{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:24:18Z","timestamp":1783538658416,"version":"3.55.0"},"reference-count":62,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute of the National Institutes of Health","award":["R03CA273609"],"award-info":[{"award-number":["R03CA273609"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["R01CA247833"],"award-info":[{"award-number":["R01CA247833"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: SCCOHT is an aggressive and often fatal cancer that belongs to the ~20% of cancers defined by mutations to subunits of the SWI\/SNF chromatin remodeling complex. In SCCOHT, mutations to the SMARCA4 gene, which encodes the SWI\/SNF ATPase BRG1, are sufficient to impair SWI\/SNF function. This single genetic lesion leads to a cascade of events that promote tumorigenesis, some of which may involve the intersection of SWI\/SNF with oncogenic pathways such as those regulated by the MYC oncogene. In SCCOHT tumors and other cancers marked by SWI\/SNF subunit mutation, MYC target genes are recurrently activated, pointing to a relationship between SWI\/SNF and MYC that has yet to be fully explored. Methods: In this study, we investigate the contribution of MYC to SCCOHT biology by performing a combination of chromatin binding and transcriptome assays in genetically engineered SCCOHT cell lines, with subsequent validation using patient tumor expression data. Results: We find that MYC binds to thousands of active promoters in the BIN-67 SCCOHT cell line and that the depletion of MYC results in a broad range of gene expression changes with a notable effect on the expression of genes related to DNA repair. We uncover an MYC-regulated DNA repair gene expression program in BIN-67 cells that is antagonized by BRG1 reintroduction. Finally, we identify a DNA repair gene signature that is upregulated in SCCOHT tumors and in tumors defined by loss of the SWI\/SNF subunit SNF5. Conclusions: Collectively, these data implicate MYC as a robust regulator of DNA repair gene expression in SCCOHT and lay a foundation for future studies focused on interrogating the relationship between BRG1 and MYC.<\/jats:p>","DOI":"10.3390\/cancers17132255","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T02:53:07Z","timestamp":1751856787000},"page":"2255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MYC Regulates a DNA Repair Gene Expression Program in Small Cell Carcinoma of the Ovary, Hypercalcemic Type"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7435-2874","authenticated-orcid":false,"given":"James R.","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA"},{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA"},{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia N.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA"},{"name":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy H.","family":"Creighton","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee B.","family":"Garrison","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail N.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Lira-Rivera","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diondre\u2019 D.","family":"Baisden","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, 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USA"},{"name":"University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53706, USA"},{"name":"Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA"},{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4505-0530","authenticated-orcid":false,"given":"April M.","family":"Weissmiller","sequence":"additional","affiliation":[{"name":"Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1097\/MPH.0b013e3181bdbc8d","article-title":"Small cell ovarian carcinoma: A rare, aggressive tumor masquerading as constipation in a teenager with a fatal outcome","volume":"32","author":"Barondeau","year":"2010","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/00000478-199411000-00004","article-title":"Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases","volume":"18","author":"Young","year":"1994","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wens, F., Hulsker, C.C.C., Fiocco, M., Zsiros, J., Smetsers, S.E., de Krijger, R.R., van der Steeg, A.F.W., Zweemer, R.P., Baas, I.O., and Roes, E.M. (2023). Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Patient Characteristics, Treatment, and Outcome-A Systematic Review. Cancers, 15.","DOI":"10.3390\/cancers15153794"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00404-011-1846-5","article-title":"Small cell carcinoma of the ovary of the hypercalcaemic type: An analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature","volume":"284","author":"Estel","year":"2011","journal-title":"Arch. Gynecol. Obs."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/annonc\/mdm376","article-title":"Results of a prospective dose-intensive regimen in 27 patients with small cell carcinoma of the ovary of the hypercalcemic type","volume":"18","author":"Pautier","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ng.2628","article-title":"Proteomic and bioinformatic analysis of mammalian SWI\/SNF complexes identifies extensive roles in human malignancy","volume":"45","author":"Kadoch","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.tig.2014.05.001","article-title":"A rationale to target the SWI\/SNF complex for cancer therapy","volume":"30","author":"Hohmann","year":"2014","journal-title":"Trends Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41556-018-0246-5","article-title":"Targeting BAF-perturbed cancers","volume":"20","author":"Reddy","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ng.2922","article-title":"Recurrent SMARCA4 mutations in small cell carcinoma of the ovary","volume":"46","author":"Jelinic","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ng.2928","article-title":"Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4","volume":"46","author":"Ramos","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/ng.2931","article-title":"Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type","volume":"46","author":"Witkowski","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/path.4633","article-title":"Dual loss of the SWI\/SNF complex ATPases SMARCA4\/BRG1 and SMARCA2\/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type","volume":"238","author":"Karnezis","year":"2016","journal-title":"J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41571-020-0357-3","article-title":"The SWI\/SNF complex in cancer\u2014biology, biomarkers and therapy","volume":"17","author":"Mittal","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111770","DOI":"10.1016\/j.isci.2025.111770","article-title":"Super-enhancers and efficacy of triptolide in small cell carcinoma of the ovary hypercalcemic type","volume":"28","author":"Lang","year":"2025","journal-title":"iScience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/s41588-019-0363-5","article-title":"The ATPase module of mammalian SWI\/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting","volume":"51","author":"Pan","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e59073","DOI":"10.7554\/eLife.59073","article-title":"Re-expression of SMARCA4\/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism","volume":"9","author":"Orlando","year":"2020","journal-title":"eLife"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/ng.3958","article-title":"SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters","volume":"49","author":"Nakayama","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng.3746","article-title":"SMARCB1-mediated SWI\/SNF complex function is essential for enhancer regulation","volume":"49","author":"Wang","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"25168657221115656","DOI":"10.1177\/25168657221115656","article-title":"Emerging Themes in Mechanisms of Tumorigenesis by SWI\/SNF Subunit Mutation","volume":"15","author":"Jones","year":"2022","journal-title":"Epigenet Insights"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"757534","DOI":"10.1155\/2014\/757534","article-title":"Mammalian MYC proteins and cancer","volume":"2014","author":"Tansey","year":"2014","journal-title":"New J. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nature21064","article-title":"Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer","volume":"542","author":"Genovese","year":"2017","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/labinvest.2010.66","article-title":"Rhabdoid tumor: Gene expression clues to pathogenesis and potential therapeutic targets","volume":"90","author":"Gadd","year":"2010","journal-title":"Lab. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Auguste, A., Blanc-Durand, F., Deloger, M., Le Formal, A., Bareja, R., Wilkes, D.C., Richon, C., Brunn, B., Caron, O., and Devouassoux-Shisheboran, M. (2020). Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis. Cells, 9.","DOI":"10.3390\/cells9061496"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/emmm.201200236","article-title":"The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer","volume":"4","author":"Romero","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1038\/s41388-021-01804-7","article-title":"Multiple interactions of the oncoprotein transcription factor MYC with the SWI\/SNF chromatin remodeler","volume":"40","author":"Woodley","year":"2021","journal-title":"Oncogene"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhu, Q., Liu, N., Orkin, S.H., and Yuan, G.C. (2019). CUT&RUNTools: A flexible pipeline for CUT&RUN processing and footprint analysis. Genome Biol., 20.","DOI":"10.1186\/s13059-019-1802-4"},{"key":"ref_27","unstructured":"Stark, R., and Brown, G. (2011). DiffBind: Differential Binding Analysis of ChIP-Seq Peak Data. Bioconductor, Cancer Research UK Cambridge Research Institute."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: An efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Love, M.I., Huber, W., and Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol., 15.","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ccell.2016.02.009","article-title":"Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways","volume":"29","author":"Chun","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1038\/s41467-020-18377-w","article-title":"Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules","volume":"11","author":"Nabet","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13148-021-01126-1","article-title":"The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes","volume":"13","author":"Beacon","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: A graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"D545","DOI":"10.1093\/nar\/gkaa970","article-title":"KEGG: Integrating viruses and cellular organisms","volume":"49","author":"Kanehisa","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: A web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Sherman","year":"2009","journal-title":"Nat. Protoc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"23312","DOI":"10.18632\/oncotarget.8196","article-title":"Genomic landscape of DNA repair genes in cancer","volume":"7","author":"Chae","year":"2016","journal-title":"Oncotarget"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8748","DOI":"10.1158\/0008-5472.CAN-10-0944","article-title":"Tumor cell kill by c-MYC depletion: Role of MYC-regulated genes that control DNA double-strand break repair","volume":"70","author":"Luoto","year":"2010","journal-title":"Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"19286","DOI":"10.1074\/jbc.M212043200","article-title":"c-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repair","volume":"278","author":"Chiang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1158\/1078-0432.CCR-04-1582","article-title":"Myc down-regulation sensitizes melanoma cells to radiotherapy by inhibiting MLH1 and MSH2 mismatch repair proteins","volume":"11","author":"Bucci","year":"2005","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1667\/RR13515.1","article-title":"DNA damage response genes and the development of cancer metastasis","volume":"181","author":"Broustas","year":"2014","journal-title":"Radiat. Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Li, L.Y., Guan, Y.D., Chen, X.S., Yang, J.M., and Cheng, Y. (2020). DNA Repair Pathways in Cancer Therapy and Resistance. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.629266"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/PAS.0000000000000475","article-title":"SMARCA4 (BRG1) loss of expression is a useful marker for the diagnosis of ovarian small cell carcinoma of the hypercalcemic type (ovarian rhabdoid tumor): A comprehensive analysis of 116 rare gynecologic tumors, 9 soft tissue tumors, and 9 melanomas","volume":"39","author":"Velasco","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/path.4912","article-title":"The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type","volume":"242","author":"Wang","year":"2017","journal-title":"J. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1177\/09287329241296242","article-title":"Clinical characteristics and prognostic analysis of patients with SMARCA4-deficient lung cancer","volume":"33","author":"Xu","year":"2025","journal-title":"Technol. Health Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1073\/pnas.1732638100","article-title":"Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression","volume":"100","author":"Karlsson","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3390\/pathophysiology30030031","article-title":"Unraveling MYC\u2019s Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance","volume":"30","author":"Doha","year":"2023","journal-title":"Pathophysiology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1128\/MCB.00658-08","article-title":"Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability","volume":"28","author":"McKenna","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13048-025-01649-8","article-title":"Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type","volume":"18","author":"Gao","year":"2025","journal-title":"J. Ovarian Res."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Zhu, X., Fu, Z., Aceto, G., St-Germain, J., Liu, K., Arabzadeh, A., Qi, Y., Xue, Y., Witkowski, L., and Graulich, E. (2025). SMARCA4 loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer. Cancer Res.","DOI":"10.1158\/0008-5472.CAN-24-3990"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8311","DOI":"10.1093\/nar\/gky625","article-title":"ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells","volume":"46","author":"Kim","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/1758834017714993","article-title":"BRCA mutation in ovarian cancer: Testing, implications and treatment considerations","volume":"9","author":"Neff","year":"2017","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40661-016-0024-7","article-title":"New treatment option for ovarian cancer: PARP inhibitors","volume":"3","author":"Meehan","year":"2016","journal-title":"Gynecol. Oncol. Res. Pract."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Mironova, E., Molinas, S., Pozo, V.D., Bandyopadhyay, A.M., Lai, Z., Kurmashev, D., Schneider, E.L., Santi, D.V., Chen, Y., and Kurmasheva, R.T. (2024). Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors. Cancers, 16.","DOI":"10.3390\/cancers16112041"},{"key":"ref_61","first-page":"vdad010","article-title":"The PARP inhibitor Rucaparib synergizes with radiation to attenuate atypical teratoid rhabdoid tumor growth","volume":"5","author":"Alimova","year":"2023","journal-title":"Neurooncol. Adv."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Frederick, M., Skinner, H.D., Kazi, S.A., Sikora, A.G., and Sandulache, V.C. (2020). High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-63448-z"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/13\/2255\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:05:34Z","timestamp":1760033134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/13\/2255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":62,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["cancers17132255"],"URL":"https:\/\/doi.org\/10.3390\/cancers17132255","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]}}}