{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:31:31Z","timestamp":1793500291418,"version":"4.5.0"},"reference-count":105,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Laryngeal papillomatosis and recurrent respiratory papillomatosis are caused by the human papillomavirus. It is characterized by papillomatous growths and is the most common benign disease of the larynx. Juvenile-onset RRP is characterized by more aggressive disease compared with adult-onset RRP. Patients often require frequent surgical procedures, with an increasing shift toward office-based treatment. A variety of surgical and adjuvant medical therapies are available with mixed responses. New targeted therapies and vaccines are currently under investigation as potential adjuncts in the management.<\/jats:p>","DOI":"10.3390\/cancers17060929","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:02:59Z","timestamp":1741608179000},"page":"929","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Laryngeal Papillomatosis"],"prefix":"10.3390","volume":"17","author":[{"given":"Jared","family":"Levinson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Northwell, New Hyde Park, NY 11042, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Edward","family":"Karle","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Northwell, New Hyde Park, NY 11042, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1097\/MLG.0b013e31816a7135","article-title":"Recurrent Respiratory Papillomatosis: A Review","volume":"118","author":"Derkay","year":"2008","journal-title":"Laryngoscope"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/lio2.545","article-title":"Recurrent Respiratory Papillomatosis: A 2020 Perspective","volume":"6","author":"Benedict","year":"2021","journal-title":"Laryngoscope Investig. 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