{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:49:40Z","timestamp":1770997780734,"version":"3.50.1"},"reference-count":66,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian Government Medical Research Future Fund","award":["EPCD000014"],"award-info":[{"award-number":["EPCD000014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Advances in endometrial cancer treatment, such as minimally invasive surgery and the introduction of targeted therapies, could influence survivorship and result in changes in issues experienced by survivors of endometrial cancer. To improve endometrial cancer survivorship, it is first necessary to understand it. Therefore, the purpose of this study was to describe contemporary endometrial cancer survivorship issues. Methods: This study involved an umbrella review and cross-sectional survey of healthcare professionals. The umbrella review involved searching Medline (2013\u20132023) to identify published reviews describing survivorship outcomes in endometrial cancer survivors. Articles were screened and survivorship outcomes were extracted. Healthcare professionals working with patients diagnosed with endometrial cancer were asked to (1) rate the relevance of each survivorship outcome identified in the review, and (2) list any additional issues considered of clinical relevance. Results: Following the screening of 201 articles (159 papers excluded: n = 1 duplicate; n = 158 ineligible), 42 review articles were included and 25 survivorship outcomes identified including physical health (e.g., fatigue, pain), fertility (e.g., parity), quality of life (e.g., cognitive wellbeing), treatment-related toxicities, and mental health outcomes (e.g., anxiety). The cross-sectional survey was completed by 37 healthcare professionals (two-thirds being medical oncologists or gynaecological oncologists) working across Australia and New Zealand, with outcomes rated as relevant by 30% (for cachexia) to 100% (for body weight\/obesity and functional wellbeing of respondents. An additional 28 survivorship issues not identified in the review were reported by healthcare professionals. Conclusions: The current endometrial cancer survivorship literature is limited. The review, together with expert input from healthcare professionals, identified 53 survivorship issues. These findings will now inform development of a survey to explore the frequency, impact, and severity of survivorship issues from the perspective of endometrial cancer survivors, the results of which will guide the provision of supportive cancer care, in addition to guiding research and clinical practice.<\/jats:p>","DOI":"10.3390\/cancers17162696","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:59:01Z","timestamp":1755601141000},"page":"2696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Understanding Contemporary Endometrial Cancer Survivorship Issues: Umbrella Review and Healthcare Professional Survey"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0285-6318","authenticated-orcid":false,"given":"Tracey","family":"DiSipio","sequence":"first","affiliation":[{"name":"School of Public Health, The University of Queensland, Herston, QLD 4006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-250X","authenticated-orcid":false,"given":"Jemma","family":"Turner","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Notre Dame, Fremantle, WA 6160, Australia"},{"name":"Australian Centre for Precision Health and Technology, Griffith University, Gold Coast, QLD 4222, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Medical School, The University of Queensland, Herston, QLD 4006, Australia"},{"name":"Department of Emergency Medicine, Albany Medical Centre, Albany, NY 12208, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Driscoll","sequence":"additional","affiliation":[{"name":"The Kinghorn Cancer Centre, Darlinghurst, NSW 2010, Australia"},{"name":"St Vincent\u2019s Clinical School, University of New South Wales, Sydney, NSW 2033, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-6310","authenticated-orcid":false,"given":"Marta","family":"Preston","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Chris O\u2019Brien Lifehouse, Camperdown, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-0747","authenticated-orcid":false,"given":"Krystel","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia"},{"name":"The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicla","family":"Varnier-Lui","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Westmead Hospital, Westmead, NSW 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-5251","authenticated-orcid":false,"given":"Hui-Ling","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Peninsula Health, Frankston, VIC 3199, Australia"},{"name":"Western Health, Footscray, VIC 3011, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayajyot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Medical School, The University of Queensland, Herston, QLD 4006, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4107-3041","authenticated-orcid":false,"given":"Kathryn","family":"Alsop","sequence":"additional","affiliation":[{"name":"Australia New Zealand Gynaecological Oncology Group (ANZGOG), Camperdown, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra C.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Cancer Council Queensland, Fortitude Valley, QLD 4006, Australia"},{"name":"Centre for Health Services Research, The University of Queensland, Woolloongabba, QLD 4102, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-8085","authenticated-orcid":false,"given":"Monika","family":"Janda","sequence":"additional","affiliation":[{"name":"Centre for Health Services Research, The University of Queensland, Woolloongabba, QLD 4102, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-5562","authenticated-orcid":false,"given":"Rosalind R.","family":"Spence","sequence":"additional","affiliation":[{"name":"Cancer Council Queensland, Fortitude Valley, QLD 4006, Australia"},{"name":"School of Health Science and Social Work, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"ref_1","unstructured":"Ferlay, J.E.M., Lam, F., Laversanne, M., Colombet, M., Mery, L., Pi\u00f1eros, M., Znaor, A., Soerjomataram, I., and Bray, F. (2024, August 13). Global Cancer Observatory: Cancer Today Lyon, France: International Agency for Research on Cancer. Available online: https:\/\/gco.iarc.who.int\/today."},{"key":"ref_2","unstructured":"Cancer Australia (2024, August 13). Uterine Sarcoma. Canberra: Australian Government, Available online: https:\/\/www.canceraustralia.gov.au\/cancer-types\/endometrial-cancer\/uterine-cancer-statistics."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.2217\/fon.14.192","article-title":"USA endometrial cancer projections to 2030: Should we be concerned?","volume":"10","author":"Sheikh","year":"2014","journal-title":"Future Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Yang, L., Yuan, Y., Zhu, R., and Zhang, X. (2023). Time trend of global uterine cancer burden: An age-period-cohort analysis from 1990 to 2019 and predictions in a 25-year period. BMC Women\u2019s Health, 23.","DOI":"10.1186\/s12905-023-02535-5"},{"key":"ref_5","unstructured":"Hewitt, M., Greenfield, S., and Stovall, E. (2006). From Cancer Patient to Cancer Survivor: Lost in Transition, The National Academies Press."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ygyno.2017.11.007","article-title":"Life after endometrial cancer: A systematic review of patient-reported outcomes","volume":"148","author":"Shisler","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fabian, A., Krug, D., and Alkatout, I. (2020). Radiotherapy and its intersections with surgery in the management of localized gynecological malignancies: A comprehensive overview for clinicians. J. Clin. Med., 10.","DOI":"10.3390\/jcm10010093"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s11764-023-01507-w","article-title":"Survivorship outcomes in patients treated with immune checkpoint inhibitors: A scoping review","volume":"19","author":"Thong","year":"2025","journal-title":"J. Cancer Surviv."},{"key":"ref_10","unstructured":"Aromataris, E.L.C., Porritt, K., Pilla, B., and Jordan, Z. (2020). Umbrella Reviews. JBI Manual for Evidence Synthesis, JBI. Available online: https:\/\/jbi-global-wiki.refined.site\/space\/MANUAL."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Michalos, A.C. (2014). Health Outcomes. Encyclopedia of Quality of Life and Well-Being Research, Springer.","DOI":"10.1007\/978-94-007-0753-5"},{"key":"ref_12","unstructured":"National Cancer Institute (2020). About Cancer Survivorship Research: Survivorship Definitions, National Cancer Institute."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2019). Cochrane Handbook for Systematic Reviews of Interventions, John Wiley & Sons. [2nd ed.].","DOI":"10.1002\/9781119536604"},{"key":"ref_14","unstructured":"Microsoft Corporation (2018). Microsoft Excel, Microsoft Corporation."},{"key":"ref_15","unstructured":"The EndNote Team (2020). EndNote, Clarivate. [20th ed.]."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Harris, P.A., Taylor, R., Minor, B.L., Elliott, V., Fernandez, M., O\u2019Neal, L., McLeod, L., Delacqua, G., Delacqua, F., and Kirby, J. (2019). The REDCap consortium: Building an international community of software platform partners. J. Biomed. Inform., 95.","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11764-019-00749-x","article-title":"Reproductive outcomes following treatment for a gynecological cancer diagnosis: A systematic review","volume":"13","author":"Gerstl","year":"2019","journal-title":"J. Cancer Surviv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.fertnstert.2013.11.028","article-title":"Prognostic factors of oncologic and reproductive outcomes in fertility-sparing management of endometrial atypical hyperplasia and adenocarcinoma: Systematic review and meta-analysis","volume":"101","author":"Koskas","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102164","DOI":"10.1016\/j.jogoh.2021.102164","article-title":"The evolving role of targeted metformin administration for the prevention and treatment of endometrial cancer: A systematic review and meta-analysis of randomized controlled trials","volume":"50","author":"Prodromidou","year":"2021","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.23736\/S0026-4806.20.07073-1","article-title":"Ultra-minimally invasive approaches for endometrial cancer treatment: Review of the literature","volume":"112","author":"Russa","year":"2021","journal-title":"Minerva Medica"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ygyno.2014.05.008","article-title":"Quality of life (QOL) in women treated for gynecologic malignancies with radiation therapy: A literature review of patient-reported outcomes","volume":"134","author":"Viswanathan","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_23","first-page":"1357","article-title":"The effect of pelvic floor muscle interventions on pelvic floor dysfunction after gynecological cancer treatment: A systematic review","volume":"100","author":"Brennen","year":"2020","journal-title":"Phys. Ther. Rehabil. J."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"SGO Clinical Practice Endometrial Cancer Working Group, Burke, W.M., Orr, J., Leitao, M., Salom, E., Gehrig, P., Olawaiye, A.B., Brewer, M., Boruta, D., and Herzog, T.J. (2014). Endometrial cancer: A review and current management strategies: Part II. Gynecol. Oncol., 134, 393\u2013402.","DOI":"10.1016\/j.ygyno.2014.06.003"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/jcsm.12402","article-title":"Orphan disease status of cancer cachexia in the USA and in the European Union: A systematic review","volume":"10","author":"Anker","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_26","first-page":"2891","article-title":"Sleep deprivation and quality of life among uterine cancer survivors: Systematic review","volume":"30","author":"Alanazi","year":"2022","journal-title":"Support Care Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"107281","DOI":"10.1016\/j.intimp.2020.107281","article-title":"Safety and efficacy of pembrolizumab plus lenvatinib versus pembrolizumab and lenvatinib monotherapies in cancers: A systematic review","volume":"91","author":"Mo","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5152\/balkanmedj.2021.20121","article-title":"Efficacy and safety of bevacizumab-combined chemotherapy for advanced and recurrent endometrial cancer: A Systematic Review and Meta-analysis","volume":"38","author":"Chen","year":"2021","journal-title":"Balk. Med. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.12688\/f1000research.17408.1","article-title":"Recent advances in endometrial cancer: A review of key clinical trials from 2015 to 2019","volume":"8","author":"Charo","year":"2019","journal-title":"F1000Research"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ejogrb.2017.02.021","article-title":"Lymphedema after treatment for endometrial cancer\u2014A review of prevalence and risk factors","volume":"211","author":"Lindqvist","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/jjco\/hyz062","article-title":"Sentinel node navigation surgery in cervical and endometrial cancer: A review","volume":"49","author":"Niikura","year":"2019","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.23736\/S0026-4806.20.07117-7","article-title":"Sentinel lymph node for endometrial cancer treatment: Review of the literature","volume":"112","author":"Zorzato","year":"2021","journal-title":"Minerva Medica"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejogrb.2021.06.007","article-title":"The results of different fertility-sparing treatment modalities and obstetric outcomes in patients with early endometrial cancer and atypical endometrial hyperplasia: Case series of 30 patients and systematic review","volume":"263","author":"Piatek","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_34","first-page":"1973","article-title":"Endometrial carcinoma in women 40 year old or younger: A case report and literature review","volume":"18","author":"Gerli","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/nur.22272","article-title":"Obesity and patient-reported sexual health outcomes in gynecologic cancer survivors: A systematic review","volume":"45","author":"Lee","year":"2022","journal-title":"Res. Nurs. Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ygyno.2015.09.020","article-title":"The impact of BMI on surgical complications and outcomes in endometrial cancer surgery\u2014An institutional study and systematic review of the literature","volume":"139","author":"Bouwman","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ygyno.2020.12.021","article-title":"Endometrial cancer: A Society of Gynecologic Oncology evidence-based review and recommendations","volume":"160","author":"Hamilton","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.ejso.2016.06.400","article-title":"Comparative safety and effectiveness of robot-assisted laparoscopic hysterectomy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis","volume":"42","author":"Park","year":"2016","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_39","first-page":"459","article-title":"Pelvic floor disorders in women with gynecologic malignancies: A systematic review","volume":"29","author":"Ramaseshan","year":"2018","journal-title":"Int. Urogynecol. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1136\/ijgc-2020-001678","article-title":"A systematic review and meta-analysis of sarcopenia as a prognostic factor in gynecological malignancy","volume":"30","author":"Allanson","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ygyno.2016.08.332","article-title":"Assessment of sexual difficulties associated with multi-modal treatment for cervical or endometrial cancer: A systematic review of measurement instruments","volume":"143","author":"White","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.3802\/jgo.2023.34.e49","article-title":"Effects of a fertility-sparing re-treatment for recurrent atypical endometrial hyperplasia and endometrial cancer: A systematic literature review","volume":"34","author":"Murakami","year":"2023","journal-title":"J. Gynecol. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Giampaolino, P., Cafasso, V., Boccia, D., Ascione, M., Mercorio, A., Viciglione, F., Palumbo, M., Serafino, P., Buonfantino, C., and De Angelis, M.C. (2022). Fertility-sparing approach in patients with endometrioid endometrial cancer grade 2 stage IA (FIGO): A qualitative systematic review. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/4070368"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/humupd\/dmab041","article-title":"Chances of pregnancy and live birth among women undergoing conservative management of early-stage endometrial cancer: A systematic review and meta-analysis","volume":"28","author":"Humann","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1080\/01443615.2021.2006164","article-title":"Uterine sparing management in patients with endometrial cancer: A narrative literature review","volume":"42","author":"Zisi","year":"2022","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.23736\/S0026-4806.20.07072-X","article-title":"Fertility-sparing management for endometrial cancer: Review of the literature","volume":"112","author":"Garzon","year":"2021","journal-title":"Minerva Medica"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e8034","DOI":"10.1097\/MD.0000000000008034","article-title":"Comparison of fertility-sparing treatments in patients with early endometrial cancer and atypical complex hyperplasia: A meta-analysis and systematic review","volume":"96","author":"Wei","year":"2017","journal-title":"Medicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejogrb.2015.09.041","article-title":"Fertility-sparing management of low-grade endometrial stromal sarcoma: Analysis of an institutional series and review of the literature","volume":"195","author":"Laurelli","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jmig.2014.08.782","article-title":"Hysteroscopic resection in the management of early-stage endometrial cancer: Report of 2 cases and review of the literature","volume":"22","author":"Arendas","year":"2015","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_50","first-page":"405","article-title":"Conservative treatment in early stage endometrial cancer: A review","volume":"90","author":"Trojano","year":"2019","journal-title":"Acta Bio-Medica L\u2019ateneo Parm."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Tanos, P., Dimitriou, S., Gullo, G., and Tanos, V. (2022). Biomolecular and genetic prognostic factors that can facilitate fertility-sparing treatment (FST) decision making in early stage endometrial cancer (ES-EC): A systematic review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052653"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/GCO.0000000000000604","article-title":"Fertility preserving treatment for gynecologic malignancies: A review of recent literature","volume":"32","author":"Coakley","year":"2020","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e27961","DOI":"10.1097\/MD.0000000000027961","article-title":"Fertility-preserving treatment in patients with early-stage endometrial cancer: A protocol for systematic review and meta-analysis","volume":"100","author":"Zhao","year":"2021","journal-title":"Medicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.critrevonc.2018.09.020","article-title":"Fertility preserving options for gynecologic malignancies: A review of current understanding and future directions","volume":"132","author":"McKenzie","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1574887110666150923115228","article-title":"Management of Endometrial Cancer: A Review","volume":"10","author":"Suri","year":"2015","journal-title":"Rev. Recent Clin. Trials"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jmig.2013.01.005","article-title":"Laparoscopic treatment of endometrial cancer: Systematic review","volume":"20","author":"He","year":"2013","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2217\/fon-2022-0111","article-title":"Assessing the quality of patient-reported outcome measurements for gynecological cancers: A systematic review","volume":"19","author":"Moss","year":"2023","journal-title":"Future Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2016.10.003","article-title":"Targeting mTOR pathway in gynecological malignancies: Biological rationale and systematic review of published data","volume":"108","author":"Kassem","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s11764-021-01042-6","article-title":"Evolving landscape of cancer survivorship research: An analysis of the Journal of Cancer Survivorship, 2007\u20132020","volume":"15","author":"Chan","year":"2021","journal-title":"J. Cancer Surviv."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s41416-018-0310-8","article-title":"Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: Improving patient selection for adjuvant therapy","volume":"119","author":"Wortman","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1470-2045(19)30395-X","article-title":"Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): Patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial","volume":"20","author":"Powell","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S1470-2045(16)30120-6","article-title":"Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): An open-label, multicentre, randomised, phase 3 trial","volume":"17","author":"Powell","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"RAINBO Research Consortium (2022). Refining adjuvant treatment in endometrial cancer based on molecular features: The RAINBO clinical trial program. Int. J. Gynecol. Cancer, 33, 109\u2013117.","DOI":"10.1136\/ijgc-2022-004039"},{"key":"ref_64","unstructured":"Surveillance Research Program National Cancer Institute (2024, August 13). SEER*Explorer: An Interactive Website for SEER Cancer Statistics, Available online: https:\/\/seer.cancer.gov\/statistics-network\/explorer\/."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00066-020-01632-w","article-title":"The brave new world of endometrial cancer: Future implications for adjuvant treatment decisions","volume":"196","author":"Marnitz","year":"2020","journal-title":"Strahlenther. Und Onkol."},{"key":"ref_66","first-page":"262","article-title":"Development of an endometrial cancer survivorship checklist: Umbrella review and expert input","volume":"20","author":"Spence","year":"2024","journal-title":"Asia-Pac. J. Clin. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/16\/2696\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:30:49Z","timestamp":1760034649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/16\/2696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":66,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["cancers17162696"],"URL":"https:\/\/doi.org\/10.3390\/cancers17162696","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]}}}