ICH), Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"},{"name":"Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/iwj.12671","article-title":"Squamous cell carcinoma complicating a chronic lesion of hidradenitis suppurativa: A case report and review of the literature","volume":"14","author":"Jourabchi","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e5857","DOI":"10.1097\/MD.0000000000005857","article-title":"Successful surgical treatment for squamous cell carcinoma arising from hidradenitis suppurativa: A case report and literature review","volume":"96","author":"Huang","year":"2017","journal-title":"Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1177\/000313481107701131","article-title":"Squamous cell carcinoma complicating chronic suppurative hydradenitis","volume":"77","author":"Losanoff","year":"2011","journal-title":"Am. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1011-1344(01)00198-1","article-title":"The epidemiology of UV induced skin cancer","volume":"63","author":"Armstrong","year":"2001","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1600-6143.2011.03589.x","article-title":"A case-control study of betapapillomavirus infection and cutaneous squamous cell carcinoma in organ transplant recipients","volume":"11","author":"Proby","year":"2011","journal-title":"Am. J. Transpl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1111\/j.1600-6143.2008.02392.x","article-title":"Molecular concepts of virus infections causing skin cancer in organ transplant recipients","volume":"8","author":"Nindl","year":"2008","journal-title":"Am. J. Transpl."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Hasche, D., Vinz\u00f3n, S.E., and R\u00f6sl, F. (2018). Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.00874"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.virol.2015.02.004","article-title":"Beta genus papillomaviruses and skin cancer","volume":"479\u2013480","author":"Howley","year":"2015","journal-title":"Virology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Skelin, J., and Tomai\u0107, V. (2023). Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis. Viruses, 15.","DOI":"10.3390\/v15112253"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gheit, T. (2019). Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00355"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e38202","DOI":"10.1097\/MD.0000000000038202","article-title":"Molecular mechanisms of human papilloma virus related skin cancers: A review","volume":"103","author":"Cozma","year":"2024","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ygyno.2017.04.004","article-title":"HPV vaccines\u2014A review of the first decade","volume":"146","author":"Harper","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1473-3099(21)00327-3","article-title":"Efficacy, immunogenicity, and safety of a quadrivalent HPV vaccine in men: Results of an open-label, long-term extension of a randomised, placebo-controlled, phase 3 trial","volume":"22","author":"Goldstone","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrmicro2872","article-title":"Understanding and learning from the success of prophylactic human papillomavirus vaccines","volume":"10","author":"Schiller","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/jama.298.7.743","article-title":"Effect of human papillomavirus 16\/18 L1 viruslike particle vaccine among young women with preexisting infection: A randomized trial","volume":"298","author":"Hildesheim","year":"2007","journal-title":"JAMA"},{"key":"ref_16","first-page":"6","article-title":"Utility of the Human Papillomavirus Vaccination in Management of HPV-associated Cutaneous Lesions","volume":"26","author":"Gay","year":"2021","journal-title":"Skin Ther. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"\u0218andru, F., Radu, A.-M., Petca, A., Dumitra\u0219cu, M.C., Petca, R.-C., and Roman, A.-M. (2024). Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases-A Comprehensive Review. Vaccines, 12.","DOI":"10.3390\/vaccines12030228"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ciccarese, G., Herzum, A., Serviddio, G., Occella, C., Parodi, A., and Drago, F. (2023). Efficacy of Human Papillomavirus Vaccines for Recalcitrant Anogenital and Oral Warts. J. Clin. Med., 12.","DOI":"10.3390\/jcm12237317"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e15384","DOI":"10.1111\/dth.15384","article-title":"Intralesional bivalent human papilloma virus vaccine as a treatment for anogenital warts versus topical podophyllin resin 25%: A pilot study","volume":"35","author":"Nofal","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1007\/s00403-023-02698-z","article-title":"Intralesional bivalent and quadrivalent human papillomavirus vaccines didn't significantly enhance the response of multiple anogenital warts when co-administered with intralesional Candida antigen immunotherapy. A randomized controlled trial","volume":"315","author":"Fawzy","year":"2023","journal-title":"Arch. Dermatol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1016\/j.jaad.2010.12.032","article-title":"Condyloma accuminatum treated with recombinant quadrivalent human papillomavirus vaccine (types 6, 11, 16, 18)","volume":"64","author":"Lee","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e13771","DOI":"10.1111\/dth.13771","article-title":"Nonavalent human papillomavirus vaccination as alternative treatment for genital warts","volume":"33","author":"Bossart","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/314111a0","article-title":"Structure and transcription of human papillomavirus sequences in cervical carcinoma cells","volume":"314","author":"Schwarz","year":"1985","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Miazga, W., Tatara, T., Gujski, M., Ostrowski, J., Pinkas, J., and Religioni, U. (2024). Analysis of Implementation Strategies for Nationwide HPV Vaccination Programs Across European Union Countries. Vaccines, 12.","DOI":"10.3390\/vaccines12121325"},{"key":"ref_25","unstructured":"Joint Committee on Vaccination and Immunisation (2015). JCVI Statement on HPV Vaccination of Men Who Have Sex with Men."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1016\/j.vaccine.2017.08.006","article-title":"Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: The time is now","volume":"35","author":"Deshmukh","year":"2017","journal-title":"Vaccine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2343552","DOI":"10.1080\/21645515.2024.2343552","article-title":"Reduced risk of CIN2+ recurrence in women immunized with a 9-valent HPV vaccine post-excision: Retrospective cohort study","volume":"20","author":"Pilka","year":"2024","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Rykkelid, M., Wennberg, H.M., Richardsen, E., and S\u00f8rbye, S.W. (2024). Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022. Pathogens, 13.","DOI":"10.20944\/preprints202404.0529.v1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/cid\/cir1036","article-title":"Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: A nonconcurrent cohort study","volume":"54","author":"Swedish","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.virol.2008.10.004","article-title":"Interaction of human papillomaviruses with the host immune system: A well evolved relationship","volume":"384","author":"Frazer","year":"2009","journal-title":"Virology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1086\/315706","article-title":"Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens","volume":"182","author":"Nakagawa","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000269836","article-title":"Clinicopathological study of 13 cases of squamous cell carcinoma complicating hidradenitis suppurativa","volume":"220","author":"Lavogiez","year":"2010","journal-title":"Dermatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/DSS.0000000000001713","article-title":"Squamous Cell Carcinoma in Perineal, Perianal, and Gluteal Hidradenitis Suppurativa: Experience in 12 Patients","volume":"45","author":"Kohorst","year":"2019","journal-title":"Dermatol. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/OLQ.0b013e31820a9324","article-title":"Incidence and predictors of human papillomavirus-6,-11,-16, and-18 infection in young Norwegian women","volume":"38","author":"Kim","year":"2011","journal-title":"Sex. Transm. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pvr.2018.03.006","article-title":"Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16\u201364 years in Puerto Rico","volume":"5","author":"Ortiz","year":"2018","journal-title":"Papillomavirus Res."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/4\/702\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:37:48Z","timestamp":1760027868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/4\/702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["cancers17040702"],"URL":"https:\/\/doi.org\/10.3390\/cancers17040702","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]}}}