{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:01:41Z","timestamp":1760058101796,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Chronic inflammation has been implicated in cancer development, but the association between allergic rhinitis (AR) and head and neck cancer (HNC) remains unclear. This study aims to investigate this potential relationship using a population-based dataset. Methods: Utilizing the Taiwan Longitudinal Health Insurance Database 2010, we conducted a case-control study encompassing 14,913 HNC patients and 59,652 propensity-score matched controls. Multivariate logistic regression analyses were performed to quantitatively evaluate the association between HNC and prior AR, adjusting for demographic factors and medical comorbidities such as hyperlipidemia, diabetes, hypertension, tobacco use disorder, HPV infection, and alcohol-related disorders. Results: This study identified that 20.19% of the entire cohort had a prior diagnosis of AR, with a significantly higher prevalence in HNC patients relative to controls (26.2% vs. 18.70%). The adjusted odds ratio (OR) for previous AR in HNC patients was 1.559 (95% CI = 1.494\u20131.627). Furthermore, site-specific analysis revealed increased odds ratios for AR among patients with cancers of the larynx (OR = 1.537, 95% CI = 1.307\u20131.807), hypopharynx (OR = 1.220, 95% CI = 1.035\u20131.437), nasopharynx (OR = 2.933, 95% CI = 2.722\u20133.160), sinonasal (OR = 3.100, 95% CI = 2.424\u20133.964), salivary glands (OR = 1.470, 95% CI = 1.158\u20131.865), and thyroid (OR = 1.566, 95% CI = 1.447\u20131.693). Conclusions: The findings robustly support a significant link between AR and an elevated risk of developing HNC, notably affecting the nasopharynx, sinonasal cavities, larynx, salivary glands, and thyroid.<\/jats:p>","DOI":"10.3390\/cancers17061000","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T04:29:28Z","timestamp":1742185768000},"page":"1000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Head and Neck Cancer with Prior Allergic Rhinitis"],"prefix":"10.3390","volume":"17","author":[{"given":"Shih-Han","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Otolaryngology, Wan Fang Hospital, Taipei 110, Taiwan"},{"name":"International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzong-Hann","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Taipei City Hospital, Taipei 106, Taiwan"},{"name":"Department of Speech, Language and Audiology, National Taipei University of Nursing and Health, Taipei 112, Taiwan"},{"name":"Department of Exercise and Health Sciences, University of Taipei, Taipei 100, Taiwan"},{"name":"Department of Otorhinolaryngology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Research Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-959X","authenticated-orcid":false,"given":"Herng-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Health Care Administration, College of Management, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Research Center of Sleep Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-8171","authenticated-orcid":false,"given":"Chin-Shyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Economics, National Taipei University, New Taipei City 237, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1158\/1055-9965.EPI-08-0347","article-title":"Interaction between Tobacco and Alcohol Use and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"18","author":"Hashibe","year":"2009","journal-title":"Cancer Epidemiol. 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