{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:17:14Z","timestamp":1789345034816,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Karen Elise Jensen foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Patients with chronic myeloid leukemia (CML) have a long life expectancy due to modern treatment. However, treatment may have adverse effects that hamper work ability. Methods: Patients aged 25\u201360 years diagnosed in 2002\u20132020 were included in this nationwide matched cohort study examining work ability from diagnosis (index date), including the need for permanent disability compensation (flexible job or disability pension). Each patient was matched 1:5 on sex, birth year, and level of comorbidity with citizens from the general Danish population without CML. The risks of requiring flexible job and disability pension were calculated by cause-specific hazard ratios (HRs) using Cox proportional hazards regression, and the Aalen\u2013Johansen estimator was used to determine cumulative risks. Results: A total of 489 patients with CML and 2445 matched comparators were included. The median age was 46 years, and males comprised 59.5% of the cohort. Matched comparators were more likely to work at index date and 1, 3, 5, and 10 years after the index date (p &lt; 0.001). The HRs of requiring both flexible job (HR 8.7 (95% confidence interval (CI): 6.1;12.2, p &lt; 0.001)) and disability pension (HR 3.7 (95% CI: 2.8;4.9, p &lt; 0.001)) were higher among patients diagnosed with CML compared to matched comparators. The cumulative risk of requiring flexible job and disability pension also increased in patients with CML compared to matched comparators (p &lt; 0.001). Conclusions: Patients with CML have a reduced work ability compared to the general population. More research is needed to determine the cause of their loss of ability to work.<\/jats:p>","DOI":"10.3390\/cancers17091585","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T04:20:26Z","timestamp":1746591626000},"page":"1585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Work Ability in Patients with Chronic Myeloid Leukemia: A Danish Nationwide Cohort Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-997X","authenticated-orcid":false,"given":"Eva Futtrup","family":"Maksten","sequence":"first","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1006-4751","authenticated-orcid":false,"given":"Jonas Faartoft","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte Rechter","family":"Zenas","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren Poulsgaard","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Udby","sequence":"additional","affiliation":[{"name":"Department of Haematology, Zealand University Hospital, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Fonager","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"},{"name":"Department of Social Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-1812","authenticated-orcid":false,"given":"Marianne Tang","family":"Severinsen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Clinical Cancer Research Center, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1056\/NEJMoa1609324","article-title":"Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia","volume":"376","author":"Hochhaus","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1038\/leu.2017.253","article-title":"Assessment of Imatinib as First-Line Treatment of Chronic Myeloid Leukemia: 10-Year Survival Results of the Randomized CML Study IV and Impact of Non-CML Determinants","volume":"31","author":"Hehlmann","year":"2017","journal-title":"Leukemia"},{"key":"ref_3","first-page":"2113","article-title":"Quality of Life of Chronic Myeloid Leukemia Patients in Brazil: Ability to Work as a Key Factor","volume":"22","author":"Hamerschlak","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s11764-013-0300-z","article-title":"Type of Hematological Malignancy Is Crucial for the Return to Work Prognosis: A Register-Based Cohort Study","volume":"7","author":"Horsboel","year":"2013","journal-title":"J. Cancer Surviv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3109\/0284186X.2013.875625","article-title":"Risk of Disability Pension for Patients Diagnosed with Haematological Malignancies: A Register-Based Cohort Study","volume":"53","author":"Horsboel","year":"2014","journal-title":"Acta Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3109\/0284186X.2014.999871","article-title":"Wage-Subsidised Employment as a Result of Permanently Reduced Work Capacity in a Nationwide Cohort of Patients Diagnosed with Haematological Malignancies","volume":"54","author":"Horsboel","year":"2015","journal-title":"Acta Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00277-018-3549-5","article-title":"The Impact of Chronic Myeloid Leukemia on Employment: The French Prospective Study","volume":"98","author":"Vayr","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1007\/s00520-022-06968-w","article-title":"Impact of the Treatment of Chronic Myeloid Leukaemia by Tyrosine-Kinase Inhibitors on Sick Leaves Refund: A Nationwide Cohort Study","volume":"30","author":"Conte","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2147\/CLEP.S9908","article-title":"Existing Data Sources for Clinical Epidemiology: The Danish National Pathology Registry and Data Bank","volume":"2","author":"Erichsen","year":"2010","journal-title":"Clin. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2147\/CLEP.S99462","article-title":"The Danish National Chronic Myeloid Neoplasia Registry","volume":"8","author":"Bak","year":"2016","journal-title":"Clin. Epidemiol."},{"key":"ref_11","first-page":"441","article-title":"The Danish Civil Registration System. A Cohort of Eight Million Persons","volume":"53","author":"Pedersen","year":"2006","journal-title":"Dan. Med. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A New Method of Classifying Prognostic Comorbidity in Longitudinal Studies: Development and Validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding Algorithms for Defining Comorbidities in ICD-9-CM and ICD-10 Administrative Data","volume":"43","author":"Quan","year":"2005","journal-title":"Med. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/MLR.0b013e3181484347","article-title":"Cross-National Comparative Performance of Three Versions of the ICD-10 Charlson Index","volume":"45","author":"Sundararajan","year":"2007","journal-title":"Med. Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish National Patient Register","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/CLEP.S91125","article-title":"The Danish National Patient Registry: A Review of Content, Data Quality, and Research Potential","volume":"7","author":"Schmidt","year":"2015","journal-title":"Clin. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish National Prescription Registry","volume":"39","author":"Hallas","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/ije\/dyx108","article-title":"Data Resource Profile: The Danish National Prescription Registry","volume":"46","author":"Schmidt","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/1403494810395825","article-title":"The Danish Psychiatric Central Research Register","volume":"39","author":"Mors","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/14034940701271882","article-title":"Register-Based Follow-up of Social Benefits and Other Transfer Payments: Accuracy and Degree of Completeness in a Danish Interdepartmental Administrative Database Compared with a Population-Based Survey","volume":"35","author":"Hjollund","year":"2007","journal-title":"Scand. J. Public Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/1403494810394715","article-title":"Danish Education Registers","volume":"39","author":"Jensen","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_23","unstructured":"UNESCO Institute for Statistics (2012). International Standard Classification of Education, ISCED 2011, UNESCO Institute for Statistics."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1403494811405098","article-title":"Danish Registers on Personal Income and Transfer Payments","volume":"39","author":"Baadsgaard","year":"2011","journal-title":"Scand. J. Public Health"},{"key":"ref_25","unstructured":"OECD (2025, March 23). What Are Equivalence Scales? OECD Projected Income Distribution Poverty [Internet]. Available online: http:\/\/www.oecd.org\/els\/soc\/OECD-Note-EquivalenceScales.pdf."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2147\/CLEP.S399488","article-title":"Work Disability and Return to Work After Lymphoma: A Danish Nationwide Cohort Study","volume":"15","author":"Maksten","year":"2023","journal-title":"Clin. Epidemiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/sim.2712","article-title":"Tutorial in Biostatistics: Competing Risks and Multi-State Models","volume":"26","author":"Putter","year":"2007","journal-title":"Stat. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1214\/aos\/1176350951","article-title":"A Class of K-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk","volume":"16","author":"Gray","year":"1988","journal-title":"Ann. Stat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1080\/0284186X.2023.2251670","article-title":"Labor Market Affiliation of Patients with Myeloproliferative Neoplasms: A Population-Based Matched Cohort Study","volume":"62","author":"Svingel","year":"2023","journal-title":"Acta Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1177\/10781552231196130","article-title":"Risk Factors Determining Adherence to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukaemia","volume":"30","year":"2024","journal-title":"J. Oncol. Pharm. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/leu.2013.51","article-title":"Chronic Fatigue Is the Most Important Factor Limiting Health-Related Quality of Life of Chronic Myeloid Leukemia Patients Treated with Imatinib","volume":"27","author":"Efficace","year":"2013","journal-title":"Leukemia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"E468","DOI":"10.1097\/HS9.0000000000000468","article-title":"Chronic Myeloid Leukemia in 2020","volume":"4","author":"Hehlmann","year":"2020","journal-title":"HemaSphere"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2147\/CLEP.S444270","article-title":"Work Disability and Return to Work After Treatment for Acute Lymphoblastic Leukemia: A Danish Nationwide Cohort Study","volume":"16","author":"Maksten","year":"2024","journal-title":"Clin. Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5271\/sjweh.3883","article-title":"Risk of Being Granted Disability Pension among Incident Cancer Patients before and after a Structural Pension Reform: A Danish Population-Based, Matched Cohort Study","volume":"46","author":"Pedersen","year":"2020","journal-title":"Scand. J. Work. Environ. Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/ajh.26538","article-title":"Mental Health among Patients with Non-Hodgkin Lymphoma: A Danish Nationwide Study of Psychotropic Drug Use in 8750 Patients and 43,750 Matched Comparators","volume":"97","author":"Jakobsen","year":"2022","journal-title":"Am. J. Hematol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/ije\/31.6.1183","article-title":"Social Determinants of Disability Pension: A 10-Year Follow-up of 62,000 People in a Norwegian County Population","volume":"31","author":"Krokstad","year":"2002","journal-title":"Int. J. Epidemiol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/9\/1585\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:28:24Z","timestamp":1760030904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/9\/1585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["cancers17091585"],"URL":"https:\/\/doi.org\/10.3390\/cancers17091585","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]}}}