{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:57:36Z","timestamp":1789559856718,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Research Executive Agency","award":["101079210\/2022"],"award-info":[{"award-number":["101079210\/2022"]}]},{"name":"European Research Executive Agency","award":["23PHE\u20442023"],"award-info":[{"award-number":["23PHE\u20442023"]}]},{"name":"UEFISCDI, Ministry of Education, Romania","award":["101079210\/2022"],"award-info":[{"award-number":["101079210\/2022"]}]},{"name":"UEFISCDI, Ministry of Education, Romania","award":["23PHE\u20442023"],"award-info":[{"award-number":["23PHE\u20442023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Pancreatic cancer remains one of the most aggressive and lethal malignancies, with limited effective treatment options for advanced stages. Microwave Ablation (MWA) has emerged as a minimally invasive therapeutic modality, offering potential benefits in tumor control. This review aims to critically assess the safety and efficacy of MWA in the treatment of pancreatic cancer, focusing on its application in various pancreatic lesions. Methods: We systematically reviewed studies published between 2010 and 2023 that evaluated the use of MWA in pancreatic tumors, including locally advanced pancreatic cancer (LAPC), pancreatic neuroendocrine tumors (PNETs), and pancreatic metastases from renal cell carcinoma (RCC). Due to limited data on survival rates and long-term outcomes, our analysis concentrated primarily on the technical aspects and immediate procedural outcomes of MWA. Results: MWA was technically feasible in all cases. The overall complication rate was approximately 16.7% (nine patients), with higher incidences in tumors located in the pancreatic head. Reported complications included pancreatitis and pseudocyst formation. Procedural parameters varied, with applied energy ranging from 20 to 80 watts and ablation times between 2 to 15 min, depending on the microwave generator type and approach (percutaneous, intraoperative or endoscopic). All cases demonstrated effective necrosis of the target tissue, and several studies reported notable tumor size reductions, averaging up to 70%. Conclusions: MWA shows promise as a therapeutic option for pancreatic cancer, achieving high technical success rates and significant tumor reductions. However, the procedure is associated with a moderate complication rate, particularly in tumors located in the pancreatic head.<\/jats:p>","DOI":"10.3390\/cancers17071197","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T05:29:19Z","timestamp":1743485359000},"page":"1197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Technical Feasibility of Microwave Ablation in Pancreatic Tumors: A Scoping Review of Procedural Efficacy and Safety"],"prefix":"10.3390","volume":"17","author":[{"given":"Daniela","family":"Tabacelia","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 010017 Bucharest, Romania"},{"name":"Elias Emergency University Hospital, 010017, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Robles-Medranda","sequence":"additional","affiliation":[{"name":"Ecuadorian Institute of Digestive Diseases, Guayaquil 090101, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artsiom","family":"Klimko","sequence":"additional","affiliation":[{"name":"Balgrist University Hospital, 8000 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-1809","authenticated-orcid":false,"given":"Stephen P.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Health, University College London, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vilmann","sequence":"additional","affiliation":[{"name":"Gastro Unit, Division of Endoscopy, Herlev and Gentofte Hospital, 2730 Herlev, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, 1050 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier P.","family":"Voermans","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology & Hepatology, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"S\u0103ftoiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 010017 Bucharest, Romania"},{"name":"Elias Emergency University Hospital, 010017, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5348-0341","authenticated-orcid":false,"given":"Cristian George","family":"Tieranu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 010017 Bucharest, Romania"},{"name":"Elias Emergency University Hospital, 010017, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezar","family":"Stroescu","sequence":"additional","affiliation":[{"name":"Surgery Department, Fundeni Clinical Institute, 010017 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.3748\/wjg.v24.i43.4846","article-title":"Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes","volume":"24","author":"McGuigan","year":"2018","journal-title":"World J. 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