{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:12:57Z","timestamp":1788455577424,"version":"build-2803163510"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Venous thromboembolism (VTE) is a major cause of non-cancer-related mortality in cancer patients. Understanding how demographic factors and cancer types influence VTE risk is critical for developing prevention strategies. This study investigates the incidence of VTE in a large cancer patient population, focusing on gender, race, and differences between solid and hematological malignancies. Methods: Data from the National Inpatient Sample (NIS) database were used to identify cancer patients diagnosed with acute VTE. The patients were divided into those with solid and hematological cancers. Key demographic and clinical characteristics were collected, and patients were matched 1:1 using propensity scoring. Statistical analyses, including logistic regression, assessed VTE incidence and its associations with demographic and cancer type variables. A p-value of &lt;0.05 indicated statistical significance. Results: Out of 1,233,832 cancer patients, 63,505 (5.1%) were diagnosed with acute VTE. Females had a higher VTE rate than males (5.5% vs. 4.8%, p &lt; 0.001). Racial disparities showed Black patients with the highest incidence (6.4%), followed by White patients (5%). Patients with solid malignancies exhibited a significantly higher incidence of VTE compared to those with hematological malignancies (5.4% vs. 4.1%; p &lt; 0.001), with lung cancer and non-Hodgkin lymphoma mostly associated with VTE. Conclusions: This study identifies demographic and cancer-specific differences in VTE risk, emphasizing the need for personalized prevention. High-risk groups, including those with solid tumors, females, and Black patients, may benefit from targeted strategies to reduce the burden of VTE and improve cancer outcomes.<\/jats:p>","DOI":"10.3390\/cancers17050729","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:53:06Z","timestamp":1740124386000},"page":"729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cancer-Associated Venous Thromboembolism Among Hospitalized Patients with Solid and Hematological Malignancies: A Comprehensive National Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8625-3953","authenticated-orcid":false,"given":"Zaid","family":"Khamis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-3010","authenticated-orcid":false,"given":"Ghada","family":"Araji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Al Saidi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Araji","sequence":"additional","affiliation":[{"name":"School of Medicine, Poznan University of Medical Sciences, 61701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chapman","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6095-5034","authenticated-orcid":false,"given":"Ahmad","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Barakat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2385-4025","authenticated-orcid":false,"given":"Varun","family":"Chowdhry","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Odaimi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Northwell Health\/Staten Island University Hospital, Staten Island, NY 10305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3949\/ccjm.91a.23017","article-title":"Management of venous thromboembolism in patients with active cancer","volume":"91","author":"Dave","year":"2024","journal-title":"Cleve Clin. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1634\/theoncologist.2016-0214","article-title":"Cancer and Venous Thromboembolic Disease: A Review","volume":"22","author":"Donnellan","year":"2017","journal-title":"Oncologist"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jval.2017.09.015","article-title":"What Impact Does Venous Thromboembolism and Bleeding Have on Cancer Patients\u2019 Quality of Life?","volume":"21","author":"Lloyd","year":"2018","journal-title":"Value Health J. Int. Soc. Pharmacoeconomics Outcomes Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1182\/blood.2020007338","article-title":"Venous thromboembolism in cancer patients: A population-based cohort study","volume":"137","author":"Mulder","year":"2021","journal-title":"Blood"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1182\/asheducation.V2012.1.626.3798655","article-title":"Cancer-associated thrombosis: Updates and controversies","volume":"2012","author":"Khorana","year":"2012","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abdol Razak, N.B., Jones, G., Bhandari, M., Berndt, M.C., and Metharom, P. (2018). Cancer-Associated Thrombosis: An Overview of Mechanisms, Risk Factors, and Treatment. Cancers, 10.","DOI":"10.3390\/cancers10100380"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1470-2045(05)70207-2","article-title":"Cancer and venous thromboembolism","volume":"6","author":"Prandoni","year":"2005","journal-title":"Lancet Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3747\/co.2008.177","article-title":"Cancer-Associated Thrombosis: Prevention and Treatment","volume":"15","author":"Brose","year":"2008","journal-title":"Curr. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1182\/bloodadvances.2021005590","article-title":"The incidence of cancer-associated thrombosis is increasing over time","volume":"6","author":"Mahajan","year":"2022","journal-title":"Blood Adv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2317945","DOI":"10.1001\/jamanetworkopen.2023.17945","article-title":"Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System","volume":"6","author":"Martens","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/archinte.166.4.458","article-title":"Incidence of venous thromboembolism and its effect on survival among patients with common cancers","volume":"166","author":"Chew","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1160\/TH15-08-0686","article-title":"Epidemiology of first and recurrent venous thromboembolism in patients with active cancer. A population-based cohort study","volume":"117","author":"Cohen","year":"2017","journal-title":"Thromb. Haemost."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1002\/cncr.23062","article-title":"Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients","volume":"110","author":"Khorana","year":"2007","journal-title":"Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.ejca.2012.10.021","article-title":"Incidence of venous thromboembolism in patients with cancer \u2013 A cohort study using linked United Kingdom databases","volume":"49","author":"Walker","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1055\/a-1777-4006","article-title":"Outcome of Cancer-Associated Venous Thromboembolism Is More Favorable among Patients with Hematologic Malignancies than in Those with Solid Tumors","volume":"122","author":"Lecumberri","year":"2022","journal-title":"Thromb. Haemost."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.critrevonc.2007.01.001","article-title":"Cancer-associated thrombosis","volume":"62","author":"Zwicker","year":"2007","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/ATVBAHA.123.318779","article-title":"Updates in the Incidence, Pathogenesis, and Management of Cancer and Venous Thromboembolism","volume":"43","author":"Girardi","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/cncr.27772","article-title":"Incidence and predictors of venous thromboembolism (VTE) among ambulatory high-risk cancer patients undergoing chemotherapy in the United States","volume":"119","author":"Khorana","year":"2013","journal-title":"Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1002\/cncr.21496","article-title":"Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study","volume":"104","author":"Khorana","year":"2005","journal-title":"Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.thromres.2014.12.013","article-title":"Risk of site-specific cancer in incident venous thromboembolism: A population-based study","volume":"135","author":"Petterson","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1182\/blood-2010-01-258624","article-title":"Thrombotic complications in adult patients with lymphoma: A meta-analysis of 29 independent cohorts including 18 018 patients and 1149 events","volume":"115","author":"Caruso","year":"2010","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/j.thromres.2012.03.019","article-title":"Incidence, risk factors and clinical features of venous thromboembolism in newly diagnosed lymphoma patients: Results from a prospective cohort study with Asian population","volume":"130","author":"Park","year":"2012","journal-title":"Thromb. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1160\/TH04-08-0506","article-title":"Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996","volume":"93","author":"White","year":"2005","journal-title":"Thromb. Haemost."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/ajh.26623","article-title":"Patterns of venous thromboembolism risk, treatment, and outcomes among patients with cancer from uninsured and vulnerable populations","volume":"97","author":"Guffey","year":"2022","journal-title":"Am. J. Hematol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/COC.0000000000000639","article-title":"Black Patients Experience Highest Rates of Cancer-associated Venous Thromboembolism","volume":"43","author":"Chudasama","year":"2020","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1158\/1055-9965.EPI-16-0354","article-title":"White-Black Differences in Cancer Incidence, Stage at Diagnosis, and Survival among Adults Aged 85 Years and Older in the United States","volume":"25","author":"Fisher","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev. Publ. Am. Assoc. Cancer Res. Cosponsored Am. Soc. Prev. 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