{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:04:36Z","timestamp":1787317476128,"version":"build-2736575974"},"reference-count":179,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Hepatocellular carcinoma (HCC) is a malignancy with a complex pathogenesis, course, and prognosis with increasing incidence. The most significant contributing factor to the development of HCC is the chronic process of inflammation and remodeling of the cirrhotic liver, in which the interaction between the tumor microenvironment (TME) and cancer cells plays a pivotal role. In recent years, increasing focus has been directed toward the role of platelets (PLTs) in mediating interactions between tumor cells and the TME and in the progression and spread of HCC, as well as other cancers. Due to their abundance in the bloodstream and intracellular granules rich in mediators facilitating their ability to modulate the immune system, PLTs play a significant role in carcinogenesis. In the context of HCC, the role of PLTs in the healing and regeneration processes of the liver has been recognized for some time. In recent years, there has been an increasing utilization of PLTs in prognostic models for patients with HCC. Given their role and the availability of clinical options that block PLTs\u2019 action, clinical trials of platelet blockers in the adjunctive treatment of HCC are becoming increasingly common. However, further research, both preclinical and clinical, is necessary to fully elucidate the role of PLTs in HCC and their potential use as a therapeutic target. In this literature review, we summarize the current knowledge on PLTs in HCC and focus on their potential use in everyday clinical practice.<\/jats:p>","DOI":"10.3390\/cancers17142391","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T13:33:27Z","timestamp":1752845607000},"page":"2391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Platelets in Hepatocellular Carcinoma\u2014From Pathogenesis to Targeted Therapy"],"prefix":"10.3390","volume":"17","author":[{"given":"Natalia","family":"Kluz","sequence":"first","affiliation":[{"name":"Medical Faculty, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0135-1315","authenticated-orcid":false,"given":"Hanna","family":"Grabowska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cardinal Stefan Wyszynski University, 5, 01-815 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Chmiel","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue\/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 00-001 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelia","family":"Rynkiewicz","sequence":"additional","affiliation":[{"name":"Medical Faculty, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Skrobucha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinical Centre, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wysoki\u0144ska","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-541X","authenticated-orcid":false,"given":"\u0141ukasz","family":"Szyma\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 01-447 Jastrz\u0119biec, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr Tomasz","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, Medical University of Gda\u0144sk, 80-214 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Semeniuk-Wojta\u015b","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Clinical Centre, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Kraj","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 01-447 Jastrz\u0119biec, Poland"},{"name":"Department of Oncology, University Clinical Centre, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hucke, F., Emmer, H., Emmer, R., Hucke, M., Bota, S., F\u00fcrstner, M., Hausegger, K., Mittermair, R., and Peck-Radosavljevic, M. (2023). Changes in the Epidemiology of Hepatocellular Carcinoma in Carinthia, Austria, 2012\u20132023. Cancers, 15.","DOI":"10.20944\/preprints202308.1830.v1"},{"key":"ref_2","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102446","DOI":"10.1016\/j.jceh.2024.102446","article-title":"Global Epidemiology of Hepatocellular Carcinoma","volume":"15","author":"Singh","year":"2025","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of NAFLD-related HCC: Trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Motta, B.M., Masarone, M., Torre, P., and Persico, M. (2023). From Non-Alcoholic Steatohepatitis (NASH) to Hepatocellular Carcinoma (HCC): Epidemiology, Incidence, Predictions, Risk Factors, and Prevention. Cancers, 15.","DOI":"10.20944\/preprints202310.1078.v1"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/ueg2.12238","article-title":"The risk of hepatocellular carcinoma in cirrhosis differs by etiology, age and sex: A Swedish nationwide population-based cohort study","volume":"10","author":"Bengtsson","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1053\/j.gastro.2023.06.027","article-title":"Incidence and Risk Factors for Hepatocellular Carcinoma in Cirrhosis: The Multicenter Hepatocellular Carcinoma Early Detection Strategy (HEDS) Study","volume":"165","author":"Reddy","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/cam4.1998","article-title":"Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases-meta-analytic assessment","volume":"8","author":"Tarao","year":"2019","journal-title":"Cancer Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-0038-1676806","article-title":"Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets","volume":"39","author":"Yang","year":"2019","journal-title":"Semin. Liver Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cld.2024.08.007","article-title":"The Diagnosis and Staging of Hepatocellular Carcinoma: A Review of Current Practices","volume":"29","author":"Vutien","year":"2025","journal-title":"Clin. Liver Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1016\/j.ajpath.2016.06.003","article-title":"Pathogenesis of Kupffer Cells in Cholestatic Liver Injury","volume":"186","author":"Sato","year":"2016","journal-title":"Am. J. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1586\/egh.11.92","article-title":"Update on hepatic stellate cells: Pathogenic role in liver fibrosis and novel isolation techniques","volume":"6","author":"Tacke","year":"2012","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sas, Z., Cendrowicz, E., Weinh\u00e4user, I., and Rygiel, T.P. (2022). Tumor Microenvironment of Hepatocellular Carcinoma: Challenges and Opportunities for New Treatment Options. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073778"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: New concepts and clinical perspectives","volume":"16","author":"Heemskerk","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Scridon, A. (2022). Platelets and Their Role in Hemostasis and Thrombosis-From Physiology to Pathophysiology and Therapeutic Implications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112772"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.187.3.329","article-title":"Adhesion of activated platelets to endothelial cells: Evidence for a GPIIbIIIa-dependent bridging mechanism and novel roles for endothelial intercellular adhesion molecule 1 (ICAM-1), alphavbeta3 integrin, and GPIbalpha","volume":"187","author":"Bombeli","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/09537104.2021.1913576","article-title":"Release of \u03b1-granule contents during platelet activation","volume":"33","author":"Smith","year":"2022","journal-title":"Platelets"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41392-024-02104-8","article-title":"Molecular mechanisms in liver repair and regeneration: From physiology to therapeutics","volume":"10","author":"Ma","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1002\/mco2.350","article-title":"The role of platelets in the regulation of tumor growth and metastasis: The mechanisms and targeted therapy","volume":"4","author":"Liao","year":"2023","journal-title":"MedComm"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3748\/wjg.v29.i6.1054","article-title":"Immunotherapy for hepatocellular carcinoma: Current status and future perspectives","volume":"29","author":"Mandlik","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41392-020-0187-x","article-title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: Theoretical basis and therapeutic aspects","volume":"5","author":"Tang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12935-021-02435-4","article-title":"Modulation of the tumour microenvironment in hepatocellular carcinoma by tyrosine kinase inhibitors: From modulation to combination therapy targeting the microenvironment","volume":"22","author":"Chen","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Latger-Cannard, V., Fenneteau, O., Salignac, S., Lecompte, T.P., and Schlegel, N. (2013). Platelet morphology analysis. Haemostasis: Methods and Protocols, Humana Press.","DOI":"10.1007\/978-1-62703-339-8_16"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1182\/blood.V68.2.386.386","article-title":"The relation of platelet density to platelet age: Survival of low- and high-density 111indium-labeled platelets in baboons","volume":"68","author":"Savage","year":"1986","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1055\/s-0038-1665333","article-title":"Evidence that platelet alpha-granules are a major determinant of platelet density: Studies in storage pool deficiency","volume":"50","author":"Vicic","year":"1983","journal-title":"Thromb. Haemost."},{"key":"ref_28","unstructured":"Han, X., Bouck, E., Zunica, E., Arachiche, A., Nieman, M., and Michelson, D. (2019). Platelets, Academic Press. [4th ed.]."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1055\/s-0044-1786387","article-title":"Platelet Physiology","volume":"50","author":"Gremmel","year":"2024","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_30","unstructured":"Ja, W. (1995). Platelet morphology, biochemistry, and function. Williams Hematology, Mcgraw-Hill."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Repsold, L., and Joubert, A.M. (2021). Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders. Cells, 10.","DOI":"10.3390\/cells10113034"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/hae.12427","article-title":"Primary haemostasis: Newer insights","volume":"20","author":"Berndt","year":"2014","journal-title":"Haemophilia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"781857","DOI":"10.1155\/2014\/781857","article-title":"Overview of platelet physiology: Its hemostatic and nonhemostatic role in disease pathogenesis","volume":"2014","author":"Ghoshal","year":"2014","journal-title":"Sci. World J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1160\/TH14-12-1067","article-title":"The role of platelets in inflammation","volume":"114","author":"Thomas","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1160\/TH09-03-0192","article-title":"Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombosis","volume":"102","author":"Jennings","year":"2009","journal-title":"Thromb. Haemost."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1182\/asheducation-2014.1.400","article-title":"Platelets: More than a sack of glue","volume":"2014","author":"Weyrich","year":"2014","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2010.04131.x","article-title":"The platelet contribution to cancer progression","volume":"9","author":"Bambace","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jss.2007.02.035","article-title":"Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro","volume":"145","author":"Matsuo","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"He, A.-D., Xie, W., Song, W., Ma, Y.-Y., Liu, G., Liang, M.-L., Da, X.-W., Yao, G.-Q., Zhang, B.-x., and Gao, C.-J. (2017). Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-02801-1"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1053\/gast.2003.50098","article-title":"ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell\u2013dependent release of TNF-\u03b1\/IL-6 in mice","volume":"124","author":"Selzner","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jss.2012.11.030","article-title":"Human platelets promote liver regeneration with Kupffer cells in SCID mice","volume":"180","author":"Takahashi","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/hep.23441","article-title":"Serotonin promotes tumor growth in human hepatocellular cancer","volume":"51","author":"Soll","year":"2010","journal-title":"Hepatology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-4598-12-14","article-title":"Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a","volume":"12","author":"Liang","year":"2013","journal-title":"Mol. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/10408363.2016.1200008","article-title":"Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond","volume":"53","author":"Xu","year":"2016","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrc3004","article-title":"Contribution of platelets to tumour metastasis","volume":"11","author":"Gay","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e28173","DOI":"10.1016\/j.heliyon.2024.e28173","article-title":"Platelet count as a predictor of vascular invasion and extrahepatic metastasis in hepatocellular carcinoma: A systematic review and meta-analysis","volume":"10","author":"Pang","year":"2024","journal-title":"Heliyon"},{"key":"ref_47","first-page":"450","article-title":"Interaction between circulating cancer cells and platelets: Clinical implication","volume":"27","author":"Lou","year":"2015","journal-title":"Chin. J. Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41392-024-01885-2","article-title":"Mechanism insights and therapeutic intervention of tumor metastasis: Latest developments and perspectives","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Morales-Pacheco, M., Valenzuela-Mayen, M., Gonzalez-Alatriste, A.M., Mendoza-Almanza, G., Cort\u00e9s-Ram\u00edrez, S.A., Losada-Garc\u00eda, A., Rodr\u00edguez-Mart\u00ednez, G., Gonz\u00e1lez-Ram\u00edrez, I., Maldonado-Lagunas, V., and Vazquez-Santillan, K. (2025). The role of platelets in cancer: From their influence on tumor progression to their potential use in liquid biopsy. Biomark. Res., 13.","DOI":"10.1186\/s40364-025-00742-w"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Hao, Y., Baker, D., and Ten Dijke, P. (2019). TGF-\u03b2-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112767"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"87174","DOI":"10.18632\/oncotarget.19912","article-title":"Platelet derived TGF-\u03b2 promotes cervical carcinoma cell growth by suppressing KLF6 expression","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","article-title":"Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis","volume":"20","author":"Labelle","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"217161","DOI":"10.1016\/j.canlet.2024.217161","article-title":"Platelets promote primary hepatocellular carcinoma metastasis through TGF-\u03b21-mediated cancer cell autophagy","volume":"600","author":"Lu","year":"2024","journal-title":"Cancer Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"180119","DOI":"10.1183\/16000617.0119-2018","article-title":"Cancer-associated thrombosis: The when, how and why","volume":"28","author":"Fernandes","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00441-016-2467-x","article-title":"Fibroblast activation in cancer: When seed fertilizes soil","volume":"365","author":"Kuzet","year":"2016","journal-title":"Cell Tissue Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","article-title":"CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer","volume":"37","author":"McLane","year":"2019","journal-title":"Annu. Rev. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e20201811","DOI":"10.1084\/jem.20201811","article-title":"LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy","volume":"218","author":"Sharma","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/ijc.20657","article-title":"Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer","volume":"113","author":"Wysoczynski","year":"2005","journal-title":"Int. J. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0959-8049(02)00596-8","article-title":"Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: Possible role of a metastasis predictor","volume":"39","author":"Kim","year":"2003","journal-title":"Eur. J. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-3-319-95294-9_12","article-title":"Platelet-Based Drug Delivery for Cancer Applications","volume":"Volume 1092","author":"Mohamed","year":"2018","journal-title":"Biomechanics in Oncology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Palacios-Acedo, A.L., M\u00e8ge, D., Crescence, L., Dignat-George, F., Dubois, C., and Panicot-Dubois, L. (2019). Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01805"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e1393598","DOI":"10.1080\/2162402X.2017.1393598","article-title":"CCL3 augments tumor rejection and enhances CD8(+) T cell infiltration through NK and CD103(+) dendritic cell recruitment via IFN\u03b3","volume":"7","author":"Allen","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ponomarev, E.D. (2018). Fresh Evidence for Platelets as Neuronal and Innate Immune Cells: Their Role in the Activation, Differentiation, and Deactivation of Th1, Th17, and Tregs during Tissue Inflammation. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00406"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.thromres.2018.01.035","article-title":"Effects of platelets on cancer progression","volume":"164","author":"Plantureux","year":"2018","journal-title":"Thromb. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF01307186","article-title":"Platelets and cancer metastasis: A causal relationship?","volume":"11","author":"Honn","year":"1992","journal-title":"Cancer Metastasis Rev."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Manouchehri Doulabi, E., Herre, M., Cedervall, J., Qiao, Q., Miao, Z., Hamidi, A., Hellman, L., Kamali-Moghaddam, M., and Olsson, A.K. (2022). Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgf\u03b2 Signaling in the Tumor Microenvironment. Cancers, 14.","DOI":"10.3390\/cancers14081947"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"155772","DOI":"10.1016\/j.cyto.2021.155772","article-title":"TGF-\u03b2 signaling and the interaction between platelets and T-cells in tumor microenvironment: Foes or friends?","volume":"150","author":"Razavi","year":"2022","journal-title":"Cytokine"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Miyashita, N., and Saito, A. (2021). Organ Specificity and Heterogeneity of Cancer-Associated Fibroblasts in Colorectal Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222010973"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in Signaling and Disease: Beyond Discovery and Development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI122955","article-title":"Functional significance of the platelet immune receptors GPVI and CLEC-2","volume":"129","author":"Rayes","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Yu, J.I., Park, H.C., Yoo, G.S., Choi, C., Choi, M.S., Nam, H., Baek, S.-Y., and Park, M. (2021). Clinical importance of the absolute count of neutrophils, lymphocytes, monocytes, and platelets in newly diagnosed hepatocellular carcinoma. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-82177-5"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1182\/blood-2007-09-113837","article-title":"Angiogenesis is regulated by a novel mechanism: Pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released","volume":"111","author":"Italiano","year":"2008","journal-title":"Blood"},{"key":"ref_73","first-page":"189","article-title":"The role of blood platelets in tumor angiogenesis","volume":"1815","author":"Sabrkhany","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF01307189","article-title":"Fatty acid modulation of tumor cell-platelet-vessel wall interaction","volume":"11","author":"Chen","year":"1992","journal-title":"Cancer Metastasis Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1476-5381.2010.00961.x","article-title":"Histamine receptors and cancer pharmacology","volume":"161","author":"Medina","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ccr.2013.05.008","article-title":"Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor","volume":"24","author":"Schumacher","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF01787021","article-title":"The role of calcium channels and serotonin (5-HT2) receptors for tumour cell lodgement in the liver","volume":"7","author":"Skolnik","year":"1989","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2013.06.009","article-title":"Platelets and tumor cells: A new form of border control","volume":"24","author":"Stanger","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood-2014-07-590513","article-title":"Platelet hyaluronidase-2: An enzyme that translocates to the surface upon activation to function in extracellular matrix degradation","volume":"125","author":"Albeiroti","year":"2015","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"39486","DOI":"10.18632\/oncotarget.8960","article-title":"Heparanase expression upregulates platelet adhesion activity and thrombogenicity","volume":"7","author":"Cui","year":"2016","journal-title":"Oncotarget"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.pmbts.2017.01.002","article-title":"Matrix Metalloproteinases and Platelet Function","volume":"147","author":"Gresele","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1160\/TH13-02-0113","article-title":"Platelets and matrix metalloproteinases","volume":"110","author":"Seizer","year":"2013","journal-title":"Thromb. Haemost."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10555-006-7886-9","article-title":"Matrix metalloproteinases and tumor metastasis","volume":"25","author":"Deryugina","year":"2006","journal-title":"Cancer Metastasis Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1073\/pnas.1633689100","article-title":"Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells","volume":"100","author":"Rolli","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, R., Ren, M., Chen, N., Luo, M., Deng, X., Xia, J., Yu, G., Liu, J., He, B., and Zhang, X. (2014). Presence of intratumoral platelets is associated with tumor vessel structure and metastasis. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-167"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.apsb.2015.07.005","article-title":"Cancer metastases: Challenges and opportunities","volume":"5","author":"Guan","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1593\/neo.121726","article-title":"PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells","volume":"15","author":"Steller","year":"2013","journal-title":"Neoplasia"},{"key":"ref_88","first-page":"3577","article-title":"Platelet-derived PDGF promotes the invasion and metastasis of cholangiocarcinoma by upregulating MMP2\/MMP9 expression and inducing EMT via the p38\/MAPK signalling pathway","volume":"12","author":"Pan","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_89","first-page":"1146","article-title":"Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3","volume":"135","author":"Sarukhanyan","year":"2020","journal-title":"Blood"},{"key":"ref_90","first-page":"e88245","article-title":"Platelet integrin \u03b16\u03b21 controls lung metastasis through direct binding to cancer cell-derived ADAM9","volume":"1","author":"Zigrino","year":"2016","journal-title":"JCI Insight"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/bloodadvances.2018016261","article-title":"Cobalt hematoporphyrin inhibits CLEC-2-podoplanin interaction, tumor metastasis, and arterial\/venous thrombosis in mice","volume":"2","author":"Tsukiji","year":"2018","journal-title":"Blood Adv."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1074\/jbc.M111.269811","article-title":"Engagement of \u03b1IIb\u03b23 (GPIIb\/IIIa) with \u03b1\u03bd\u03b23 integrin mediates interaction of melanoma cells with platelets: A connection to hematogenous metastasis: A connection to hematogenous metastasis","volume":"287","author":"Lonsdorf","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_93","unstructured":"(2025, April 10). National Comprehensive Cancer Network National Comprehensive Cancer Network Compendium. Available online: https:\/\/www.nccn.org\/compendia-templates\/compendia\/nccn-compendia."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/j.1538-7836.2009.03559.x","article-title":"Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models","volume":"7","author":"Jain","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1073\/pnas.0700625104","article-title":"Platelet glycoprotein Ib alpha supports experimental lung metastasis","volume":"104","author":"Jain","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1172\/JCI113411","article-title":"Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo","volume":"81","author":"Karpatkin","year":"1988","journal-title":"J. Clin. Investig."},{"key":"ref_97","first-page":"2824","article-title":"Multiple roles for platelet GPIIb\/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis","volume":"62","author":"Trikha","year":"2002","journal-title":"Cancer Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1172\/JCI200422123","article-title":"Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer","volume":"114","author":"Boucharaba","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1182\/blood-2014-04-568683","article-title":"Interaction of platelet-derived autotaxin with tumor integrin \u03b1V\u03b23 controls metastasis of breast cancer cells to bone","volume":"124","author":"Leblanc","year":"2014","journal-title":"Blood"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"E3053","DOI":"10.1073\/pnas.1411082111","article-title":"Platelets guide the formation of early metastatic niches","volume":"111","author":"Labelle","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Yan, M., Wang, Z., Qiu, Z., Cui, Y., and Xiang, Q. (2024). Platelet signaling in immune landscape: Comprehensive mechanism and clinical therapy. Biomark. Res., 12.","DOI":"10.1186\/s40364-024-00700-y"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41591-019-0379-5","article-title":"Platelet GPIb\u03b1 is a mediator and potential interventional target for NASH and subsequent liver cancer","volume":"25","author":"Malehmir","year":"2019","journal-title":"Nat. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"Semple","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: Functional links and key pathways","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/jcp.24539","article-title":"Platelets in tumor progression: A host factor that offers multiple potential targets in the treatment of cancer","volume":"229","author":"Sharma","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1073\/pnas.0611533104","article-title":"Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer","volume":"104","author":"Hamanishi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"10307","DOI":"10.18632\/oncotarget.2537","article-title":"Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma","volume":"5","author":"Wei","year":"2014","journal-title":"Oncotarget"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"328rv324","DOI":"10.1126\/scitranslmed.aad7118","article-title":"PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations","volume":"8","author":"Zou","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1111\/jth.15478","article-title":"Platelets stimulate programmed death-ligand 1 expression by cancer cells: Inhibition by anti-platelet drugs","volume":"19","author":"Asgari","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Cho, M.S., Lee, H., Gonzalez-Delgado, R., Li, D., Sasano, T., Carlos-Alcalde, W., Ma, Q., Liu, J., Sood, A.K., and Afshar-Kharghan, V. (2022). Platelets Increase the Expression of PD-L1 in Ovarian Cancer. Cancers, 14.","DOI":"10.3390\/cancers14102498"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zaslavsky, A.B., Adams, M.P., Cao, X., Maj, T., Choi, J.E., Stangl-Kremser, J., Patel, S., Putelo, A., Lee, S.K., and Nallandhighal, S. (2020). Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-76351-4"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"eaai7911","DOI":"10.1126\/sciimmunol.aai7911","article-title":"Platelets subvert T cell immunity against cancer via GARP-TGF\u03b2 axis","volume":"2","author":"Rachidi","year":"2017","journal-title":"Sci. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1160\/TH11-01-0020","article-title":"Platelets regulate CD4\u207a T-cell differentiation via multiple chemokines in humans","volume":"106","author":"Gerdes","year":"2011","journal-title":"Thromb. Haemost."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.canlet.2020.06.014","article-title":"Platelet factor 4 regulates T cell effector functions in malignant pleural effusions","volume":"491","author":"Mulet","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.pbj.2017.05.005","article-title":"Role of platelets in immune system and inflammation","volume":"2","author":"Sonmez","year":"2017","journal-title":"Porto Biomed. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12272-019-01146-9","article-title":"T helper 17 (Th17) cells and interleukin-17 (IL-17) in cancer","volume":"42","author":"Chang","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Polasky, C., Wendt, F., Pries, R., and Wollenberg, B. (2020). Platelet Induced Functional Alteration of CD4(+) and CD8(+) T Cells in HNSCC. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207507"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2018.02.022","article-title":"CXCL4 and CXCL4L1 in cancer","volume":"109","author":"Ruytinx","year":"2018","journal-title":"Cytokine"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Herr, N., Bode, C., and Duerschmied, D. (2017). The Effects of Serotonin in Immune Cells. Front. Cardiovasc. Med., 4.","DOI":"10.3389\/fcvm.2017.00048"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbi.2009.10.015","article-title":"The immunoregulatory role of dopamine: An update","volume":"24","author":"Sarkar","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/09553009014552221","article-title":"Cell Death Induced in a Murine Mastocytoma by 42\u201347 \u00b0C Heating in Vitro: Evidence that the Form of Death Changes from Apoptosis to Necrosis Above a Critical Heat Load","volume":"58","author":"Harmon","year":"1990","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1101\/gad.9.15.1831","article-title":"Kip\/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta","volume":"9","author":"Polyak","year":"1995","journal-title":"Genes Dev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000323936","article-title":"Modulation of natural killer cell anti-tumor reactivity by platelets","volume":"3","author":"Placke","year":"2011","journal-title":"J. Innate Immun."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ccell.2022.08.004","article-title":"Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD","volume":"40","author":"Ma","year":"2022","journal-title":"Cancer Cell"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"103042","DOI":"10.1016\/j.transci.2020.103042","article-title":"Platelet supernatant with longer storage inhibits tumor cell growth","volume":"60","author":"Pu","year":"2021","journal-title":"Transfus. Apher. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Cluxton, C.D., Spillane, C., O\u2019Toole, S.A., Sheils, O., Gardiner, C.M., and O\u2019Leary, J.J. (2019). Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211538"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/ijc.28174","article-title":"Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the \u201ca disintegrin and metalloproteases\u201d 10 and 17","volume":"133","author":"Chitadze","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1158\/0008-5472.CAN-07-6768","article-title":"Tumor-associated MICA is shed by ADAM proteases","volume":"68","author":"Waldhauer","year":"2008","journal-title":"Cancer Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/curroncol29030124","article-title":"Low Platelet Count Predicts Reduced Survival in Potentially Resectable Hepatocellular Carcinoma","volume":"29","author":"Schrecker","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000354416","article-title":"Hepatocellular carcinoma size: Platelets, \u03b3-glutamyl transpeptidase, and alkaline phosphatase","volume":"85","author":"Carr","year":"2013","journal-title":"Oncology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1111\/liv.14560","article-title":"Thrombocytosis is Associated with Worse Survival in Patients with Hepatocellular Carcinoma","volume":"40","author":"Liu","year":"2020","journal-title":"Liver Int."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.3748\/wjg.v21.i25.7895","article-title":"Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis","volume":"21","author":"Pang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Belluco, C., Forlin, M., Delrio, P., Rega, D., Degiuli, M., Sofia, S., Olivieri, M., Pucciarelli, S., Zuin, M., and Manzoni, G.D. (2018). Elevated platelet count is a negative predictive and prognostic marker in locally advanced rectal cancer undergoing neoadjuvant chemoradiation: A retrospective multi-institutional study on 965 patients. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-5022-1"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/JHC.S398591","article-title":"High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells","volume":"10","author":"Lu","year":"2023","journal-title":"J. Hepatocell. Carcinoma"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e11763","DOI":"10.1097\/MD.0000000000011763","article-title":"The prognostic role of pretreatment thrombocytosis in gastric cancer: A systematic review and meta-analysis","volume":"97","author":"Yang","year":"2018","journal-title":"Medicine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3324\/haematol.2018.209114","article-title":"The Khorana score for prediction of venous thromboembolism in cancer patients: A systematic review and meta-analysis","volume":"104","author":"Mulder","year":"2019","journal-title":"Haematologica"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e038172","DOI":"10.1136\/bmjopen-2020-038172","article-title":"Association between platelet count and hepatocellular carcinoma overall survival: A large retrospective cohort study","volume":"10","author":"Lu","year":"2020","journal-title":"BMJ Open"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/sj.bjc.6604282","article-title":"Prognostic factors and treatment effects for hepatocellular carcinoma in Child C cirrhosis","volume":"98","author":"Nouso","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Kraj, L., Chmiel, P., Gryziak, M., Grabowska-Derlatka, L., Szyma\u0144ski, \u0141., and Wysoki\u0144ska, E. (2024). Impact of Thrombocytopenia on Survival in Patients with Hepatocellular Carcinoma: Updated Meta-Analysis and Systematic Review. Cancers, 16.","DOI":"10.3390\/cancers16071293"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.jss.2015.08.038","article-title":"Preoperative thrombocytopenia and outcomes of hepatectomy for hepatocellular carcinoma","volume":"201","author":"Venkat","year":"2016","journal-title":"J. Surg. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s11605-011-1538-2","article-title":"Significance of Platelet Count in the Outcomes of Hepatectomized Patients with Hepatocellular Carcinoma Exceeding the Milan Criteria","volume":"15","author":"Amano","year":"2011","journal-title":"J. Gastrointest. Surg."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/cncr.20976","article-title":"The Impact of Preoperative Serum C-Reactive Protein on the Prognosis of Patients with Hepatocellular Carcinoma","volume":"103","author":"Hashimoto","year":"2005","journal-title":"Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/hep.25832","article-title":"Resection of Hepatocellular Cancer <=2 cm: Results From Two Western Centers","volume":"57","author":"Roayaie","year":"2012","journal-title":"Hepatology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1097-0142(19980701)83:1<58::AID-CNCR8>3.0.CO;2-A","article-title":"Natural killer cell activity in patients with hepatocellular carcinoma A new prognostic indicator after hepatectomy","volume":"83","author":"Taketomi","year":"1998","journal-title":"Cancer"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/MCG.0b013e31822b36cc","article-title":"Younger Hepatocellular Carcinoma Patients Have Better Prognosis After Percutaneous Radiofrequency Ablation Therapy","volume":"46","author":"Kao","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/cncr.24031","article-title":"High Serum Des-gamma-carboxy Prothrombin Level Predicts Poor Prognosis After Radiofrequency Ablation of Hepatocellular Carcinoma","volume":"115","author":"Kobayashi","year":"2009","journal-title":"Cancer"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00535-012-0690-0","article-title":"Radiofrequency ablation for hepatocellular carcinoma:the relationship between a new grading system for the ablative margin and clinical outcomes","volume":"48","author":"Nishikawa","year":"2013","journal-title":"J. Gastroenterol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jhep.2004.11.042","article-title":"Treatment of hepatocellular carcinoma in compensated cirrhosis with radio-frequency thermal ablation (RFTA): A prospective study","volume":"42","author":"Orlando","year":"2005","journal-title":"J. Hepatol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Xie, H., Wang, H., An, W., Ma, W., Qi, R., Yang, B., Liu, C., Gao, Y., Xu, B., and Wang, W. (2014). The Efficacy of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for Primary Hepatocellular Carcinoma in a Cohort of 487 Patients. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089081"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Yan, H., Zhou, D., Liu, X., Wang, P., Jiang, T., and Yang, Z. (2025). Survival analysis of patients with hepatocellular carcinoma based on the ratio of platelet count to spleen diameter. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1449603"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"836","DOI":"10.7326\/M16-0577","article-title":"Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: U.S. Preventive Services Task Force Recommendation Statement","volume":"164","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.hpb.2020.09.024","article-title":"Impact of Aspirin on clinical outcome in advanced HCC patients receiving sorafenib and regorafenib","volume":"23","author":"Rovesti","year":"2021","journal-title":"HPB"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Hayashi, T., Shibata, M., Oe, S., Miyagawa, K., Honma, Y., and Harada, M. (2020). Antiplatelet Therapy Improves the Prognosis of Patients with Hepatocellular Carcinoma. Cancers, 12.","DOI":"10.3390\/cancers12113215"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Ielasi, L., Tovoli, F., Tonnini, M., Tortora, R., Magini, G., Sacco, R., Pressiani, T., Trevisani, F., Sansone, V., and Marasco, G. (2021). Beneficial Prognostic Effects of Aspirin in Patients Receiving Sorafenib for Hepatocellular Carcinoma: A Tale of Multiple Confounders. Cancers, 13.","DOI":"10.3390\/cancers13246376"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"E2165","DOI":"10.1073\/pnas.1209182109","article-title":"Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B","volume":"109","author":"Sitia","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/cgt.2013.29","article-title":"Aspirin enhances IFN-\u03b1-induced growth inhibition and apoptosis of hepatocellular carcinoma via JAK1\/STAT1 pathway","volume":"20","author":"Li","year":"2013","journal-title":"Cancer Gene Ther."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ebiom.2019.06.048","article-title":"Aspirin targets P4HA2 through inhibiting NF-\u03baB and LMCD1-AS1\/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma","volume":"45","author":"Wang","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1093\/jnci\/djs452","article-title":"Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma","volume":"104","author":"Sahasrabuddhe","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1158\/1940-6207.CAPR-15-0126","article-title":"NSAID Use and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: The Liver Cancer Pooling Project","volume":"8","author":"Petrick","year":"2015","journal-title":"Cancer Prev. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa1912035","article-title":"Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality","volume":"382","author":"Simon","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1245\/s10434-016-5520-9","article-title":"Antiplatelet Therapy is Associated with a Better Prognosis for Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma after Liver Resection","volume":"23","author":"Lee","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jfma.2019.04.018","article-title":"Aspirin is associated with low recurrent risk in hepatitis B virus-related hepatocellular carcinoma patients after curative resection","volume":"119","author":"Young","year":"2020","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2018.4154","article-title":"Association Between Aspirin Use and Risk of Hepatocellular Carcinoma","volume":"4","author":"Simon","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1111\/liv.15011","article-title":"Association of aspirin and statin use with the risk of liver cancer in chronic hepatitis B: A nationwide population-based study","volume":"41","author":"Choi","year":"2021","journal-title":"Liver Int."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Li, X., Wu, S., and Yu, Y. (2020). Aspirin Use and the Incidence of Hepatocellular Carcinoma in Patients With Hepatitis B Virus or Hepatitis C Virus Infection: A Meta-Analysis of Cohort Studies. Front. Med., 7.","DOI":"10.3389\/fmed.2020.569759"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"16349","DOI":"10.18632\/oncotarget.7648","article-title":"AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin","volume":"7","author":"Gao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/abbs\/gmv112","article-title":"Down-regulation of SDF1-\u03b1 expression in tumor microenvironment is associated with aspirin-mediated suppression of the pro-metastasis effect of sorafenib in hepatocellular carcinoma","volume":"47","author":"Lu","year":"2015","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Lu, L., Sun, H.C., Zhang, W., Chai, Z.T., Zhu, X.D., Kong, L.Q., Wang, W.Q., Zhang, K.Z., Zhang, Y.Y., and Zhang, Q.B. (2013). Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065023"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.canlet.2017.06.029","article-title":"Aspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition","volume":"406","author":"Sun","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"17058","DOI":"10.1038\/cddiscovery.2017.58","article-title":"Simultaneous silencing of ACSL4 and induction of GADD45B in hepatocellular carcinoma cells amplifies the synergistic therapeutic effect of aspirin and sorafenib","volume":"3","author":"Xia","year":"2017","journal-title":"Cell Death Discov."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Xie, Z.Y., Liu, M.S., Zhang, C., Cai, P.C., Xiao, Z.H., and Wang, F.F. (2018). Aspirin enhances the sensitivity of hepatocellular carcinoma side population cells to doxorubicin via miR-491\/ABCG2. Biosci. Rep., 38.","DOI":"10.1042\/BSR20180854"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0016-5085(83)80119-X","article-title":"Acetylsalicylic acid suppresses the renal hemodynamic effect and reduces the diuretic action of furosemide in cirrhosis with ascites","volume":"84","author":"Planas","year":"1983","journal-title":"Gastroenterology"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.2147\/CMAR.S167560","article-title":"Nonsteroidal anti-inflammatory drugs, especially aspirin, are linked to lower risk and better survival of hepatocellular carcinoma: A meta-analysis","volume":"10","author":"Tao","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/cmi.2014.124","article-title":"Chronic hepatitis B: Role of anti-platelet therapy in inflammation control","volume":"12","author":"Aiolfi","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1172\/JCI121985","article-title":"Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1\/thromboxane A2","volume":"129","author":"Lucotti","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jhepr.2019.10.001","article-title":"Platelets in chronic liver disease, from bench to bedside","volume":"1","author":"Ramadori","year":"2019","journal-title":"JHEP Rep."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1161\/01.CIR.103.20.2501","article-title":"Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: Correlation with leukocyte recruitment to adherent platelets 1 hour after injury","volume":"103","author":"Smyth","year":"2001","journal-title":"Circulation"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"119612","DOI":"10.1016\/j.lfs.2021.119612","article-title":"Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment","volume":"277","author":"Kopsida","year":"2021","journal-title":"Life Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"195","DOI":"10.14740\/wjon1601","article-title":"Impact of Aspirin Use on Outcomes in Patients With Hepatocellular Cancer: A Nationwide Analysis","volume":"14","author":"Dhaliwal","year":"2023","journal-title":"World J. 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