{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:02:58Z","timestamp":1760058178001,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation","award":["493665037"],"award-info":[{"award-number":["493665037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: In bilateral nephroblastoma and high-risk neuroblastoma in children with extensive tumor involvement of the renal vessels or pedicle, complete tumor resection with preservation of healthy renal tissue is not feasible with in situ nephron-sparing surgery or vascular replacement. The aim of this study was to present our experience with ante situ tumor resection and renal autotransplantation (RATX) in these children. Methods: A retrospective study of children with bilateral nephroblastoma and high-risk neuroblastoma who underwent tumor resection and RATX at an international referral center for pediatric surgical oncology between 2006 and 2024 was performed. RATX was performed by transection of renal vessels, ante situ mobilization, and perfusion of the kidney with Bretschneider\u2019s solution. Tumor resection was performed on a bloodless kidney under hypothermia. Results: Ante situ tumor resection and RATX were performed at a median age of 36 months (range 13\u201362) in 4 children with bilateral nephroblastoma and 4 children with high-risk neuroblastoma. Complete tumor resection was achieved in all patients. One patient with neuroblastoma died of sepsis after 14 days. The 7 surviving patients showed no evidence of disease and normal to slightly decreased glomerulofiltration rates at a median follow-up of 20 months (range 3\u2013155). Limitations include the retrospective design, small sample size, and heterogeneity of the study population due to very rare indication. Conclusions: Ante situ tumor resection and RATX is a feasible surgical approach for children with multifocal bilateral nephroblastoma or high-risk neuroblastoma who are ineligible for in situ nephron-sparing surgery or vascular reconstruction.<\/jats:p>","DOI":"10.3390\/cancers17060989","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T15:24:56Z","timestamp":1742225096000},"page":"989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Autotransplantation for Resection of Bilateral Nephroblastoma and High-Risk Neuroblastoma in Children"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-3496","authenticated-orcid":false,"given":"Benjamin F. B.","family":"Mayer","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery and Paediatric Urology, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias C.","family":"Schunn","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Charit\u00e9 University Hospital Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-0484","authenticated-orcid":false,"given":"Cristian","family":"Urla","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Paediatric Urology, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Weinpert","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Paediatric Urology, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-4689","authenticated-orcid":false,"given":"Ilias","family":"Tsiflikas","sequence":"additional","affiliation":[{"name":"Division of Paediatric Radiology, Department of Diagnostic Radiology, University Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-8058","authenticated-orcid":false,"given":"Martin","family":"Ebinger","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hematology, Oncology, Gastroenterology, Nephrology and Rheumatology, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 1, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-8992","authenticated-orcid":false,"given":"Frank","family":"Fideler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Neunhoeffer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology, Pulmonology and Intensive Care Medicine, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Weitz","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hematology, Oncology, Gastroenterology, Nephrology and Rheumatology, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 1, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-6670","authenticated-orcid":false,"given":"Silvio","family":"Nadalin","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplant Surgery, University Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven W.","family":"Warmann","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Charit\u00e9 University Hospital Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-2391","authenticated-orcid":false,"given":"J\u00f6rg","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Paediatric Urology, University Children\u2019s Hospital T\u00fcbingen, Hoppe-Seyler Stra\u00dfe 3, 72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"key":"ref_1","unstructured":"Kaatsch, P., Grabow, D., and Spix, C. 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