{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:34:51Z","timestamp":1790087691826,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Objectives: Inflammatory fibroid polyps, also known as Vanek\u2019s tumors, are rare benign lesions of the gastrointestinal tract. Although the exact cause remains unclear, several theories suggest an association with inflammatory processes and genetic factors. This study aims to present the largest cohort of inflammatory fibroid polyp cases to date, analyzing their clinical presentation, diagnostic methods, and treatment approaches. Materials and methods: A retrospective multicentric analysis was conducted on 67 patients diagnosed with inflammatory fibroid polyps between 2013 and 2023 across four hospitals. Clinical data regarding tumor location, size, symptoms, and treatment were collected. Non-parametric statistical tests, including the chi-square test, Cram\u00e9r\u2019s V coefficient, and the Mann\u2013Whitney U test, were used to identify association between tumor characteristics, location, and treatment outcomes. Results: The cohort included 67 patients (58.2% female, median age 60 years). The stomach was the most common tumor site (47.8%), followed by the colon (32.8%), and small intestine (10.4%). The majority of patients (73.1%) were asymptomatic, while 9% experienced intestinal obstruction, all of which were located in the small intestine. Endoscopic resection was successful in 77.6% of cases, but surgical intervention was more frequently required for tumors in the small intestine. A significant association was found between larger tumor size, emergency presentation, intestinal location, and the need for surgery. Conclusions: Inflammatory fibroid polyps are commonly managed with endoscopic resection, particularly in gastric and colonic locations. However, small intestinal tumors more often need surgical treatment, especially when presenting with complications like intestinal obstruction.<\/jats:p>","DOI":"10.3390\/cancers17071209","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T16:26:31Z","timestamp":1743611191000},"page":"1209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inflammatory Fibroid Polyp (Vanek\u2019s Tumor): A Retrospective Multicentric Analysis of 67 Cases"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0186-1094","authenticated-orcid":false,"given":"Mario Mart\u00edn","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1354-5056","authenticated-orcid":false,"given":"V\u00edctor","family":"Dom\u00ednguez-Prieto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-1724","authenticated-orcid":false,"given":"Siyuan","family":"Qian Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n Dar\u00edo","family":"Quiceno Arias","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Bernarda","family":"\u00c1lvarez \u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montiel Jim\u00e9nez","family":"Fuertes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Meliga","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santos","family":"Jim\u00e9nez-Galanes","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital Infanta Elena, 28342 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-9347","authenticated-orcid":false,"given":"H\u00e9ctor Guadalajara","family":"Labajo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"},{"name":"Department of Surgery, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-2338","authenticated-orcid":false,"given":"Dami\u00e1n Garc\u00eda","family":"Olmo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"},{"name":"Department of Surgery, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-5593","authenticated-orcid":false,"given":"Pedro Villarejo","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Avenida de los Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"},{"name":"Department of Surgery, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"ref_1","first-page":"397","article-title":"Gastric Submucosal Granuloma with Eosinophilic Infiltration","volume":"25","author":"Vanek","year":"1949","journal-title":"Am. 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