{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:44:56Z","timestamp":1792093496002,"version":"4.4.0"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Butterfield Chair in Cancer Survivorship Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Adolescent and young adult (AYA) cancer survivors have unique needs, yet few tailored rehabilitation programs exist. CaRE-AYA is an 8-week multidimensional rehabilitation program for AYAs that targets impairments, activity limitations and participation restrictions and comprises an individualized exercise prescription and weekly group-based exercise and self-management education. Methods: We conducted a single-arm multi-method pragmatic feasibility study evaluating CaRE-AYA\u2019s feasibility, acceptability, and safety (primary outcomes) and assessed disability, physical functioning, mental health, and social functioning at baseline (T0), immediately post-intervention (T1), and 3 months post-intervention (T2). Results: Twenty-five participants (median age: 32.8, 76% female) were enrolled. Participation (60%), retention (84% at T1, 72% at T2), and program adherence (76% for education classes, 74% for exercise classes) supported feasibility. Qualitative interviews (n = 9) supported strong perceptions of feasibility and acceptability. No serious adverse events (\u2265grade 3) attributed to CaRE-AYA occurred. Conclusions: The results suggest CaRE-AYA is feasible, acceptable, and safe. A randomized controlled trial is needed to determine the effectiveness.<\/jats:p>","DOI":"10.3390\/cancers17071066","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:48:18Z","timestamp":1742791698000},"page":"1066","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Pilot Study to Evaluate the Feasibility and Acceptability of a Tailored Multicomponent Rehabilitation Program for Adolescent and Young Adult (AYA) Cancer Survivors"],"prefix":"10.3390","volume":"17","author":[{"given":"Lauren","family":"Corke","sequence":"first","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, ON M5S3K3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-5084","authenticated-orcid":false,"given":"David M.","family":"Langelier","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division on PM&R, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha A.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Divison of Hematology\/Oncology, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada"},{"name":"Adolescent and Young Adult Oncology Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Capozza","sequence":"additional","affiliation":[{"name":"Yale New Haven Health Outpatient Oncology Rehabilitation Services, Smilow Cancer Hospital Adult Cancer Survivorship Clinic, New Haven, CT 06519, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Antonen","sequence":"additional","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, ON M5S3K3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-0702","authenticated-orcid":false,"given":"Gabrielle","family":"Trepanier","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 3K3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Avery","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-7090","authenticated-orcid":false,"given":"Christian","family":"Lopez","sequence":"additional","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, ON M5S3K3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Edwards","sequence":"additional","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8514","authenticated-orcid":false,"given":"Jennifer M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Cancer Rehabilitation and Survivorship Program, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, ON M5S3K3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"ref_1","unstructured":"Canadian Cancer Society, Government of Canada (2023). 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