{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:04:14Z","timestamp":1791515054568,"version":"4.3.4"},"reference-count":38,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: In many cases, the detection of a single lesion could revolutionise patient clinical management; not all localisations, especially those with a low uptake and, consequently, a low Tumour-to-Background Ratio (TBR), are readily detectable using [18F]F-FDG PET\/CT. LAFOV-PET offers a potential enhancement in lesion detection, but the proportion of patients who would benefit from its use has yet to be determined. With the present analysis, we aimed to assess which clinical contexts the enhancement in lesion detection could affect the most. Methods: This retrospective study included 764 patients who underwent [18F]F-FDG PET\/CT between January and April 2024. Data were obtained through a review of PET\/CT reports. Inclusion criteria comprised patients who attended our centre for cancer pathologies or masses of undetermined nature (MUNs) in a staging setting, excluding patients who had undergone a prior [18F]F-FDG PET\/CT scan or who had received therapy for any cancer pathology. This analysis focused on the total number of lesions identified, as well as the SUVmax of the lesion with the highest uptake. We analysed the proportion of patients who were within the range of number of lesions between 1 and 2, as well as who had an SUVmax of the lesion with the highest uptake between 2 and 5, either in the whole patient population or in the pathologies with a larger numerosity in the present study. Results: Among the 862 scans analysed, 289 (34%) were found to be negative, while 573 (66%) presented at least one localisation. In total, 4.5% of patients presented both a lesion number of between 1 and 2 and an SUVmax of the lesion with the highest uptake between 2 and 5. Among the malignancies that were the most common in the analysed population, a higher-than-average proportion of patients meeting these criteria were found in melanoma (6.2%), breast cancer (5.9%), and multiple myeloma (4.8%) patients. Conversely, the conditions that presented a lower proportion of patients in this range were suffering from MUNs (4.0%), lung cancer (2.1%), head\u2013neck cancer (2.1%), suspected lymphoma (2.0%), and colon cancer (0.0%). Conclusions: Our analysis shows that almost 1 in 20 patients evaluated at oncological staging with [18F]F-FDG PET\/CT could benefit from the increased diagnostic sensitivity offered by LAFOV-PET scanners. These data, although preliminary, support the need for future prospective controlled studies to confirm the actual clinical impact of implementing LAFOV-PET in current practice.<\/jats:p>","DOI":"10.3390\/cancers17121927","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:48:56Z","timestamp":1749538136000},"page":"1927","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing the Potential Usefulness of FDG LAFOV-PET for Oncological Staging: An Evaluation of Lesion Number and Uptake"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0158-1708","authenticated-orcid":false,"given":"Valentino","family":"Dragonetti","sequence":"first","affiliation":[{"name":"Nuclear Medicine, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1924-1093","authenticated-orcid":false,"given":"Sara","family":"Peluso","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-925X","authenticated-orcid":false,"given":"Gastone","family":"Castellani","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy"},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-2624","authenticated-orcid":false,"given":"Stefano","family":"Fanti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy"},{"name":"Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0256-4947.75771","article-title":"18F-FDG PET\/CT Imaging in Oncology","volume":"31","author":"Almuhaideb","year":"2011","journal-title":"Ann. Saudi Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1088\/0031-9155\/53\/14\/002","article-title":"Measured Count-Rate Performance of the Discovery STE PET\/CT Scanner in 2D, 3D and Partial Collimation Acquisition Modes","volume":"53","author":"MacDonald","year":"2008","journal-title":"Phys. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40658-022-00487-7","article-title":"Comparison of Image Quality and Spatial Resolution between 18F, 68Ga, and 64Cu Phantom Measurements Using a Digital Biograph Vision PET\/CT","volume":"9","author":"Braune","year":"2022","journal-title":"EJNMMI Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1148\/rg.2016150073","article-title":"Malignancies with Low Fluorodeoxyglucose Uptake at PET\/CT: Pitfalls and Prognostic Importance: Resident and Fellow Education Feature","volume":"36","author":"Flavell","year":"2016","journal-title":"RadioGraphics"},{"key":"ref_5","first-page":"20220144","article-title":"A Case Series of FDG PET Scan: Hypometabolic Lesions That Matter in Oncology","volume":"9","author":"Chan","year":"2023","journal-title":"BJRCase Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40644-023-00540-3","article-title":"Long-Axial Field-of-View PET\/CT: Perspectives and Review of a Revolutionary Development in Nuclear Medicine Based on Clinical Experience in over 7000 Patients","volume":"23","author":"Alberts","year":"2023","journal-title":"Cancer Imaging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1007\/s00259-021-05282-7","article-title":"Clinical Performance of Long Axial Field of View PET\/CT: A Head-to-Head Intra-Individual Comparison of the Biograph Vision Quadra with the Biograph Vision PET\/CT","volume":"48","author":"Alberts","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5260305","DOI":"10.1155\/2017\/5260305","article-title":"Advanced Functional Tumor Imaging and Precision Nuclear Medicine Enabled by Digital PET Technologies","volume":"2017","author":"Wright","year":"2017","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12149-023-01827-y","article-title":"Impact of the New Ultra-High Sensitivity Mode in a Long Axial Field-of-View PET\/CT","volume":"37","author":"Mingels","year":"2023","journal-title":"Ann. Nucl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00259-023-06534-4","article-title":"Total-Body PET\/CT or LAFOV PET\/CT? Axial Field-of-View Clinical Classification","volume":"51","author":"Mingels","year":"2024","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.25259\/JCIS_93_2020","article-title":"Whole-Body versus Routine Skull Base to Mid-Thigh 18F-Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography in Patients with Malignant Melanoma","volume":"10","author":"Ozdemir","year":"2020","journal-title":"J. Clin. Imaging Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40658-023-00573-4","article-title":"A Proper Protocol for Routine 18F-FDG uEXPLORER Total-Body PET\/CT Scans","volume":"10","author":"Hu","year":"2023","journal-title":"EJNMMI Phys."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Calder\u00f3n, E., Schmidt, F.P., Lan, W., Castaneda-Vega, S., Brendlin, A.S., Trautwein, N.F., Dittmann, H., la Foug\u00e8re, C., and Kiefer, L.S. (2023). Image Quality and Quantitative PET Parameters of Low-Dose [18F]FDG PET in a Long Axial Field-of-View PET\/CT Scanner. Diagnostics, 13.","DOI":"10.20944\/preprints202310.0113.v1"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Honor\u00e9 d\u2019Este, S., Andersen, F.L., Andersen, J.B., Jakobsen, A.L., Sanchez Saxtoft, E., Schulze, C., Hansen, N.L., Andersen, K.F., Reichkendler, M.H., and H\u00f8jgaard, L. (2023). Potential Clinical Impact of LAFOV PET\/CT: A Systematic Evaluation of Image Quality and Lesion Detection. Diagnostics, 13.","DOI":"10.3390\/diagnostics13213295"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"110565","DOI":"10.1016\/j.radonc.2024.110565","article-title":"Beyond Lesion Count: Emphasizing Disease Pace in Oligometastatic Management","volume":"201","author":"Chang","year":"2024","journal-title":"Radiother. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1758835921988996","DOI":"10.1177\/1758835921988996","article-title":"Baseline Lesion Number as an Efficacy Predictive and Independent Prognostic Factor and Its Joint Utility with TMB for PD-1 Inhibitor Treatment in Advanced Gastric Cancer","volume":"13","author":"Wei","year":"2021","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Leong, S.P., Nathanson, S.D., and Zager, J.S. (2022). Imaging Modalities in the Detection and Diagnosis of Metastatic Disease. Cancer Metastasis Through the Lymphovascular System, Springer International Publishing.","DOI":"10.1007\/978-3-030-93084-4"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.6004\/jnccn.2204.0023","article-title":"Non\u2013Small Cell Lung Cancer, Version 4.2024, NCCN Clinical Practice Guidelines in Oncology","volume":"22","author":"Riely","year":"2024","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/annonc\/mdv187","article-title":"2nd ESMO Consensus Conference in Lung Cancer: Locally Advanced Stage III Non-Small-Cell Lung Cancer","volume":"26","author":"Eberhardt","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_20","unstructured":"(2024, December 09). Discovery MI. Available online: https:\/\/www.gehealthcare.com\/products\/molecular-imaging\/pet-ct\/discovery-mi."},{"key":"ref_21","unstructured":"United-Imaging Healthcare (2024, December 09). uMI Vista: Digital PET\/CT. Available online: https:\/\/www.united-imaging.com\/en\/product-service\/products\/mi\/umi-vista."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00259-014-2961-x","article-title":"FDG PET\/CT: EANM Procedure Guidelines for Tumour Imaging: Version 2.0","volume":"42","author":"Boellaard","year":"2015","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1007\/s00259-024-06921-5","article-title":"Long-Axial Field-of-View PET\/CT Improves Radiomics Feature Reliability","volume":"52","author":"Alberts","year":"2025","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/MNM.0000000000001745","article-title":"Investigating the Influence of Long-Axial versus Short-Axial Field of View PET\/CT on Stage Migration in Lymphoma and Non-Small Cell Lung Cancer","volume":"44","author":"Alberts","year":"2023","journal-title":"Nucl. Med. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1007\/s00259-023-06222-3","article-title":"Long Axial Field of View (LAFOV) PET-CT: Implementation in Static and Dynamic Oncological Studies","volume":"50","author":"Pan","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103756","DOI":"10.1016\/j.breast.2024.103756","article-title":"6th and 7th International Consensus Guidelines for the Management of Advanced Breast Cancer (ABC Guidelines 6 and 7)","volume":"76","author":"Cardoso","year":"2024","journal-title":"Breast"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.6004\/jnccn.2021.0018","article-title":"NCCN Guidelines\u00ae Insights: Melanoma: Cutaneous, Version 2.2021: Featured Updates to the NCCN Guidelines","volume":"19","author":"Swetter","year":"2021","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Filippi, L., Bianconi, F., Schillaci, O., Spanu, A., and Palumbo, B. (2022). The Role and Potential of 18F-FDG PET\/CT in Malignant Melanoma: Prognostication, Monitoring Response to Targeted and Immunotherapy, and Radiomics. Diagnostics, 12.","DOI":"10.3390\/diagnostics12040929"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Chen, M., Jiang, Y., Zhou, X., Wu, D., and Xie, Q. (2024). Dual-Energy Computed Tomography in Detecting and Predicting Lymph Node Metastasis in Malignant Tumor Patients: A Comprehensive Review. Diagnostics, 14.","DOI":"10.20944\/preprints202401.0935.v1"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.annonc.2024.11.006","article-title":"Cutaneous Melanoma: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up","volume":"36","author":"Amaral","year":"2025","journal-title":"Ann. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9235638","DOI":"10.1155\/2020\/9235638","article-title":"Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions","volume":"2020","author":"Ralli","year":"2020","journal-title":"J. Immunol. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41392-021-00827-6","article-title":"Signal Pathways of Melanoma and Targeted Therapy","volume":"6","author":"Guo","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1007\/s00259-023-06394-y","article-title":"[18F]FDG PET\/CT for Predicting Triple-Negative Breast Cancer Outcomes after Neoadjuvant Chemotherapy with or without Pembrolizumab","volume":"50","author":"Seban","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa020128","article-title":"Twenty-Five-Year Follow-up of a Randomized Trial Comparing Radical Mastectomy, Total Mastectomy, and Total Mastectomy Followed by Irradiation","volume":"347","author":"Fisher","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJMoa2207586","article-title":"Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer","volume":"388","author":"Kunkler","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.soc.2023.03.002","article-title":"Advances in Radiotherapy for Breast Cancer","volume":"32","author":"Upadhyay","year":"2023","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"102375","DOI":"10.1016\/j.ctrv.2022.102375","article-title":"Adjuvant and Neoadjuvant Breast Cancer Treatments: A Systematic Review of Their Effects on Mortality","volume":"105","author":"Kerr","year":"2022","journal-title":"Cancer Treat. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-023-01805-y","article-title":"Advancements in Clinical Aspects of Targeted Therapy and Immunotherapy in Breast Cancer","volume":"22","author":"Ye","year":"2023","journal-title":"Mol. Cancer"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/12\/1927\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:49:20Z","timestamp":1760032160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/12\/1927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["cancers17121927"],"URL":"https:\/\/doi.org\/10.3390\/cancers17121927","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}