{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:31:23Z","timestamp":1793849483431,"version":"4.6.1"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Japanese Society of Oral and Maxillofacial Surgeons"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: This systematic review aimed to evaluate the efficacy of immunoenhancing nutritional therapy compared to conventional nutritional care in reducing perioperative complications in adult patients undergoing surgery for oral cancer. Given the unclear role of immunonutrition in this specific surgical setting, we synthesized available randomized controlled trials to assess outcomes such as surgical site infections, wound healing complications, hospital stay, and adverse events. Methods: Patients who underwent planned oral cancer surgery were included. The intervention group received oral or enteral immunoenhancing nutritional agents preoperatively, postoperatively, or both, while the control group received standard care (intravenous fluids) and\/or macromolecular nutritional supplements. PubMed, Cochrane CENTRAL, and Central Medical Journal were comprehensively searched for randomized controlled trials (RCTs); eight RCTs were included. The primary outcomes were mortality, suture\/healing failure, surgical site infection (SSI), and hospital stay length, with evidence certainty assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. Results: Although mortality estimation was not feasible, hazard ratios from the meta-analysis showed that the intervention significantly improved suture\/healing failure, SSI, and hospital stay length. The certainty of evidence was \u201clow\u201d for suture\/healing failure and SSI and \u201cmoderate\u201d for hospital stay length. Conclusions: Perioperative management with enteral nutritional agents fortified with immunonutrients should be considered in adult patients scheduled for (advanced) oral cancer surgery.<\/jats:p>","DOI":"10.3390\/cancers17111855","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:09:12Z","timestamp":1748840952000},"page":"1855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Beneficial Outcomes of Immunoenhancing Nutritional Interventions in Perioperative Care for Oral Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-9523","authenticated-orcid":false,"given":"Shin-ichiro","family":"Hiraoka","sequence":"first","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, The University of Osaka, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Abe","sequence":"additional","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Department of Oral and Maxillofacial Surgery, Kanagawa Dental University, Yokosuka 238-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5878-8871","authenticated-orcid":false,"given":"Daisuke","family":"Takeda","sequence":"additional","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemichi","family":"Yuasa","sequence":"additional","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Oral and Maxillofacial Surgery, Toyohashi Medical Center, Toyohashi 440-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Adachi","sequence":"additional","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Department of Oral and Maxillofacial Surgery, Akiru Municipal Medical Center, Tokyo 197-0834, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narikazu","family":"Uzawa","sequence":"additional","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Department of Oral & Maxillofacial Oncology and Surgery, Graduate School of Dentistry, The University of Osaka, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kurita","sequence":"additional","affiliation":[{"name":"The Guidelines Committee, Japanese Society of Oral and Maxillofacial Surgeons, Minato-ku, Tokyo 108-0014, Japan"},{"name":"Department of Dentistry and Oral Surgery, School of Medicine, Shinshu University, Matsumoto 390-0802, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.oooo.2022.01.009","article-title":"Preoperative nutritional evaluation, surgical site infection, and prognosis in patients with oral cancer","volume":"134","author":"Hiraoka","year":"2022","journal-title":"Oral Surg. 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