{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:06:22Z","timestamp":1787785582169,"version":"build-2784847793"},"reference-count":73,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Postoperative pain management is complex and crucial in major gynecology oncological surgery. Currently, there is no well-defined standardized approach, resulting in significant variability in practices worldwide. This systematic review evaluates the effectiveness of analgesic strategies used postoperatively in gynecological cancer surgery. Methods: A systematic review was conducted from inception to June 26th 2024 to identify all randomized controlled trials (RCTs) assessing pain management following any surgery for gynecological cancer. This was performed on the CENTRAL, PubMed, Embase, and MEDLINE databases. Results: A total of 46 RCTs met the inclusion criteria. Of these 5316 patients, 1844 patients had cervical cancer, 99 had endometrial cancer, and 158 had ovarian cancer. The remaining 3215 participants had unspecified gynecological cancers or benign pathology. No studies focused on postoperative analgesia for vulval cancer. A meta-analysis was not feasible due to heterogeneity in study design, analgesic interventions (i.e., opioids, local anesthetics, paracetamol, NSAIDs, and holistic and complementary therapies), and multiple routes of administration (i.e., oral, parenteral, regional, neuraxial, local infiltration, intraperitoneal, intramuscular, patient-controlled, topical, and rectal). No single analgesic modality demonstrated clear superiority. The median Jadad score for methodological quality of the included trials was 4. Conclusions: The limited cancer-specific RCTs and diversity of analgesia modalities utilized reflect the wide range of applications. Postoperative pain is multifactorial and cannot be adequately managed with a single agent. National and international guidelines should aim to establish a standardized framework for postoperative pain management in gynecological cancers, ensuring accessible, evidence-based care that enhances both short- and long-term patient quality of life.<\/jats:p>","DOI":"10.3390\/cancers17162718","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:46:04Z","timestamp":1755787564000},"page":"2718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postoperative Pain Following Gynecology Oncological Surgery: A Systematic Review by Tumor Site"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3337-6816","authenticated-orcid":false,"given":"Selina","family":"Chiu","sequence":"first","affiliation":[{"name":"Division of Surgery and Cancer, Imperial College London, London W12 0NN, UK"},{"name":"Department of Gynaecology Oncology, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6077-4737","authenticated-orcid":false,"given":"Helen","family":"Staley","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Chelsea and Westminster Hospital NHS Foundation Trust, London SW10 9NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-5285","authenticated-orcid":false,"given":"Xiaoxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics, Imperial College Healthcare NHS Trust, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mitra","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Imperial College London, London W12 0NN, UK"},{"name":"Department of Gynaecology Oncology, West Hertfordshire Teaching Hospitals NHS Trust, Watford WD18 0HB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-6420","authenticated-orcid":false,"given":"Flavia","family":"Sorbi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Florence, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Richard","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Yazbek","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaf","family":"Ghaem-Maghami","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Imperial College London, London W12 0NN, UK"},{"name":"Department of Gynaecology Oncology, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanooj","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics, Imperial College Healthcare NHS Trust, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Fotopoulou","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Imperial College London, London W12 0NN, UK"},{"name":"Department of Gynaecology Oncology, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdjan","family":"Saso","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Imperial College London, London W12 0NN, UK"},{"name":"Department of Gynaecology Oncology, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdm056","article-title":"Prevalence of Pain in Patients with Cancer: A Systematic Review of the Past 40 Years","volume":"18","author":"Kessels","year":"2007","journal-title":"Ann. 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