{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:02:06Z","timestamp":1792987326612,"version":"4.5.0"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Far Eastern Memorial Hospital and Fu Jen Catholic University Joint Research Program","award":["111-FEMH-FJU-05"],"award-info":[{"award-number":["111-FEMH-FJU-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: This study aimed to evaluate the prognostic significance of lymph node density (LND) and the log odds of positive lymph nodes (LODDS) in patients with oral squamous cell carcinoma (OSCC) using a nationwide database. Methods: A retrospective cohort study was conducted using the Taiwan Cancer Registry to identify patients diagnosed with OSCC who underwent surgery for both the primary tumor and neck dissection. Clinicopathological variables were collected, and survival outcomes were analyzed using Cox proportional hazards models. LND was categorized as negative, &lt;0.05, and \u22650.05; LODDS was grouped into four categories: &lt;\u22124, \u22124 to \u22123.5, \u22123.5 to \u22122.5, and \u2265\u22122.5. Results: A total of 1643 female and 15,475 male patients were included, with a mean age of 57.4 years (range, 20\u201398 years). In multivariable Cox regression analyses, LND and LODDS were identified as independent prognostic factors for overall survival. Compared with patients with negative LND, the hazard ratios for LND &lt; 0.05 and LND \u22650.05 were 2.12 (95% CI, 1.90\u20132.36) and 3.35 (95% CI, 3.05\u20133.67), respectively (p &lt; 0.01). Similarly, relative to the lowest LODDS group (&lt;\u22124), the hazard ratios for the higher categories were 1.51 (95% CI, 1.32\u20131.74) for \u22124 to \u22123.5, 2.30 (95% CI, 2.05\u20132.57) for \u22123.5 to \u22122.5, and 4.32 (95% CI, 3.85\u20134.86) for \u2265\u22122.5 (p &lt; 0.01). Conclusions: LND and LODDS are significant prognostic indicators in OSCC. Incorporating these lymph node\u2013based metrics into prognostic models may enhance risk stratification and inform clinical decision-making.<\/jats:p>","DOI":"10.3390\/cancers17162704","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T07:50:46Z","timestamp":1755676246000},"page":"2704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Cervical Lymph Node Positive Metastatic Probability Is a Significant Predictor of Survival for Oral Squamous Cell Carcinoma\u2014A Nationwide Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-1597","authenticated-orcid":false,"given":"Li-Jen","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan 320315, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Master Program of Big Data in Medical Health Care Industry, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-0983","authenticated-orcid":false,"given":"Ping-Chia","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1007-3003","authenticated-orcid":false,"given":"Yong-Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Master Program of Big Data in Medical Health Care Industry, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"},{"name":"Post-Baccalaureate Program in Nursing, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-5319","authenticated-orcid":false,"given":"Chun-Ju","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10055, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-7672","authenticated-orcid":false,"given":"Wen-Chung","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10055, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Lin","family":"You","sequence":"additional","affiliation":[{"name":"Genomics Research Center, Academia Sinica, Taipei 115201, Taiwan"},{"name":"Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-6070","authenticated-orcid":false,"given":"Wan-Lun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Master Program of Big Data in Medical Health Care Industry, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"},{"name":"Data Science Center, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2991\/jegh.k.191008.001","article-title":"Current Cancer Epidemiology","volume":"9","author":"Mattiuzzi","year":"2019","journal-title":"J. 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JOMFP"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/16\/2704\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:31:25Z","timestamp":1760034685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/16\/2704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":30,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["cancers17162704"],"URL":"https:\/\/doi.org\/10.3390\/cancers17162704","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]}}}