{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:02:04Z","timestamp":1775869324964,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Malignancies of the female upper reproductive tract, especially endometrial and ovarian cancers, generate a significant burden for women worldwide. The possible etiopathogenetic role of chronic human papillomavirus (HPV) infection in the carcinogenesis of the female upper genital tract is neither clearly established not completely understood. Therefore, we performed a literature review, using the PubMed and SCOPUS electronic databases, of the prevalence of HPV DNA in endometrial, primary fallopian tube, ovarian, and primary peritoneal cancers, as well as uterine sarcomas. The present investigation covered 35 studies from different countries on various continents. Overall, the prevalence of HPV was approximately 15% in all the above cancers. HPV DNA was isolated from 11%, 0%, 0%, and 14% of endometrial carcinomas, uterine sarcomas, primary fallopian tube cancers, and ovarian malignant neoplasms, respectively. No relevant studies on primary peritoneal cancers were retrieved. The predominant HPV strain from tumors of the upper female reproductive tract, regardless of the tumor site, was HPV-16, followed by HPV-18. The HPV DNA identified was exclusively from subtypes HPV-6, HPV-11, HPV-16, HPV-18, and HPV-33, which are responsible for the development of not only cervical cancer, but also condylomata acuminata. The findings of the present review indicate that HPV vaccination might prove to be a useful strategy in the prevention of HPV-related carcinomas of the upper genital tract in women.<\/jats:p>","DOI":"10.3390\/cancers17121995","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T04:06:24Z","timestamp":1750046784000},"page":"1995","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human Papillomaviruses and Malignant Neoplasms of the Female Upper Reproductive Tract: A Comprehensive Review of the Literature"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5258-4701","authenticated-orcid":false,"given":"Charalampos","family":"Karachalios","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Unit, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Liapis","sequence":"additional","affiliation":[{"name":"Birmingham Women\u2019s Hospital, Birmingham B15 2TG, West Midlands, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-0406","authenticated-orcid":false,"given":"Stamatios","family":"Petousis","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-0143","authenticated-orcid":false,"given":"Emmanouela-Aliki","family":"Almperi","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-4003","authenticated-orcid":false,"given":"Chrysoula","family":"Margioula-Siarkou","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Margioula-Siarkou","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-3470","authenticated-orcid":false,"given":"Stefanos","family":"Flindris","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-6104","authenticated-orcid":false,"given":"Evangelos","family":"Karamitrousis","sequence":"additional","affiliation":[{"name":"International Oncology Center, Interbalkan Medical Center, 55535 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-2840","authenticated-orcid":false,"given":"Konstantinos","family":"Dinas","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113955","DOI":"10.1016\/j.addr.2021.113955","article-title":"Drug Delivery Strategies for Management of Women\u2019s Health Issues in the Upper Genital Tract","volume":"177","author":"Patel","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/ijgo.13865","article-title":"Cancer of the Cervix Uteri: 2021 Update","volume":"155","author":"Bhatla","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ijgo.13866","article-title":"Cancer of the Corpus Uteri: 2021 Update","volume":"155","author":"Koskas","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ijgo.12613","article-title":"Uterine Sarcomas","volume":"143","author":"Mbatani","year":"2018","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ijgo.13878","article-title":"Cancer of the Ovary, Fallopian Tube, and Peritoneum: 2021 Update","volume":"155","author":"Berek","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/ijc.35278","article-title":"The GLOBOCAN 2022 Cancer Estimates: Data Sources, Methods, and a Snapshot of the Cancer Burden Worldwide","volume":"156","author":"Filho","year":"2025","journal-title":"Int. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human Papillomavirus Is a Necessary Cause of Invasive Cervical Cancer Worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1525-1381.1999.99723.x","article-title":"Papillomaviruses in Human Cancers","volume":"111","year":"1999","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nachira, D., Congedo, M.T., D\u2019Argento, E., Meacci, E., Evangelista, J., Sassorossi, C., Calabrese, G., Nocera, A., Kuzmych, K., and Santangelo, R. (2024). The Role of Human Papilloma Virus (HPV) in Primary Lung Cancer Development: State of the Art and Future Perspectives. Life, 14.","DOI":"10.3390\/life14010110"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jiph.2023.02.014","article-title":"Human Papillomavirus in Cancer: Infection, Disease Transmission, and Progress in Vaccines","volume":"16","author":"Oyouni","year":"2023","journal-title":"J. Infect. Public. Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13027-016-0087-4","article-title":"High-Risk HPV Is Not Associated with Epithelial Ovarian Cancer in a Caucasian Population","volume":"11","author":"Ingerslev","year":"2016","journal-title":"Infect. Agent. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000506050","article-title":"Detection of Human Papillomavirus Prevalence in Ovarian Cancer by Different Test Systems","volume":"62","author":"Kisseljova","year":"2020","journal-title":"Intervirology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00292-021-00933-w","article-title":"Aktuelle WHO-Klassifikation Des Weiblichen Genitale","volume":"42","author":"Mayr","year":"2021","journal-title":"Pathologe"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jclinepi.2020.01.008","article-title":"A Full Systematic Review Was Completed in 2 Weeks Using Automation Tools: A Case Study","volume":"121","author":"Clark","year":"2020","journal-title":"J. Clin. Epidemiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jiph.2019.08.017","article-title":"Human Papillomavirus as an Independent Risk Factor of Invasive Cervical and Endometrial Carcinomas in Jordan","volume":"13","author":"Jarajreh","year":"2020","journal-title":"J. Infect. Public. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/PGP.0b013e318199943b","article-title":"Does Human Papillomavirus Play a Role in Endometrial Carcinogenesis?","volume":"28","author":"Fedrizzi","year":"2009","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s12032-013-0597-5","article-title":"Association between Human Papillomavirus and Endometrial Adenocarcinoma","volume":"30","author":"Karadayi","year":"2013","journal-title":"Med. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/00313020310001602611","article-title":"The Value of HPV DNA Typing in the Distinction between Adenocarcinoma of Endocervical and Endometrial Origin","volume":"35","author":"Plunkett","year":"2003","journal-title":"Pathology"},{"key":"ref_20","first-page":"151","article-title":"Failure to Demonstrate the Role of High Risk Human Papilloma Virus in Epithelial Ovarian Cancer","volume":"7","author":"Alavi","year":"2012","journal-title":"Iran. J. Pathol."},{"key":"ref_21","first-page":"e39666","article-title":"Detection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples","volume":"12","author":"Dadashi","year":"2017","journal-title":"Arch. Clin. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00004347-199207000-00007","article-title":"Human Papillomavirus in Benign and Malignant Ovarian and Endometrial Tissues","volume":"11","author":"Lai","year":"1992","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"111089","DOI":"10.1016\/j.humimm.2024.111089","article-title":"The Clinical Importance of IFN-\u03b3 and Human Epididymis Protein 4 in Egyptian Patients with Epithelial Ovarian Cancer Combined with HPV Infection","volume":"85","author":"Mohamed","year":"2024","journal-title":"Hum. Immunol."},{"key":"ref_24","first-page":"220","article-title":"Infection of Human Papillomavirus (HPV) and P53 over-Expression in Human Female Genital Tract Carcinoma","volume":"46","author":"Anwar","year":"1996","journal-title":"J.-Pak. Med. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0046-8177(98)90120-4","article-title":"Human Papillomavirus and Mixed Epithelial Tumors of the Endometrium","volume":"29","author":"Landers","year":"1998","journal-title":"Hum. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/PGP.0b013e3181b8e951","article-title":"Endometrial Endometrioid Adenocarcinoma of the Uterine Corpus Involving the Cervix: Some Cases Probably Represent Independent Primaries","volume":"29","author":"Jiang","year":"2010","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/PGP.0b013e31828cb0be","article-title":"Primary Squamous Cell Carcinoma of the Endometrium: Clinicopathologic and Molecular Characteristics","volume":"32","author":"Bures","year":"2013","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/0046-8177(95)90171-X","article-title":"Association of Human Papillomavirus with Malignant and Premalignant Lesions of the Uterine Endometrium","volume":"26","author":"Fujita","year":"1995","journal-title":"Hum. Pathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/00313029600169463","article-title":"Human Papilloma Virus and P53 Overexpression in Carcinomas of the Uterine Cervix, Lower Uterine Segment and Endometrium","volume":"28","author":"Hachisuga","year":"1996","journal-title":"Pathology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1136\/ijgc-00009577-200607000-00018","article-title":"Detection of Human Papillomavirus in Organs of Upper Genital Tract in Women with Cervical Cancer","volume":"16","author":"Giordano","year":"2006","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1699-0463.1997.tb00575.x","article-title":"Adenocarcinoma of the Cervix and Adenocarcinoma of the Endometrium: Distinction with PCR-Mediated Detection of HPV DNA","volume":"105","author":"Hording","year":"1997","journal-title":"Apmis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1006\/gyno.2002.6784","article-title":"Detection of Human Papillomavirus DNA in Malignant Lesions from Chinese Women with Carcinomas of the Upper Genital Tract","volume":"87","author":"Ip","year":"2002","journal-title":"Gynecol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000292496","article-title":"Detection of Human Papillomavirus RNA in Ovarian and Endometrial Carcinomas by Reverse Transcription\/Polymerase Chain Reaction","volume":"38","author":"Lai","year":"1994","journal-title":"Gynecol. Obstet. Invest."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.humpath.2008.03.005","article-title":"Transitional Cell Carcinoma of the Endometrium and Endometrial Carcinoma with Transitional Cell Differentiation: A Clinicopathologic Study of 5 Cases and Review of the Literature","volume":"39","author":"Burgos","year":"2008","journal-title":"Hum. Pathol."},{"key":"ref_35","first-page":"829","article-title":"The Diagnostic Utility of Human Papillomavirus-Testing in Combination with Immunohistochemistry in Advanced Gynaecologic Pelvic Tumours: A New Diagnostic Approach","volume":"24","author":"Park","year":"2004","journal-title":"Int. J. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000076463","article-title":"Comparison of Human Papillomavirus DNA Levels in Gynecological Cancers: Implication for Cancer Development","volume":"24","author":"Yang","year":"2003","journal-title":"Tumour Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/path.1480","article-title":"The Presence of High-Risk HPV Combined with Specific P53 and P16INK4a Expression Patterns Points to High-Risk HPV as the Main Causative Agent for Adenocarcinoma in Situ and Adenocarcinoma of the Cervix","volume":"201","author":"Zielinski","year":"2003","journal-title":"J. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/gyno.1999.5534","article-title":"Does Human Papillomavirus Have a Role in Cancers of the Uterine Corpus?","volume":"75","author":"Brewster","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/bjc.1996.510","article-title":"P53 Mutation Is Associated with High S-Phase Fraction in Primary Fallopian Tube Adenocarcinoma","volume":"74","author":"Runnebaum","year":"1996","journal-title":"Br. J. Cancer"},{"key":"ref_40","first-page":"189","article-title":"Detection of Ras Gene Mutations and HPV in Lesions of the Human Female Reproductive Tract","volume":"5","author":"Koffa","year":"1994","journal-title":"Int. J. Oncol."},{"key":"ref_41","first-page":"573","article-title":"Human Papillomavirus Integration Is Not Associated with Advanced Epithelial Ovarian Cancer in German Patients","volume":"4","author":"Runnebaum","year":"1995","journal-title":"Cancer Epidemiol.-Biomark. Prev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/gyno.1998.5255","article-title":"Absence of Human Papillomavirus E6-E7 Transforming Genes from HPV 16 and 18 in Malignant Ovarian Carcinoma","volume":"72","author":"Chen","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"ref_43","first-page":"169","article-title":"Human Papillomavirus Genotypes and Methylation of CADM1, PAX1, MAL and ADCYAP1 Genes in Epithelial Ovarian Cancer Patients","volume":"18","author":"Hassan","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.2147\/CMAR.S262678","article-title":"Evaluation of P16 in Epithelial Ovarian Cancer for a 10-Year Study in Northeast China: Significance of Hpv in Correlation with Pd-L1 Expression","volume":"12","author":"Yang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jarych, D., Mikulski, D., Wilczy\u0144ski, M., Wilczy\u0144ski, J.R., Kania, K.D., Har\u0119\u017ca, D., Malinowski, A., Perdas, E., Nowak, M., and Paradowska, E. (2024). Differential MicroRNA Expression Analysis in Patients with HPV-Infected Ovarian Neoplasms. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25020762"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1479-828X.1993.tb02388.x","article-title":"Detection of Human Papilloma Virus (HPV) Infection in Paraffin-Embedded Tissues of Endometrial Carcinoma","volume":"33","author":"Wong","year":"1993","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.ygyno.2004.11.019","article-title":"Primary Squamous Cell Carcinoma of the Endometrium: A Case Report with Immunohistochemical and Molecular Study","volume":"96","author":"Giordano","year":"2005","journal-title":"Gynecol. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2739\/kurumemedj.44.67","article-title":"Squamous Cell Carcinoma of the Endometrium with Human Papillomavirus Type 31","volume":"44","author":"Kataoka","year":"1997","journal-title":"Kurume Med. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/gyno.1996.4597","article-title":"Squamous Cell Carcinoma of the Endometrium with Human Papillomavirus Type 31 and without Tumor Suppressor Gene P53 Mutation","volume":"65","author":"Kataoka","year":"1997","journal-title":"Gynecol. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3325\/cmj.2008.5.669","article-title":"Low Grade Peritoneal Mucinous Carcinomatosis Associated with Human Papilloma Virus Infection: Case Report","volume":"49","author":"Gatalica","year":"2008","journal-title":"Croat. Med. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/aogs.12254","article-title":"Prevalence of Human Papillomavirus in Epithelial Ovarian Cancer Tissue. A Meta-Analysis of Observational Studies","volume":"93","author":"Svahn","year":"2014","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ygyno.2014.02.040","article-title":"Prevalence of Human Papillomavirus in Endometrial Cancer: A Systematic Review and Meta-Analysis","volume":"134","author":"Olesen","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/IGC.0b013e318280f3e0","article-title":"The Prevalence of Human Papillomavirus in Ovarian Cancer: A Systematic Review","volume":"23","author":"Rosa","year":"2013","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"105086","DOI":"10.1016\/j.meegid.2021.105086","article-title":"V Human Papillomavirus and Ovarian Cancer (Review of Literature and Meta-Analysis)","volume":"95","author":"Ibragimova","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s10096-021-04282-7","article-title":"Prevalence of Human Papillomavirus Detection in Ovarian Cancer: A Meta-Analysis","volume":"40","author":"Cherif","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00404-007-0333-5","article-title":"HPV Induced Ovarian Squamous Cell Carcinoma: Case Report and Review of the Literature","volume":"276","author":"Verguts","year":"2007","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ijc.31819","article-title":"HPV-MRNA and HPV-DNA Detection in Samples Taken up to Seven Years before Severe Dysplasia of Cervix Uteri","volume":"144","author":"Forslund","year":"2019","journal-title":"Int. J. 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