{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:41:27Z","timestamp":1788594087566,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Radiomics is changing clinical practice by providing quantitative information from images to improve diagnosis, prognosis, and treatment planning. This study aims to investigate a radiomics model developed from contrast-enhanced mammography (CEM) images to predict disease-free survival (DFS) and overall survival (OS) in breast cancer (BC) patients. Methods: From January 2013 to December 2015, all consecutive BC patients who underwent CEM before biopsy at a referral center were enrolled. Clinical data included histological results, receptor profiles, and follow-up (DFS and OS). A region of interest (ROI) of the enhancing lesion was selected from recombined CEM images by experienced radiologists, and radiomic features were extracted. A Cox-LASSO model assigned coefficients to the features, generating patient radiomic scores (RSs), which were dichotomized for graphical representation. Model performance was assessed using the C index. Results: The study included 126 BC patients with predominantly \u201cmass\u201d-type lesions (95%) and a median follow-up of 6.88 years (IQR 3.10\u20138.15). The median age of the patients at the time of examination was 49.2 years (IQR: [42.33\u201356.98]). Radiomic and clinical\u2013radiomic models showed significant associations between RS, DFS, and OS, with patients with RS below the median showing a better prognosis (p &lt; 0.001). Bootstrap testing confirmed a good model fit for OS prediction, with median C-index values of 0.82 for the clinical model and 0.84 for the clinical\u2013radiomic model. Conclusions: Radiomic analysis of CEM images may predict DFS and OS in BC patients, offering additional prognostic value beyond clinical models alone.<\/jats:p>","DOI":"10.3390\/cancers17121926","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:48:56Z","timestamp":1749538136000},"page":"1926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preliminary Evaluation of Radiomics in Contrast-Enhanced Mammography for Prognostic Prediction of Breast Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-8075","authenticated-orcid":false,"given":"Luca","family":"Nicosia","sequence":"first","affiliation":[{"name":"Division of Breast Radiology, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7299-161X","authenticated-orcid":false,"given":"Luciano","family":"Mariano","sequence":"additional","affiliation":[{"name":"Division of Breast Radiology, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4944-7685","authenticated-orcid":false,"given":"Aurora","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, 20141 Milano, Italy"},{"name":"Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-9049","authenticated-orcid":false,"given":"Sara","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-5054","authenticated-orcid":false,"given":"Filippo","family":"Pesapane","sequence":"additional","affiliation":[{"name":"Division of Breast Radiology, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9269-0146","authenticated-orcid":false,"given":"Giovanni","family":"Corso","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, IEO European Institute of Oncology IRCCS, 20141 Milano, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-7219","authenticated-orcid":false,"given":"Paolo","family":"De Marco","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, IEO European Institute of Oncology IRCCS, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-312X","authenticated-orcid":false,"given":"Daniela","family":"Origgi","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, IEO European Institute of Oncology IRCCS, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sangalli","sequence":"additional","affiliation":[{"name":"Clinical Trial Office, IEO European Institute of Oncology IRCCS, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-7765","authenticated-orcid":false,"given":"Nadia","family":"Bianco","sequence":"additional","affiliation":[{"name":"Division of Medical Senology, IEO European Institute of Oncology IRCCS, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Carriero","sequence":"additional","affiliation":[{"name":"Radiology Department, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Santicchia","sequence":"additional","affiliation":[{"name":"Radiology Department, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-8939","authenticated-orcid":false,"given":"Enrico","family":"Cassano","sequence":"additional","affiliation":[{"name":"Division of Breast Radiology, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Subhan, A., Parveen, F., Shah, H., Yalamarty, S.S.K., Ataide, J.A., and Torchilin, V.P. 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Exp."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/12\/1926\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:49:19Z","timestamp":1760032159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/12\/1926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["cancers17121926"],"URL":"https:\/\/doi.org\/10.3390\/cancers17121926","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}