{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:39:45Z","timestamp":1760060385912,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Aim: This study aimed to investigate the effectiveness and safety of whole-body hyperthermia (WBH) in cancer patients, identifying predictive factors for successful treatment (reaching target temperature \u2265 38.5 \u00b0C) and assessing adverse effects. Methods: We conducted a retrospective analysis of 397 cancer patients receiving a total of 855 WBH treatment sessions at a single institution between January 2018 and December 2018. Results: A total of 855 WBH treatments were performed on 397 patients (76.6% female; median age 58 years). The most common cancer types included breast cancer (52.4%), followed by prostate cancer (13.1%) and gynecological cancers (10.6%), with 54.7% of patients having metastatic disease. Target temperature was reached in 90.1% (770 of 855) of sessions, with a median treatment time of 202 min and maximum temperature of 40.4 \u00b0C. Common side effects included headache (54.9%), skin reactions (11.7%), and cardiac effects (9.4%), with no serious adverse events. Serum creatinine (p = 0.01, OR 0.30, 95% CI: 0.11\u20130.78) and secale cornutum\/galena co-medication during WBH (p &lt; 0.001, OR 0.26 [0.12, 0.54]) emerged as independent predictors of achieving target temperature in multivariate analysis. Both elevated creatinine levels and the use of secale cornutum\/galena were associated with an approximately 70% lower probability of achieving the target temperature. Conclusions: WBH demonstrates safety in cancer patients with high success rates in reaching target temperatures. Both elevated creatinine levels and the use of secale cornutum\/galena were associated with a lower chance of reaching the target temperature and thus impacting and predicting WBH success.<\/jats:p>","DOI":"10.3390\/cancers17162716","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:46:04Z","timestamp":1755787564000},"page":"2716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Successful Whole-Body Hyperthermia in Cancer Patients: Target Temperature Achievement and Safety Analysis"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-2770","authenticated-orcid":false,"given":"Anna Lena","family":"Hohneck","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Heidelberg, Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) Partner Site Heidelberg\/Mannheim, 68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivien","family":"Schmitz-Solheid","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Gencer","sequence":"additional","affiliation":[{"name":"Klinik Oeschelbronn, Center of Integrative Oncology, Pain Management and Palliative Medicine, 75223 Oeschelbronn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maik","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Klinik Oeschelbronn, Center of Integrative Oncology, Pain Management and Palliative Medicine, 75223 Oeschelbronn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Riess","sequence":"additional","affiliation":[{"name":"AnthroMed \u00d6schelbronn, Centrum f\u00fcr Integrative Medizin, 75223 Oeschelbronn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Gerhards","sequence":"additional","affiliation":[{"name":"AnthroMed \u00d6schelbronn, Centrum f\u00fcr Integrative Medizin, 75223 Oeschelbronn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-7262","authenticated-orcid":false,"given":"Iris","family":"Burkholder","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Fulda University of Applied Sciences, 36037 Fulda, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Heckel-Reusser","sequence":"additional","affiliation":[{"name":"Heckel Medizintechnik GmbH, 73728 Esslingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Gottfried","sequence":"additional","affiliation":[{"name":"Stuttgart Cancer Center (SCC)-Tumorzentrum Eva Mayr-Stihl, Zentrum f\u00fcr Integrative Tumormedizin, 70174 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-8504","authenticated-orcid":false,"given":"Ralf-Dieter","family":"Hofheinz","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10238-022-00846-9","article-title":"Systematic Review about Complementary Medical Hyperthermia in Oncology","volume":"22","author":"Liebl","year":"2022","journal-title":"Clin. 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Fit."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/16\/2716\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:32:42Z","timestamp":1760034762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/16\/2716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":30,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["cancers17162716"],"URL":"https:\/\/doi.org\/10.3390\/cancers17162716","relation":{},"ISSN":["2072-6694"],"issn-type":[{"type":"electronic","value":"2072-6694"}],"subject":[],"published":{"date-parts":[[2025,8,21]]}}}