{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:28:59Z","timestamp":1790785739060,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Santelys association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Non-Hodgkin lymphoma (NHL) represents 63% of all hematological malignancies in France, with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) being the two most frequent forms. With the improvement of therapeutics, the issue of health-related quality of life (HRQoL) is becoming increasingly crucial for these patients. The aim was to compare HRQoL of NHL survivors with that of the general French population and to identify factors associated with HRQoL in NHL survivors. Methods: We conducted a population-based study among living patients from three registries of hematological malignancies, using standardized questionnaires, including the SF-12, in September 2023. The data collected were compared to those of a normative general French cohort. Results: In total, 493 patients completed the study questionnaires, yielding a response rate of 36%. The median time since diagnosis was 8 years (IQR 6\u201310) These NHL survivors reported lower HRQoL compared to the general French population, except in terms of bodily pain (p &lt; 0.01). Each one-year increase in the time since diagnosis was associated with an increase in social functioning (p = 0.009). Men had better general health (p = 0.01) and less bodily pain (p = 0.007) than women. Higher income was associated with better HRQoL (p &lt; 0.01). Underweight or obesity were associated with poorer physical functioning (p = 0.008). The presence of comorbidities, socioeconomic deprivation, anxiety, and depression were associated with poorer HRQoL (p &lt; 0.01). Conclusions: This study provides valuable information of HRQoL values for comparison in further follow-up studies and proposes measures that could be implemented to improve the HRQoL of NHL survivors.<\/jats:p>","DOI":"10.3390\/cancers17040711","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:49:27Z","timestamp":1739965767000},"page":"711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Health-Related Quality of Life in Long-Term Survivors of Non-Hodgkin Lymphoma: A French Population-Based Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-2847","authenticated-orcid":false,"given":"Stephane Kroudia","family":"Wasse","sequence":"first","affiliation":[{"name":"Registry of Hematological Malignancies of C\u00f4te d\u2019Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France"},{"name":"INSERM, UMR1231, Bourgogne Franche-Comt\u00e9 University, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerline","family":"Assogba","sequence":"additional","affiliation":[{"name":"INSERM, UMR1231, Bourgogne Franche-Comt\u00e9 University, 21000 Dijon, France"},{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d\u2019Or, Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Orazio","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of Gironde, Bergoni\u00e9 Institute, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kueshivi Midodji","family":"Atsou","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of C\u00f4te d\u2019Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France"},{"name":"INSERM, UMR1231, Bourgogne Franche-Comt\u00e9 University, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Rossi","sequence":"additional","affiliation":[{"name":"Clinical Hematology Unit, Dijon Bourgogne University Hospital, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1161-297X","authenticated-orcid":false,"given":"Adrien","family":"Guilloteau","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of C\u00f4te d\u2019Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France"},{"name":"INSERM, UMR1231, Bourgogne Franche-Comt\u00e9 University, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of C\u00f4te d\u2019Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France"},{"name":"INSERM, UMR1231, Bourgogne Franche-Comt\u00e9 University, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Girard","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of C\u00f4te d\u2019Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France"},{"name":"INSERM, UMR1231, Bourgogne Franche-Comt\u00e9 University, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Poncet","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gandhi","family":"Damaj","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France"},{"name":"Clinical Hematology Unit, Caen University Hospital, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-9992","authenticated-orcid":false,"given":"Xavier","family":"Troussard","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of Caen, Caen University Hospital, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-1397","authenticated-orcid":false,"given":"Alain","family":"Monnereau","sequence":"additional","affiliation":[{"name":"Clinical Hematology Unit, Caen University Hospital, 14000 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-1222","authenticated-orcid":false,"given":"Sandrine Tienhan","family":"Dabakuyo-Yonli","sequence":"additional","affiliation":[{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d\u2019Or, Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre, 21000 Dijon, France"},{"name":"Clinical Hematology Unit, Dijon Bourgogne University Hospital, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Maynadie","sequence":"additional","affiliation":[{"name":"Registry of Hematological Malignancies of C\u00f4te d\u2019Or, Dijon-Bourgogne University Hospital, 21000 Dijon, France"},{"name":"INSERM, UMR1231, Bourgogne Franche-Comt\u00e9 University, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref_1","unstructured":"Defossez, G., Le Guyader-Peyrou, S., Uhry, Z., Grosclaude, P., Colonna, M., Dantony, E., Delafosse, P., Molini\u00e9, F., Woronoff, A.-S., and Bouvier, A.-M. 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