{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:23:50Z","timestamp":1760059430503,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding-Scientific Research Seed Fund of Peking University First Hospital","award":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"],"award-info":[{"award-number":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"]}]},{"name":"Peking University People\u2019s Hospital Scientific Research Development Funds","award":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"],"award-info":[{"award-number":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"]}]},{"name":"Peking University Clinical Scientist Training Program","award":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"],"award-info":[{"award-number":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"]}]},{"name":"Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities","award":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"],"award-info":[{"award-number":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"]}]},{"name":"Beijing Physician Scientist Training Project","award":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"],"award-info":[{"award-number":["2025SF070","RDX2022-01","BMU2024PYJH026","PKU2024LCXQ027","BJPSTP-2024-10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: The optimal treatment for proximal tibial osteosarcoma (OS) in skeletally immature patients remains controversial. A custom hinged endoprosthesis has been used to preserve the growth potential of the distal femur. This study aims to report (1) the 2-year follow-up outcomes after surgery for pediatric proximal tibial OS; (2) the complications associated with this endoprosthesis; and (3) the extent to which the growth potential of the adjacent open physis can be preserved. Methods: Seven skeletally immature patients (mean age, 11.1 years; range, 9\u201313 years) with proximal tibial OS were included between November 2020 and December 2022. All underwent tumor resection and reconstruction by this custom endoprosthesis. Postoperative limb function was evaluated by the Musculoskeletal Tumor Society (MSTS) score system and complications were recorded. Overall leg length and femoral length were measured radiographically to determine the growth rate. Results: The mean follow-up time was 34.7 months (standard deviation (SD), 8.9 months). One patient presented with local recurrence 12 months after surgery, and another patient had pulmonary metastasis 3 months postoperatively. The range of flexion of the knee after rehabilitation was between 90\u00b0 and 125\u00b0, with an average of 103.6\u00b0 (SD, 12.5\u00b0). The average MSTS score of the patients after surgery was 27.4 (SD, 1.5). Wound dehiscence took place in three patients after chemotherapy. At the last follow-up, the overall limb length discrepancy was 2.1 cm (SD, 2.4 cm). Growth at the distal femoral physis after surgery was observed in all patients during follow-up, with an average of 81.4% (range, 57.78\u2013100%) of growth of the contralateral distal femoral physis. Conclusions: This custom hinged endoprosthesis can preserve the growth potential of the adjacent distal femur and provide satisfying functional outcomes with lower postoperative complication rate. It could serve as an alternative for proximal tibial OS in skeletally immature children.<\/jats:p>","DOI":"10.3390\/cancers17121952","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T03:59:17Z","timestamp":1749700757000},"page":"1952","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Custom Hinged Endoprosthesis for the Treatment of Proximal Tibial Osteosarcoma in Skeletally Immature Patients"],"prefix":"10.3390","volume":"17","author":[{"given":"Zhiqing","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7194-0192","authenticated-orcid":false,"given":"Jichuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Musculoskeletal Tumor Centre, Peking University People\u2019s Hospital, No. 11 Xizhimen South Road, Xicheng District, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Musculoskeletal Tumor Centre, Peking University People\u2019s Hospital, No. 11 Xizhimen South Road, Xicheng District, Beijing 100044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3982-1052","authenticated-orcid":false,"given":"Taiqiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4419-0284-9_1","article-title":"The epidemiology of osteosarcoma","volume":"152","author":"Ottaviani","year":"2009","journal-title":"Cancer Treat. 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