{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T17:31:58Z","timestamp":1777743118539,"version":"3.51.4"},"reference-count":47,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"MEXT\/JSPS KAKENHI","doi-asserted-by":"publisher","award":["19K16939"],"award-info":[{"award-number":["19K16939"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"MEXT\/JSPS KAKENHI","doi-asserted-by":"publisher","award":["21K18288"],"award-info":[{"award-number":["21K18288"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Cancer-related neuropathic pain (CR-NP) is challenging to manage, and the effectiveness of corticosteroids remains underexplored. Objectives: This study investigated the analgesic and functional benefits of corticosteroids in CR-NP. Methods: This multicenter, prospective observational study enrolled patients with CR-NP who initiated or escalated corticosteroid therapy. Pain intensity and daily activities were assessed at baseline (T0), 72 (T1), and 168 h (T2). A paired-sample t-test compared pain intensity changes. Linear regression analysis examined the association between changes in opioid daily dose and pain intensity, while Pearson\u2019s correlation coefficient assessed the relationship between changes in daily activities and pain intensity. Results: In total, 107 patients were consecutively enrolled. The mean worst pain intensity decreased from 8.2 \u00b1 1.9 at T0 to 5.2 \u00b1 2.9 at T1 and further to 4.4 \u00b1 3.0 at T2. No significant correlation was found between changes in opioid daily dose and pain intensity. However, daily activities improved significantly in correlation with pain reduction (r = \u22120.36, p &lt; 0.01). Over 75% of patients reported satisfaction with CR-NP management. Adverse events occurred in 21 cases and were generally mild. Conclusions: Corticosteroids provided rapid and considerable analgesic and functional benefits for patients with CR-NP in this observational setting; further validation through comparative controlled studies is required.<\/jats:p>","DOI":"10.3390\/cancers17101630","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T04:21:23Z","timestamp":1747023683000},"page":"1630","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Systemic Corticosteroids in Managing Cancer-Related Neuropathic Pain: A Multicenter Prospective Observational Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8081-5979","authenticated-orcid":false,"given":"Keita","family":"Tagami","sequence":"first","affiliation":[{"name":"Department of Home-Based Palliative Care, Yushoukai Home Medical Clinic Nerima, 1-22-11, Hazawa, Nerima-ku, Tokyo 176-0003, Japan"},{"name":"Department of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi","family":"Kessoku","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine and Gastroenterology, International University of Health and Welfare Narita Hospital, 852 Hatagateda, Narita 286-8250, Chiba, Japan"},{"name":"Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 1-4-1 Okina-cho, Naka-ku, Yokohama 231-0028, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-9029","authenticated-orcid":false,"given":"Hideaki","family":"Hasuo","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-2161","authenticated-orcid":false,"given":"Hiroto","family":"Ishiki","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuoku, Tokyo 104-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Konan Medical Center, 1-5-16 Kamokogahara, Higashinada-ku, Kobe 658-0064, Hyogo, Japan"},{"name":"Department of Palliative Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5489-9395","authenticated-orcid":false,"given":"Masanori","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Palliative and Supportive Care, Seirei Mikatahara General Hospital, 3453 Mikatahara-cho, Chuo-ku, Hamamatsu 433-8558, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2334-3893","authenticated-orcid":false,"given":"Yusuke","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan"},{"name":"Department of Palliative Medicine, Takeda General Hospital, 3-27 Yamagamachi, Aizuwakamatsu 965-8585, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa 277-8577, Chiba, Japan"},{"name":"Department of Palliative and Supportive Care, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba 305-8576, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-3940","authenticated-orcid":false,"given":"Yuka","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi 641-8509, Wakayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeya","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, JCHO Kyushu Hospital, 1-8-1 Kishinoura, Yahatanishi-ku, Kitakyushu 806-8501, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyofumi","family":"Oya","sequence":"additional","affiliation":[{"name":"Peace Home Care Clinic Kyoto, 11-43 Kamate-cho, Yamashina-ku, Kyoto 607-8031, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshika","family":"Koinuma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4728-0965","authenticated-orcid":false,"given":"Naoto","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Tohoku Rosai Hospital, 4-3 Dainohara, Aoba-ku, Sendai 981-8563, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Oyamada","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, JORTC Data Center, 2-54-6-302, Nishinippori, Arakawa-ku, Tokyo 116-0013, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8896-2572","authenticated-orcid":false,"given":"Keisuke","family":"Ariyoshi","sequence":"additional","affiliation":[{"name":"Department of Data Management, JORTC Data Center, 2-54-6-302, Nishinippori, Arakawa-ku, Tokyo 116-0013, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Eiju General Hospital, 2-23-16, Higashi-Ueno, Taito-ku, Tokyo 110-8645, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Mawatari","sequence":"additional","affiliation":[{"name":"Department of Palliative and Supportive Care, Yokohama Minami Kyosai Hospital, 1-11-10, Mutsuurahigashi, Kanazawa-ku, Yokohama 236-0037, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine and Gastroenterology, International University of Health and Welfare Narita Hospital, 852 Hatagateda, Narita 286-8250, Chiba, Japan"},{"name":"Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 1-4-1 Okina-cho, Naka-ku, Yokohama 231-0028, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3021-1401","authenticated-orcid":false,"given":"Mariko","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Kansai Medical University, 2-5-1 Shinmachi, Hirakata 573-1010, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kiuchi","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuoku, Tokyo 104-0045, Japan"},{"name":"Department of Palliative Care, Center Hospital of the National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiro","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 1-4-1 Okina-cho, Naka-ku, Yokohama 231-0028, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9611-4634","authenticated-orcid":false,"given":"Rintaro","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Nursing for Advanced Practice, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8575, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018). 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