{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:21:57Z","timestamp":1789230117239,"version":"build-2803163510"},"reference-count":84,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>With the increasing use of imaging modalities such as ultrasonography, computed tomography, and magnetic resonance imaging, incidental findings of pancreatic abnormalities, including pancreatic cysts and fatty pancreas (FP), have become more common. FP, also referred to as pancreatic steatosis, intra-pancreatic fat deposition, or fatty pancreas disease, is characterized by the accumulation of fat in the pancreas. Although FP has been associated with metabolic syndromes such as obesity and diabetes, its clinical significance remains unclear. Recent evidence suggests that FP may play a role in pancreatic carcinogenesis. Metabolic disorders, including obesity, insulin resistance, and diabetes, have been implicated in the development of FP. Additionally, FP has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), possibly due to chronic inflammation, lipotoxicity, and an altered pancreatic microenvironment. While early detection of PDAC remains challenging, surveillance strategies for high-risk individuals, such as those with pancreatic cysts, new-onset diabetes, or a genetic predisposition, may be crucial. In this context, FP may be incorporated into this surveillance of high-risk individuals. Some pharmacological interventions, including glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT2) inhibitors, have shown potential in reducing pancreatic fat accumulation, although further studies are needed to confirm their efficacy.<\/jats:p>","DOI":"10.3390\/cancers17111765","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:16:22Z","timestamp":1748204182000},"page":"1765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Fatty Pancreas: Its Potential as a Risk Factor for Pancreatic Cancer and Clinical Implications"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8578-6792","authenticated-orcid":false,"given":"Nao","family":"Otsuka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Institute of Gastroenterology, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Shimamatsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Gastroenterology, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryunosuke","family":"Hakuta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Gastroenterology, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-0298","authenticated-orcid":false,"given":"Yukiko","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Gastroenterology, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-1385","authenticated-orcid":false,"given":"Yousuke","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institute of Gastroenterology, Tokyo Women\u2019s Medical University, Tokyo 162-8666, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/MPA.0b013e3181f6fce2","article-title":"Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease","volume":"39","author":"Smits","year":"2010","journal-title":"Pancreas"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.metabol.2016.12.012","article-title":"Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression","volume":"69","author":"Singh","year":"2017","journal-title":"Metabolism"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1475-2840-12-77","article-title":"Association between non-alcoholic fatty pancreatic disease (NAFPD) and the metabolic syndrome: Case-control retrospective study","volume":"12","author":"Wu","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/MPA.0000000000000833","article-title":"Prevalence of Pancreatic Cystic Lesions Is Associated With Diabetes Mellitus and Obesity: An Analysis of 5296 Individuals Who Underwent a Preventive Medical Examination","volume":"46","author":"Mizuno","year":"2017","journal-title":"Pancreas"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1038\/ctg.2014.5","article-title":"Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma","volume":"5","author":"Hori","year":"2014","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1111\/cas.13766","article-title":"Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans","volume":"109","author":"Takahashi","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s11605-019-04417-4","article-title":"A Systematic Review of Intra-pancreatic Fat Deposition and Pancreatic Carcinogenesis","volume":"24","author":"Sreedhar","year":"2020","journal-title":"J. Gastrointest. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Frendi, S., Martineau, C., Cazier, H., Nicolle, R., Chassac, A., Albuquerque, M., Raffenne, J., Le Faouder, J., Paradis, V., and Cros, J. (2024). Role of the fatty pancreatic infiltration in pancreatic oncogenesis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-57294-6"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mizuno, S., Nakai, Y., Ishigaki, K., Saito, K., Oyama, H., Hamada, T., Suzuki, Y., Inokuma, A., Kanai, S., and Noguchi, K. (2020). Screening Strategy of Pancreatic Cancer in Patients with Diabetes Mellitus. Diagnostics, 10.","DOI":"10.3390\/diagnostics10080572"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1053\/j.gastro.2019.08.032","article-title":"Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms","volume":"158","author":"Oyama","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/jamaoncol.2024.1930","article-title":"Pancreatic Cancer Surveillance and Survival of High-Risk Individuals","volume":"10","author":"Blackford","year":"2024","journal-title":"JAMA Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1158\/1078-0432.CCR-14-2385","article-title":"Obesity and Fatty Pancreatic Infiltration Are Risk Factors for Pancreatic Precancerous Lesions (PanIN)","volume":"21","author":"Rebours","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41575-021-00551-0","article-title":"Intra-pancreatic fat deposition: Bringing hidden fat to the fore","volume":"19","author":"Petrov","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Otsuka, N., Shimizu, K., Taniai, M., and Tokushige, K. (2023). Risk factors for fatty pancreas and effects of fatty infiltration on pancreatic cancer. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1243983"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Truong, E., Pandol, S., and Jeon, C. (2022). Uniting epidemiology and experimental models: Pancreatic steatosis and pancreatic cancer. EBioMedicine, 79.","DOI":"10.1016\/j.ebiom.2022.103996"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1440-1827.1998.tb03951.x","article-title":"Lipomatous pseudohypertrophy of the pancreas in a patient with cirrhosis due to chronic hepatitis B","volume":"48","author":"Sasaki","year":"1998","journal-title":"Pathol. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejim.2014.11.007","article-title":"The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis","volume":"26","author":"Uygun","year":"2015","journal-title":"Eur. J. Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14740\/gr731w","article-title":"Non-Alcoholic Fatty Pancreatic Disease: A Review of Literature","volume":"9","author":"Tariq","year":"2016","journal-title":"Gastroenterol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mahyoub, M.A., Elhoumed, M., Maqul, A.H., Almezgagi, M., Abbas, M., Jiao, Y., Wang, J., Alnaggar, M., Zhao, P., and He, S. (2023). Fatty infiltration of the pancreas: A systematic concept analysis. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1227188"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1679\/aohc.58.365","article-title":"Changes in the mouse exocrine pancreas after pancreatic duct ligation: A qualitative and quantitative histological study","volume":"58","author":"Watanabe","year":"1995","journal-title":"Arch. Histol. Cytol."},{"key":"ref_21","first-page":"408","article-title":"Chronic pancreatitis: Evolution of the disease","volume":"38","author":"Maillet","year":"1991","journal-title":"Hepatogastroenterology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01605976","article-title":"The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis","volume":"420","author":"Maillet","year":"1992","journal-title":"Virchows Arch. A Pathol. Anat. Histopathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.gie.2011.01.015","article-title":"A prospective evaluation of fatty pancreas by using EUS","volume":"73","author":"Sepe","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ou, H.Y., Wang, C.Y., Yang, Y.C., Chen, M.F., and Chang, C.J. (2013). The association between nonalcoholic fatty pancreas disease and diabetes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062561"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Virtue, S., and Vidal-Puig, A. (2008). It\u2019s not how fat you are, it\u2019s what you do with it that counts. PLoS Biol., 6.","DOI":"10.1371\/journal.pbio.0060237"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S2213-8587(19)30084-1","article-title":"Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: A position statement","volume":"7","author":"Neeland","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_27","first-page":"209","article-title":"Non-alcoholic fatty pancreas disease\u2014Practices for clinicians","volume":"57","author":"Pinte","year":"2019","journal-title":"Rom. J. Intern. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2955","DOI":"10.1002\/dmrr.2955","article-title":"Type 2 diabetes: Does pancreatic fat really matter?","volume":"34","author":"Guglielmi","year":"2018","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.2337\/diabetes.51.2007.S134","article-title":"Lipotoxicity in human pancreatic islets and the protective effect of metformin","volume":"51","author":"Lupi","year":"2002","journal-title":"Diabetes"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/MPA.0000000000001155","article-title":"Harnessing Analytic Morphomics for Early Detection of Pancreatic Cancer","volume":"47","author":"Petrov","year":"2018","journal-title":"Pancreas"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrgastro.2011.4","article-title":"The clinical significance of pancreatic steatosis","volume":"8","author":"Smits","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s40265-024-02022-7","article-title":"The Pharmacological Landscape for Fatty Change of the Pancreas","volume":"84","author":"Petrov","year":"2024","journal-title":"Drugs"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e2918","DOI":"10.1002\/dmrr.2918","article-title":"Ectopic fat accumulation in the pancreas and its biomarkers: A systematic review and meta-analysis","volume":"33","author":"Singh","year":"2017","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ajg.2014.1","article-title":"Fatty pancreas, insulin resistance, and \u03b2-cell function: A population study using fat-water magnetic resonance imaging","volume":"109","author":"Wong","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e000297","DOI":"10.1161\/JAHA.113.000297","article-title":"Enigmatic ectopic fat: Prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population","volume":"3","author":"Wang","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lesmana, C.R., Pakasi, L.S., Inggriani, S., Aidawati, M.L., and Lesmana, L.A. (2015). Prevalence of Non-Alcoholic Fatty Pancreas Disease (NAFPD) and its risk factors among adult medical check-up patients in a private hospital: A large cross sectional study. BMC Gastroenterol., 15.","DOI":"10.1186\/s12876-015-0404-1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.pan.2016.03.008","article-title":"The correlation between pancreatic steatosis and metabolic syndrome in a Chinese population","volume":"16","author":"Zhou","year":"2016","journal-title":"Pancreatology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1148\/radiol.13122883","article-title":"Quantitative assessment of pancreatic fat by using unenhanced CT: Pathologic correlation and clinical implications","volume":"271","author":"Kim","year":"2014","journal-title":"Radiology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"485","DOI":"10.5833\/jjgs.2017.0181","article-title":"Predicting postoperative pancreatic fistula after distal pancreatectomy by measuring the CT value ratio of future pancreas remnant to spleen (P\/S ratio) in preoperative unenhanced CT images","volume":"52","author":"Mori","year":"2019","journal-title":"Jpn. J. Gastroenterol. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1210\/jc.2009-0584","article-title":"Noninvasive quantification of pancreatic fat in humans","volume":"94","author":"Lingvay","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/oby.2009.352","article-title":"Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans","volume":"18","author":"Hu","year":"2010","journal-title":"Obesity"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10334-013-0421-4","article-title":"Initial clinical application of modified Dixon with flexible echo times: Hepatic and pancreatic fat assessments in comparison with (1)H MRS","volume":"27","author":"Livingstone","year":"2014","journal-title":"MAGMA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s00330-009-1351-4","article-title":"Noninvasive quantitation of human liver steatosis using magnetic resonance and bioassay methods","volume":"19","author":"Ruel","year":"2009","journal-title":"Eur. Radiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dong, Z., Luo, Y., Zhang, Z., Cai, H., Li, Y., Chan, T., Wu, L., Li, Z.P., and Feng, S.T. (2014). MR quantification of total liver fat in patients with impaired glucose tolerance and healthy subjects. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111283"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"G806","DOI":"10.1152\/ajpgi.00385.2018","article-title":"Intrapancreatic fat deposition and visceral fat volume are associated with the presence of diabetes after acute pancreatitis","volume":"316","author":"Singh","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/MPA.0000000000001252","article-title":"Association of Pancreatic Steatosis With Chronic Pancreatitis, Obesity, and Type 2 Diabetes Mellitus","volume":"48","author":"Tirkes","year":"2019","journal-title":"Pancreas"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/s41366-021-00854-x","article-title":"Untargeted metabolomics reveals plasma metabolites predictive of ectopic fat in pancreas and liver as assessed by magnetic resonance imaging: The TOFI_Asia study","volume":"45","author":"Wu","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.2337\/dc07-0326","article-title":"Pancreatic fat content and beta-cell function in men with and without type 2 diabetes","volume":"30","author":"Tushuizen","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/dmrr.1073","article-title":"Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and\/or impaired glucose tolerance: A nuclear magnetic resonance study","volume":"26","author":"Heni","year":"2010","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_50","first-page":"1229","article-title":"Fatty Pancreas: Linking Pancreas Pathophysiology to Nonalcoholic Fatty Liver Disease","volume":"10","author":"Rugivarodom","year":"2022","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"100998","DOI":"10.1016\/j.jhepr.2023.100998","article-title":"Intrapancreatic fat deposition is unrelated to liver steatosis in metabolic dysfunction-associated steatotic liver disease","volume":"6","author":"Mak","year":"2024","journal-title":"JHEP Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/MPA.0b013e3181a9d5af","article-title":"Risk factors for hyperechogenic pancreas on endoscopic ultrasound: A case-control study","volume":"38","author":"Khashab","year":"2009","journal-title":"Pancreas"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"498296","DOI":"10.1155\/2013\/498296","article-title":"Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls","volume":"2013","author":"Patel","year":"2013","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kato, S., Iwasaki, A., Kurita, Y., Arimoto, J., Yamamoto, T., Hasegawa, S., Sato, T., Imajo, K., Hosono, K., and Kobayashi, N. (2019). Three-dimensional analysis of pancreatic fat by fat-water magnetic resonance imaging provides detailed characterization of pancreatic steatosis with improved reproducibility. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224921"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"107ra110","DOI":"10.1126\/scitranslmed.3002573","article-title":"Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity","volume":"3","author":"Navina","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1007\/s00464-022-09070-8","article-title":"Impact of pancreatic fat on the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis","volume":"36","author":"Park","year":"2022","journal-title":"Surg. Endosc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.dld.2024.10.005","article-title":"Pancreatic steatosis is a strong risk factor for post-ERCP pancreatitis: An emerging concept","volume":"57","author":"Prouvot","year":"2025","journal-title":"Dig. Liver Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1535-6108(03)00309-X","article-title":"Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse","volume":"4","author":"Hingorani","year":"2003","journal-title":"Cancer Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1073\/pnas.0802864106","article-title":"Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion","volume":"106","author":"Khasawneh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Carter, R., Mouralidarane, A., Soeda, J., Ray, S., Pombo, J., Saraswati, R., Novelli, M., Fusai, G., Rappa, F., and Saracino, C. (2014). Non-alcoholic fatty pancreas disease pathogenesis: A role for developmental programming and altered circadian rhythms. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089505"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jand.2017.07.005","article-title":"Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer","volume":"118","author":"Eibl","year":"2018","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000507457","article-title":"Pancreatic Fat Infiltration Is Associated with a Higher Risk of Pancreatic Ductal Adenocarcinoma","volume":"36","author":"Desai","year":"2020","journal-title":"Visc. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/1751-2980.12801","article-title":"Pancreatic fat content may increase the risk of imaging progression in low-risk branch duct intraductal papillary mucinous neoplasm","volume":"20","author":"Kashiwagi","year":"2019","journal-title":"J. Dig. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.pan.2017.07.007","article-title":"Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas","volume":"17","author":"Tanaka","year":"2017","journal-title":"Pancreatology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/dom.12680","article-title":"Exenatide decreases liver fat content and epicardial adipose tissue in patients with obesity and type 2 diabetes: A prospective randomized clinical trial using magnetic resonance imaging and spectroscopy","volume":"18","author":"Dutour","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1210\/jc.2015-3906","article-title":"Mechanisms of Action of Liraglutide in Patients With Type 2 Diabetes Treated With High-Dose Insulin","volume":"101","author":"Vanderheiden","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2337\/dc16-0836","article-title":"Pancreatic Effects of Liraglutide or Sitagliptin in Overweight Patients With Type 2 Diabetes: A 12-Week Randomized, Placebo-Controlled Trial","volume":"40","author":"Smits","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1007\/s00125-020-05265-7","article-title":"Effect of dulaglutide on liver fat in patients with type 2 diabetes and NAFLD: Randomised controlled trial (D-LIFT trial)","volume":"63","author":"Kuchay","year":"2020","journal-title":"Diabetologia"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.clnesp.2023.12.005","article-title":"Effects of liraglutide on intrapancreatic fat deposition in patients with type 2 diabetes","volume":"59","author":"Kuriyama","year":"2024","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/osp4.482","article-title":"Amelioration of pancreatic fat accumulation in Japanese type 2 diabetes patients treated with sodium-glucose cotransporter 2 inhibitors: A retrospective study","volume":"7","author":"Horii","year":"2021","journal-title":"Obes. Sci. Pract."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12933-021-01237-2","article-title":"Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: The EMPACEF study","volume":"20","author":"Gaborit","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/dom.14733","article-title":"Eight weeks of empagliflozin does not affect pancreatic fat content and insulin secretion in people with prediabetes","volume":"24","author":"Hummel","year":"2022","journal-title":"Diabetes Obes. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e2267","DOI":"10.1210\/clinem\/dgac138","article-title":"Dapagliflozin Improves Body Fat Patterning, and Hepatic and Pancreatic Fat in Patients With Type 2 Diabetes in North India","volume":"107","author":"Ghosh","year":"2022","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"108610","DOI":"10.1016\/j.jdiacomp.2023.108610","article-title":"Effect of dapagliflozin on liver and pancreatic fat in patients with type 2 diabetes and non-alcoholic fatty liver disease","volume":"37","author":"Shi","year":"2023","journal-title":"J. Diabetes Complicat."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/CS20100061","article-title":"Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL\/6 mice fed on a very high-fat diet","volume":"119","author":"Aguila","year":"2010","journal-title":"Clin. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.2006.126193","article-title":"The physiology of a local renin-angiotensin system in the pancreas","volume":"580","author":"Leung","year":"2007","journal-title":"J. Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.clnesp.2018.01.008","article-title":"The effect of long-term weight-loss intervention strategies on the dynamics of pancreatic-fat and morphology: An MRI RCT study","volume":"24","author":"Tene","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jiang, Y., Spurny, M., Sch\u00fcbel, R., Nonnenmacher, T., Schlett, C.L., von Stackelberg, O., Ulrich, C.M., Kaaks, R., Kauczor, H.U., and K\u00fchn, T. (2019). Changes in Pancreatic Fat Content Following Diet-Induced Weight Loss. Nutrients, 11.","DOI":"10.3390\/nu11040912"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1007\/s00125-019-4956-4","article-title":"A carbohydrate-reduced high-protein diet improves HbA","volume":"62","author":"Skytte","year":"2019","journal-title":"Diabetologia"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00125-021-05628-8","article-title":"Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: A randomised controlled trial","volume":"65","author":"Thomsen","year":"2022","journal-title":"Diabetologia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.2337\/dc22-0605","article-title":"An Isoenergetic Multifactorial Diet Reduces Pancreatic Fat and Increases Postprandial Insulin Response in Patients With Type 2 Diabetes: A Randomized Controlled Trial","volume":"45","author":"Brancato","year":"2022","journal-title":"Diabetes Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s00125-018-4627-x","article-title":"Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: A randomised controlled trial","volume":"61","author":"Heiskanen","year":"2018","journal-title":"Diabetologia"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S2468-1253(23)00064-X","article-title":"Fatty change of the pancreas: The Pandora\u2019s box of pancreatology","volume":"8","author":"Petrov","year":"2023","journal-title":"Lancet Gastroenterol. 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