{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:38:20Z","timestamp":1787319500819,"version":"build-2736575974"},"reference-count":219,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Central nervous system (CNS) tumors are the most common solid malignancy in the pediatric population. These lesions are the result of the aberrant cell signaling step proteins, which normally regulate cell proliferation. Mitogen-activated protein kinase (MAPK) pathways and tyrosine kinase receptors are involved in tumorigenesis of low-grade gliomas. High-grade gliomas may carry similar mutations, but loss of epigenetic control is the dominant molecular event; it can occur either due to histone mutations or inappropriate binding or unbinding of DNA on histones. Therefore, despite the absence of genetic alteration in the classic oncogenes or tumor suppressor genes, uncontrolled transcription results in tumorigenesis. Isocitric dehydrogenase (IDH) mutations do not predominate compared to their adult counterpart. Embryonic tumors include medulloblastomas, which bear mutations of transcription-regulating pathways, such as wingless-related integration sites or sonic hedgehog pathways. They may also relate to high expression of Myc family genes. Atypical teratoid rhabdoid tumors harbor alterations of molecules that contribute to ATP hydrolysis of chromatin. Embryonic tumors with multilayered rosettes are associated with microRNA mutations and impaired translation. Ependymomas exhibit great variability. As far as supratentorial lesions are concerned, the major events are mutations either of NFkB or Hippo pathways. Posterior fossa tumors are further divided into two types with different prognoses. Type A group is associated with mutations of DNA damage repair molecules. Lastly, germ cell tumors are a heterogeneous group. Among them, germinomas manifest KIT receptor mutations, a subgroup of the tyrosine kinase receptor family.<\/jats:p>","DOI":"10.3390\/cancers17091566","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:09:14Z","timestamp":1746389354000},"page":"1566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Molecular Basis of Pediatric Brain Tumors: A Review with Clinical Implications"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-5363","authenticated-orcid":false,"given":"Elias","family":"Antoniades","sequence":"first","affiliation":[{"name":"Second Department of Neurosurgery, Aristotle University School of Medicine, 546 36 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4299-1865","authenticated-orcid":false,"given":"Nikolaos","family":"Keffes","sequence":"additional","affiliation":[{"name":"Second Department of Neurosurgery, Aristotle University School of Medicine, 546 36 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-1985","authenticated-orcid":false,"given":"Stamatia","family":"Vorri","sequence":"additional","affiliation":[{"name":"New York City Health and Hospital\u2014Jacobi Medical Center Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Tsitouras","sequence":"additional","affiliation":[{"name":"Second Department of Neurosurgery, Aristotle University School of Medicine, 546 36 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-6880","authenticated-orcid":false,"given":"Nikolaos","family":"Gkantsinikoudis","sequence":"additional","affiliation":[{"name":"Second Department of Neurosurgery, Aristotle University School of Medicine, 546 36 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parmenion","family":"Tsitsopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Neurosurgery, Aristotle University School of Medicine, 546 36 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Magras","sequence":"additional","affiliation":[{"name":"Second Department of Neurosurgery, Aristotle University School of Medicine, 546 36 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64564","DOI":"10.18632\/oncotarget.18478","article-title":"High-grade glioma in very young children: A rare and particular patient population","volume":"8","author":"Ansari","year":"2017","journal-title":"Oncotarget"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40478-020-00904-x","article-title":"Low-grade developmental and epilepsy associated brain tumors: A critical update 2020","volume":"8","author":"Slegers","year":"2020","journal-title":"Acta Neuropathol. 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