{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:54:55Z","timestamp":1789667695354,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["CUP J33C22002920006"],"award-info":[{"award-number":["CUP J33C22002920006"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: The aim of the study was to compare the perioperative and oncologic outcomes of patients who underwent surgery for colorectal cancer (CRC) performed using laparoscopy or using the Medtronic Hugo\u2122 Robotic-Assisted Surgery (RAS) system. Methods: This is a retrospective comparative single-center study of consecutive minimally invasive surgeries for CRC performed by two colorectal surgeons with extensive laparoscopic experience at the beginning of their robotic expertise. Patients were not selected for the surgical approach, but waiting lists and operating room availability determined whether the patients were in the robotic group or the laparoscopic group. The primary outcome was to compare 30-day postoperative complications according to the Clavien\u2013Dindo classification and the Complication Comprehensive Index (CCI). The secondary outcomes included operating times, conversion rates, intraoperative complications, length of hospital stays (LOS), readmission rates, and short-term oncologic outcomes, such as the R0 resection, the number of lymph nodes harvested, the total mesorectal excision (TME) quality, and the circumferential resection margin (CRM). Results: Of the 109 patients, 52 underwent robotic and 57 laparoscopic CRC surgery. Patient demographic and clinical characteristics were similar in the two groups. There was no significant difference between the robotic and the laparoscopic groups regarding postoperative complications, the Clavien\u2013Dindo classification, and the CCI. They also had similar operating times, conversion rates, intraoperative complications, LOSs, readmission rates, and short-term oncologic outcomes (the lymph nodes harvested, the R0 resection, TME quality, and CRM status). Conclusions: This study reports the largest cohort of CRC surgery performed using the Medtronic Hugo\u2122 RAS system and is the first comparative study with laparoscopy. The perioperative and oncologic outcomes were similar, demonstrating that the Medtronic Hugo\u2122 RAS system is safe and feasible for CRC as compared to laparoscopic surgery, even at the beginning of the robotic experience.<\/jats:p>","DOI":"10.3390\/cancers17071164","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T01:59:36Z","timestamp":1743386376000},"page":"1164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Colorectal Cancer Outcomes of Robotic Surgery Using the Hugo\u2122 RAS System: The First Worldwide Comparative Study of Robotic Surgery and Laparoscopy"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7460-9578","authenticated-orcid":false,"given":"Giacomo","family":"Calini","sequence":"first","affiliation":[{"name":"Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cardelli","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Diana","family":"Alexa","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7078-2983","authenticated-orcid":false,"given":"Francesca","family":"Andreotti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4794-8723","authenticated-orcid":false,"given":"Michele","family":"Giorgini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Maria","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella","family":"Agama","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Gori","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-4888","authenticated-orcid":false,"given":"Dajana","family":"Cuicchi","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Poggioli","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-4139","authenticated-orcid":false,"given":"Matteo","family":"Rottoli","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40139 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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