{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:22:15Z","timestamp":1792120935532,"version":"4.4.0"},"reference-count":55,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Multiple myeloma (MM) predominantly affects older adults, a heterogeneous population. Comprehensive Geriatric Assessment (CGA) and abbreviated tools support individualized treatment planning. This study aimed to evaluate the feasibility of CGA and its impact on clinical outcomes in this subgroup of patients. Methods: Prospective, observational, and single-center study including patients aged \u226565 years assessed at MM diagnosis and one year later in an onco-hematogeriatrics clinic. A CGA was performed, and frailty was evaluated using the following: G8, Geriatric Assessment in Hematology (GAH), Clinical Frailty Scale (CFS), Frail-VIG Index (FI-VIG), modified Fried phenotype, International Myeloma Working Group Frailty Index (IMWG-FI), and Revised Myeloma Comorbidity Index (R-MCI). At one year, patients were reassessed; treatment response (IMWG criteria), adverse events (CTCAE v5.03), and mortality were recorded. Results: Fifty-five patients (mean age 78.0 \u00b1 5.4 years, 58.2% female) diagnosed between December 2019 and May 2024 were included. CGA completion exceeded 90% at both time points. At one year, 9 patients (16.4%) had died, and 16 (29.1%) achieved complete response, with daratumumab-lenalidomide-dexamethasone (DRd) being the most used regimen. Frailty prevalence significantly declined (FRAIL: p = 0.012; CFS: p = 0.016; IMWG-FI: p = 0.020). GAH was significantly associated with \u2265grade 3 hematologic toxicity (OR = 5.67, p = 0.004) and mortality (AUC = 0.750, p = 0.027). FI-VIG also predicted mortality (OR = 14.67, p = 0.026). Conclusions: CGA and its abbreviated forms are feasible and clinically valuable tools for identifying vulnerable older adults with MM, enabling treatment individualization and improved risk stratification.<\/jats:p>","DOI":"10.3390\/cancers17172904","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T15:31:21Z","timestamp":1756999881000},"page":"2904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comprehensive Geriatric Assessment of Older Patients with Multiple Myeloma: A Prospective Observational Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-5164","authenticated-orcid":false,"given":"Paula","family":"Sobrini-Morillo","sequence":"first","affiliation":[{"name":"Servicio de Geriatr\u00eda, Hospital Universitario Puerta de Hierro de Majadahonda, 28222 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3298-1486","authenticated-orcid":false,"given":"Celia","family":"Corral-Tuesta","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"S\u00e1nchez-Castellano","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-8851","authenticated-orcid":false,"given":"Tamara","family":"Guti\u00e9rrez-Blanco","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1618-0905","authenticated-orcid":false,"given":"Pablo","family":"Palomo-Rumschisky","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Gabriela","family":"\u00c1lvarez-Pinheiro","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Blanchard-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1698-0624","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Serra-Rexach","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Institute for Health Research of the Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Biomedical Research Networking Centre on Frailty and Healthy Ageing, CIBERFES, 28029 Madrid, Spain"},{"name":"Department of Medicine, School of Medicine, Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso J.","family":"Cruz-Jentoft","sequence":"additional","affiliation":[{"name":"Servicio de Geriatr\u00eda, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.annonc.2020.11.014","article-title":"Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up","volume":"32","author":"Dimopoulos","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_2","first-page":"17","article-title":"Cancer Statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2015.08.003","article-title":"Cancer and Aging","volume":"32","author":"Li","year":"2016","journal-title":"Clin. Geriatr. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jnci\/djy111","article-title":"Competing Risks in Older Patients with Cancer: A Systematic Review of Geriatric Oncology Trials","volume":"110","author":"Burdett","year":"2018","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"afac104","DOI":"10.1093\/ageing\/afac104","article-title":"Comprehensive Geriatric Assessment in Older People: An Umbrella Review of Health Outcomes","volume":"51","author":"Veronese","year":"2022","journal-title":"Age Ageing"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/ageing\/afx166","article-title":"What Is Comprehensive Geriatric Assessment (CGA)? An Umbrella Review","volume":"47","author":"Parker","year":"2018","journal-title":"Age Ageing"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41408-022-00779-2","article-title":"The Prevalence and Outcomes of Frail Older Adults in Clinical Trials in Multiple Myeloma: A Systematic Review","volume":"13","author":"Mian","year":"2023","journal-title":"Blood Cancer J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1182\/blood-2014-12-615187","article-title":"Geriatric Assessment Predicts Survival and Toxicities in Elderly Myeloma Patients: An International Myeloma Working Group Report","volume":"125","author":"Palumbo","year":"2015","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1200\/JCO.2013.54.8347","article-title":"International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients with Cancer","volume":"32","author":"Wildiers","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1200\/JCO.23.00933","article-title":"Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Systemic Cancer Therapy: ASCO Guideline Update","volume":"41","author":"Dale","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.6004\/jnccn.2021.0043","article-title":"NCCN Guidelines\u00ae Insights: Older Adult Oncology, Version 1.2021: Featured Updates to the NCCN Guidelines","volume":"19","author":"Dotan","year":"2021","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_12","first-page":"101401","article-title":"Geriatric Assessment in Hematology Scale Predicts Treatment Tolerability in Older Patients Diagnosed with Hematological Malignancies: The RETROGAH Study","volume":"14","author":"Iglesias","year":"2022","journal-title":"J. Geriatr. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ramos, F., Gonz\u00e1lez-Carmona, P., Porras-Guerra, M.I., Jim\u00e9nez-Mola, S., Mart\u00ednez-Pel\u00e1ez, A.M., Blanco-Cabielles, A., Conde, S., Ahmadi, A., Castellanos, M., and Cerd\u00e1, S. (2020). Patient General Condition at Diagnosis: A Systematic Evaluation for Adults Diagnosed with Hematologic Malignancies. J. Pers. Med., 10.","DOI":"10.3390\/jpm10030106"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1200\/JCO.21.00165","article-title":"Decision Making in Older Adults with Cancer","volume":"39","author":"DuMontier","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0140-6736(21)01789-X","article-title":"Evaluation of Geriatric Assessment and Management on the Toxic Effects of Cancer Treatment (GAP70+): A Cluster-Randomised Study","volume":"398","author":"Mohile","year":"2021","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jgo.2018.09.003","article-title":"Multidisciplinary Care in the Hematology Clinic: Implementation of Geriatric Oncology","volume":"10","author":"Goede","year":"2019","journal-title":"J. Geriatr. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3324\/haematol.2021.278802","article-title":"Randomized Controlled Trial of Geriatric Consultation versus Standard Care in Older Adults with Hematologic Malignancies","volume":"107","author":"DuMontier","year":"2021","journal-title":"Haematologica"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jgo.2022.04.008","article-title":"Geriatric Assessment in the Management of Older Patients with Cancer\u2014A Systematic Review (Update)","volume":"13","author":"Hamaker","year":"2022","journal-title":"J. Geriatr. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e209265","DOI":"10.1001\/jamanetworkopen.2020.9265","article-title":"Association of Geriatric Comanagement and 90-Day Postoperative Mortality Among Patients Aged 75 Years and Older with Cancer","volume":"3","author":"Shahrokni","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"afab211","DOI":"10.1093\/ageing\/afab211","article-title":"Comprehensive Geriatric Assessment in Newly Diagnosed Older Myeloma Patients: A Multicentre, Prospective, Non-Interventional Study","volume":"51","author":"Yao","year":"2022","journal-title":"Age Ageing"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/CCO.0000000000000792","article-title":"Geriatric Assessments and Frailty Scores in Multiple Myeloma Patients: A Needed Tool for Individualized Treatment?","volume":"33","author":"Gengenbach","year":"2021","journal-title":"Curr. Opin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group Updated Criteria for the Diagnosis of Multiple Myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A New Method of Classifying Prognostic Comorbidity in Longitudinal Studies: Development and Validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1200\/JCO.2015.61.2267","article-title":"Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group","volume":"33","author":"Palumbo","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0895-4356(89)90065-6","article-title":"Improving the Sensitivity of the Barthel Index for Stroke Rehabilitation","volume":"42","author":"Shah","year":"1989","journal-title":"J. Clin. Epidemiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.3390\/curroncol28050339","article-title":"Cognitive Assessment Tools Recommended in Geriatric Oncology Guidelines: A Rapid Review","volume":"28","author":"Tuch","year":"2021","journal-title":"Curr. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"De la Iglesia, J.M., Vilches, M.C.O., Herrero, R.D., Colomer, C.A., Tabern\u00e9, C.A., and Luque, R.L. (2002). Versi\u00f3n espa\u00f1ola del cuestionario de Yesavage abreviado (GDS) para el despistaje de depresi\u00f3n en mayores de 65 a\u00f1os: Adaptaci\u00f3n y validaci\u00f3n. Medifam, 12, (In Spanish).","DOI":"10.4321\/S1131-57682002001000003"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jcsm.12383","article-title":"GLIM Criteria for the Diagnosis of Malnutrition\u2014A Consensus Report from the Global Clinical Nutrition Community","volume":"10","author":"Cederholm","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e2138911","DOI":"10.1001\/jamanetworkopen.2021.38911","article-title":"Evaluation of Clinical Practice Guidelines on Fall Prevention and Management for Older Adults: A Systematic Review","volume":"4","author":"Kamkar","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101407","DOI":"10.1016\/j.regg.2023.101407","article-title":"Versi\u00f3n en espa\u00f1ol de los criterios STOPP\/START 3. Avances en la detecci\u00f3n de la prescripci\u00f3n inapropiada de medicamentos en personas mayores","volume":"58","author":"Mendoza","year":"2023","journal-title":"Rev. Esp. Geriatr\u00eda Gerontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","article-title":"ESPEN Practical Guideline: Clinical Nutrition in Cancer","volume":"40","author":"Muscaritoli","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100401","DOI":"10.1016\/j.jnha.2024.100401","article-title":"Global Consensus on Optimal Exercise Recommendations for Enhancing Healthy Longevity in Older Adults (ICFSR)","volume":"29","author":"Izquierdo","year":"2025","journal-title":"J. Nutr. Health Aging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jgo.2019.04.016","article-title":"A Systematic Review on the Association of the G8 with Geriatric Assessment, Prognosis and Course of Treatment in Older Patients with Cancer","volume":"10","author":"Scheepers","year":"2019","journal-title":"J. Geriatr. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.regg.2016.09.003","article-title":"\u00cdndice fr\u00e1gil-VIG: Dise\u00f1o y evaluaci\u00f3n de un \u00edndice de fragilidad basado en la Valoraci\u00f3n Integral Geri\u00e1trica","volume":"52","author":"Martori","year":"2017","journal-title":"Rev. Esp. Geriatr\u00eda Gerontol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJMra2301292","article-title":"Frailty in Older Adults","volume":"391","author":"Kim","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European Consensus on Definition and Diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1016\/S1470-2045(16)30206-6","article-title":"International Myeloma Working Group Consensus Criteria for Response and Minimal Residual Disease Assessment in Multiple Myeloma","volume":"17","author":"Kumar","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_39","unstructured":"U.S. Department of Health and Human Services, National Institutes of Health, and National Cancer Institute (2025, August 30). Common Terminology Criteria for Adverse Events (CTCAE), Available online: https:\/\/dctd.cancer.gov\/research\/ctep-trials\/for-sites\/adverse-events\/ctcae-v5-5x7.pdf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1182\/blood-2024-203170","article-title":"GEM2017Fit Phase 3 Trial in Fit Elderly Patients (Aged 65\u201380) with Newly Diagnosed Myeloma: Impact of Daratumumab at Induction and\/or Consolidation","volume":"144","author":"Mateos","year":"2024","journal-title":"Blood"},{"key":"ref_41","unstructured":"Mateos, M.V., Mart\u00ednez-L\u00f3pez, J., Hern\u00e1ndez-Rivas, J.\u00c1., de la Rubia, J., Garc\u00eda-Sanz, R., Ocio, E.M., Rosi\u00f1ol, L., Blade, J., Alegre, A., and Paiva, B. (2021). Gu\u00eda de Pr\u00e1ctica Cl\u00ednica en Mieloma M\u00faltiple, Sociedad Espa\u00f1ola de Hematolog\u00eda y Hemoterapia. Grupo Espa\u00f1ol de Mieloma."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3324\/haematol.2021.279927","article-title":"For Older Adults with Hematologic Malignancies, a Comprehensive Geriatric Assessment Matters","volume":"107","author":"Cordoba","year":"2022","journal-title":"Haematologica"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"E754","DOI":"10.1016\/S2666-7568(21)00182-3","article-title":"Implementation of Geriatric Haematology Programmes for the Treatment of Older People with Haematological Malignancies in Low-Resource Settings","volume":"2","author":"Loh","year":"2021","journal-title":"Lancet Healthy Longev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41408-023-00843-5","article-title":"Dynamic Frailty Risk Assessment among Older Adults with Multiple Myeloma: A Population-Based Cohort Study","volume":"13","author":"Mian","year":"2023","journal-title":"Blood Cancer J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1080\/10428194.2024.2340052","article-title":"Prevalence of Geriatric Impairments and Frailty Categorization among Real-World Patients with Multiple Myeloma: A Prospective Cohort Study (MFRAIL)","volume":"65","author":"Haider","year":"2024","journal-title":"Leuk. Lymphoma"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jgo.2018.03.014","article-title":"The Effect of a Geriatric Evaluation on Treatment Decisions and Outcome for Older Cancer Patients\u2014A Systematic Review","volume":"9","author":"Hamaker","year":"2018","journal-title":"J. Geriatr. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jgo.2016.12.008","article-title":"Further Psychometric Validation of the GAH Scale: Responsiveness and Effect Size","volume":"8","author":"Rivas","year":"2017","journal-title":"J. Geriatr. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ambl\u00e0s-Novellas, J., Martori, J.C., Espaulella, J., Oller, R., Molist-Brunet, N., Inzitari, M., and Romero-Ortuno, R. (2018). Frail-VIG Index: A Concise Frailty Evaluation Tool for Rapid Geriatric Assessment. BMC Geriatr., 18.","DOI":"10.1186\/s12877-018-0718-2"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"105208","DOI":"10.1016\/j.archger.2023.105208","article-title":"Frailty and Mortality: Utility of Frail-VIG Index in ED Short-Stay Units for Older Adults","volume":"115","year":"2023","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s41999-025-01167-2","article-title":"Validation of the Frail-VIG Frailty Index in Geriatric Population with Femur Fracture","volume":"16","author":"Moreno","year":"2025","journal-title":"Eur. Geriatr. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3324\/haematol.2016.148189","article-title":"Geriatric Assessment in Multiple Myeloma Patients: Validation of the International Myeloma Working Group (IMWG) Score and Comparison with Other Common Comorbidity Scores","volume":"101","author":"Engelhardt","year":"2016","journal-title":"Haematologica"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Muzyka, M., Ottaviani, S., Caffa, I., Bonfiglio, T., Parisi, E., Guijarro, A., Tagliafico, L., Lemoli, R.M., Ponzano, M., and Marelli, C. (2025). Prognostic Frailty-Based Determinants of Long-Term Mortality in Older Patients with Newly Diagnosed Multiple Myeloma. Cancers, 17.","DOI":"10.3390\/cancers17050789"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jgo.2018.10.010","article-title":"Performance of the International Myeloma Working Group Myeloma Frailty Score among Patients 75 and Older","volume":"10","author":"Murillo","year":"2018","journal-title":"J. Geriatr. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/10428194.2024.2419375","article-title":"Frailty Measures in Multiple Myeloma: Evaluating the Impact on Outcomes and Quality-of-Life in Clinical Trials and Real-World Practice","volume":"66","author":"Pianko","year":"2025","journal-title":"Leuk. Lymphoma"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1007\/s00277-018-3449-8","article-title":"Survival of Non-Transplant Patients with Multiple Myeloma in Routine Care Differs from That in Clinical Trials\u2014Data from the Prospective German Tumour Registry Lymphatic Neoplasms","volume":"97","author":"Knauf","year":"2018","journal-title":"Ann. Hematol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/17\/2904\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:39:30Z","timestamp":1760035170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/17\/2904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":55,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["cancers17172904"],"URL":"https:\/\/doi.org\/10.3390\/cancers17172904","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]}}}