{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:19:28Z","timestamp":1790709568544,"version":"4.1.0"},"reference-count":131,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s (EU) Horizon 2020 research and innovation program","award":["945175"],"award-info":[{"award-number":["945175"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cardiotoxicity is a leading cause of mortality in the growing populations of elderly breast cancer (BC) patients. Breast cancer treatment in the elderly is highly challenging due to its heterogeneous nature and the lack of specific evidence, as this population is usually underrepresented in randomized clinical trials. Decision making requires a comprehensive approach, considering the type and stage of BC, the patient\u2019s overall health status, life expectancy, geriatric and frailty assessment, the risk of cancer recurrence, comorbidities, cardiotoxicity risk, and the patient\u2019s preferences. The cardiotoxic effects of BC treatments cover the whole spectrum of cardiovascular diseases: heart failure, hypertension, arrhythmias, and myocardial ischemia. Cardiotoxicity risk in these patients is defined by several factors: anticancer therapies, polypharmacy, established cardiovascular disease, comorbidities, frailty, cellular senescence, hormonal changes, and genetic predisposition. Preventive oncological and cardio-oncological strategies, as well as patients\u2019 education, are critical for improved outcomes. Prospective clinical trials in this population are urgently needed.<\/jats:p>","DOI":"10.3390\/cancers17132198","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T06:18:36Z","timestamp":1751264316000},"page":"2198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiotoxicity in Elderly Breast Cancer Patients"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-6951","authenticated-orcid":false,"given":"Kalliopi","family":"Keramida","sequence":"first","affiliation":[{"name":"2nd Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Athens University Hospital Attikon, 11527 Athens, Greece"},{"name":"Cardiology Department, General Anti-Cancer Oncological Hospital, Agios Savvas, 11522 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-7574","authenticated-orcid":false,"given":"Anastasia","family":"Constantinidou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Bank of Cyprus Oncology Centre, 32 Acropoleos Avenue, Nicosia 2006, Cyprus"},{"name":"School of Medicine, University of Cyprus, Panepistimiou 1, Nicosia 2408, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-964X","authenticated-orcid":false,"given":"Dorothea","family":"Tsekoura","sequence":"additional","affiliation":[{"name":"2nd Department of Surgery, Aretaieio University Hospital, National and Kapodistrian University of Athens, 76 Vas. 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Sofias Av., 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrissovalantis","family":"Aidarinis","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Saloustros","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-0375","authenticated-orcid":false,"given":"Georgia","family":"Karanasiou","sequence":"additional","affiliation":[{"name":"Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia Giulia Angela","family":"Sacco","sequence":"additional","affiliation":[{"name":"European Institute of 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-1450","authenticated-orcid":false,"given":"Manolis","family":"Tsiknakis","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Hellenic Mediterranean University, 71410 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-0620","authenticated-orcid":false,"given":"Cameron","family":"Brown","sequence":"additional","affiliation":[{"name":"Stremble Ventures Ltd., 59 Christaki Kranou, Limassol 4042, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5789-5103","authenticated-orcid":false,"given":"Athos","family":"Antoniades","sequence":"additional","affiliation":[{"name":"Stremble Ventures Ltd., 59 Christaki Kranou, Limassol 4042, 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